BG64710B1 - Модулатори на телесното тегло, съответните нуклеинови киселини и протеини и тяхното приложение в диагностиката и терапията - Google Patents

Модулатори на телесното тегло, съответните нуклеинови киселини и протеини и тяхното приложение в диагностиката и терапията Download PDF

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Publication number
BG64710B1
BG64710B1 BG101228A BG10122897A BG64710B1 BG 64710 B1 BG64710 B1 BG 64710B1 BG 101228 A BG101228 A BG 101228A BG 10122897 A BG10122897 A BG 10122897A BG 64710 B1 BG64710 B1 BG 64710B1
Authority
BG
Bulgaria
Prior art keywords
polypeptide
seq
sequence
histidine
serine
Prior art date
Application number
BG101228A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG101228A (en
Inventor
Jeffrey FRIEDMAN
Yiying Zhang
Ricardo Proenca
Margherita Maffei
Jeffrey Halaas
Ketan Gajiwala
Stephen BURLEY
Original Assignee
The Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/292,345 external-priority patent/US6001968A/en
Priority claimed from US08/438,431 external-priority patent/US6429290B1/en
Application filed by The Rockefeller University filed Critical The Rockefeller University
Publication of BG101228A publication Critical patent/BG101228A/xx
Publication of BG64710B1 publication Critical patent/BG64710B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/06—Preparations for care of the skin for countering cellulitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
BG101228A 1994-08-17 1997-02-12 Модулатори на телесното тегло, съответните нуклеинови киселини и протеини и тяхното приложение в диагностиката и терапията BG64710B1 (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/292,345 US6001968A (en) 1994-08-17 1994-08-17 OB polypeptides, modified forms and compositions
US08/347,563 US5935810A (en) 1994-08-17 1994-11-30 Mammalian ob polypeptides capable of modulating body weight, corresponding nucleic acids, and diagnostic and therapeutic uses thereof
US08/438,431 US6429290B1 (en) 1994-08-17 1995-05-10 OB polypeptides, modified forms and derivatives
US08/483,211 US6309853B1 (en) 1994-08-17 1995-06-07 Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
BG101228A BG101228A (en) 1997-09-30
BG64710B1 true BG64710B1 (bg) 2005-12-30

Family

ID=27501568

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101228A BG64710B1 (bg) 1994-08-17 1997-02-12 Модулатори на телесното тегло, съответните нуклеинови киселини и протеини и тяхното приложение в диагностиката и терапията

Country Status (32)

Country Link
US (1) US6309853B1 (fr)
EP (1) EP0777732B1 (fr)
JP (1) JP3479080B2 (fr)
CN (1) CN1162978B (fr)
AP (1) AP815A (fr)
BG (1) BG64710B1 (fr)
BR (1) BR9508596A (fr)
CA (1) CA2195955C (fr)
CZ (1) CZ295018B6 (fr)
DE (2) DE19531931A1 (fr)
EE (1) EE04377B1 (fr)
ES (1) ES2108663T3 (fr)
FI (1) FI121709B (fr)
GB (1) GB2292382B (fr)
GE (1) GEP20022701B (fr)
GR (1) GR970300021T1 (fr)
HK (1) HK1001495A1 (fr)
HU (1) HU223563B1 (fr)
IL (2) IL114987A (fr)
IS (1) IS4416A (fr)
LV (1) LV11868B (fr)
MD (1) MD2311G2 (fr)
MX (1) MX9701200A (fr)
NO (2) NO323847B1 (fr)
NZ (1) NZ291689A (fr)
OA (1) OA10596A (fr)
PL (1) PL183352B1 (fr)
RO (1) RO121036B1 (fr)
SI (1) SI9520090A (fr)
SK (1) SK287191B6 (fr)
TR (1) TR199501021A2 (fr)
WO (1) WO1996005309A2 (fr)

Families Citing this family (347)

* Cited by examiner, † Cited by third party
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US6429290B1 (en) 1994-08-17 2002-08-06 The Rockefeller University OB polypeptides, modified forms and derivatives
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
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OA10596A (en) 2002-06-26
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CA2195955A1 (fr) 1996-02-22
EP0777732A1 (fr) 1997-06-11
PL183352B1 (pl) 2002-06-28
GB2292382A (en) 1996-02-21
JP3479080B2 (ja) 2003-12-15
CZ295018B6 (cs) 2005-05-18
FI970656A7 (fi) 1997-02-17
TR199501021A2 (tr) 1996-06-21
FI970656A0 (fi) 1997-02-17
IL162093A0 (en) 2005-11-20
RO121036B1 (ro) 2006-11-30
NZ291689A (en) 2000-01-28
DE19531931A1 (de) 1996-03-07
HUT78052A (hu) 1999-07-28
AP815A (en) 2000-03-10
GB2292382B (en) 1997-07-16
EE9700030A (et) 1997-08-15
IL114987A0 (en) 1995-12-08
NO20065287L (no) 1997-04-16
WO1996005309A3 (fr) 1996-03-21
MD970100A (en) 1998-04-30
US6309853B1 (en) 2001-10-30
NO970683D0 (no) 1997-02-14
LV11868A (lv) 1997-10-20
MX9701200A (es) 1998-05-31
FI121709B (fi) 2011-03-15
ES2108663T1 (es) 1998-01-01
BG101228A (en) 1997-09-30
MD2311G2 (ro) 2004-08-31
CN1162978B (zh) 2010-06-16
GR970300021T1 (en) 1997-07-30
HK1001495A1 (en) 1998-06-19
NO323847B1 (no) 2007-07-09
NO970683L (no) 1997-04-16
NO326376B1 (no) 2008-11-17
EE04377B1 (et) 2004-10-15
GB9516947D0 (en) 1995-10-18

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