BG64668B1 - Фармацевтични състави на пептиди, притежаващи малка разтворимост във физиологична среда - Google Patents

Фармацевтични състави на пептиди, притежаващи малка разтворимост във физиологична среда Download PDF

Info

Publication number: BG64668B1
Authority: BG; Bulgaria
Prior art keywords: antide; nicotinamide; solubility; peptide; pharmaceutical composition
Prior art date: 1997-05-28

Application number

BG103884A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG103884A (en

Inventor

Peter Richardson

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-28

Filing date

1999-11-15

Publication date

2005-11-30

1997-05-28 Priority claimed from EP97108593A external-priority patent/EP0880968A1/de

1999-11-15 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

2000-07-31 Publication of BG103884A publication Critical patent/BG103884A/xx

2005-11-30 Publication of BG64668B1 publication Critical patent/BG64668B1/bg

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DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 131
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 27
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 claims abstract description 18
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
239000004480 active ingredient Substances 0.000 claims abstract description 7
QRYFGTULTGLGHU-NBERXCRTSA-N iturelix Chemical group C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CCCCNC(=O)C=1C=NC=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)CCCNC(=O)C1=CC=CN=C1 QRYFGTULTGLGHU-NBERXCRTSA-N 0.000 claims description 75
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235000005152 nicotinamide Nutrition 0.000 claims description 65
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DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 51
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 41
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WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract description 6
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LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 15
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Classifications

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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/08—Peptides having 5 to 11 amino acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Zoology (AREA)
Dermatology (AREA)
Toxicology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

BG103884A 1997-05-28 1999-11-15 Фармацевтични състави на пептиди, притежаващи малка разтворимост във физиологична среда BG64668B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97108593A EP0880968A1 (de)	1997-05-28	1997-05-28	In physiologischem Medium schwerlösliche pharmazeutische Peptidezusammensetzungen
EP97121246A EP0880969A1 (de)	1997-05-28	1997-12-03	Im physiologischem Medium schwerlösliche pharmazeutische Peptidezusammensetzungen

Publications (2)

Publication Number	Publication Date
BG103884A BG103884A (en)	2000-07-31
BG64668B1 true BG64668B1 (bg)	2005-11-30

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BG103884A BG64668B1 (bg)	1997-05-28	1999-11-15	Фармацевтични състави на пептиди, притежаващи малка разтворимост във физиологична среда

Country Status (26)

Country	Link
US (1)	US6331520B1 (de)
EP (2)	EP0880969A1 (de)
JP (1)	JP2002502384A (de)
KR (1)	KR100552546B1 (de)
CN (1)	CN1159062C (de)
AR (1)	AR012868A1 (de)
AT (1)	ATE252909T1 (de)
AU (1)	AU743152B2 (de)
BG (1)	BG64668B1 (de)
BR (1)	BR9809708A (de)
CA (1)	CA2291765A1 (de)
CZ (1)	CZ298825B6 (de)
DE (1)	DE69819322T2 (de)
DK (1)	DK0984788T3 (de)
EA (1)	EA002227B1 (de)
EE (1)	EE04001B1 (de)
ES (1)	ES2210772T3 (de)
IL (2)	IL133176A0 (de)
NO (1)	NO323697B1 (de)
NZ (1)	NZ500777A (de)
PL (1)	PL192647B1 (de)
PT (1)	PT984788E (de)
SI (1)	SI0984788T1 (de)
SK (1)	SK284640B6 (de)
TR (1)	TR199902865T2 (de)
WO (1)	WO1998053844A1 (de)

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US8343186B2 (en)	2004-04-06	2013-01-01	Arthrex, Inc.	Fully threaded suture anchor with transverse anchor pin
EP1064934A1 (de)	1999-06-30	2001-01-03	Applied Research Systems ARS Holding N.V.	Gefriergetrocknete GRF-enthaltende Arzneimittel
WO2001087322A2 (en) *	2000-05-17	2001-11-22	Bionebraska, Inc.	Peptide pharmaceutical formulations
US20040229334A1 (en) *	2003-05-15	2004-11-18	Mendoza Christine B.	Process for manufacture of nematode-extracted anticoagulant protein (NAP)
MX2009010675A (es) *	2007-04-04	2009-10-23	Theratechnologies Inc	Formulaciones farmaceuticas de moleculas de la hormona liberadora de la hormona delcrecimiento humana.
US20150157619A1 (en)	2012-07-10	2015-06-11	Takeda Pharmaceutical Company Limited	Pharmaceutical preparation for injection
US9018177B2 (en)	2012-10-12	2015-04-28	L'oreal S.A.	Cosmetic compositions for increasing bioavailability of the active compounds baicalin and/or vitamin C
US9072919B2 (en)	2012-10-12	2015-07-07	L'oreal S.A.	Synergistic antioxidant cosmetic compositions containing at least one of baicalin and taxifolin, at least one of caffeine and nicotinamide, at least one of vitamin C and resveratrol and ferulic acid
KR102261301B1 (ko) *	2012-10-12	2021-06-07	로레알	적어도 하나의 하이드로트로프 및 적어도 하나의 활성제을 포함하는 화장용 조성물
US9107853B2 (en)	2012-10-12	2015-08-18	L'oreal S.A.	Compositions containing phenolic compounds and hydrotropes for cosmetic use
US9023826B2 (en)	2012-10-12	2015-05-05	L'oreal S.A.	Compositions containing adenosine and the hydrotropes caffeine and nicotinamide for cosmetic use
US9669242B2 (en) *	2013-07-01	2017-06-06	L'oreal	Compositions containing at least two phenolic compounds, a lipid-soluble antioxidant and at least one hydrotrope for cosmetic use
JP6634758B2 (ja) *	2015-09-25	2020-01-22	ニプロ株式会社	液体組成物及び凍結乾燥製剤
CA3014406A1 (en)	2016-02-16	2017-08-24	Strongbridge Biopharma plc	Veldoreotide with poor solubitliy in physiological conditions for use in the treatment of acromegaly, acromegaly cancer, sst-r5 expressing tumors, type 2 diabetes, hyperglycemia,and hormone-related tumors
TWI829687B (zh)	2018-05-07	2024-01-21	丹麥商諾佛儂迪克股份有限公司	包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
US20200093884A1 (en)	2018-09-20	2020-03-26	Mark C. Manning	Stable intranasal formulations of carbetocin

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1998
- 1998-05-26 TR TR1999/02865T patent/TR199902865T2/xx unknown
- 1998-05-26 AU AU81062/98A patent/AU743152B2/en not_active Ceased
- 1998-05-26 DK DK98930729T patent/DK0984788T3/da active
- 1998-05-26 EE EEP199900545A patent/EE04001B1/xx not_active IP Right Cessation
- 1998-05-26 DE DE69819322T patent/DE69819322T2/de not_active Expired - Fee Related
- 1998-05-26 WO PCT/EP1998/003079 patent/WO1998053844A1/en not_active Ceased
- 1998-05-26 CZ CZ0423199A patent/CZ298825B6/cs not_active IP Right Cessation
- 1998-05-26 CN CNB988054671A patent/CN1159062C/zh not_active Expired - Fee Related
- 1998-05-26 SI SI9830555T patent/SI0984788T1/xx unknown
- 1998-05-26 BR BR9809708-3A patent/BR9809708A/pt not_active Application Discontinuation
- 1998-05-26 PL PL336982A patent/PL192647B1/pl unknown
- 1998-05-26 IL IL13317698A patent/IL133176A0/xx not_active IP Right Cessation
- 1998-05-26 KR KR1019997010204A patent/KR100552546B1/ko not_active Expired - Fee Related
- 1998-05-26 EP EP98930729A patent/EP0984788B1/de not_active Expired - Lifetime
- 1998-05-26 AT AT98930729T patent/ATE252909T1/de not_active IP Right Cessation
- 1998-05-26 NZ NZ500777A patent/NZ500777A/en unknown
- 1998-05-26 SK SK1597-99A patent/SK284640B6/sk unknown
- 1998-05-26 JP JP50021999A patent/JP2002502384A/ja not_active Withdrawn
- 1998-05-26 PT PT98930729T patent/PT984788E/pt unknown
- 1998-05-26 EA EA199901089A patent/EA002227B1/ru not_active IP Right Cessation
- 1998-05-26 CA CA002291765A patent/CA2291765A1/en not_active Abandoned
- 1998-05-26 ES ES98930729T patent/ES2210772T3/es not_active Expired - Lifetime
- 1998-05-27 AR ARP980102454A patent/AR012868A1/es active IP Right Grant
1999
- 1999-11-15 BG BG103884A patent/BG64668B1/bg unknown
- 1999-11-24 NO NO19995763A patent/NO323697B1/no unknown
- 1999-11-28 IL IL133176A patent/IL133176A/en unknown
- 1999-11-29 US US09/451,013 patent/US6331520B1/en not_active Expired - Fee Related

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Also Published As

Publication number	Publication date
SK284640B6 (sk)	2005-08-04
HK1029928A1 (en)	2001-04-20
DK0984788T3 (da)	2004-03-08
ES2210772T3 (es)	2004-07-01
EE9900545A (et)	2000-06-15
SK159799A3 (en)	2000-07-11
IL133176A0 (en)	2001-03-19
JP2002502384A (ja)	2002-01-22
PT984788E (pt)	2004-01-30
EP0880969A1 (de)	1998-12-02
AU8106298A (en)	1998-12-30
US6331520B1 (en)	2001-12-18
AR012868A1 (es)	2000-11-22
EA002227B1 (ru)	2002-02-28
KR100552546B1 (ko)	2006-02-14
NO995763L (no)	1999-11-24
NZ500777A (en)	2001-09-28
NO995763D0 (no)	1999-11-24
EP0984788B1 (de)	2003-10-29
BG103884A (en)	2000-07-31
BR9809708A (pt)	2000-07-11
CN1263469A (zh)	2000-08-16
EP0984788A1 (de)	2000-03-15
KR20010012253A (ko)	2001-02-15
CA2291765A1 (en)	1998-12-03
CN1159062C (zh)	2004-07-28
PL336982A1 (en)	2000-07-31
EA199901089A1 (ru)	2000-06-26
SI0984788T1 (en)	2004-02-29
AU743152B2 (en)	2002-01-17
CZ298825B6 (cs)	2008-02-20
PL192647B1 (pl)	2006-11-30
NO323697B1 (no)	2007-06-25
WO1998053844A1 (en)	1998-12-03
DE69819322D1 (de)	2003-12-04
CZ423199A3 (cs)	2000-05-17
TR199902865T2 (xx)	2000-05-22
DE69819322T2 (de)	2004-07-29
IL133176A (en)	2006-08-01
ATE252909T1 (de)	2003-11-15
EE04001B1 (et)	2003-04-15

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