ES2118343T3 - Nuevos derivados de 2-(1h)-quinoleinona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de 2-(1h)-quinoleinona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2118343T3
ES2118343T3 ES94401926T ES94401926T ES2118343T3 ES 2118343 T3 ES2118343 T3 ES 2118343T3 ES 94401926 T ES94401926 T ES 94401926T ES 94401926 T ES94401926 T ES 94401926T ES 2118343 T3 ES2118343 T3 ES 2118343T3
Authority
ES
Spain
Prior art keywords
substituted
branched
linear
unsubstituted
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94401926T
Other languages
English (en)
Inventor
Alex Cordi
Patrice Desos
Jean Lepagnol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Servier de Medecine Translationnelle SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2118343T3 publication Critical patent/ES2118343T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/5765—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTOS DE FORMULA (I): DONDE: R1,R2 Y R3 IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO, DE HALOGENO O DE UN GRUPO ALQUILO, NITRO, CIANO O AMINOSULFONILO, O BIEN CUANDO DOS DE ELLOS ESTAN SITUADOS SOBRE CARBONOS ADYACENTES, FORMAN CON LOS ATOMOS DE CARBONO A LOS QUE ESTAN UNIDOS UN CICLO CICLOALQUILO (C3 UIDO, R4 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO (C1 O UN GRUPO DONDE R6 Y R7 IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO (C1 FICADO SUSTITUIDO O NO SUSTITUIDO, R5 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO HIDROXI, ALCOXI (C1 C6) LINEAL O RAMIFICADO, FENOXI, MERCAPTO, ALQUILTIO (C1 STITUIDO NO SUSTITUIDO, FENILO SUSTITUIDO O NO SUSTITUIDO, AMINO SUSTITUIDO O NO SUSTITUIDO, O UN GRUPO DONDE R6 Y R7 SON TAL COMO SE DEFINEN ANTERIORMENTE, SUS ISOMEROS ASI COMO SUS SALES DE ADICION A UN ACIDO O A UNA BASE FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
ES94401926T 1993-08-31 1994-08-31 Nuevos derivados de 2-(1h)-quinoleinona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2118343T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9310379A FR2709489B1 (fr) 1993-08-31 1993-08-31 Nouveaux dérivés de 2-(1H)-quinoléinone, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2118343T3 true ES2118343T3 (es) 1998-09-16

Family

ID=9450460

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94401926T Expired - Lifetime ES2118343T3 (es) 1993-08-31 1994-08-31 Nuevos derivados de 2-(1h)-quinoleinona, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.

Country Status (12)

Country Link
US (2) US5536709A (es)
EP (1) EP0640612B1 (es)
JP (1) JP2672262B2 (es)
AT (1) ATE165362T1 (es)
AU (1) AU676348B2 (es)
CA (1) CA2117600A1 (es)
DE (1) DE69409734T2 (es)
DK (1) DK0640612T3 (es)
ES (1) ES2118343T3 (es)
FR (1) FR2709489B1 (es)
NZ (1) NZ264338A (es)
ZA (1) ZA946659B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000309585A (ja) * 1999-02-26 2000-11-07 Kyorin Pharmaceut Co Ltd ６−置換ヘテロキノリンカルボン酸誘導体とその付加塩及びそれらの製造方法
FR2805260A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides 6-sulfamoyl-3-quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2805262A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides aryle ou heteroaryle quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2805261A1 (fr) * 2000-02-18 2001-08-24 Adir Nouveaux derives d'acides 6-amino ou 6-hydrazinosulfonyl-3- quinolinyl phosphoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
US8222431B2 (en) * 2007-10-16 2012-07-17 Janssen Pharmaceutica N.V. Process for synthesizing phosphonic and phosphinic acid compounds
WO2012164085A1 (en) 2011-06-03 2012-12-06 Merz Pharma Gmbh & Co. Kgaa Glycine b antagonists
KR102509217B1 (ko) * 2020-08-28 2023-03-14 기초과학연구원 시스테인 선택적 결합 퀴놀리논 유도체 화합물, 이의 펩티드 결합체 및 이를 포함하는 항체-약물 접합체

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124588A (en) * 1976-03-01 1978-11-07 Sandoz, Inc. 4-Hydroxy-quinolin-2-one-3-phosphonic acid esters
US4093637A (en) * 1977-01-31 1978-06-06 The United States Of America As Represented By The Secretary Of Agriculture Alkyl 9,9(10,10)-bis(acyloxymethyl)octadecanoates as primary plasticizers for polyvinylchloride
US4906621A (en) * 1985-05-24 1990-03-06 Ciba-Geigy Corporation Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
FR2683818B1 (fr) * 1991-11-14 1993-12-31 Adir Cie Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IS4233A (is) * 1993-12-22 1995-06-23 Astra Aktiebolag Misleit hringtengd efnasambönd

Also Published As

Publication number Publication date
US5536709A (en) 1996-07-16
FR2709489A1 (fr) 1995-03-10
FR2709489B1 (fr) 1995-10-20
CA2117600A1 (fr) 1995-03-01
ZA946659B (en) 1995-04-20
ATE165362T1 (de) 1998-05-15
DE69409734D1 (de) 1998-05-28
EP0640612A1 (fr) 1995-03-01
JPH07149778A (ja) 1995-06-13
US5646132A (en) 1997-07-08
AU7152094A (en) 1995-03-16
DK0640612T3 (da) 1999-02-15
DE69409734T2 (de) 1998-11-12
AU676348B2 (en) 1997-03-06
NZ264338A (en) 1995-10-26
EP0640612B1 (fr) 1998-04-22
JP2672262B2 (ja) 1997-11-05

Similar Documents

Publication Publication Date Title
MX9204622A (es) Nuevos derivados de 3,5-di-tert-butil-4-hidroxifenilo, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9202282A (es) Nuevos derivados de 3-amino piridazinas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
SE7601207L (sv) Acetylenderivat av acetyleniska aminosyror
DK71780A (da) Fremgangsmaade til fremstilling af difenylhydantoinderivater
ES2064156T3 (es) Derivados de 3-sulfonil-amino-2-(1h)-quinoleinona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AU643290B2 (en) Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their preparation and their therapeutic application
ES2010284A6 (es) Procedimiento para preparar derivados de tiourea.
AU676348B2 (en) New 2(1H)-quinolone compounds, process for their preparationand the pharmaceutical compositions which contain them
ES2119106T3 (es) Nuevos benzo-espiro-alquenos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
NO890440D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater.
DE69416683D1 (de) Benzolactam-derivate
ES547604A0 (es) Un procedimiento para preparar derivados de 2-piridin-tiol
DE69005318D1 (de) 1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen.
DE69301639D1 (de) Tetrahydronaphtalenderivate, ihre Herstellung und ihre therapeutische Verwendung
ES2060095T3 (es) Nuevas imidazobenzodiazepinas y sus sales, procedimiento de preparacion, aplicacion como medicamentos y composiciones que los contienen.
ES2123038T3 (es) Nuevos derivados pirrolo-tieno-pirazinicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
SE8500963D0 (sv) Nitraminodiaryl sulfoxide derivatives, process for their preparation and pharmaceutical and pesticidal compositions containing them

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 640612

Country of ref document: ES