NO925008L - Tetrahydroisokinolinylkarbamater av 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyl-pyrrolo(2,3-b)indol - Google Patents

Tetrahydroisokinolinylkarbamater av 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyl-pyrrolo(2,3-b)indol

Info

Publication number: NO925008L
Authority: NO; Norway
Prior art keywords: tetrahydroisokinolinyl; hexsahydro; carbamates; pyrrolo; indol
Prior art date: 1990-06-27

Application number

NO92925008A

Other languages

English (en)

Other versions

NO925008D0 (no

NO179910B (no

NO179910C (no

Inventor

Russell Richard Lee Hamer

Grover Cleveland Helsley

Edward Joseph Glamkowski

Yulin Chiang

Brian Scott Freed

Barbara Elaine Kurys

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-27

Filing date

1992-12-23

Publication date

1992-12-23

1992-12-23 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1992-12-23 Publication of NO925008D0 publication Critical patent/NO925008D0/no

1992-12-23 Publication of NO925008L publication Critical patent/NO925008L/no

1996-09-30 Publication of NO179910B publication Critical patent/NO179910B/no

1997-01-08 Publication of NO179910C publication Critical patent/NO179910C/no

Links

KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
YQLFNHRHQDLFTQ-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinolin-1-ylcarbamic acid Chemical class C1=CC=C2C(NC(=O)O)NCCC2=C1 YQLFNHRHQDLFTQ-UHFFFAOYSA-N 0.000 abstract 1
KLJZEHNRALYISE-UHFFFAOYSA-N 3,4,8b-trimethyl-2,3a-dihydro-1h-pyrrolo[2,3-b]indole Chemical compound C1=CC=C2C3(C)CCN(C)C3N(C)C2=C1 KLJZEHNRALYISE-UHFFFAOYSA-N 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000006735 deficit Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 loweralkyl Inorganic materials 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO925008A 1990-06-27 1992-12-23 Tetrahydroisokinolinylkarbamater av 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyl-pyrrolo[2,3-bÅindol NO179910C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1990/003552 WO1992000072A1 (en)	1990-06-27	1990-06-27	Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole

Publications (4)

Publication Number	Publication Date
NO925008D0 NO925008D0 (no)	1992-12-23
NO925008L true NO925008L (no)	1992-12-23
NO179910B NO179910B (no)	1996-09-30
NO179910C NO179910C (no)	1997-01-08

Family

ID=22220922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO925008A NO179910C (no)	1990-06-27	1992-12-23	Tetrahydroisokinolinylkarbamater av 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyl-pyrrolo[2,3-bÅindol

Country Status (18)

Country	Link
EP (1)	EP0538248B1 (no)
KR (1)	KR0172971B1 (no)
AT (1)	ATE163183T1 (no)
AU (1)	AU649953B2 (no)
BG (1)	BG61188B1 (no)
DE (1)	DE69032046T2 (no)
DK (1)	DK0538248T3 (no)
ES (1)	ES2113859T3 (no)
FI (1)	FI97229C (no)
GE (1)	GEP19991747B (no)
LT (1)	LT3598B (no)
LV (1)	LV10189B (no)
MC (1)	MC2287A1 (no)
NO (1)	NO179910C (no)
RO (1)	RO110501B1 (no)
RU (1)	RU2124516C1 (no)
SG (1)	SG70968A1 (no)
WO (1)	WO1992000072A1 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
IT1271679B (it) *	1994-07-18	1997-06-04	Mediolanum Farmaceutici Srl	Derivati del fenilcarbammato atti all'impiego come anticolinesterasici
US5665880A (en) *	1996-10-31	1997-09-09	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseretholes
US5677457A (en) *	1996-12-19	1997-10-14	Hoechst Marion Roussel, Inc.	Method of preparation of physostigmine carbamate derivatives from eseroline ethers
ATE264844T1 (de) *	1999-02-04	2004-05-15	Sk Corp	Tetrahydroisochinolinalkanol-derivate und diese enthaltende pharmazeutische zubereitungen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1547689A3 (ru) *	1984-10-18	1990-02-28	Щиба-Гейги Аг (Фирма)	Инсектицидное средство
US4791107A (en) *	1986-07-16	1988-12-13	Hoechst-Roussel Pharmaceuticals, Inc.	Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
DK168069B1 (da) *	1987-11-11	1994-01-31	Hoffmann La Roche	Isoquinolinderivater og en fremgangsmaade til fremstilling af octahydroisoquinoliner ud fra derivaterne
US4914102A (en) *	1989-09-28	1990-04-03	Hoechst Roussel Pharmaceuticals, Inc.	N-aminocarbamates related to physostigmine, pharmacentical compositions and use
AU634380B2 (en) *	1990-05-17	1993-02-18	Hoechst-Roussel Pharmaceuticals Incorporated	Alpha-oxopyrrolo(2,3-b)indole acetic acids, esters, amides and related analogs, a process for their preparation and their use as medicaments
SU1746663A1 (ru) *	1990-06-26	1994-05-30	Институт Органической Химии Ан Усср	Метил-n-(n-перфторалкилтиофенил)карбаматы, обладающие свойствами регулятора роста растений, фунгицида, бактерицида

1990
- 1990-06-27 RU RU92016550A patent/RU2124516C1/ru active
- 1990-06-27 AT AT90910230T patent/ATE163183T1/de not_active IP Right Cessation
- 1990-06-27 MC MC90@@D patent/MC2287A1/xx unknown
- 1990-06-27 AU AU59313/90A patent/AU649953B2/en not_active Ceased
- 1990-06-27 DE DE69032046T patent/DE69032046T2/de not_active Expired - Fee Related
- 1990-06-27 WO PCT/US1990/003552 patent/WO1992000072A1/en not_active Ceased
- 1990-06-27 EP EP90910230A patent/EP0538248B1/en not_active Expired - Lifetime
- 1990-06-27 DK DK90910230T patent/DK0538248T3/da active
- 1990-06-27 SG SG1996003071A patent/SG70968A1/en unknown
- 1990-06-27 RO RO92-01561A patent/RO110501B1/ro unknown
- 1990-06-27 ES ES90910230T patent/ES2113859T3/es not_active Expired - Lifetime
- 1990-06-27 KR KR1019920703313A patent/KR0172971B1/ko not_active Expired - Fee Related
1992
- 1992-12-23 FI FI925872A patent/FI97229C/fi active
- 1992-12-23 NO NO925008A patent/NO179910C/no not_active IP Right Cessation
- 1992-12-23 BG BG97231A patent/BG61188B1/bg unknown
1993
- 1993-06-15 LV LVP-93-575A patent/LV10189B/en unknown
- 1993-07-29 GE GEAP19931278A patent/GEP19991747B/en unknown
- 1993-09-03 LT LTIP923A patent/LT3598B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
BG97231A (bg)	1993-12-24
DE69032046D1 (de)	1998-03-19
NO925008D0 (no)	1992-12-23
EP0538248B1 (en)	1998-02-11
RU2124516C1 (ru)	1999-01-10
LT3598B (en)	1995-12-27
EP0538248A4 (no)	1994-08-03
FI97229C (fi)	1996-11-11
AU649953B2 (en)	1994-06-09
LV10189A (lv)	1994-10-20
WO1992000072A1 (en)	1992-01-09
DE69032046T2 (de)	1998-08-27
BG61188B1 (bg)	1997-02-28
NO179910B (no)	1996-09-30
DK0538248T3 (da)	1998-09-23
FI925872L (fi)	1992-12-23
ATE163183T1 (de)	1998-02-15
FI925872A0 (fi)	1992-12-23
FI97229B (fi)	1996-07-31
LV10189B (en)	1995-08-20
EP0538248A1 (en)	1993-04-28
NO179910C (no)	1997-01-08
RO110501B1 (ro)	1996-01-30
SG70968A1 (en)	2000-03-21
ES2113859T3 (es)	1998-05-16
LTIP923A (en)	1995-03-27
GEP19991747B (en)	1999-09-10
MC2287A1 (fr)	1993-07-14
KR0172971B1 (ko)	1999-02-01
AU5931390A (en)	1992-01-23

Legal Events

Date	Code	Title	Description
2001-01-29	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN DECEMBER 2000

Publication	Publication Date	Title
HU9302733D0 (en)	1993-12-28	Process for producing heterocyclic amine derivatives
AU639943B2 (en)	1993-08-12	N-aminocarbamates related to physostigmine, a process for their preparation and their use as medicaments
ES2077071T3 (es)	1995-11-16	Derivados de quinolin-3-carboxamida.
NO925008L (no)	1992-12-23	Tetrahydroisokinolinylkarbamater av 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyl-pyrrolo(2,3-b)indol
AU1801592A (en)	1992-12-10	{(arylalkylpiperdin-4-yl)methyl}-2a,3,4,5-tetrahydro-1(2h)- acenaphthylen-1-ones and related compounds
NO923686D0 (no)	1992-09-22	Substituerte pyridinylamino-1h-indoler, 1h-indazoler, 2h-indazoler, benzo(b)-thiofener og 1,2-benzisotiazoler, en fremgangsmaate for deres fremstilling og deres anvendelse som legemidler
NO177053C (no)	1995-07-12	Analogifremgangsmåte for fremstilling av terapeutisk aktive (1,2,3,4-tetrahydro-9-akridinimino)cykloheksankarboksylsyrer
CA2276203A1 (en)	1998-07-09	N-(pyridinylamino)isoindolines and related compounds
CA2085216A1 (en)	1991-12-28	Tetrahydroisoquinolinylcarbamates of 1,2,3,3a,8,8a- hexahydro-1,3a,8-trimethylpyrrolo ¬2,3-b\| indole
RU92016550A (ru)	1995-06-19	Тетрагидроизохинолинилкарбаматы 1,2,3,3а,8,8a-гексагидро-1,3a-8-три-метилпирроло(2,3-b)индола, фармацевтическая композиция и способ лечения
DE69114404D1 (de)	1995-12-14	1-(Pyridinylalkyl)-1H-indole, -indoline und Analoge.
NO902556D0 (no)	1990-06-08	4,5,5a,6-tetrahydro-3h-isoksazol(5,4,3-kl)akridinderivater og fremgangsmaate for fremstilling derav.
MX9706606A (es)	1997-11-29	Procedimiento para la preparacion del monohidrato de loracarbef.