BG52073B2 - Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine - Google Patents

Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Info

Publication number: BG52073B2
Authority: BG; Bulgaria
Prior art keywords: interferon; preparation; recombinant human; noncystein; free
Prior art date: 1990-01-24

Application number

BG9100690A

Other languages

English (en)

Inventor

Ljuben N Marekov

Rositsa A Vasileva

Veselin P Ivanov

Adriana A Sarafova

Rumen G Tsanev

Ivan G Ivanov

Vesela S Ivanova

Original Assignee

Inst Molekuljarna Biolog

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-24

Filing date

1990-01-24

Publication date

1996-04-30

1990-01-24 Application filed by Inst Molekuljarna Biolog filed Critical Inst Molekuljarna Biolog

1990-01-24 Priority to BG9100690A priority Critical patent/BG52073B2/xx

1991-01-22 Priority to EP19910100777 priority patent/EP0446582B1/en

1991-01-22 Priority to DE1991606407 priority patent/DE69106407T2/de

1991-01-22 Priority to ES91100777T priority patent/ES2066237T3/es

1991-01-24 Priority to JP707491A priority patent/JPH05176789A/ja

1991-01-24 Priority to SU4894482 priority patent/RU2054044C1/ru

1996-04-30 Publication of BG52073B2 publication Critical patent/BG52073B2/xx

Links

229940079322 interferon Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 title 1
229930182817 methionine Natural products 0.000 title 1
241000588724 Escherichia coli Species 0.000 abstract 1
108700005078 Synthetic Genes Proteins 0.000 abstract 1
238000005273 aeration Methods 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000004108 freeze drying Methods 0.000 abstract 1
239000012535 impurity Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

BG9100690A 1990-01-24 1990-01-24 Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine BG52073B2 (en)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
BG9100690A BG52073B2 (en)	1990-01-24	1990-01-24	Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine
EP19910100777 EP0446582B1 (en)	1990-01-24	1991-01-22	Method for producing of recombinant human cysteineless gamma-interferon free of methionine at n-terminal
DE1991606407 DE69106407T2 (de)	1990-01-24	1991-01-22	Verfahren zur Herstellung von rekombinantem menschlichem gamma-Interferon ohne Cystein und ohne Methionin am N-Terminal.
ES91100777T ES2066237T3 (es)	1990-01-24	1991-01-22	Procedimiento para producir gamma-interferon humano recombinante sin cisteina carente de metionina en el extremo n-terminal.
JP707491A JPH05176789A (ja)	1990-01-24	1991-01-24	Ｎ−末端にメチオニンを含有しない、遺伝子組換えによるヒト・システイン非含有γ− インターフェロンの製造方法
SU4894482 RU2054044C1 (ru)	1990-01-24	1991-01-24	Способ получения рекомбинантного человеческого свободного от метионина на n-конце гамма-интерферона

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
BG9100690A BG52073B2 (en)	1990-01-24	1990-01-24	Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Publications (1)

Publication Number	Publication Date
BG52073B2 true BG52073B2 (en)	1996-04-30

Family

ID=3922678

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG9100690A BG52073B2 (en)	1990-01-24	1990-01-24	Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine

Country Status (6)

Country	Link
EP (1)	EP0446582B1 (es)
JP (1)	JPH05176789A (es)
BG (1)	BG52073B2 (es)
DE (1)	DE69106407T2 (es)
ES (1)	ES2066237T3 (es)
RU (1)	RU2054044C1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2132386C1 (ru) *	1997-06-20	1999-06-27	Государственный научный центр вирусологии и биотехнологии "Вектор"	Способ получения рекомбинантного интерферона-гамма человека
US7230081B1 (en)	1999-11-12	2007-06-12	Maxygen Holdings, Ltd.	Interferon gamma conjugates
SK8292002A3 (en)	1999-11-12	2002-12-03	Maxygen Holdings Ltd	A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
US20040214271A1 (en) *	2000-07-31	2004-10-28	Hidekazu Sawada	Process for producing recombined protein
RU2296130C2 (ru) *	2001-04-06	2007-03-27	Максиджен Холдингз Лтд.	Варианты полипептида гамма-интерферона
US6958388B2 (en)	2001-04-06	2005-10-25	Maxygen, Aps	Interferon gamma polypeptide variants
KR20030094336A (ko) *	2001-04-06	2003-12-11	맥시겐 홀딩스 엘티디	인터페론 감마 폴리펩티드 변이체
US7038015B2 (en)	2001-04-06	2006-05-02	Maxygen Holdings, Ltd.	Interferon gamma polypeptide variants
WO2004005341A2 (en)	2002-07-03	2004-01-15	Maxygen Holdings Ltd.	Full-length interferon gamma polypeptide variants
RU2214832C1 (ru) *	2002-07-25	2003-10-27	Общество с ограниченной ответственностью "Научно-производственное предприятие "Фармаклон"	Рекомбинантная плазмидная днк, кодирующая синтез, способ получения и препарат рекомбинантного интерферона гамма человека
BG66458B1 (bg)	2005-03-21	2014-10-31	Иван Иванов	Средство за конкурентно инхибиране на ендогенен гама интерферон
BG66517B1 (bg)	2008-04-08	2016-02-29	Tigo Gmbh	Супресор на ендогенния човешки гама - интерферон
US9359421B2 (en)	2008-04-08	2016-06-07	Tigo Gmbh	Suppressor of the endogenous interferon-gamma
FR3052462A1 (fr)	2016-06-14	2017-12-15	Dna Script	Variants d'une adn polymerase de la famille polx

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4855238A (en) *	1983-12-16	1989-08-08	Genentech, Inc.	Recombinant gamma interferons having enhanced stability and methods therefor
EP0168008A3 (en) *	1984-07-10	1986-12-30	Takeda Chemical Industries, Ltd.	Stable composition of gamma-interferon
KR930007429B1 (ko) *	1984-12-27	1993-08-10	산도리 가부시기가이샤	인터페론의 정제방법
JPS61177996A (ja) *	1985-02-02	1986-08-09	Green Cross Corp:The	インタ−フエロン−γの製造法
DK623188A (da) *	1987-11-09	1989-05-10	Otsuka Pharma Co Ltd	Fremgangsmaade til inkubation af rekombinante proteinekspressionsceller

1990
- 1990-01-24 BG BG9100690A patent/BG52073B2/xx unknown
1991
- 1991-01-22 EP EP19910100777 patent/EP0446582B1/en not_active Expired - Lifetime
- 1991-01-22 DE DE1991606407 patent/DE69106407T2/de not_active Expired - Fee Related
- 1991-01-22 ES ES91100777T patent/ES2066237T3/es not_active Expired - Lifetime
- 1991-01-24 JP JP707491A patent/JPH05176789A/ja active Pending
- 1991-01-24 RU SU4894482 patent/RU2054044C1/ru not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69106407T2 (de)	1995-05-18
JPH05176789A (ja)	1993-07-20
ES2066237T3 (es)	1995-03-01
EP0446582A1 (en)	1991-09-18
EP0446582B1 (en)	1995-01-04
RU2054044C1 (ru)	1996-02-10
DE69106407D1 (de)	1995-02-16

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