BG33586A3 - Method for pentahydrate of cephalosporine derivative obtaining - Google Patents

Method for pentahydrate of cephalosporine derivative obtaining

Info

Publication number: BG33586A3
Authority: BG; Bulgaria
Prior art keywords: pentahydrate; cef; acetamide; carboxylic acid; derivative obtaining
Prior art date: 1979-10-02

Application number

BG049206A

Other languages

Bulgarian (bg)

English (en)

Inventor

Alastair Brodie

Lewis Wetherill

Original Assignee

Glaxo Group Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-02

Filing date

1980-10-01

Publication date

1983-03-15

1980-10-01 Application filed by Glaxo Group Ltd. filed Critical Glaxo Group Ltd.

1983-03-15 Publication of BG33586A3 publication Critical patent/BG33586A3/xx

Links

150000004686 pentahydrates Chemical class 0.000 title abstract 4
HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 title 1
DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 4
229930186147 Cephalosporin Natural products 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
229940124587 cephalosporin Drugs 0.000 abstract 1
150000001780 cephalosporins Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG049206A 1979-10-02 1980-10-01 Method for pentahydrate of cephalosporine derivative obtaining BG33586A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7934204		1979-10-02

Publications (1)

Publication Number	Publication Date
BG33586A3 true BG33586A3 (en)	1983-03-15

Family

ID=10508246

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG049206A BG33586A3 (en)	1979-10-02	1980-10-01	Method for pentahydrate of cephalosporine derivative obtaining

Country Status (36)

Country	Link
US (1)	US4329453A (pt)
JP (1)	JPS5657791A (pt)
KR (1)	KR840001776B1 (pt)
AT (1)	AT368161B (pt)
AU (1)	AU539519B2 (pt)
BE (1)	BE885489A (pt)
BG (1)	BG33586A3 (pt)
CA (1)	CA1142919A (pt)
CH (1)	CH645118A5 (pt)
CS (1)	CS214721B2 (pt)
CY (1)	CY1338A (pt)
DD (1)	DD153376A5 (pt)
DE (1)	DE3037102C2 (pt)
DK (1)	DK155525C (pt)
EC (1)	ECSP941099A (pt)
ES (1)	ES8106908A1 (pt)
FI (1)	FI71157C (pt)
FR (1)	FR2466467A1 (pt)
GB (1)	GB2063871B (pt)
GR (1)	GR69123B (pt)
HK (1)	HK78686A (pt)
HU (1)	HU184835B (pt)
IT (1)	IT1144006B (pt)
KE (1)	KE3641A (pt)
MX (1)	MX6545E (pt)
MY (1)	MY8500315A (pt)
NL (1)	NL190329C (pt)
NO (1)	NO156246C (pt)
PL (1)	PL126606B1 (pt)
PT (1)	PT71860B (pt)
RO (1)	RO82721B (pt)
SE (1)	SE449614B (pt)
SU (1)	SU942599A3 (pt)
UA (1)	UA7208A1 (pt)
YU (1)	YU42357B (pt)
ZA (1)	ZA806081B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4443444A (en) *	1980-08-11	1984-04-17	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
US4427677A (en)	1980-12-31	1984-01-24	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds
US4474954A (en) *	1981-12-07	1984-10-02	Bristol-Myers Company	Intermediates for cephalosporin derivatives
US4394503A (en)	1981-12-07	1983-07-19	Bristol-Myers Company	Cephalosporin derivatives
JPS58198489A (ja) *	1982-05-14	1983-11-18	Meiji Seika Kaisha Ltd	７β−（２Ｄ−２−アミノ−２−カルボキシエチルチオアセトアミド）−７α−メトキシ−３−（１−メチル−１Ｈ−テトラゾ−ル−５−イル）−チオメチル−３−セフエム−４−カルボン酸ナトリウム塩の七水和物及びその製造方法
ES525492A0 (es) *	1982-09-10	1985-02-01	Glaxo Group Ltd	Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
DE3313818A1 (de) *	1983-04-16	1984-10-18	Hoechst Ag, 6230 Frankfurt	Neue kristallmodifikation von ceftazidim
DE3313816A1 (de) *	1983-04-16	1984-10-18	Hoechst Ag, 6230 Frankfurt	Neue kristallmodifikation von ceftazidim
GB8406218D0 (en) *	1984-03-09	1984-04-11	Glaxo Group Ltd	Process
US4537959A (en) *	1984-03-26	1985-08-27	Eli Lilly And Company	Crystalline cephalosporin antibiotic salt
JPS60231683A (ja) *	1984-05-02	1985-11-18	Teijin Ltd	セフアロスポリン誘導体その製造法及びそれを有効成分とする抗菌剤
US4616080A (en) *	1984-07-02	1986-10-07	Eli Lilly And Company	Simplified process of forming crystalline ceftazidime pentahydrate
US4626534A (en) *	1984-07-23	1986-12-02	Eli Lilly And Company	Pharmaceutical formulation
IL75800A (en) *	1984-07-23	1988-11-30	Lilly Co Eli	Pharmaceutical formulations comprising ceftazidime pentahydrate and amorphous lactose
EP0187450B1 (en) *	1984-11-08	1991-01-30	Eli Lilly And Company	Process for the preparation of crystalline ceftazidime pentahydrate
US4659813A (en) *	1984-11-08	1987-04-21	Eli Lilly And Company	Crystallization process for ceftazidime derivative
WO1988010263A1 (fr) *	1987-06-25	1988-12-29	Banyu Pharmaceutical Co., Ltd.	Composes cristallins de cephalosporine, procede de preparation et produits intermediaires pour la preparation de ces composes
US4994451A (en) *	1988-01-19	1991-02-19	Bristol-Myers Company	Cephalosporin salts and injectable compositions
US5244891A (en) *	1985-08-05	1993-09-14	Bristol-Myers Squibb Company	Injectable compositions of cefepime dihydrochloride hydrate
US4910301A (en) *	1985-08-05	1990-03-20	Bristol-Myers Company	Cefepime cephalosporin salts
US4954624A (en) *	1986-10-07	1990-09-04	Sandoz Ltd.	Process for the production of cephalosporin derivatives
AT387390B (de) *	1986-10-07	1989-01-10	Biochemie Gmbh	Verfahren zur herstellung des antibiotikums (6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-(2-carboxy
US5021564A (en) *	1987-02-02	1991-06-04	Eli Lilly And Company	Process for preparing ceftazidime pentahydrate
DE3871542T2 (de) *	1987-02-02	1992-12-24	Lilly Co Eli	Verfahren zur herstellung von ceftazidime-pentahydrat.
WO1988010262A1 (en) *	1987-06-25	1988-12-29	Banyu Pharmaceutical Co., Ltd.	Crystalline cephalosporin compound
GB8802622D0 (en) *	1988-02-05	1988-03-02	Glaxo Group Ltd	Chemical compound
KR940000112B1 (ko) *	1990-07-05	1994-01-05	주식회사 대웅제약	신규의 3-치환 세펨화합물 및 그의 제조방법
US5831085A (en) *	1997-01-16	1998-11-03	Lupin Laboratories Limited	Process for manufacture of cephalosporin such as ceftazidime and intermediate thereof
CN1328281C (zh) *	2004-11-16	2007-07-25	广州白云山制药股份有限公司	头孢他啶的纯化方法
CN102875576A (zh) *	2012-10-31	2013-01-16	苏州致君万庆药业有限公司	一种抗菌素头孢他啶的合成、注射用头孢他啶及其制备方法
CN102924483B (zh) *	2012-10-31	2015-06-17	海南合瑞制药股份有限公司	一种头孢他啶晶体化合物、其制备方法及其无菌混合粉形式的药物组合物
CN104876949A (zh) *	2015-05-28	2015-09-02	浙江长典医药有限公司	一种小儿用头孢他啶化合物实体及其制剂
CN106420658A (zh) *	2016-09-23	2017-02-22	临沂草之美医药科技有限公司	一种治疗外科手术感染的药物头孢他啶胶囊
CN109111467A (zh) *	2017-06-22	2019-01-01	宁应	一种51/4水头孢他啶化合物及其药物组合物制剂

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR228726A1 (es) *	1978-05-26	1983-04-15	Glaxo Group Ltd	Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato

1980
- 1980-09-09 US US06/185,883 patent/US4329453A/en not_active Expired - Lifetime
- 1980-10-01 HU HU802393A patent/HU184835B/hu unknown
- 1980-10-01 PT PT71860A patent/PT71860B/pt unknown
- 1980-10-01 BG BG049206A patent/BG33586A3/xx unknown
- 1980-10-01 GB GB8031703A patent/GB2063871B/en not_active Expired
- 1980-10-01 DD DD80224266A patent/DD153376A5/de not_active IP Right Cessation
- 1980-10-01 DE DE3037102A patent/DE3037102C2/de not_active Expired
- 1980-10-01 CH CH734180A patent/CH645118A5/de not_active IP Right Cessation
- 1980-10-01 FR FR8021033A patent/FR2466467A1/fr active Granted
- 1980-10-01 CS CS806627A patent/CS214721B2/cs unknown
- 1980-10-01 SE SE8006861A patent/SE449614B/sv not_active IP Right Cessation
- 1980-10-01 NO NO802913A patent/NO156246C/no unknown
- 1980-10-01 IT IT49783/80A patent/IT1144006B/it active Protection Beyond IP Right Term
- 1980-10-01 SU SU802987392A patent/SU942599A3/ru active
- 1980-10-01 BE BE0/202301A patent/BE885489A/fr not_active IP Right Cessation
- 1980-10-01 UA UA2987392A patent/UA7208A1/uk unknown
- 1980-10-01 GR GR63023A patent/GR69123B/el unknown
- 1980-10-01 FI FI803126A patent/FI71157C/fi not_active IP Right Cessation
- 1980-10-01 DK DK414780A patent/DK155525C/da not_active IP Right Cessation
- 1980-10-01 AT AT0490080A patent/AT368161B/de not_active IP Right Cessation
- 1980-10-01 JP JP13822480A patent/JPS5657791A/ja active Granted
- 1980-10-01 MX MX809068U patent/MX6545E/es unknown
- 1980-10-01 YU YU2497/80A patent/YU42357B/xx unknown
- 1980-10-01 CY CY1338A patent/CY1338A/en unknown
- 1980-10-01 ES ES495534A patent/ES8106908A1/es not_active Expired
- 1980-10-01 NL NLAANVRAGE8005443,A patent/NL190329C/xx not_active IP Right Cessation
- 1980-10-01 ZA ZA00806081A patent/ZA806081B/xx unknown
- 1980-10-01 CA CA000361346A patent/CA1142919A/en not_active Expired
- 1980-10-01 PL PL1980227019A patent/PL126606B1/pl unknown
- 1980-10-01 AU AU62882/80A patent/AU539519B2/en not_active Expired
- 1980-10-01 RO RO102255A patent/RO82721B/ro unknown
- 1980-10-02 KR KR1019800003810A patent/KR840001776B1/ko not_active Expired
1985
- 1985-12-30 MY MY315/85A patent/MY8500315A/xx unknown
1986
- 1986-05-29 KE KE3641A patent/KE3641A/xx unknown
- 1986-10-16 HK HK786/86A patent/HK78686A/xx not_active IP Right Cessation
1994
- 1994-05-26 EC EC1994001099A patent/ECSP941099A/es unknown

Also Published As

Publication number	Publication date
NO802913L (no)	1981-04-03
FI803126L (fi)	1981-04-03
ECSP941099A (es)	1995-01-16
FI71157B (fi)	1986-08-14
YU42357B (en)	1988-08-31
ES495534A0 (es)	1981-09-01
YU249780A (en)	1983-02-28
HU184835B (en)	1984-10-29
HK78686A (en)	1986-10-24
DD153376A5 (de)	1982-01-06
US4329453A (en)	1982-05-11
FI71157C (fi)	1986-11-24
ATA490080A (de)	1982-01-15
PL126606B1 (en)	1983-08-31
CY1338A (en)	1987-01-16
CH645118A5 (de)	1984-09-14
GR69123B (pt)	1982-05-03
RO82721B (ro)	1984-10-30
JPH0128036B2 (pt)	1989-05-31
FR2466467B1 (pt)	1984-02-10
CA1142919A (en)	1983-03-15
NL190329B (nl)	1993-08-16
NL190329C (nl)	1994-01-17
SE449614B (sv)	1987-05-11
DE3037102C2 (de)	1986-04-10
SE8006861L (sv)	1981-04-03
JPS5657791A (en)	1981-05-20
BE885489A (fr)	1981-04-01
KR840001776B1 (ko)	1984-10-19
IT1144006B (it)	1986-10-29
DK155525C (da)	1989-09-04
NO156246B (no)	1987-05-11
UA7208A1 (uk)	1995-06-30
GB2063871B (en)	1983-06-02
CS214721B2 (en)	1982-05-28
MX6545E (es)	1985-07-10
NO156246C (no)	1987-08-19
PT71860B (en)	1982-04-02
PT71860A (en)	1980-11-01
RO82721A (ro)	1984-09-29
PL227019A1 (pt)	1981-06-05
GB2063871A (en)	1981-06-10
KR830004317A (ko)	1983-07-09
SU942599A3 (ru)	1982-07-07
ZA806081B (en)	1982-05-26
DK155525B (da)	1989-04-17
ES8106908A1 (es)	1981-09-01
FR2466467A1 (fr)	1981-04-10
IT8049783A0 (it)	1980-10-01
AU6288280A (en)	1981-04-09
NL8005443A (nl)	1981-04-06
DE3037102A1 (de)	1981-04-23
AT368161B (de)	1982-09-27
AU539519B2 (en)	1984-10-04
KE3641A (en)	1986-07-11
DK414780A (da)	1981-04-03
MY8500315A (en)	1985-12-31

Publication	Publication Date	Title
UA7208A1 (uk)	1995-06-30	Спосіб одержання пентагідрату (6r,7r)-7-[(z)-2-(2-амінотіазол-4-іл)-2-(2-карбоксіпроп-2-оксііміно)-ацетамідо]-3-(1-пирідинійметил)-цеф-3-ем-4-карбоксилату
IL57400A (en)	1982-08-31	(6r,7r)-7-((z)-2-(2-aminothiazol-4-yl-2(2-carboxyprop-2-oxyimino)acetamido)-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylic acid and its derivatives,process for their preparation and pharmaceutical compositions comprising them
HK39780A (en)	1980-08-08	Process for the preparation of cephadroxil
PT71946A (en)	1980-11-01	Process for preparing derivatives of 6beta-hydroxyalkylpenicillanic acids as beta-lactamase inhibitors
JPS53103493A (en)	1978-09-08	Cephalosporin derivatives and process for their preparation
IE45015L (en)	1977-07-23	Cephalosporin derivatives.
OA06016A (fr)	1981-06-30	Procédé de préparation d'une forme cristalline du sel de sodium d'un dérivé oximiné de l'acide 7- amino thiazolyl acétamido céphalosporanique.
ES412859A1 (es)	1976-06-01	Un procedimiento para la preparacion de un derivado de 7- (alfa hidroxi-alfa-fenil) acetamido - 3 - (1 - metil - 1h - tetrazol - 5 - iltiometil) cefalosporina.
BG40966A3 (en)	1987-03-14	Method for preparing cephalosporine derivatives
GB1493676A (en)	1977-11-30	Antibiotic method and pharmaceutical compositions
ATE122678T1 (de)	1995-06-15	Ceftazidim-dihydrochlorid-ameisensäuresolvate.
DE3476663D1 (en)	1989-03-16	Crystalline form of ceftazidim
SE8001177L (sv)	1980-08-16	Forfarande for framstellning av natriumcefuroxim
PT73455B (fr)	1983-02-28	Procede pour la preparation de derives de cephalosporine
ES8702918A1 (es)	1987-01-16	Un procedimiento para la preparacion de dihidrobromuro de acido (6r,7r)-7-((z)-2-(2-tritilaminotiazol-4-il)-2-(2-t-butiloxicarbonil-prop-2-oximino)acetamido)-3-(1piridiniometil)-3-cefem-4-carboxilico cristalino.
FR2279754A1 (fr)	1976-02-20	Procede de preparation de derives de l'acide 7-aminocephalosporanique
SE8701193D0 (sv)	1987-03-23	Nya mellanprodukter for framstellning av 2-(2-aminotiazol-4-yl)-glyoxylsyraderivat eller ett salt derav samt forfarande for framstellning av mellanprodukterna
GB2012270A (en)	1979-07-25	Crystallisation process for sodium cefuroxime
SE7703689L (sv)	1977-10-03	Cefalosporiner
ES531583A0 (es)	1984-12-01	Procedimiento para preparar (6r, 7r)-7-( (z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oximino)-acetamido)-3-(1-piridiniometil)-cef-3-em-carboxilato x 1, 5 moles de agua, cristalizado
NZ194895A (en)	1983-07-15	Non-hygroscopic sodium salt of (6r 7r)-3-acetoxymethyl-7-((z)-2(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid and pharmaceutical compositions
BE870861A (fr)	1979-03-28	Nouveau derive de la cephalosporine c, procede de preparation et application a la preparation de l'acide 7-amino cephalosporanique
JPS5484590A (en)	1979-07-05	2-methyl-7-substituted-2 or 3-cephem-4-carboxylic acid, its salt, and their preparation
KR920021562A (ko)	1992-12-18	3-피라진 유도체 치환된 세팔로스포린 화합물
CA959051A (en)	1974-12-10	Physical forms of the sodium salt of 7-(1h-tetrazol-1-ylacetamido)-3-(5-methyl-1,3,4-thiadiazol-2-yl-thiomethyl)-3-cephem-4-carboxylic acid and new 7-acylated amino-3-thiolated methyl)ceph-3-em-4-carboxylic acid and their salts