MC2287A1 - Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole - Google Patents

Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole

Info

Publication number: MC2287A1
Authority: MC; Monaco
Prior art keywords: trimethylpyrrolo; hexahydro; indole; tetrahydroisoquinoleinylcarbamates; loweralkyl
Prior art date: 1990-06-27

Application number

MC90@@D

Other languages

English (en)

Inventor

Russel Hamer

Grover Helsley

Edward Glamzowski

Yulin Chiang

Brian Freed

Barbara Kurys

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-27

Filing date

1990-06-27

Publication date

1993-07-14

1990-06-27 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1993-07-14 Publication of MC2287A1 publication Critical patent/MC2287A1/fr

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
YQLFNHRHQDLFTQ-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinolin-1-ylcarbamic acid Chemical class C1=CC=C2C(NC(=O)O)NCCC2=C1 YQLFNHRHQDLFTQ-UHFFFAOYSA-N 0.000 abstract 1
KLJZEHNRALYISE-UHFFFAOYSA-N 3,4,8b-trimethyl-2,3a-dihydro-1h-pyrrolo[2,3-b]indole Chemical compound C1=CC=C2C3(C)CCN(C)C3N(C)C2=C1 KLJZEHNRALYISE-UHFFFAOYSA-N 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 loweralkyl Inorganic materials 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MC90@@D 1990-06-27 1990-06-27 Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole MC2287A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1990/003552 WO1992000072A1 (fr)	1990-06-27	1990-06-27	Tetrahydroisoquinolinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimenthylpyrrolo[2,3-b] indole

Publications (1)

Publication Number	Publication Date
MC2287A1 true MC2287A1 (fr)	1993-07-14

Family

ID=22220922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MC90@@D MC2287A1 (fr)	1990-06-27	1990-06-27	Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole

Country Status (18)

Country	Link
EP (1)	EP0538248B1 (fr)
KR (1)	KR0172971B1 (fr)
AT (1)	ATE163183T1 (fr)
AU (1)	AU649953B2 (fr)
BG (1)	BG61188B1 (fr)
DE (1)	DE69032046T2 (fr)
DK (1)	DK0538248T3 (fr)
ES (1)	ES2113859T3 (fr)
FI (1)	FI97229C (fr)
GE (1)	GEP19991747B (fr)
LT (1)	LT3598B (fr)
LV (1)	LV10189B (fr)
MC (1)	MC2287A1 (fr)
NO (1)	NO179910C (fr)
RO (1)	RO110501B1 (fr)
RU (1)	RU2124516C1 (fr)
SG (1)	SG70968A1 (fr)
WO (1)	WO1992000072A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1271679B (it) *	1994-07-18	1997-06-04	Mediolanum Farmaceutici Srl	Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
US5665880A (en) *	1996-10-31	1997-09-09	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) *	1996-12-19	1997-10-14	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseroline ethers
ATE264844T1 (de) *	1999-02-04	2004-05-15	Sk Corp	Tetrahydroisochinolinalkanol-derivate und diese enthaltende pharmazeutische zubereitungen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1547689A3 (ru) *	1984-10-18	1990-02-28	Щиба-Гейги Аг (Фирма)	Инсектицидное средство
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
DK168069B1 (da) *	1987-11-11	1994-01-31	Hoffmann La Roche	Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
AU634380B2 (en) *	1990-05-17	1993-02-18	Hoechst-Roussel Pharmaceuticals Incorporated	Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments
SU1746663A1 (ru) *	1990-06-26	1994-05-30	Институт Органической Химии Ан Усср	Метил-n-(n-перфторалкилтиофенил)карбаматы, обладающие свойствами регулятора роста растений, фунгицида, бактерицида

1990
- 1990-06-27 RU RU92016550A patent/RU2124516C1/ru active
- 1990-06-27 AT AT90910230T patent/ATE163183T1/de not_active IP Right Cessation
- 1990-06-27 MC MC90@@D patent/MC2287A1/fr unknown
- 1990-06-27 AU AU59313/90A patent/AU649953B2/en not_active Ceased
- 1990-06-27 DE DE69032046T patent/DE69032046T2/de not_active Expired - Fee Related
- 1990-06-27 WO PCT/US1990/003552 patent/WO1992000072A1/fr not_active Ceased
- 1990-06-27 EP EP90910230A patent/EP0538248B1/fr not_active Expired - Lifetime
- 1990-06-27 DK DK90910230T patent/DK0538248T3/da active
- 1990-06-27 SG SG1996003071A patent/SG70968A1/en unknown
- 1990-06-27 RO RO92-01561A patent/RO110501B1/ro unknown
- 1990-06-27 ES ES90910230T patent/ES2113859T3/es not_active Expired - Lifetime
- 1990-06-27 KR KR1019920703313A patent/KR0172971B1/ko not_active Expired - Fee Related
1992
- 1992-12-23 FI FI925872A patent/FI97229C/fi active
- 1992-12-23 NO NO925008A patent/NO179910C/no not_active IP Right Cessation
- 1992-12-23 BG BG97231A patent/BG61188B1/bg unknown
1993
- 1993-06-15 LV LVP-93-575A patent/LV10189B/en unknown
- 1993-07-29 GE GEAP19931278A patent/GEP19991747B/en unknown
- 1993-09-03 LT LTIP923A patent/LT3598B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
BG97231A (bg)	1993-12-24
DE69032046D1 (de)	1998-03-19
NO925008D0 (no)	1992-12-23
EP0538248B1 (fr)	1998-02-11
RU2124516C1 (ru)	1999-01-10
LT3598B (en)	1995-12-27
EP0538248A4 (fr)	1994-08-03
FI97229C (fi)	1996-11-11
AU649953B2 (en)	1994-06-09
LV10189A (lv)	1994-10-20
WO1992000072A1 (fr)	1992-01-09
DE69032046T2 (de)	1998-08-27
BG61188B1 (bg)	1997-02-28
NO179910B (no)	1996-09-30
DK0538248T3 (da)	1998-09-23
FI925872L (fi)	1992-12-23
ATE163183T1 (de)	1998-02-15
FI925872A0 (fi)	1992-12-23
FI97229B (fi)	1996-07-31
LV10189B (en)	1995-08-20
EP0538248A1 (fr)	1993-04-28
NO179910C (no)	1997-01-08
RO110501B1 (ro)	1996-01-30
SG70968A1 (en)	2000-03-21
ES2113859T3 (es)	1998-05-16
LTIP923A (en)	1995-03-27
GEP19991747B (en)	1999-09-10
NO925008L (no)	1992-12-23
KR0172971B1 (ko)	1999-02-01
AU5931390A (en)	1992-01-23

Publication	Publication Date	Title
HU9302733D0 (en)	1993-12-28	Process for producing heterocyclic amine derivatives
HU9301362D0 (en)	1993-09-28	Method for producing 4-aryl-piperazines and 4-aryl-piperidines
ATE32077T1 (de)	1988-02-15	7-amino-azolo(1,5-a>-pyrimidine und diese enthaltende fungizide.
DE69815161D1 (de)	2003-07-03	Azindolethylaminderivate als Nikotin-acetylcholin-Rezeptor Bindung Verbindungen
ES2077071T3 (es)	1995-11-16	Derivados de quinolin-3-carboxamida.
MC2287A1 (fr)	1993-07-14	Tetrahydroisoquinoleinylcarbamates de 1,2,3,3a,8,8a-hexahydro-1,31,8-trimethylpyrrolo(2,3,-b)indole
PL294803A1 (en)	1993-07-26	Method of obtaining novel ((aryloalkyl-piperidin-4-yl)methyl)-2a,3,4.5-tetrahydro-1(2h)-acenaphtylen-1-ones
NO902813D0 (no)	1990-06-25	(1,2,3,4-tetrahydro-9-acridinimino)cykloheksankarboksylsyre og relaterte forbindelser, fremgangsmaate for fremstilling og anvendelse som medikamenter.
PT84136B (pt)	1989-07-31	Processo para a preparacao de derivados de pirrolo {1,2-a} {4,1} benzoxazepina
GR3024483T3 (en)	1997-11-28	Indano pyrrolidine carbamates
CA2085216A1 (fr)	1991-12-28	Tetrahydroisoquinolinylcarbamates de 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b\| indole
IL133392A0 (en)	2001-04-30	Benzo (5, 6) cyclohepta (1, 2b) pyridine derivatives useful for inhibition of farnesyl protein transferase
DE3678015D1 (en)	1991-04-18	N-carboxyalcoyl-2-oxo-3-diaryl-5-6 triazine als heilmittel.
NO902556D0 (no)	1990-06-08	4,5,5a,6-tetrahydro-3h-isoksazol(5,4,3-kl)akridinderivater og fremgangsmaate for fremstilling derav.
FI912499A0 (fi)	1991-05-23	Pyrido/3,4-b/pyrrolo/1,2-e//1,4,5/ oxadiazepiner och daermed naerbeslaektade analoger, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
IT1270054B (it)	1997-04-28	Composti ad attivita' ipocolesterolemica