BG60678B1 - Нови антихистаминови средства,производни на бензимидазолите - Google Patents

Нови антихистаминови средства,производни на бензимидазолите Download PDF

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Publication number
BG60678B1
BG60678B1 BG96180A BG9618092A BG60678B1 BG 60678 B1 BG60678 B1 BG 60678B1 BG 96180 A BG96180 A BG 96180A BG 9618092 A BG9618092 A BG 9618092A BG 60678 B1 BG60678 B1 BG 60678B1
Authority
BG
Bulgaria
Prior art keywords
radical
general formula
acceptable salts
compound
alkyl
Prior art date
Application number
BG96180A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG96180A (bg
Inventor
Maria Cuberes-Altisent
Constansa Jordi Frigola
Corominas Juan Pares
Original Assignee
Laboratorios Del Dr.Esteve S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Del Dr.Esteve S.A. filed Critical Laboratorios Del Dr.Esteve S.A.
Publication of BG96180A publication Critical patent/BG96180A/bg
Publication of BG60678B1 publication Critical patent/BG60678B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG96180A 1991-04-05 1992-04-03 Нови антихистаминови средства,производни на бензимидазолите BG60678B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9104171A FR2674856B1 (fr) 1991-04-05 1991-04-05 Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.

Publications (2)

Publication Number Publication Date
BG96180A BG96180A (bg) 1993-12-24
BG60678B1 true BG60678B1 (bg) 1995-12-29

Family

ID=9411523

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96180A BG60678B1 (bg) 1991-04-05 1992-04-03 Нови антихистаминови средства,производни на бензимидазолите

Country Status (28)

Country Link
US (1) US5214040A (cs)
EP (1) EP0507696B1 (cs)
JP (1) JP3060054B2 (cs)
KR (1) KR970011298B1 (cs)
CN (1) CN1028367C (cs)
AT (1) ATE126228T1 (cs)
AU (1) AU647904B2 (cs)
BG (1) BG60678B1 (cs)
BR (1) BR1100983A (cs)
CA (1) CA2065061A1 (cs)
CZ (1) CZ279506B6 (cs)
DE (1) DE69203911T2 (cs)
DK (1) DK0507696T3 (cs)
ES (1) ES2046110B1 (cs)
FI (1) FI99112C (cs)
FR (1) FR2674856B1 (cs)
GR (1) GR3017643T3 (cs)
HU (1) HU214316B (cs)
IL (1) IL101483A (cs)
IS (1) IS1639B (cs)
MX (1) MX9201556A (cs)
NO (1) NO179552C (cs)
NZ (1) NZ242208A (cs)
PL (1) PL167720B1 (cs)
RO (1) RO109198B1 (cs)
RU (1) RU2099336C1 (cs)
TW (1) TW208003B (cs)
YU (1) YU48826B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264456B1 (it) * 1993-05-14 1996-09-23 Dompe Farmaceutici Spa Derivati del 2-(benzimidazol-2-il)-1,3-diaminopropano farmacologicamente attivi.
FR2727865B1 (fr) * 1994-12-08 1997-07-18 Esteve Labor Dr Utilisation des derives de 2-(4-(azolybutyl)-piperazinyl- (methyl))-benzimidazole et analogues ainsi que de leurs sels, pour la preparation de medicaments destines au traitement ou a la prophylaxie de l'asthme
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
WO1996025411A1 (en) * 1995-02-15 1996-08-22 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
FR2731618B1 (fr) * 1995-03-14 1997-08-01 Esteve Labor Dr Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
MXPA00011470A (es) * 1998-05-22 2002-10-17 Avanir Pharmaceuticals Analogos de bencimidazol como reguladores de la disminucion de ige.
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
ES2449194T3 (es) * 2000-01-19 2014-03-18 Cadila Healthcare Limited Compuestos que tienen actividades hipolipidémica e hipocolesterolémica, procedimiento para su preparación y composiciones farmacéuticas que los contienen
CZ2003952A3 (cs) * 2000-10-31 2003-11-12 Basf Drucksysteme Gmbh Použití hyperrozvětvených polyurethanů
PL364279A1 (en) * 2001-02-02 2004-12-13 Bristol-Myers Squibb Company Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
WO2003060475A2 (en) * 2002-01-10 2003-07-24 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
DK1784404T3 (da) * 2004-09-03 2012-02-13 Yuhan Corp Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling
CN101089000B (zh) * 2006-06-16 2011-01-05 北京大学 螺环哌嗪季铵盐类化合物及其制备方法和应用
US8835648B2 (en) * 2009-06-11 2014-09-16 Siena Biotech S.P.A. Hedgehog pathway antagonists and therapeutic applications thereof
CN105008333B (zh) * 2012-12-27 2018-02-09 雅尔兹普罗泰特公司 N‑(3‑(4‑(3‑(二异丁基氨基)丙基)哌嗪‑1‑基)丙基)‑1H‑苯并[d]咪唑‑2‑胺的硫酸盐、其制备及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
DE3336409A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Chinazolinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5010075A (en) * 1987-04-24 1991-04-23 Syntex Pharmaceuticals Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.

Also Published As

Publication number Publication date
CZ279506B6 (cs) 1995-05-17
FI99112B (fi) 1997-06-30
RU2099336C1 (ru) 1997-12-20
ES2046110B1 (es) 1994-08-01
FI921473A0 (fi) 1992-04-03
FI99112C (fi) 1997-10-10
ES2046110A1 (es) 1994-01-16
IS3832A (is) 1992-10-06
AU647904B2 (en) 1994-03-31
CS101792A3 (en) 1992-10-14
NO921315D0 (no) 1992-04-03
AU1397992A (en) 1992-10-08
HU9201145D0 (en) 1992-06-29
FI921473L (fi) 1992-10-06
DE69203911D1 (de) 1995-09-14
JP3060054B2 (ja) 2000-07-04
BR1100983A (pt) 1999-10-13
RO109198B1 (ro) 1994-12-30
IS1639B (is) 1997-03-25
US5214040A (en) 1993-05-25
IL101483A (en) 1995-12-08
HU214316B (hu) 1998-03-02
NO179552B (no) 1996-07-22
JPH0597846A (ja) 1993-04-20
PL167720B1 (pl) 1995-10-31
DK0507696T3 (da) 1995-09-18
NO179552C (no) 1996-10-30
TW208003B (cs) 1993-06-21
FR2674856B1 (fr) 1993-07-30
EP0507696B1 (fr) 1995-08-09
CN1065460A (zh) 1992-10-21
MX9201556A (es) 1992-10-01
YU48826B (sh) 2002-03-18
KR970011298B1 (ko) 1997-07-09
FR2674856A1 (fr) 1992-10-09
NZ242208A (en) 1993-10-26
IL101483A0 (en) 1992-12-30
NO921315L (no) 1992-10-06
DE69203911T2 (de) 1995-12-07
CA2065061A1 (fr) 1992-10-06
KR920019781A (ko) 1992-11-20
CN1028367C (zh) 1995-05-10
ATE126228T1 (de) 1995-08-15
PL294101A1 (en) 1992-11-30
HUT60732A (en) 1992-10-28
GR3017643T3 (en) 1996-01-31
EP0507696A1 (fr) 1992-10-07
YU33692A (sh) 1995-03-27
BG96180A (bg) 1993-12-24

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