BG96200A - Гранулат,съдържащ натриев 2-меркаптоетансулфонат като активно вещество и метод за получаването му - Google Patents

Гранулат,съдържащ натриев 2-меркаптоетансулфонат като активно вещество и метод за получаването му

Info

Publication number
BG96200A
BG96200A BG096200A BG9620092A BG96200A BG 96200 A BG96200 A BG 96200A BG 096200 A BG096200 A BG 096200A BG 9620092 A BG9620092 A BG 9620092A BG 96200 A BG96200 A BG 96200A
Authority
BG
Bulgaria
Prior art keywords
mercaptoethanesulfonate
active substance
preparation
containing sodium
granulate containing
Prior art date
Application number
BG096200A
Other languages
English (en)
Other versions
BG60901B1 (bg
Inventor
Dieter Sauerbier
Juergen Engel
Eckhard Milsmann
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of BG96200A publication Critical patent/BG96200A/bg
Publication of BG60901B1 publication Critical patent/BG60901B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glanulating (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Гранулатът ще намери приложение за предпазване на пикочните органи при терапия на туморни заболявания с ифосфамид. Гранулите се получават, като активното вещество 2-меркаптоетансулфонат се смесва с с1-с4-алкохол или ацетон или смес от тези вещества с вода и се добавят свързващо и смазващо вещество и пълнител. Сместа се суши, покрива се с тънък филм и се добавят обичайните вкусови, подслаждащи и ароматизиращи вещества, след което тя се хомогенизира и покрива с филм.3 претенции
BG96200A 1990-07-16 1992-04-08 Гранулат,съдържащ натриев 2-меркаптоетансулфонаткато активно вещество и метод за получаването му BG60901B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4022525 1990-07-16
SG142394A SG142394G (en) 1990-07-16 1994-10-03 Tablet and granulate containing mesna as active agent

Publications (2)

Publication Number Publication Date
BG96200A true BG96200A (bg) 1993-12-24
BG60901B1 BG60901B1 (bg) 1996-06-28

Family

ID=25895027

Family Applications (2)

Application Number Title Priority Date Filing Date
BG94824A BG60851B1 (bg) 1990-07-16 1991-07-16 Таблетка, съдържаща натриев 2-меркаптоетансулфонат (месна), като активно вещество и метод за получаването й
BG96200A BG60901B1 (bg) 1990-07-16 1992-04-08 Гранулат,съдържащ натриев 2-меркаптоетансулфонаткато активно вещество и метод за получаването му

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG94824A BG60851B1 (bg) 1990-07-16 1991-07-16 Таблетка, съдържаща натриев 2-меркаптоетансулфонат (месна), като активно вещество и метод за получаването й

Country Status (31)

Country Link
US (1) US5262169A (bg)
EP (1) EP0468245B1 (bg)
JP (1) JP3068894B2 (bg)
KR (1) KR100189666B1 (bg)
CN (1) CN1072484C (bg)
AT (1) ATE104548T1 (bg)
AU (1) AU638586B2 (bg)
BG (2) BG60851B1 (bg)
CA (1) CA2047027C (bg)
DE (2) DE4122167A1 (bg)
DK (1) DK0468245T3 (bg)
EG (1) EG20019A (bg)
ES (1) ES2063412T3 (bg)
FI (1) FI97949C (bg)
HK (1) HK129894A (bg)
HR (1) HRP920889B1 (bg)
HU (1) HU206630B (bg)
IE (1) IE65373B1 (bg)
IL (1) IL98836A (bg)
LT (1) LT3527B (bg)
LV (1) LV10040B (bg)
MC (1) MC2273A1 (bg)
MX (1) MX174407B (bg)
NO (1) NO178362C (bg)
NZ (1) NZ238941A (bg)
PT (1) PT98325B (bg)
RO (1) RO113713B1 (bg)
RU (1) RU2070040C1 (bg)
SG (1) SG142394G (bg)
SI (1) SI9111226A (bg)
ZA (1) ZA915515B (bg)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0560092B1 (de) * 1992-03-11 1997-12-03 ASTA Medica Aktiengesellschaft Tabletten, Granulate und Pellets mit hohem Gehalt an Wirkstoffen für hochkonzentrierte, feste Darreichungsformen
US5773031A (en) * 1996-02-27 1998-06-30 L. Perrigo Company Acetaminophen sustained-release formulation
DE19733305A1 (de) * 1997-08-01 1999-02-04 Asta Medica Ag Pharmazeutische Zusammensetzung enthaltend Ifosfamid und Carnitin
CA2305179A1 (en) * 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Oral administration preparation
EP0955040A1 (de) * 1998-04-27 1999-11-10 ASTA Medica Aktiengesellschaft Arzneiform zur oralen Applikation von Mesna
DE19826517B4 (de) * 1998-06-15 2006-03-23 Baxter Healthcare S.A. Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette
RU2151595C1 (ru) * 1999-01-27 2000-06-27 Закрытое акционерное общество "Биофит", ЛТД Скользящее для таблетируемых масс
US6075053A (en) * 1999-02-09 2000-06-13 Bionumerik Pharmaceuticals, Inc. Method of reducing or reversing neuropathy
DE10051266A1 (de) * 2000-10-16 2002-04-25 Basf Ag Verfahren zur Filtration einer Flüssigkeit, mit einem Filterhilfsmittel und Verfahren zu deren Herstellung
WO2009022430A1 (en) * 2007-08-10 2009-02-19 Ki Pharmaceuticals, Inc. Skin whitening agent
CA2936741C (en) 2014-10-31 2018-11-06 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1307786C (en) * 1984-12-14 1992-09-22 Keiichi Yokoyama Quinazoline derivatives and antihypertensive preparations containing same as effective components
IT1185551B (it) * 1985-04-15 1987-11-12 Schering Spa Composizioni farmaceutiche a base di acido mercaptoetansolfonico ad attivita' terapeutica,derivati salini organici dell'acido mercaptoetansolfonico utili per tali composizioni e relativo procedimento di preparazione
DE58900183D1 (de) * 1988-03-19 1991-08-29 Asta Pharma Ag Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.

Also Published As

Publication number Publication date
MC2273A1 (fr) 1993-06-23
DE4122167A1 (de) 1992-01-23
ZA915515B (en) 1992-04-29
LV10040A (lv) 1994-05-10
HK129894A (en) 1994-12-02
SI9111226A (en) 1995-04-30
KR920002154A (ko) 1992-02-28
EG20019A (en) 1997-01-30
PT98325A (pt) 1992-05-29
PT98325B (pt) 1999-01-29
HRP920889A2 (en) 1996-04-30
HRP920889B1 (en) 1998-02-28
NO178362B (no) 1995-12-04
HUT59317A (en) 1992-05-28
IL98836A (en) 1994-11-28
FI97949B (fi) 1996-12-13
CA2047027C (en) 1996-09-17
FI913409L (fi) 1992-01-17
NO912771D0 (no) 1991-07-15
EP0468245A1 (de) 1992-01-29
JP3068894B2 (ja) 2000-07-24
DE59101431D1 (de) 1994-05-26
EP0468245B1 (de) 1994-04-20
FI913409A0 (fi) 1991-07-15
BG60901B1 (bg) 1996-06-28
ATE104548T1 (de) 1994-05-15
RO113713B1 (ro) 1998-10-30
JPH04230319A (ja) 1992-08-19
AU8044591A (en) 1992-01-16
NO912771L (no) 1992-01-17
HU912374D0 (en) 1991-12-30
ES2063412T3 (es) 1995-01-01
IE912463A1 (en) 1992-01-29
SG142394G (en) 1995-01-13
AU638586B2 (en) 1993-07-01
BG60851B1 (bg) 1996-05-31
LV10040B (en) 1995-06-20
KR100189666B1 (ko) 1999-06-01
MX174407B (es) 1994-05-13
US5262169A (en) 1993-11-16
NZ238941A (en) 1993-03-26
IL98836A0 (en) 1992-07-15
RU2070040C1 (ru) 1996-12-10
HU206630B (en) 1992-12-28
BG94824A (bg) 1993-12-24
CA2047027A1 (en) 1992-01-17
LTIP920A (en) 1995-03-27
CN1058337A (zh) 1992-02-05
FI97949C (fi) 1997-03-25
NO178362C (no) 1996-03-13
DK0468245T3 (da) 1994-05-16
IE65373B1 (en) 1995-10-18
CN1072484C (zh) 2001-10-10
LT3527B (en) 1995-11-27

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