ES2044981T3 - Un proceso para la preparacion de nuevos derivados de 4(3h)-quinazolinona. - Google Patents

Un proceso para la preparacion de nuevos derivados de 4(3h)-quinazolinona.

Info

Publication number
ES2044981T3
ES2044981T3 ES88101148T ES88101148T ES2044981T3 ES 2044981 T3 ES2044981 T3 ES 2044981T3 ES 88101148 T ES88101148 T ES 88101148T ES 88101148 T ES88101148 T ES 88101148T ES 2044981 T3 ES2044981 T3 ES 2044981T3
Authority
ES
Spain
Prior art keywords
group
quinazolinone
preparation
hydrogen atom
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88101148T
Other languages
English (en)
Inventor
Toshihiro Takahashi
Tatsuo Horaguchi
Koichi Nakamura
Yoshikuni Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nisshin Seifun Group Inc
Original Assignee
Nisshin Seifun Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nisshin Seifun Group Inc filed Critical Nisshin Seifun Group Inc
Application granted granted Critical
Publication of ES2044981T3 publication Critical patent/ES2044981T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DE 4(3H)-QUINAZOLINONA DE FORMULA (I), DONDE R1 ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE 1 A 6 C, ARILO, ARILO SUSTITUIDO O ALQUILO; R2 ES UN GRUPO ALQUILAMINO DE 1 A 6 C, FENILO, FENILO SUSTITUIDO O UN GRUPO HETEROCICLICO DE 5 O 6 MIEMBROS QUE CONTIENE UNO O MAS N, O O S COMO HETEROATOMOS, Y QUE PUEDE ESTAR SUSTITUIDO O CONDENSADO CON UN ANILLO BENCENICO; N ES 1 O 2, O BIEN R2 REPRESENTA UN GRUPO GERANILO O DIPIRIDILMETILO JUNTO CON EL GRUPO -(CH2)N-; Y X ES UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO DE 1 A 6 C O UN ATOMO DE HALOGENO. TAMBIEN SE REFIERE LA INVENCION A LAS SALES DE ADICION DE ACIDO, FARMACEUTICAMENTE ACEPTABLE.
ES88101148T 1987-01-30 1988-01-27 Un proceso para la preparacion de nuevos derivados de 4(3h)-quinazolinona. Expired - Lifetime ES2044981T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012387 1987-01-30
JP62205071A JPH07107056B2 (ja) 1987-01-30 1987-08-20 ４（３ｈ）−キナゾリノン誘導体、その製造方法およびそれを有効成分とする抗潰瘍剤

Publications (1)

Publication Number Publication Date
ES2044981T3 true ES2044981T3 (es) 1994-01-16

Family

ID=26357018

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88101148T Expired - Lifetime ES2044981T3 (es) 1987-01-30 1988-01-27 Un proceso para la preparacion de nuevos derivados de 4(3h)-quinazolinona.

Country Status (6)

Country Link
US (2) US4861780A (es)
EP (1) EP0276825B1 (es)
JP (1) JPH07107056B2 (es)
KR (1) KR960010346B1 (es)
DE (1) DE3874358T2 (es)
ES (1) ES2044981T3 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07107056B2 (ja) * 1987-01-30 1995-11-15 日清製粉株式会社 ４（３ｈ）−キナゾリノン誘導体、その製造方法およびそれを有効成分とする抗潰瘍剤
DE3737826A1 (de) * 1987-11-06 1989-05-18 Schatz Oskar Verfahren zur nachladung eines verbrennungsmotors der kolbenbauart und vorrichtung zur durchfuehrung des verfahrens
JPH01261386A (ja) * 1988-04-11 1989-10-18 Nisshin Flour Milling Co Ltd 新規な２―ピリジルメチルチオ誘導体及びそれを含有する抗潰瘍剤
HU203736B (en) * 1989-04-06 1991-09-30 Gyogyszerkutato Intezet Process for producing new thiouracil-derivatives and pharmaceutical compositions containing them
JPH05504969A (ja) * 1990-02-13 1993-07-29 メルク・エンド・カムパニー・インコーポレーテツド 置換ベンジル要素を含有するアンギオテンシン２アンタゴニスト類
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
CN1050355C (zh) * 1993-05-12 2000-03-15 纳幕尔杜邦公司 稠合双环嘧啶酮类化合物、含有它们的杀真菌组合物及其应用
UA56992C2 (uk) * 1995-05-08 2003-06-16 Фармація Енд Апджон Компані <font face="Symbol">a</font>-ПІРИМІДИНТІОАЛКІЛЗАМІЩЕНІ ТА <font face="Symbol">a</font>-ПІРИМІДИНОКСОАЛКІЛЗАМІЩЕНІ СПОЛУКИ
DE69618959T2 (de) * 1995-07-05 2002-08-29 E.I. Du Pont De Nemours And Co., Wilmington Pyrimidone und ihre verwendug als fungizide
US6262058B1 (en) 1996-03-11 2001-07-17 Syngenta Crop Protection, Inc. Pyrimidin-4-one derivatives as pesticide
US6255311B1 (en) * 1998-01-14 2001-07-03 E. I. Du Pont De Nemours And Company Fungicidal fused bicyclic pyrimidinones
HU227948B1 (en) * 2003-04-30 2012-07-30 Pecsi Tudomanyegyetem Quinazoline derivatives and their use for the preparation of pharmaceutical compositions inhibiting parp enzyme
US20050038051A1 (en) * 2003-06-09 2005-02-17 Jodi Nunnari Novel molecules for regulating cell death
JP2011521941A (ja) * 2008-05-30 2011-07-28 ミトロジクス Ａｎｔ−リガンド分子および生物学的アプリケ−ション
ES2353093B1 (es) * 2009-05-20 2012-01-03 Consejo Superior De Investigaciones Científicas (Csic) Uso de derivados de quinazolinas y sus composiciones farmacéuticas en enfermedades neurodegenerativas.
CN102838601A (zh) * 2011-06-24 2012-12-26 山东亨利医药科技有限责任公司 选择性磷酰肌醇3-激酶δ抑制剂
US12454514B2 (en) 2019-02-27 2025-10-28 Cerepeut, Inc. Quinazolinone compounds
WO2022194261A1 (zh) * 2021-03-19 2022-09-22 南京药石科技股份有限公司 嘧啶并环类化合物及其用于制备治疗疼痛、脊髓损伤药物中的用途
CN113880777A (zh) * 2021-09-22 2022-01-04 贵州大学 一类含二硫醚结构的喹唑啉酮类衍生物的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD225131A1 (de) * 1984-01-30 1985-07-24 Akad Wissenschaften Ddr Verfahren zur herstellung 2-substituierter 3,4-dihydrochinazolin-4-one
JPS62258369A (ja) * 1986-05-02 1987-11-10 Nippon Soda Co Ltd キナゾリノン誘導体及びその製造方法
JPH0749423B2 (ja) * 1987-01-30 1995-05-31 日清製粉株式会社 ２−アルキルスルフイニル−４（３ｈ）−キナゾリノン誘導体、その製造方法およびそれを有効成分とする抗潰瘍薬
JPH07107056B2 (ja) * 1987-01-30 1995-11-15 日清製粉株式会社 ４（３ｈ）−キナゾリノン誘導体、その製造方法およびそれを有効成分とする抗潰瘍剤

Also Published As

Publication number Publication date
EP0276825B1 (en) 1992-09-09
US5008266A (en) 1991-04-16
JPS63295565A (ja) 1988-12-01
DE3874358D1 (de) 1992-10-15
EP0276825A1 (en) 1988-08-03
JPH07107056B2 (ja) 1995-11-15
KR960010346B1 (ko) 1996-07-30
US4861780A (en) 1989-08-29
KR880008996A (ko) 1988-09-13
DE3874358T2 (de) 1993-01-28

Similar Documents

Publication Publication Date Title
BR8704582A (pt) Processo para preparar derivados de piridinacarboxamida
PT87163A (pt) Process for preparing 1-phenyl-3-naphthalenyloxipropanamines
PA8463501A1 (es) Derivados de acido hidroxamico como inhibidores de metaloproteasas de matriz (mmp)
ES2061471T5 (es) Derivados de la piridina, compuestos farmaceuticos que comprenden la misma, su utilizacion para la fabricacion de medicamentos con valor terapeutico o preventivo y procedimiento para su fabricacion.
ES2040879T3 (es) Procedimiento de preparacion de derivados pirimidinilaminicos de piperidina.
ES553936A0 (es) Un procedimiento para la preparacion de nuevas n-((4-piperidinil)alquil)oxazol y tiazolaminas condensadas biciclicas sustituidas
DZ1417A1 (fr) Composés nouveaux 8-substitués-2-aminotétraline.
ATE79257T1 (de) Verwendung von tetrahydrobenz(c,d&gt;indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
DK26289A (da) Anvendelse af 1,4-disubstitueret piperidinyl til fremstilling af et farmaceutisk praeparat til behandling af insomnia
DK493485D0 (da) Piperazinylindanderivater, syreadditionssalte deraf og farmaceutiskekompositioner
AT389108B (de) Neue pyridazinonderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
ES2058247T3 (es) 4-hidroxicinnolin-carboxamidas, su utilizacion y metodo de preparacion.
FR2584713B1 (fr) Nouveaux derives de l&#39;indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant
ES480671A1 (es) Un procedimiento para la preparacion de nuevos derivados de quinazolina.
ES520774A0 (es) Procedimiento para la preparacion de derivados de tiometilpiridina.
NO164593C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive karbamat- eller urea-derivater.
ES2038218T3 (es) Un procedimiento para preparar nuevos derivados de 2-alquilsulfinil-4(3h)-quinazolinona.
ES2016017A6 (es) Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
ES2063771T3 (es) Nuevos derivados de amida del acido 4-oxo-4h-pirido (1,2-a) pirimidin-3-carboxilicos, su preparacion y elaboracion de medicamentos que contienen estos compuestos, asi como la preparacion de los mismos.
ES8207505A1 (es) Procedimiento para la preparacion de derivados de fenoxi- aminopropanol substituidos
PT92494A (pt) Processo para a preparacao de novos derivados do indol
DK119886A (da) Hidtil ukendte carbacykliner, fremgangsmaade til deres fremstillingog deres anvendelse som laegemiddel
ATE138374T1 (de) Benzo(b)thiophen-2-carboxamide zur behandlung von krankheiten des zentralnervensystems
ES8703457A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiacetona.
ES8201525A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,1&#39;-bifenil-2-il-alquilamina

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 276825

Country of ref document: ES