ES2046110A1 - Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol. - Google Patents

Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol.

Info

Publication number
ES2046110A1
ES2046110A1 ES9200813A ES9200813A ES2046110A1 ES 2046110 A1 ES2046110 A1 ES 2046110A1 ES 9200813 A ES9200813 A ES 9200813A ES 9200813 A ES9200813 A ES 9200813A ES 2046110 A1 ES2046110 A1 ES 2046110A1
Authority
ES
Spain
Prior art keywords
derivatives
general formula
aryl
alkyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9200813A
Other languages
English (en)
Other versions
ES2046110B1 (es
Inventor
Altisent Cuberes
Constansa Frigola
Corominas Pares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2046110A1 publication Critical patent/ES2046110A1/es
Application granted granted Critical
Publication of ES2046110B1 publication Critical patent/ES2046110B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS COMPUESTOS DERIVADOS DE BENCIMIDAZOL. CARACTERIZADO PORQUE COMPRENDE LA REACCION ENTRE UN COMPUESTO DE FORMULA GENERAL IIA CON OTRO DE FORMULA GENERAL III, OBTENIENDOSE DICHOS DERIVADOS DE BENCIMIDAZOL, DE FORMULA GENERAL Y SUS SALES TERAPEUTICAMENTE ACEPTABLES, CUYOS RADICALES REPRESENTAN: RSI1 SC Y RSI2 SC IGUALES O DIFERENTES, HIDROGENO, HALOGENO, ALQUILO INFERIOR HIDROXI, ALCOXI, CARBOXILATO DE ALQUILO, ARIL O ARIL SUSTITUIDO; N ES 0 O 1; M VALORES ENTRE 2 Y 4; X, Y, Z, W, IGUALES O DIFERENTES E INCLUSO FORMANDO PARTE DE OTRO CICLO, AROMATICO O NO, NITROGENO O CARBONO UNIDO A HIDROGENO, HALOGENO, ALQUILO, ARILO, CARBOXILALQUILO, CARBOXILICO, HIDROXILO, ALQUILHIDROXI, SULFONICO Y ALQUILSULFONICO; A, HALOGENO, O UN GRUPO ESCOGIDO ENTRE TOSILOXI O MESILOXI. DICHOS DERIVADOS DE BENCIMIDAZOL SON ANTIHISTAMINICOS EXENTOS DE EFECTOS SEDATIVOS.
ES09200813A 1991-04-05 1992-04-03 Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol. Expired - Lifetime ES2046110B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9104171A FR2674856B1 (fr) 1991-04-05 1991-04-05 Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments.

Publications (2)

Publication Number Publication Date
ES2046110A1 true ES2046110A1 (es) 1994-01-16
ES2046110B1 ES2046110B1 (es) 1994-08-01

Family

ID=9411523

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09200813A Expired - Lifetime ES2046110B1 (es) 1991-04-05 1992-04-03 Procedimiento de preparacion de nuevos compuestos derivados de bencimidazol.

Country Status (28)

Country Link
US (1) US5214040A (es)
EP (1) EP0507696B1 (es)
JP (1) JP3060054B2 (es)
KR (1) KR970011298B1 (es)
CN (1) CN1028367C (es)
AT (1) ATE126228T1 (es)
AU (1) AU647904B2 (es)
BG (1) BG60678B1 (es)
BR (1) BR1100983A (es)
CA (1) CA2065061A1 (es)
CZ (1) CZ279506B6 (es)
DE (1) DE69203911T2 (es)
DK (1) DK0507696T3 (es)
ES (1) ES2046110B1 (es)
FI (1) FI99112C (es)
FR (1) FR2674856B1 (es)
GR (1) GR3017643T3 (es)
HU (1) HU214316B (es)
IL (1) IL101483A (es)
IS (1) IS1639B (es)
MX (1) MX9201556A (es)
NO (1) NO179552C (es)
NZ (1) NZ242208A (es)
PL (1) PL167720B1 (es)
RO (1) RO109198B1 (es)
RU (1) RU2099336C1 (es)
TW (1) TW208003B (es)
YU (1) YU48826B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264456B1 (it) * 1993-05-14 1996-09-23 Dompe Farmaceutici Spa Derivati del 2-(benzimidazol-2-il)-1,3-diaminopropano farmacologicamente attivi.
FR2727865B1 (fr) * 1994-12-08 1997-07-18 Esteve Labor Dr Utilisation des derives de 2-(4-(azolybutyl)-piperazinyl- (methyl))-benzimidazole et analogues ainsi que de leurs sels, pour la preparation de medicaments destines au traitement ou a la prophylaxie de l'asthme
WO1996025411A1 (en) * 1995-02-15 1996-08-22 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
FR2731618B1 (fr) * 1995-03-14 1997-08-01 Esteve Labor Dr Composition ophtalmique topique comprenant un derive de 2-(4-(azolylbutyl)-piperazinyl-methyl)-benzimidazole, notamment pour le traitement de la conjonctivite allergique
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
RU2236220C2 (ru) * 1998-05-22 2004-09-20 Аванир Фармасьютикэлз Аналоги бензимидазола в качестве понижающих регуляторов ige
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
ES2449194T3 (es) * 2000-01-19 2014-03-18 Cadila Healthcare Limited Compuestos que tienen actividades hipolipidémica e hipocolesterolémica, procedimiento para su preparación y composiciones farmacéuticas que los contienen
SK5132003A3 (en) * 2000-10-31 2003-09-11 Basf Ag Use of hyperbranched polyurethanes for producing printing inks
IL157029A0 (en) * 2001-02-02 2004-02-08 Bristol Myers Squibb Co Azaindoleoxoacetic piperazine derivatives and pharmaceutical compositions containing the same
CA2473236A1 (en) * 2002-01-10 2003-07-24 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 2-(4-benzyl-piperazin-1-ylmethyl)- and 2-(4-benzyl-diazepan-1-ylmethyl)-1h-benzoimidazole analogues
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
DK1784404T3 (da) * 2004-09-03 2012-02-13 Yuhan Corp Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling
CN101089000B (zh) 2006-06-16 2011-01-05 北京大学 螺环哌嗪季铵盐类化合物及其制备方法和应用
JP2012529449A (ja) * 2009-06-11 2012-11-22 シエナ ビオテク ソシエタ ペル アチオニ ヘッジホッグ経路アンタゴニストおよびそれらの治療的応用
LT2938597T (lt) * 2012-12-27 2017-01-25 Alzprotect N-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amino sulfatinės druskos, jų paruošimas ir panaudojimas

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
EP0297661A1 (en) * 1987-07-01 1989-01-04 Janssen Pharmaceutica N.V. [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines
FR2665161A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336409A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Chinazolinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5010075A (en) * 1987-04-24 1991-04-23 Syntex Pharmaceuticals Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
EP0297661A1 (en) * 1987-07-01 1989-01-04 Janssen Pharmaceutica N.V. [(Bicyclic heterocyclyl)methyl and -hetero] substituted hexahydro-1H-azepines and pyrrolidines
FR2665161A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.

Also Published As

Publication number Publication date
ES2046110B1 (es) 1994-08-01
JPH0597846A (ja) 1993-04-20
ATE126228T1 (de) 1995-08-15
YU33692A (sh) 1995-03-27
EP0507696A1 (fr) 1992-10-07
NO179552B (no) 1996-07-22
HU214316B (hu) 1998-03-02
BG60678B1 (bg) 1995-12-29
JP3060054B2 (ja) 2000-07-04
PL294101A1 (en) 1992-11-30
CA2065061A1 (fr) 1992-10-06
US5214040A (en) 1993-05-25
NO179552C (no) 1996-10-30
CS101792A3 (en) 1992-10-14
HUT60732A (en) 1992-10-28
DE69203911T2 (de) 1995-12-07
RO109198B1 (ro) 1994-12-30
YU48826B (sh) 2002-03-18
KR970011298B1 (ko) 1997-07-09
NO921315D0 (no) 1992-04-03
GR3017643T3 (en) 1996-01-31
FR2674856B1 (fr) 1993-07-30
FI921473A0 (fi) 1992-04-03
IS3832A (is) 1992-10-06
TW208003B (es) 1993-06-21
IL101483A (en) 1995-12-08
MX9201556A (es) 1992-10-01
IL101483A0 (en) 1992-12-30
FI99112C (fi) 1997-10-10
HU9201145D0 (en) 1992-06-29
NO921315L (no) 1992-10-06
BG96180A (bg) 1993-12-24
CN1028367C (zh) 1995-05-10
IS1639B (is) 1997-03-25
RU2099336C1 (ru) 1997-12-20
CN1065460A (zh) 1992-10-21
AU647904B2 (en) 1994-03-31
AU1397992A (en) 1992-10-08
DE69203911D1 (de) 1995-09-14
KR920019781A (ko) 1992-11-20
PL167720B1 (pl) 1995-10-31
BR1100983A (pt) 1999-10-13
FI921473L (fi) 1992-10-06
EP0507696B1 (fr) 1995-08-09
CZ279506B6 (cs) 1995-05-17
FI99112B (fi) 1997-06-30
FR2674856A1 (fr) 1992-10-09
DK0507696T3 (da) 1995-09-18
NZ242208A (en) 1993-10-26

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