LV10040B - Tablets, method of their preparation, granulates and method of their preparation - Google Patents

Tablets, method of their preparation, granulates and method of their preparation Download PDF

Info

Publication number: LV10040B
Authority: LV; Latvia
Prior art keywords: mesna; weight; parts; sowie; und
Prior art date: 1990-07-16

Application number

LVP-92-168A

Other languages

English (en)

Latvian (lv)

Other versions

LV10040A (lv

Inventor

Dieter Sauerbier

Juergen Prof Dr Engel

Eckhard Dr Milsmann

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-16

Filing date

1992-10-27

Publication date

1995-06-20

1992-10-27 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

1994-05-10 Publication of LV10040A publication Critical patent/LV10040A/xx

1995-06-20 Publication of LV10040B publication Critical patent/LV10040B/lv

Links

239000008187 granular material Substances 0.000 title claims abstract description 22
238000000034 method Methods 0.000 title claims 4
229960004635 mesna Drugs 0.000 claims abstract description 66
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
239000000945 filler Substances 0.000 claims abstract 8
239000000203 mixture Substances 0.000 claims abstract 8
239000011230 binding agent Substances 0.000 claims abstract 7
239000003795 chemical substances by application Substances 0.000 claims abstract 3
239000007884 disintegrant Substances 0.000 claims abstract 3
239000000126 substance Substances 0.000 claims description 11
241000252073 Anguilliformes Species 0.000 claims description 3
239000006260 foam Substances 0.000 claims description 3
ZNEWHQLOPFWXOF-UHFFFAOYSA-N coenzyme M Chemical compound OS(=O)(=O)CCS ZNEWHQLOPFWXOF-UHFFFAOYSA-N 0.000 claims 21
125000003118 aryl group Chemical group 0.000 claims 6
239000000796 flavoring agent Substances 0.000 claims 6
235000019634 flavors Nutrition 0.000 claims 6
238000005187 foaming Methods 0.000 claims 6
239000013543 active substance Substances 0.000 claims 2
239000012530 fluid Substances 0.000 claims 2
240000005979 Hordeum vulgare Species 0.000 claims 1
235000007340 Hordeum vulgare Nutrition 0.000 claims 1
238000007664 blowing Methods 0.000 claims 1
239000004067 bulking agent Substances 0.000 claims 1
239000012628 flowing agent Substances 0.000 claims 1
230000004907 flux Effects 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
150000007524 organic acids Chemical class 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
238000005201 scrubbing Methods 0.000 claims 1
XOGTZOOQQBDUSI-UHFFFAOYSA-M Mesna Chemical compound [Na+].[O-]S(=O)(=O)CCS XOGTZOOQQBDUSI-UHFFFAOYSA-M 0.000 abstract description 44
239000003826 tablet Substances 0.000 abstract 2
239000007938 effervescent tablet Substances 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 16
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 15
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 14
229920000036 polyvinylpyrrolidone Polymers 0.000 description 13
239000001267 polyvinylpyrrolidone Substances 0.000 description 11
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 8
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
239000000243 solution Substances 0.000 description 6
229920006316 polyvinylpyrrolidine Polymers 0.000 description 5
-1 Sorbit Chemical compound 0.000 description 4
240000008042 Zea mays Species 0.000 description 4
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 4
235000002017 Zea mays subsp mays Nutrition 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
239000008101 lactose Substances 0.000 description 4
235000019359 magnesium stearate Nutrition 0.000 description 4
235000009973 maize Nutrition 0.000 description 4
239000000725 suspension Substances 0.000 description 4
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
239000011575 calcium Substances 0.000 description 3
229910052791 calcium Inorganic materials 0.000 description 3
235000010980 cellulose Nutrition 0.000 description 3
230000018044 dehydration Effects 0.000 description 3
238000006297 dehydration reaction Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
238000005469 granulation Methods 0.000 description 3
235000019813 microcrystalline cellulose Nutrition 0.000 description 3
239000008108 microcrystalline cellulose Substances 0.000 description 3
229940016286 microcrystalline cellulose Drugs 0.000 description 3
239000001301 oxygen Substances 0.000 description 3
229910052760 oxygen Inorganic materials 0.000 description 3
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
229920003148 Eudragit® E polymer Polymers 0.000 description 2
229920003134 Eudragit® polymer Polymers 0.000 description 2
229930091371 Fructose Natural products 0.000 description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
239000005715 Fructose Substances 0.000 description 2
239000001828 Gelatine Substances 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229940072056 alginate Drugs 0.000 description 2
235000010443 alginic acid Nutrition 0.000 description 2
229920000615 alginic acid Polymers 0.000 description 2
AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 2
NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 2
235000013681 dietary sucrose Nutrition 0.000 description 2
229950009278 dimesna Drugs 0.000 description 2
KQYGMURBTJPBPQ-UHFFFAOYSA-L disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)CCSSCCS([O-])(=O)=O KQYGMURBTJPBPQ-UHFFFAOYSA-L 0.000 description 2
210000001035 gastrointestinal tract Anatomy 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
239000002054 inoculum Substances 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
229920001277 pectin Polymers 0.000 description 2
159000000000 sodium salts Chemical class 0.000 description 2
229960004793 sucrose Drugs 0.000 description 2
NOVZFMNCTCKLPF-UHFFFAOYSA-N 2,5-bis(aziridin-1-yl)-3,6-dipropoxycyclohexa-2,5-diene-1,4-dione Chemical compound O=C1C(OCCC)=C(N2CC2)C(=O)C(OCCC)=C1N1CC1 NOVZFMNCTCKLPF-UHFFFAOYSA-N 0.000 description 1
QLIBJPGWWSHWBF-UHFFFAOYSA-N 2-aminoethyl methacrylate Chemical compound CC(=C)C(=O)OCCN QLIBJPGWWSHWBF-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
244000099147 Ananas comosus Species 0.000 description 1
235000007119 Ananas comosus Nutrition 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
101100290380 Caenorhabditis elegans cel-1 gene Proteins 0.000 description 1
244000248349 Citrus limon Species 0.000 description 1
240000004784 Cymbopogon citratus Species 0.000 description 1
235000017897 Cymbopogon citratus Nutrition 0.000 description 1
241000283074 Equus asinus Species 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
229920003136 Eudragit® L polymer Polymers 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
244000141359 Malus pumila Species 0.000 description 1
ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 description 1
244000288157 Passiflora edulis Species 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
244000235659 Rubus idaeus Species 0.000 description 1
239000003708 ampul Substances 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
235000012216 bentonite Nutrition 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
235000014121 butter Nutrition 0.000 description 1
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000004512 die casting Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000007937 eating Effects 0.000 description 1
235000005686 eating Nutrition 0.000 description 1
210000000720 eyelash Anatomy 0.000 description 1
229960002737 fructose Drugs 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000001685 glycyrrhizic acid Substances 0.000 description 1
HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
229960001101 ifosfamide Drugs 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
235000012054 meals Nutrition 0.000 description 1
239000013081 microcrystal Substances 0.000 description 1
230000000510 mucolytic effect Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
125000000962 organic group Chemical group 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
239000008188 pellet Substances 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
230000011514 reflex Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Glanulating (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

LVP-92-168A 1990-07-16 1992-10-27 Tablets, method of their preparation, granulates and method of their preparation LV10040B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4022525		1990-07-16
SG142394A SG142394G (en)	1990-07-16	1994-10-03	Tablet and granulate containing mesna as active agent

Publications (2)

Publication Number	Publication Date
LV10040A LV10040A (lv)	1994-05-10
LV10040B true LV10040B (en)	1995-06-20

Family

ID=25895027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LVP-92-168A LV10040B (en)	1990-07-16	1992-10-27	Tablets, method of their preparation, granulates and method of their preparation

Country Status (31)

Country	Link
US (1)	US5262169A (bg)
EP (1)	EP0468245B1 (bg)
JP (1)	JP3068894B2 (bg)
KR (1)	KR100189666B1 (bg)
CN (1)	CN1072484C (bg)
AT (1)	ATE104548T1 (bg)
AU (1)	AU638586B2 (bg)
BG (2)	BG60851B1 (bg)
CA (1)	CA2047027C (bg)
DE (2)	DE4122167A1 (bg)
DK (1)	DK0468245T3 (bg)
EG (1)	EG20019A (bg)
ES (1)	ES2063412T3 (bg)
FI (1)	FI97949C (bg)
HK (1)	HK129894A (bg)
HR (1)	HRP920889B1 (bg)
HU (1)	HU206630B (bg)
IE (1)	IE65373B1 (bg)
IL (1)	IL98836A (bg)
LT (1)	LT3527B (bg)
LV (1)	LV10040B (bg)
MC (1)	MC2273A1 (bg)
MX (1)	MX174407B (bg)
NO (1)	NO178362C (bg)
NZ (1)	NZ238941A (bg)
PT (1)	PT98325B (bg)
RO (1)	RO113713B1 (bg)
RU (1)	RU2070040C1 (bg)
SG (1)	SG142394G (bg)
SI (1)	SI9111226A (bg)
ZA (1)	ZA915515B (bg)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59307753D1 (de) *	1992-03-11	1998-01-15	Asta Medica Ag	Tabletten, Granulate und Pellets mit hohem Gehalt an Wirkstoffen für hochkonzentrierte, feste Darreichungsformen
US5773031A (en) *	1996-02-27	1998-06-30	L. Perrigo Company	Acetaminophen sustained-release formulation
DE19733305A1 (de) *	1997-08-01	1999-02-04	Asta Medica Ag	Pharmazeutische Zusammensetzung enthaltend Ifosfamid und Carnitin
EP1020193A4 (en) *	1997-09-30	2006-05-24	Daiichi Seiyaku Co	ORAL PREPARATION
EP0955040A1 (de)	1998-04-27	1999-11-10	ASTA Medica Aktiengesellschaft	Arzneiform zur oralen Applikation von Mesna
DE19826517B4 (de) *	1998-06-15	2006-03-23	Baxter Healthcare S.A.	Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette
RU2151595C1 (ru) *	1999-01-27	2000-06-27	Закрытое акционерное общество "Биофит", ЛТД	Скользящее для таблетируемых масс
US6075053A (en) *	1999-02-09	2000-06-13	Bionumerik Pharmaceuticals, Inc.	Method of reducing or reversing neuropathy
DE10051266A1 (de) *	2000-10-16	2002-04-25	Basf Ag	Verfahren zur Filtration einer Flüssigkeit, mit einem Filterhilfsmittel und Verfahren zu deren Herstellung
WO2009022430A1 (en) *	2007-08-10	2009-02-19	Ki Pharmaceuticals, Inc.	Skin whitening agent
CA2902911C (en)	2014-10-31	2017-06-27	Purdue Pharma	Methods and compositions particularly for treatment of attention deficit disorder
US10722473B2 (en)	2018-11-19	2020-07-28	Purdue Pharma L.P.	Methods and compositions particularly for treatment of attention deficit disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4734418A (en) *	1984-12-14	1988-03-29	Mitsui Petrochemical Industries, Ltd.	Quinazoline compounds and antihypertensives
IT1185551B (it) *	1985-04-15	1987-11-12	Schering Spa	Composizioni farmaceutiche a base di acido mercaptoetansolfonico ad attivita' terapeutica,derivati salini organici dell'acido mercaptoetansolfonico utili per tali composizioni e relativo procedimento di preparazione
EP0334083B1 (de) *	1988-03-19	1991-07-24	ASTA Pharma Aktiengesellschaft	Ifosfamid-Mesna-Lyophilisat und Verfahren zu dessen Herstellung

1991
- 1991-07-04 EP EP91111125A patent/EP0468245B1/de not_active Expired - Lifetime
- 1991-07-04 AT AT9191111125T patent/ATE104548T1/de not_active IP Right Cessation
- 1991-07-04 DK DK91111125.0T patent/DK0468245T3/da active
- 1991-07-04 DE DE4122167A patent/DE4122167A1/de not_active Withdrawn
- 1991-07-04 ES ES91111125T patent/ES2063412T3/es not_active Expired - Lifetime
- 1991-07-04 DE DE59101431T patent/DE59101431D1/de not_active Expired - Lifetime
- 1991-07-11 MC MC912205A patent/MC2273A1/fr unknown
- 1991-07-11 RU SU915001036A patent/RU2070040C1/ru active
- 1991-07-11 MX MX9100169A patent/MX174407B/es unknown
- 1991-07-12 JP JP3172291A patent/JP3068894B2/ja not_active Expired - Lifetime
- 1991-07-12 SI SI9111226A patent/SI9111226A/sl unknown
- 1991-07-12 NZ NZ238941A patent/NZ238941A/en not_active IP Right Cessation
- 1991-07-14 EG EG42391A patent/EG20019A/xx active
- 1991-07-15 AU AU80445/91A patent/AU638586B2/en not_active Expired
- 1991-07-15 KR KR1019910012014A patent/KR100189666B1/ko not_active Expired - Lifetime
- 1991-07-15 CA CA002047027A patent/CA2047027C/en not_active Expired - Lifetime
- 1991-07-15 NO NO912771A patent/NO178362C/no not_active IP Right Cessation
- 1991-07-15 IL IL9883691A patent/IL98836A/en not_active IP Right Cessation
- 1991-07-15 ZA ZA915515A patent/ZA915515B/xx unknown
- 1991-07-15 FI FI913409A patent/FI97949C/fi not_active IP Right Cessation
- 1991-07-15 HU HU912374A patent/HU206630B/hu unknown
- 1991-07-15 PT PT98325A patent/PT98325B/pt not_active IP Right Cessation
- 1991-07-15 CN CN91104805A patent/CN1072484C/zh not_active Expired - Lifetime
- 1991-07-15 RO RO148005A patent/RO113713B1/ro unknown
- 1991-07-15 IE IE246391A patent/IE65373B1/en not_active IP Right Cessation
- 1991-07-16 BG BG94824A patent/BG60851B1/bg unknown
- 1991-07-16 US US07/730,178 patent/US5262169A/en not_active Expired - Lifetime
1992
- 1992-04-08 BG BG96200A patent/BG60901B1/bg unknown
- 1992-10-02 HR HRP-1226/91A patent/HRP920889B1/xx not_active IP Right Cessation
- 1992-10-27 LV LVP-92-168A patent/LV10040B/lv unknown
1993
- 1993-09-03 LT LTIP920A patent/LT3527B/lt not_active IP Right Cessation
1994
- 1994-10-03 SG SG142394A patent/SG142394G/en unknown
- 1994-11-24 HK HK129894A patent/HK129894A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT98325B (pt)	1999-01-29
LV10040A (lv)	1994-05-10
SG142394G (en)	1995-01-13
AU638586B2 (en)	1993-07-01
EG20019A (en)	1997-01-30
DE4122167A1 (de)	1992-01-23
LTIP920A (en)	1995-03-27
IL98836A0 (en)	1992-07-15
BG96200A (bg)	1993-12-24
AU8044591A (en)	1992-01-16
FI97949C (fi)	1997-03-25
NO912771L (no)	1992-01-17
FI913409L (fi)	1992-01-17
RU2070040C1 (ru)	1996-12-10
BG60901B1 (bg)	1996-06-28
HRP920889A2 (en)	1996-04-30
HRP920889B1 (en)	1998-02-28
MC2273A1 (fr)	1993-06-23
CA2047027C (en)	1996-09-17
HU912374D0 (en)	1991-12-30
FI97949B (fi)	1996-12-13
HU206630B (en)	1992-12-28
NO178362C (no)	1996-03-13
ZA915515B (en)	1992-04-29
SI9111226A (en)	1995-04-30
IE65373B1 (en)	1995-10-18
ATE104548T1 (de)	1994-05-15
LT3527B (en)	1995-11-27
EP0468245B1 (de)	1994-04-20
NO178362B (no)	1995-12-04
HK129894A (en)	1994-12-02
RO113713B1 (ro)	1998-10-30
DK0468245T3 (da)	1994-05-16
IE912463A1 (en)	1992-01-29
JPH04230319A (ja)	1992-08-19
CA2047027A1 (en)	1992-01-17
EP0468245A1 (de)	1992-01-29
NZ238941A (en)	1993-03-26
FI913409A0 (fi)	1991-07-15
NO912771D0 (no)	1991-07-15
US5262169A (en)	1993-11-16
JP3068894B2 (ja)	2000-07-24
MX174407B (es)	1994-05-13
BG94824A (bg)	1993-12-24
BG60851B1 (bg)	1996-05-31
IL98836A (en)	1994-11-28
DE59101431D1 (de)	1994-05-26
HUT59317A (en)	1992-05-28
ES2063412T3 (es)	1995-01-01
CN1072484C (zh)	2001-10-10
CN1058337A (zh)	1992-02-05
KR920002154A (ko)	1992-02-28
PT98325A (pt)	1992-05-29
KR100189666B1 (ko)	1999-06-01

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