BG43188A3 - Method for preparing of n- heterocyclyl- 4- piperidine amines - Google Patents

Method for preparing of n- heterocyclyl- 4- piperidine amines

Info

Publication number: BG43188A3
Authority: BG; Bulgaria
Prior art keywords: heterocyclyl; piperidinamines; preparing; piperidine; residue
Prior art date: 1983-11-30

Application number

BG067673A

Other languages

Bulgarian (bg)

English (en)

Inventor

Frans Janssen

Joseph Torremans

Josef Hens

Theophilus Vanoffenwert

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-11-30

Filing date

1984-11-26

Publication date

1988-04-15

1984-10-12 Priority claimed from US06/660,608 external-priority patent/US4695569A/en

1984-11-26 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1988-04-15 Publication of BG43188A3 publication Critical patent/BG43188A3/xx

Links

238000000034 method Methods 0.000 title abstract 2
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
229940125715 antihistaminic agent Drugs 0.000 abstract 1
239000000739 antihistaminic agent Substances 0.000 abstract 1
229940082988 antihypertensives serotonin antagonists Drugs 0.000 abstract 1
239000003420 antiserotonin agent Substances 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BG067673A 1983-11-30 1984-11-26 Method for preparing of n- heterocyclyl- 4- piperidine amines BG43188A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US55674283A	1983-11-30	1983-11-30
US06/660,608 US4695569A (en)	1983-11-30	1984-10-12	Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines

Publications (1)

Publication Number	Publication Date
BG43188A3 true BG43188A3 (en)	1988-04-15

Family

ID=27071241

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG067673A BG43188A3 (en)	1983-11-30	1984-11-26	Method for preparing of n- heterocyclyl- 4- piperidine amines

Country Status (20)

Country	Link
EP (1)	EP0144101B1 (fr)
JP (1)	JPH0692389B2 (fr)
AU (1)	AU579121B2 (fr)
BG (1)	BG43188A3 (fr)
CA (1)	CA1257258A (fr)
CZ (1)	CZ281114B6 (fr)
DE (1)	DE3484096D1 (fr)
DK (1)	DK567884A (fr)
FI (1)	FI80446C (fr)
GR (1)	GR81097B (fr)
HU (1)	HU199837B (fr)
IL (1)	IL73686A (fr)
MA (1)	MA20281A1 (fr)
NO (1)	NO164171C (fr)
NZ (1)	NZ210339A (fr)
PH (2)	PH23692A (fr)
PT (1)	PT79562B (fr)
RO (1)	RO90414A (fr)
SK (1)	SK278443B6 (fr)
ZW (1)	ZW19484A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4588722A (en) *	1984-01-09	1986-05-13	Janssen Pharmaceutica N.V.	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
CA1260474A (fr) *	1984-12-03	1989-09-26	Raymond A. Stokbroekx	Derives de benzoxazol- et de benzothiazolamine
US4804663A (en) *	1985-03-27	1989-02-14	Janssen Pharmaceutica N.V.	3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB8515934D0 (en) *	1985-06-24	1985-07-24	Janssen Pharmaceutica Nv	(4-piperidinomethyl and-hetero)purines
FR2587029B1 (fr) *	1985-09-11	1987-10-30	Synthelabo	Derives de benzimidazole, leur preparation et leur application en therapeutique
CA1327579C (fr) *	1986-02-03	1994-03-08	Frans Eduard Janssens	Compositions antihistaminiques renfermant des n-heterocyclylpiperidin-4-amines
NZ223654A (en) *	1987-03-09	1990-03-27	Janssen Pharmaceutica Nv	1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
GB8900380D0 (en) *	1989-01-09	1989-03-08	Janssen Pharmaceutica Nv	2-aminopyrimidinone derivatives
CA2043564A1 (fr) *	1990-07-06	1992-01-07	Alfons G. M. De Knaep	3-[(5-methyl-2-furyl)methyl]-n-(4-piperidyl)-3h-imidazo[4,5-b]pyridin-2-amine 2-hydroxypropane-1,2,3-tricarboxylate
DK0920865T3 (da) *	1992-09-03	2004-04-19	Sepracor Inc	Farmaceutiske sammensætninger indeholdende norastemizol
CN1052224C (zh) *	1993-04-07	2000-05-10	大塚制药株式会社	哌啶衍生物、含有它的外周血管舒张剂及其应用
FR2731707B1 (fr) *	1995-03-13	1997-04-30	Synthelabo	Derives de benzimidazole, leur preparation et leur application en therapeutique
IL132575A0 (en) *	1997-05-01	2001-03-19	Nissan Chemical Ind Ltd	Benzimidazole derivative
EP1400519B1 (fr) *	1999-06-28	2007-03-07	Janssen Pharmaceutica N.V.	Inhibiteur du virus respiratoire syncytial
EP1418175A1 (fr)	1999-06-28	2004-05-12	Janssen Pharmaceutica N.V.	Inhibiteurs de réplication du virus respiratoire syncytial
ATE258928T1 (de)	1999-06-28	2004-02-15	Janssen Pharmaceutica Nv	Respiratorisches syncytialvirus replikation inhibitoren
JO2352B1 (en) *	2000-06-22	2006-12-12	جانسين فارماسيوتيكا ان. في	Compounds for the treatment of non-adaptation of the bottom of the uterus
JP4155351B2 (ja) *	2001-02-20	2008-09-24	中外製薬株式会社	代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤としてのアゾール
US7709510B2 (en)	2001-02-20	2010-05-04	Chugai Seiyaku Kabushiki Kaisha	Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
JP4727579B2 (ja)	2003-08-01	2011-07-20	中外製薬株式会社	マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用なシアノアミド化合物
EP2208495B1 (fr)	2003-08-01	2011-12-14	Chugai Seiyaku Kabushiki Kaisha	Composes azole a base de cyanoguanidine-utilises comme inhibiteurs de malonyl-coa decarboxylase
EP1653957B1 (fr)	2003-08-01	2008-07-09	Chugai Seiyaku Kabushiki Kaisha	Composes de piperidine utiles en tant qu'inhibiteurs de malonyl-coa decarboxylase
DE602004030017D1 (de)	2003-08-01	2010-12-23	Chugai Pharmaceutical Co Ltd	Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer
MY142362A (en)	2004-01-29	2010-11-30	Otsuka Pharma Co Ltd	Pharmaceutical composition for promoting angiogenesis
ATE460402T1 (de) *	2004-05-12	2010-03-15	Bristol Myers Squibb Co	Für die behandlung von thrombotischen leiden geeignete harnstoffantagonisten des p2y1- rezeptors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1140119A (fr) *	1978-04-03	1983-01-25	Joseph Torremans	Nouvelles n-heterocycle-4-piperidinamines
US4219559A (en) *	1979-01-10	1980-08-26	Janssen Pharmaceutica N.V.	N-Heterocyclyl-4-piperidinamines
US4556660A (en) *	1982-07-12	1985-12-03	Janssen Pharmaceutica N.V.	N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
PH23995A (en) *	1984-01-09	1990-02-09	Janssen Pharmaceutica Nv	4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4588722A (en) *	1984-01-09	1986-05-13	Janssen Pharmaceutica N.V.	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives

1984
- 1984-11-07 EP EP84201611A patent/EP0144101B1/fr not_active Expired - Lifetime
- 1984-11-07 DE DE8484201611T patent/DE3484096D1/de not_active Expired - Fee Related
- 1984-11-23 PH PH31479A patent/PH23692A/en unknown
- 1984-11-26 CA CA000468587A patent/CA1257258A/fr not_active Expired
- 1984-11-26 NZ NZ210339A patent/NZ210339A/en unknown
- 1984-11-26 BG BG067673A patent/BG43188A3/xx unknown
- 1984-11-28 CZ CS849128A patent/CZ281114B6/cs unknown
- 1984-11-28 MA MA20505A patent/MA20281A1/fr unknown
- 1984-11-28 PT PT79562A patent/PT79562B/pt not_active IP Right Cessation
- 1984-11-28 SK SK9128-84A patent/SK278443B6/sk unknown
- 1984-11-29 JP JP59250660A patent/JPH0692389B2/ja not_active Expired - Lifetime
- 1984-11-29 DK DK567884A patent/DK567884A/da not_active Application Discontinuation
- 1984-11-29 FI FI844708A patent/FI80446C/fi not_active IP Right Cessation
- 1984-11-29 NO NO844755A patent/NO164171C/no unknown
- 1984-11-29 GR GR81097A patent/GR81097B/el unknown
- 1984-11-29 AU AU36028/84A patent/AU579121B2/en not_active Ceased
- 1984-11-29 ZW ZW194/84A patent/ZW19484A1/xx unknown
- 1984-11-29 IL IL73686A patent/IL73686A/xx unknown
- 1984-11-30 RO RO84116474A patent/RO90414A/fr unknown
- 1984-11-30 HU HU844444A patent/HU199837B/hu not_active IP Right Cessation
1991
- 1991-01-18 PH PH41871A patent/PH30787A/en unknown

Also Published As

Publication number	Publication date
DK567884D0 (da)	1984-11-29
CA1257258A (fr)	1989-07-11
NO844755L (no)	1985-05-31
MA20281A1 (fr)	1985-07-01
PT79562A (en)	1984-12-01
EP0144101B1 (fr)	1991-02-06
EP0144101A3 (en)	1985-07-24
EP0144101A2 (fr)	1985-06-12
FI80446B (fi)	1990-02-28
DE3484096D1 (de)	1991-03-14
AU3602884A (en)	1985-06-06
CZ281114B6 (cs)	1996-06-12
ZW19484A1 (en)	1986-05-07
FI844708A0 (fi)	1984-11-29
PH30787A (en)	1997-10-17
GR81097B (en)	1985-04-04
HU199837B (en)	1990-03-28
NO164171C (no)	1990-09-05
RO90414A (fr)	1986-12-10
HUT35677A (en)	1985-07-29
NZ210339A (en)	1987-05-29
SK912884A3 (en)	1997-05-07
FI80446C (fi)	1990-06-11
IL73686A0 (en)	1985-02-28
JPH0692389B2 (ja)	1994-11-16
DK567884A (da)	1985-05-31
NO164171B (no)	1990-05-28
IL73686A (en)	1988-05-31
AU579121B2 (en)	1988-11-17
FI844708L (fi)	1985-05-31
SK278443B6 (en)	1997-05-07
JPS60149583A (ja)	1985-08-07
CZ912884A3 (en)	1996-01-17
PT79562B (en)	1986-12-15
PH23692A (en)	1989-09-27

Publication	Publication Date	Title
BG43007A3 (en)	1988-03-15	Method for preparing n- (bicyclo- hetero- cyclyl)- 4- piperidinamines
ATE86110T1 (de)	1993-03-15	Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
YU29892A (sh)	1994-12-28	Postupak za stereoselektivno dobijanje supstituisanih piperidina
ATE121389T1 (de)	1995-05-15	Ringverknüpfte analoge von stickstoffenthaltenden nichtaromatischen heterocyclen.
KR860004918A (ko)	1986-07-16	트리사이클로 화합물의 제조방법
MY101863A (en)	1992-01-31	Carbocyclic or heterocyclic carboxylic acid esters and amides of a cyclic alkohol and its use in the treatment of psychiatric disorders
AT386201B (de)	1988-07-25	Verfahren zum herstellen neuer n-imidazolylderivate von bicyclischen verbindungen und ihren pharmazeutisch annehmbaren salzen
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
ES2078962T3 (es)	1996-01-01	Nuevas 8-sustituidas-2-amino-tetralinas.
UY23624A1 (es)	1993-08-10	Procedimiento para la preparacion de nuevos derivados de indol
ES2044981T3 (es)	1994-01-16	Un proceso para la preparacion de nuevos derivados de 4(3h)-quinazolinona.
DE69407407D1 (de)	1998-01-29	Ampa antagonisten und behandlungsmethode
ATE101147T1 (de)	1994-02-15	Pharmazeutisch verwendbare polymorphe modifikation von buspiron.
ES2058247T3 (es)	1994-11-01	4-hidroxicinnolin-carboxamidas, su utilizacion y metodo de preparacion.
DE3852246D1 (de)	1995-01-12	Ethyl-(+)-Apovincaminat zur Behandlung der Demyelinisierung klinischer Erscheinungen autoimmunen Ursprungs.
DE3667789D1 (de)	1990-02-01	Piperazin-1-yl-ergolinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES2056873T3 (es)	1994-10-16	Derivados de 1-acil-2,3-dihidro-4-(1h)-quinolinona-4-oxima, procedimiento para producirlos y uso de los mismos.
ATA154883A (de)	1987-06-15	Verfahren zum herstellen neuer kondensierter cycloaliphatischer derivate von substituierten pyrido-(1,2-a)-pyrimidinen
DK85083D0 (da)	1983-02-24	Fremgangsmade til fremstilling af dodecahydrotriphenylen-, decahydro-1h-cyclopenta(1)phenanthren-, decahydro-1h-pyrido(1,2-f)phenanthridin- eller decahydropyrrolo(1,2-f)phenanthridin-forbindelser eller farmaceutisk acceptable salte deraf
AT194849B (de)	1958-01-25	Verfahren zur Herstellung von neuen 2-(Stilbyl-4")-(4,5-arylo)-1,2,3-triazolsulfonylverbindungen
IT8322736A0 (it)	1983-09-01	Processo per la preparazione di 2-alogeno ergoline per via elettrochimica.
DE3664044D1 (de)	1989-07-27	N,n-dialkylaminoalkyl-hexahydro-5-oxo-1h-pyrrolizine-3-carboxamides
AT375368B (de)	1984-07-25	Verfahren zur herstellung von als histamin h2rezeptor-antagonisten wirkenden 3-nitropyrrolderivaten
BR9706491A (pt)	1999-05-18	Compostos de elipticina processo para a sua preparação e composições farmacêuticas contendo os mesmos