BRPI0109200B8 - compostos e composições farmacêuticas - Google Patents

compostos e composições farmacêuticas

Info

Publication number
BRPI0109200B8
BRPI0109200B8 BRPI0109200A BR0109200A BRPI0109200B8 BR PI0109200 B8 BRPI0109200 B8 BR PI0109200B8 BR PI0109200 A BRPI0109200 A BR PI0109200A BR 0109200 A BR0109200 A BR 0109200A BR PI0109200 B8 BRPI0109200 B8 BR PI0109200B8
Authority
BR
Brazil
Prior art keywords
compounds
pharmaceutical compositions
preparation
relates
novel
Prior art date
Application number
BRPI0109200A
Other languages
English (en)
Other versions
BR0109200A (pt
BRPI0109200B1 (pt
Inventor
Aissaoui Hamed
Clozel Martine
Cappi Michael
Koberstein Ralf
Fischli Walter
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BR0109200A publication Critical patent/BR0109200A/pt
Publication of BRPI0109200B1 publication Critical patent/BRPI0109200B1/pt
Publication of BRPI0109200B8 publication Critical patent/BRPI0109200B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"compostos, processo para a preparação de compostos, composições farmacêuticas, e, processo para a fabricação das mesmas". a invenção refere-se a novos derivados de 1,2,3,4-tetraidroisoquinolina da fórmula (i) e a seu uso como ingredientes ativos na preparação de composições farmacêuticas. a invenção também se refere a aspectos relacionados, incluindo processos para a preparação dos compostos, composições farmacêuticas contendo um ou mais dos compostos e especialmente seu uso como antagonistas de receptor de orexina.
BRPI0109200A 2000-03-14 2001-03-12 compostos e composições farmacêuticas BRPI0109200B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0002245 2000-03-14
PCT/EP2001/002733 WO2001068609A1 (en) 2000-03-14 2001-03-12 1,2,3,4-tetrahydroisoquinoline derivatives

Publications (3)

Publication Number Publication Date
BR0109200A BR0109200A (pt) 2003-06-03
BRPI0109200B1 BRPI0109200B1 (pt) 2015-08-11
BRPI0109200B8 true BRPI0109200B8 (pt) 2021-05-25

Family

ID=8163870

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0109200A BRPI0109200B8 (pt) 2000-03-14 2001-03-12 compostos e composições farmacêuticas

Country Status (18)

Country Link
US (1) US6703392B2 (pt)
JP (1) JP4009460B2 (pt)
KR (2) KR20070087103A (pt)
CN (1) CN100393703C (pt)
AT (1) ATE286500T1 (pt)
AU (2) AU2001260113B2 (pt)
BR (1) BRPI0109200B8 (pt)
CA (1) CA2402431C (pt)
DE (1) DE60108236T2 (pt)
ES (1) ES2234840T3 (pt)
HU (1) HU227811B1 (pt)
IL (2) IL150986A0 (pt)
MX (1) MXPA02008797A (pt)
NO (1) NO324932B1 (pt)
NZ (1) NZ520624A (pt)
PT (1) PT1274687E (pt)
WO (1) WO2001068609A1 (pt)
ZA (1) ZA200206467B (pt)

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WO2001068609A1 (en) 2001-09-20
WO2001068609B1 (en) 2002-02-21
US6703392B2 (en) 2004-03-09
JP4009460B2 (ja) 2007-11-14
HU227811B1 (en) 2012-03-28
NO324932B1 (no) 2008-01-07
PT1274687E (pt) 2005-04-29
ZA200206467B (en) 2003-11-13
IL150986A0 (en) 2003-02-12
IL150986A (en) 2007-07-04
KR20070087103A (ko) 2007-08-27
NO20024339L (no) 2002-09-11
CA2402431A1 (en) 2001-09-20
ES2234840T3 (es) 2005-07-01
KR100842698B1 (ko) 2008-07-01
HUP0300207A3 (en) 2005-07-28
JP2003527374A (ja) 2003-09-16
DE60108236T2 (de) 2005-12-22
MXPA02008797A (es) 2005-09-08
US20030176415A1 (en) 2003-09-18
CN100393703C (zh) 2008-06-11
BR0109200A (pt) 2003-06-03
CN1416420A (zh) 2003-05-07
NO20024339D0 (no) 2002-09-11
ATE286500T1 (de) 2005-01-15
KR20020080465A (ko) 2002-10-23
DE60108236D1 (de) 2005-02-10
NZ520624A (en) 2004-02-27
AU2001260113B2 (en) 2006-04-06
BRPI0109200B1 (pt) 2015-08-11
CA2402431C (en) 2009-10-06
HUP0300207A2 (en) 2003-05-28
AU6011301A (en) 2001-09-24

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