BG97231A - Тетрахидроизохинолинилкарбамати на 1,2,3,3а,8,8а-хексахидро- 1,3а,8-триметилпироло(2,3-в)индол - Google Patents

Тетрахидроизохинолинилкарбамати на 1,2,3,3а,8,8а-хексахидро- 1,3а,8-триметилпироло(2,3-в)индол Download PDF

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Publication number
BG97231A
BG97231A BG097231A BG9723192A BG97231A BG 97231 A BG97231 A BG 97231A BG 097231 A BG097231 A BG 097231A BG 9723192 A BG9723192 A BG 9723192A BG 97231 A BG97231 A BG 97231A
Authority
BG
Bulgaria
Prior art keywords
tetrahydroisoquinolinylcarbamates
hexaxhydro
trimethylpyrrolo
indole
hydrogen
Prior art date
Application number
BG097231A
Other languages
English (en)
Other versions
BG61188B1 (bg
Inventor
Russell Richard Hamer
Grover Helsley
Edward Glamkowski
Yulin Chiang
Brian Freed
Barbara KURYS
Original Assignee
Hoechst Marion Roussel, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Inc. filed Critical Hoechst Marion Roussel, Inc.
Publication of BG97231A publication Critical patent/BG97231A/bg
Publication of BG61188B1 publication Critical patent/BG61188B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1. Съединения с формула в която r е водород или нисш алкил и х е водород, нисш алкил, халоген, нисш алкокси или хидрокси, които намират приложение за облекчаване дисфункцията на паметта, за която е характерен холинергичен дефицит, или техни фармацевтично приемливи присъединителни с киселина соли. 19 претенции
BG97231A 1990-06-27 1992-12-23 ТЕТРАХИДРОИЗОХИНОЛИНИЛКАРБАМАТИ НА 1,2,3,ЗА,8,8А-ХЕКСАХИДРО-1,ЗА,8- ТРИМЕТИЛ ПИРОЛО [2,З-b] ИНДОЛ BG61188B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/003552 WO1992000072A1 (en) 1990-06-27 1990-06-27 Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole

Publications (2)

Publication Number Publication Date
BG97231A true BG97231A (bg) 1993-12-24
BG61188B1 BG61188B1 (bg) 1997-02-28

Family

ID=22220922

Family Applications (1)

Application Number Title Priority Date Filing Date
BG97231A BG61188B1 (bg) 1990-06-27 1992-12-23 ТЕТРАХИДРОИЗОХИНОЛИНИЛКАРБАМАТИ НА 1,2,3,ЗА,8,8А-ХЕКСАХИДРО-1,ЗА,8- ТРИМЕТИЛ ПИРОЛО [2,З-b] ИНДОЛ

Country Status (18)

Country Link
EP (1) EP0538248B1 (bg)
KR (1) KR0172971B1 (bg)
AT (1) ATE163183T1 (bg)
AU (1) AU649953B2 (bg)
BG (1) BG61188B1 (bg)
DE (1) DE69032046T2 (bg)
DK (1) DK0538248T3 (bg)
ES (1) ES2113859T3 (bg)
FI (1) FI97229C (bg)
GE (1) GEP19991747B (bg)
LT (1) LT3598B (bg)
LV (1) LV10189B (bg)
MC (1) MC2287A1 (bg)
NO (1) NO179910C (bg)
RO (1) RO110501B1 (bg)
RU (1) RU2124516C1 (bg)
SG (1) SG70968A1 (bg)
WO (1) WO1992000072A1 (bg)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1271679B (it) * 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
US5665880A (en) * 1996-10-31 1997-09-09 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) * 1996-12-19 1997-10-14 Hoechst Marion Roussel, Inc. Method of preparation of physostigmine carbamate derivatives from eseroline ethers
WO2000046204A1 (en) * 1999-02-04 2000-08-10 Sk Corporation Tetrahydro isoquino linealkanol derivatives and pharmaceutical compositions containing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1547689A3 (ru) * 1984-10-18 1990-02-28 Щиба-Гейги Аг (Фирма) Инсектицидное средство
US4791107A (en) 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
DK168069B1 (da) * 1987-11-11 1994-01-31 Hoffmann La Roche Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
AU634380B2 (en) * 1990-05-17 1993-02-18 Hoechst-Roussel Pharmaceuticals Incorporated Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments
SU1746663A1 (ru) * 1990-06-26 1994-05-30 Институт Органической Химии Ан Усср Метил-n-(n-перфторалкилтиофенил)карбаматы, обладающие свойствами регулятора роста растений, фунгицида, бактерицида

Also Published As

Publication number Publication date
EP0538248A4 (bg) 1994-08-03
NO179910B (no) 1996-09-30
DE69032046T2 (de) 1998-08-27
FI97229C (fi) 1996-11-11
GEP19991747B (en) 1999-09-10
ATE163183T1 (de) 1998-02-15
LV10189B (en) 1995-08-20
EP0538248B1 (en) 1998-02-11
SG70968A1 (en) 2000-03-21
DE69032046D1 (de) 1998-03-19
LV10189A (lv) 1994-10-20
RU2124516C1 (ru) 1999-01-10
LTIP923A (en) 1995-03-27
ES2113859T3 (es) 1998-05-16
NO925008D0 (no) 1992-12-23
NO925008L (no) 1992-12-23
KR0172971B1 (ko) 1999-02-01
FI925872L (fi) 1992-12-23
AU5931390A (en) 1992-01-23
EP0538248A1 (en) 1993-04-28
LT3598B (en) 1995-12-27
DK0538248T3 (da) 1998-09-23
RO110501B1 (ro) 1996-01-30
BG61188B1 (bg) 1997-02-28
FI97229B (fi) 1996-07-31
MC2287A1 (fr) 1993-07-14
FI925872A0 (fi) 1992-12-23
WO1992000072A1 (en) 1992-01-09
NO179910C (no) 1997-01-08
AU649953B2 (en) 1994-06-09

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