BG62776B1 - Метод за получаване на дроспиренон (6 бета,7 бета:15 бета,16 бета- диметилен-3-оксо-17 алфа-прегн-4-ен-21, 17-карболактон,drsр) както и на (6 бета,7 бета:15 бета,16 бета-диметилен-5 бета-хидрокси-3-оксо-17 алфа-андростан-21,17 -карболактон (90965) като междинни съединения за метода - Google Patents

Метод за получаване на дроспиренон (6 бета,7 бета:15 бета,16 бета- диметилен-3-оксо-17 алфа-прегн-4-ен-21, 17-карболактон,drsр) както и на (6 бета,7 бета:15 бета,16 бета-диметилен-5 бета-хидрокси-3-оксо-17 алфа-андростан-21,17 -карболактон (90965) като междинни съединения за метода Download PDF

Info

Publication number: BG62776B1
Authority: BG; Bulgaria
Prior art keywords: beta; dimethylene; oxo; alpha; carbolacton
Prior art date: 1996-08-12

Application number

BG102976A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG102976A (en

Inventor

Joerg-Thorsten Mohr

Klaus Nickisch

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-12

Filing date

1998-12-01

Publication date

2000-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7803224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62776(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-12-01 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

1999-08-31 Publication of BG102976A publication Critical patent/BG102976A/xx

2000-07-31 Publication of BG62776B1 publication Critical patent/BG62776B1/bg

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/007—3 membered carbocyclic rings in position 6-7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Fats And Perfumes (AREA)
Polyesters Or Polycarbonates (AREA)

BG102976A 1996-08-12 1998-12-01 Метод за получаване на дроспиренон (6 бета,7 бета:15 бета,16 бета- диметилен-3-оксо-17 алфа-прегн-4-ен-21, 17-карболактон,drsр) както и на (6 бета,7 бета:15 бета,16 бета-диметилен-5 бета-хидрокси-3-оксо-17 алфа-андростан-21,17 -карболактон (90965) като междинни съединения за метода BG62776B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19633685A DE19633685C1 (de)	1996-08-12	1996-08-12	Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
PCT/EP1997/004342 WO1998006738A1 (de)	1996-08-12	1997-08-11	Verfahren zur herstellung von drospirenon und zwischenprodukten davon

Publications (2)

Publication Number	Publication Date
BG102976A BG102976A (en)	1999-08-31
BG62776B1 true BG62776B1 (bg)	2000-07-31

Family

ID=7803224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102976A BG62776B1 (bg)	1996-08-12	1998-12-01	Метод за получаване на дроспиренон (6 бета,7 бета:15 бета,16 бета- диметилен-3-оксо-17 алфа-прегн-4-ен-21, 17-карболактон,drsр) както и на (6 бета,7 бета:15 бета,16 бета-диметилен-5 бета-хидрокси-3-оксо-17 алфа-андростан-21,17 -карболактон (90965) като междинни съединения за метода

Country Status (26)

Country	Link
US (2)	US6121465A (pl)
EP (4)	EP2168974B1 (pl)
JP (1)	JP3333524B2 (pl)
KR (1)	KR100473297B1 (pl)
CN (1)	CN1158300C (pl)
AT (3)	ATE446966T1 (pl)
AU (1)	AU729149B2 (pl)
BG (1)	BG62776B1 (pl)
BR (1)	BR9711060A (pl)
CA (1)	CA2261137C (pl)
CZ (1)	CZ297255B6 (pl)
DE (4)	DE19633685C1 (pl)
DK (4)	DK0918791T3 (pl)
EA (1)	EA001947B1 (pl)
ES (4)	ES2438941T3 (pl)
HU (1)	HU223106B1 (pl)
IL (1)	IL127963A (pl)
IS (1)	IS2100B (pl)
NZ (1)	NZ333697A (pl)
PL (1)	PL187474B1 (pl)
PT (4)	PT1149841E (pl)
SI (3)	SI1149841T1 (pl)
SK (1)	SK283546B6 (pl)
TR (1)	TR199900262T2 (pl)
UA (1)	UA55423C2 (pl)
WO (1)	WO1998006738A1 (pl)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19633685C1 (de)	1996-08-12	1997-10-09	Schering Ag	Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
DK1380301T3 (da)	1999-08-31	2009-04-20	Bayer Schering Pharma Ag	Farmaceutisk sammensætning af ethinylestradiol og drospirenon til anvendelse som svangerskabsforebyggende middel
US6787531B1 (en) *	1999-08-31	2004-09-07	Schering Ag	Pharmaceutical composition for use as a contraceptive
EP2305267A3 (en)	1999-08-31	2011-08-17	Bayer Schering Pharma Aktiengesellschaft	Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive
AU2001225413B2 (en) *	2000-01-18	2005-06-23	Bayer Schering Pharma Aktiengesellschaft	Drospirenone for hormone replacement therapy
US20020132801A1 (en) *	2001-01-11	2002-09-19	Schering Aktiengesellschaft	Drospirenone for hormone replacement therapy
WO2003006027A1 (en)	2001-07-13	2003-01-23	Schering Aktiengesellschaft	Combination of drospirenone and an estrogen sulphamate for hrt
BR0309780A (pt)	2002-04-26	2005-03-22	Schering Aktiengellschaft	Tratamento da hipertensão em mulheres recebendo terapia de reposição hormonal
US7786101B2 (en) *	2002-11-05	2010-08-31	Bayer Schering Pharma Ag	Cardiovascular protection using anti-aldosteronic progestins
CL2004000574A1 (es) *	2003-03-21	2005-02-11	Pharmacia Corp Sa Organizada B	Proceso para preparar un compuesto 17-espirolactona o la sal de lactona abierta por carbonilacion del correspondiente 17-alquenil o alquinil derivado, los intermediarios que se usan y su proceso de obtencion.
ITMI20040367A1 (it) *	2004-03-01	2004-06-01	Ind Chimica Srl	Processo per la preparazione di drospirenone
HUP0402465A2 (en) *	2004-11-30	2006-07-28	Richter Gedeon Vegyeszet	Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) *	2004-11-30	2006-07-28	Richter Gedeon Vegyeszet	Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
DE102004058300B4 (de) *	2004-12-02	2016-09-15	Austriamicrosystems Ag	Schaltungsanordnung zur Erzeugung eines komplexen Signals und Verwendung in einem Hochfrequenz-Sender oder -Empfänger
ITMI20042338A1 (it)	2004-12-06	2005-03-06	Ind Chimica Srl	Processo per la preparazione di drospirenone
PT2527356T (pt) *	2005-07-21	2018-03-26	Bayer Ip Gmbh	Processo para a produção de 3-oxo-pregn-4-eno-21,17-carbolactonas através da oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-diidroxiandrostanos
US7319154B2 (en)	2005-07-21	2008-01-15	Bayer Schering Pharma Ag	Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
ES2311927T5 (es) *	2005-07-21	2014-09-08	Bayer Pharma Aktiengesellschaft	Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos
WO2007127266A2 (en)	2006-04-27	2007-11-08	Covidien Ag	Electrode pad packaging systems and methods
EP1902711A1 (en) *	2006-09-20	2008-03-26	KAIROSmed GmbH	Oral modified release formulations containing Drospirenon and 8-Prenylnaringenin for use in Hormone Replacement Therapy (HRT)
MX2008016571A (es) *	2007-05-01	2009-03-09	Sicor Inc	Proceso para preparar drospirenona y su intermediarios.
DE102007030596B3 (de) *	2007-06-28	2009-03-12	Bayer Schering Pharma Aktiengesellschaft	Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
EP2265629B1 (en) *	2008-03-05	2015-06-24	Evestra, Inc.	Bismethylene-17 carbolactones and related uses
US8222237B2 (en) *	2008-11-25	2012-07-17	Evestra, Inc.	Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
CA2752805A1 (en)	2009-02-18	2010-08-26	Bayer Pharma Aktiengesellschaft	Formulation comprising drospirenone for subcutaneous or intramuscular administration
US20120114757A1 (en)	2009-02-18	2012-05-10	Bayer Pharma Aktiengesellschaft	Particles comprising drospirenone encapsulated in a polymer
US8334375B2 (en) *	2009-04-10	2012-12-18	Evestra, Inc.	Methods for the preparation of drospirenone
ES2432063T3 (es) *	2009-06-16	2013-11-29	Crystal Pharma, S.A.U.	Procedimiento para la obtención de 17-espirolactonas en esteroides
DE102009031909B4 (de)	2009-07-01	2017-02-09	Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg	Verfahren zur Herstellung von Drospirenon aus Prasteron
CN102395596B (zh)	2010-03-16	2013-02-13	台州太法药业有限公司	屈螺酮制备方法
CN101830959B (zh) *	2010-05-27	2012-07-18	杭州龙山化工有限公司	一种曲螺酮的合成方法
US11351122B1 (en)	2010-07-28	2022-06-07	Laboratorios Leon Farma Sa	Synthetic progestogens and pharmaceutical compositions comprising the same
AR081670A1 (es)	2010-06-29	2012-10-10	Leon Farma Sa Lab	Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en)	2010-07-28	2020-12-01	Laboratorios Leon Farma Sa	Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US9603860B2 (en)	2010-07-28	2017-03-28	Laboratorios Leon Farma Sa	Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
ES2419663T3 (es)	2010-08-03	2013-08-21	Newchem S.P.A.	Métodos para la preparación de Drospirenona y productos intermedios de la misma
WO2012107513A1 (en)	2011-02-10	2012-08-16	Crystal Pharma, S.A.U.	Process for obtaining drospirenone
ITMI20111383A1 (it)	2011-07-25	2013-01-26	Ind Chimica Srl	Processo per la preparazione di drospirenone
BR112014010590A2 (pt) *	2011-11-04	2017-05-02	Bayer Ip Gmbh	18-metil-6,7-metilen-3-oxo-17-pregn-4-eno-21,17?-carbolactonas, preparações farmacêuticas contendo os compostos mencionados e seu uso na terapia da endometriose
CA2856324C (en)	2011-11-22	2019-08-13	Industriale Chimica S.R.L.	Process for the preparation of drospirenone
EP2597101A1 (en)	2011-11-22	2013-05-29	Industriale Chimica S.R.L.	Process for the preparation of drospirenone
ES2651145T3 (es)	2013-02-20	2018-01-24	Industriale Chimica S.R.L.	Proceso para la preparación de drospirenona
HUE032858T2 (en)	2013-04-12	2017-11-28	Ind Chimica Srl	Method for producing drospirenone
JP6827962B2 (ja)	2015-06-23	2021-02-10	ラボラトリオスレオンファーマエスエー	過剰体重に影響される女性患者のためのドロスピレノン系避妊薬
EP3108889A1 (en)	2015-06-23	2016-12-28	Philippe Perrin	Drospirenone-based contraceptive for a female patient affected with excess weight
CN113387993A (zh) *	2021-07-06	2021-09-14	江西百思康瑞药业有限公司	一种屈螺酮的合成方法
EP4134082A1 (en)	2021-08-12	2023-02-15	Chemo Research, S.L.	Method for treating endometriosis and providing effective contraception
WO2023152658A1 (en)	2022-02-10	2023-08-17	Lupin Limited	Slow release drospirenone tablet composition
EP4486311A1 (en)	2022-03-01	2025-01-08	Chemo Research, S.L.	Chewable oral contraceptive

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2652761C2 (de)	1976-11-16	1985-11-21	Schering AG, 1000 Berlin und 4709 Bergkamen	15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3022337A1 (de) *	1980-06-11	1982-01-07	Schering Ag Berlin Und Bergkamen, 1000 Berlin	Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen
DE3042136A1 (de) *	1980-11-03	1982-06-09	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
EP0075189B1 (en) *	1981-09-21	1985-08-28	Schering Aktiengesellschaft	3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
DE3414508A1 (de) *	1984-04-13	1985-10-24	Schering AG, 1000 Berlin und 4709 Bergkamen	Mehrfach tritiierte steroid-20.17-spirolactone und ihre verwendung als tracersubstanzen
DE3626838A1 (de) *	1986-08-08	1988-02-11	Schering Ag	Verfahren zur herstellung von 17(alpha)-pregnan-21,17-carbolactonen
US5106995A (en) *	1989-05-05	1992-04-21	Isp Investments Inc.	Production of lactones from diols
DE19633685C1 (de)	1996-08-12	1997-10-09	Schering Ag	Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens

1996
- 1996-08-12 DE DE19633685A patent/DE19633685C1/de not_active Expired - Fee Related
1997
- 1997-08-11 DK DK97937562T patent/DK0918791T3/da active
- 1997-08-11 BR BR9711060A patent/BR9711060A/pt not_active IP Right Cessation
- 1997-08-11 EA EA199900153A patent/EA001947B1/ru not_active IP Right Cessation
- 1997-08-11 ES ES09100011.7T patent/ES2438941T3/es not_active Expired - Lifetime
- 1997-08-11 ES ES97937562T patent/ES2175451T7/es active Active
- 1997-08-11 DK DK09100011.7T patent/DK2168974T3/da active
- 1997-08-11 EP EP09100011.7A patent/EP2168974B1/de not_active Revoked
- 1997-08-11 CN CNB971960356A patent/CN1158300C/zh not_active Expired - Lifetime
- 1997-08-11 EP EP01250277.9A patent/EP1149840B2/de not_active Expired - Lifetime
- 1997-08-11 CZ CZ0047099A patent/CZ297255B6/cs not_active IP Right Cessation
- 1997-08-11 DE DE59713018T patent/DE59713018D1/de not_active Expired - Lifetime
- 1997-08-11 EP EP01250278A patent/EP1149841B1/de not_active Expired - Lifetime
- 1997-08-11 AT AT01250278T patent/ATE446966T1/de active
- 1997-08-11 PT PT01250278T patent/PT1149841E/pt unknown
- 1997-08-11 TR TR1999/00262T patent/TR199900262T2/xx unknown
- 1997-08-11 EP EP97937562A patent/EP0918791B3/de not_active Expired - Lifetime
- 1997-08-11 SI SI9730790T patent/SI1149841T1/sl unknown
- 1997-08-11 ES ES01250278T patent/ES2335860T3/es not_active Expired - Lifetime
- 1997-08-11 DK DK01250278.7T patent/DK1149841T3/da active
- 1997-08-11 IL IL12796397A patent/IL127963A/en not_active IP Right Cessation
- 1997-08-11 WO PCT/EP1997/004342 patent/WO1998006738A1/de not_active Ceased
- 1997-08-11 SK SK194-99A patent/SK283546B6/sk not_active IP Right Cessation
- 1997-08-11 AT AT97937562T patent/ATE215557T1/de active
- 1997-08-11 CA CA002261137A patent/CA2261137C/en not_active Expired - Lifetime
- 1997-08-11 AU AU40144/97A patent/AU729149B2/en not_active Expired
- 1997-08-11 NZ NZ333697A patent/NZ333697A/xx not_active IP Right Cessation
- 1997-08-11 SI SI9730350T patent/SI0918791T1/xx unknown
- 1997-08-11 AT AT01250277T patent/ATE420098T1/de active
- 1997-08-11 KR KR10-1999-7001166A patent/KR100473297B1/ko not_active Expired - Lifetime
- 1997-08-11 DE DE59706887T patent/DE59706887D1/de not_active Expired - Lifetime
- 1997-08-11 PL PL97331530A patent/PL187474B1/pl unknown
- 1997-08-11 ES ES01250277T patent/ES2320626T5/es not_active Expired - Lifetime
- 1997-08-11 PT PT01250277T patent/PT1149840E/pt unknown
- 1997-08-11 DK DK01250277.9T patent/DK1149840T5/da active
- 1997-08-11 HU HU9903089A patent/HU223106B1/hu active Protection Beyond IP Right Term
- 1997-08-11 DE DE59712991T patent/DE59712991D1/de not_active Expired - Lifetime
- 1997-08-11 PT PT97937562T patent/PT918791E/pt unknown
- 1997-08-11 US US09/242,334 patent/US6121465A/en not_active Expired - Lifetime
- 1997-08-11 SI SI9730786T patent/SI1149840T2/sl unknown
- 1997-08-11 JP JP50938998A patent/JP3333524B2/ja not_active Expired - Lifetime
- 1997-08-11 PT PT91000117T patent/PT2168974E/pt unknown
- 1997-11-08 UA UA99031342A patent/UA55423C2/uk unknown
1998
- 1998-12-01 BG BG102976A patent/BG62776B1/bg unknown
1999
- 1999-01-29 IS IS4965A patent/IS2100B/is unknown
2000
- 2000-08-18 US US09/640,748 patent/US6933395B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
SI1149840T2 (sl)	2013-08-30
US6933395B1 (en)	2005-08-23
PL187474B1 (pl)	2004-07-30
SK283546B6 (sk)	2003-09-11
SI1149840T1 (sl)	2009-06-30
EP1149840A3 (de)	2004-12-01
DK1149841T3 (da)	2010-03-08
NZ333697A (en)	2000-08-25
AU729149B2 (en)	2001-01-25
EP2168974A3 (de)	2013-03-06
CA2261137C (en)	2005-03-15
EP1149841A3 (de)	2004-12-01
ES2320626T3 (es)	2009-05-27
UA55423C2 (uk)	2003-04-15
PT1149841E (pt)	2010-01-29
AU4014497A (en)	1998-03-06
CN1223662A (zh)	1999-07-21
PT918791E (pt)	2002-09-30
ES2320626T5 (es)	2013-09-05
KR100473297B1 (ko)	2005-03-07
EP2168974A2 (de)	2010-03-31
EP1149840A2 (de)	2001-10-31
EP0918791A1 (de)	1999-06-02
DK0918791T3 (da)	2002-07-15
ES2335860T3 (es)	2010-04-06
KR20000029939A (ko)	2000-05-25
EP1149841B1 (de)	2009-10-28
BR9711060A (pt)	1999-08-17
JP2000516226A (ja)	2000-12-05
EP0918791B1 (de)	2002-04-03
HK1021190A1 (en)	2000-06-02
DK1149840T3 (da)	2009-04-27
PL331530A1 (en)	1999-07-19
JP3333524B2 (ja)	2002-10-15
ATE215557T1 (de)	2002-04-15
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KR100473297B1 (ko)	2005-03-07	드로스피레논의 제조 방법, 및 17α-(3-히드록시-1-프로필)-6β,7β；15β,16β-디메틸렌-5β-안드로스탄-3β,5,17β-트리올 및 6β,7β；15β,16β-디메틸렌-5β-히드록시-3-옥소-17α-안드로스탄-21,17-카르보락톤
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