BG46003A3 - Метод за получаване на 1-(хидроксистирил) -5н-2,3-бензодиазепинови съединения - Google Patents

Метод за получаване на 1-(хидроксистирил) -5н-2,3-бензодиазепинови съединения

Info

Publication number
BG46003A3
BG46003A3 BG079835A BG7983587A BG46003A3 BG 46003 A3 BG46003 A3 BG 46003A3 BG 079835 A BG079835 A BG 079835A BG 7983587 A BG7983587 A BG 7983587A BG 46003 A3 BG46003 A3 BG 46003A3
Authority
BG
Bulgaria
Prior art keywords
hydroxystyryl
preparation
benzodiazepine compounds
polar
compounds
Prior art date
Application number
BG079835A
Other languages
English (en)
Inventor
Tibor Lang
Jeno Korosi
Gyorgy Rabloczky
Tamas Hamori
Maria Kuhar
Istvan Polgari
Istvan Elekes
Gabor Zolyomi
Krisztina Heltai
Judit Sarossy
Zsuzsanna Lang
Imre Moravcsik
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of BG46003A3 publication Critical patent/BG46003A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Получените по метода бензодиазепинови съединения намират приложение във фармацевтичната промишленост. Те имат ценни положителни кардиотонични ефекти, които са потвърдени при експерименти ин витро. Съединенията се получават при взаимодействие на 2-бензопирилов перхлорат с с хидразинхидрат в присъствие на разтворител, който може да бъде полярен или неполярен, като вода, алкохол, диоксан, тетрахидрофуран, дихлорметан, диметилформамид, диметилсулфоокис или техни смеси. Реакцията обикновено се провежда при температура от 10 до 20'с. 1 претенция
BG079835A 1986-05-21 1987-05-21 Метод за получаване на 1-(хидроксистирил) -5н-2,3-бензодиазепинови съединения BG46003A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862140A HU195788B (en) 1986-05-21 1986-05-21 Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BG46003A3 true BG46003A3 (bg) 1989-09-15

Family

ID=10957976

Family Applications (1)

Application Number Title Priority Date Filing Date
BG079835A BG46003A3 (bg) 1986-05-21 1987-05-21 Метод за получаване на 1-(хидроксистирил) -5н-2,3-бензодиазепинови съединения

Country Status (24)

Country Link
US (1) US4840948A (bg)
JP (1) JPS6322082A (bg)
AT (1) AT395009B (bg)
BE (1) BE1000573A4 (bg)
BG (1) BG46003A3 (bg)
CA (1) CA1280748C (bg)
CH (1) CH671226A5 (bg)
CS (1) CS262690B2 (bg)
DD (1) DD268943A5 (bg)
DE (1) DE3717080C2 (bg)
DK (1) DK258187A (bg)
ES (1) ES2005582A6 (bg)
FI (1) FI91964C (bg)
FR (1) FR2599034B1 (bg)
GB (1) GB2190677B (bg)
HU (1) HU195788B (bg)
IL (1) IL82613A (bg)
IT (1) IT1205665B (bg)
NL (1) NL8701213A (bg)
PL (1) PL147687B1 (bg)
PT (1) PT84923B (bg)
SE (1) SE468560B (bg)
SU (1) SU1503681A3 (bg)
YU (1) YU46675B (bg)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380721A (en) * 1990-09-10 1995-01-10 Sterling Winthrop Inc. Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
EP0726257B1 (en) * 1995-02-09 2001-04-11 Egis Gyogyszergyar Rt. 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders, and benzopyrylium intermediates for their preparation
SK283859B6 (sk) * 1995-02-09 2004-03-02 Egis Gy�Gyszergy�R Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
US20040152695A1 (en) * 2002-12-03 2004-08-05 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine and uses thereof
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
FI91964B (fi) 1994-05-31
CA1280748C (en) 1991-02-26
SU1503681A3 (ru) 1989-08-23
GB8712005D0 (en) 1987-06-24
IT1205665B (it) 1989-03-31
ES2005582A6 (es) 1989-03-16
FR2599034A1 (fr) 1987-11-27
DE3717080C2 (de) 1996-02-08
HU195788B (en) 1988-07-28
CS262690B2 (en) 1989-03-14
IL82613A0 (en) 1987-11-30
JPS6322082A (ja) 1988-01-29
GB2190677A (en) 1987-11-25
PL265812A1 (en) 1988-05-12
BE1000573A4 (fr) 1989-02-07
DD268943A5 (de) 1989-06-14
PL147687B1 (en) 1989-07-31
IL82613A (en) 1991-03-10
YU46675B (sh) 1994-01-20
GB2190677B (en) 1990-01-10
SE468560B (sv) 1993-02-08
HUT44521A (en) 1988-03-28
PT84923A (en) 1987-06-01
SE8702120L (sv) 1987-11-22
US4840948A (en) 1989-06-20
DK258187D0 (da) 1987-05-21
SE8702120D0 (sv) 1987-05-21
IT8720619A0 (it) 1987-05-21
AT395009B (de) 1992-08-25
CH671226A5 (bg) 1989-08-15
DE3717080A1 (de) 1987-11-26
FI872255A7 (fi) 1987-11-22
PT84923B (pt) 1990-02-08
ATA130287A (de) 1992-01-15
DK258187A (da) 1987-11-22
YU90687A (en) 1988-08-31
FI872255A0 (fi) 1987-05-21
NL8701213A (nl) 1987-12-16
FR2599034B1 (fr) 1989-06-09
FI91964C (fi) 1994-09-12
CS369087A2 (en) 1988-08-16

Similar Documents

Publication Publication Date Title
EP0678519B1 (en) Intermediates for the preparation of pyrazoloazole photographic couplers, processes of making and using them
FR2434163A1 (fr) Nouveaux 1-(2-aryl-4,5-disubstitue-1,3-dioxolane-2-ylmethyl)-1h-imidazoles et 1h-1,2,4-triazoles, leur procede de preparation et application en phytopharmacie pour combattre des champignons
YU46675B (sh) Postupak za dobijanje derivata 1-(hidrok-sistirol)-5h- 2,3-benzodiazepina
ATE10371T1 (de) Verfahren zur herstellung von isosorbidmononitraten.
KR860007251A (ko) 트리아졸 유도체의 제조방법
Huff et al. Alkylation of 5-substituted tetrazoles
Pilli et al. Reaction of N-(p-tolylsulfonyl) diphenylcyclopropenimine with pyridinium and isoquinolinium ylides
Ding et al. New Efficient Synthesis of 6, 7, 8, 9-Tetrahydro-benzothieno [2, 3-d]-1, 2, 4-triazolo [1, 5-a] pyrimidin-10 (3H)-ones via a Tandem aza-Wittig/Heterocumulene-Mediated Annulation
Kunieda et al. Selective N-methylations of heterocycles with dimethyloxosulfonium methylide
Nakatsuka et al. METHYL GROUP AT I-POSITION OF STABILIZED INDOLE AS A PROTECTIVE GROUP
US3536725A (en) Cyanoethylated derivatives of 2,3,4,6,7,12-hexahydroindolo(2,3-alpha)-quinolizine
Okada et al. Model experiments on surugatoxin synthesis. an approach in the construction of the pentacyclic ring system
YANAGISAWA et al. Synthesis and Anti-peptic Activity of Compounds Related to the Metabolites of Sodium 3-Ethyl-7-isopropyl-1-azulenesulfonate (KT1-32)
Leonard et al. Synthesis of cytosine radiolysis products: cis-and trans-1-carbamoyl-4, 5-dihydroxyimidazolidin-2-one
Dallemagne et al. A convenient route to new phenyltetrahydroindolizines
Ogata et al. N-(Chlorosulfinyl)-Imidazole as a New Imidazole Transfer Reagent1
Lin et al. Potassium phosphate promoted aza-Markovnikov addition of N-heterocycles to vinyl esters
PT86154B (pt) Processo para a preparacao de novos pirrolobenzimidazoles e de composicoes farmaceuticas que os contem
Sato et al. Synthesis of Evolitrine, an Alkaloid of Evodia littoralis
GB1563578A (en) Preparation of benzodiazepines
SU417947A3 (ru) Способ получения производных хиназолинона-2 или их солей
CA1055491A (en) Process for the manufacture of benzodiazepine derivatives
US4065465A (en) Process for the preparation of substituted trichloroacetamidine derivatives
DK566181A (da) Fremgangsmaade til fremstilling af n-pyrrolylpyridazinaminderivater
Abed et al. Studies on 3, 5-diaminopyrazole derivatives