BR0007760A - Composto, processo para preparar o mesmo,método para inibir mudanças patológicas mediadaspela enzima que converte o tnf-alfa (tace) em ummamìfero em necessidade deste, método paratratar um paciente que sofre de uma condição, e,composição farmacêutica - Google Patents

Composto, processo para preparar o mesmo,método para inibir mudanças patológicas mediadaspela enzima que converte o tnf-alfa (tace) em ummamìfero em necessidade deste, método paratratar um paciente que sofre de uma condição, e,composição farmacêutica

Info

Publication number
BR0007760A
BR0007760A BR0007760-7A BR0007760A BR0007760A BR 0007760 A BR0007760 A BR 0007760A BR 0007760 A BR0007760 A BR 0007760A BR 0007760 A BR0007760 A BR 0007760A
Authority
BR
Brazil
Prior art keywords
tace
enzyme
alpha
prepare
condition
Prior art date
Application number
BR0007760-7A
Other languages
English (en)
Inventor
Jeremy Ian Levin
James Ming Chen
Xue-Mei Du
Jay Albright Donald
Arie Zask
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of BR0007760A publication Critical patent/BR0007760A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/41—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C07C309/42—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78—Halides of sulfonic acids
    • C07C309/86—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/87—Halides of sulfonic acids having halosulfonyl groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)

Abstract

"COMPOSTO, PROCESSO PARA PREPARAR O MESMO,MéTODO PARA INIBIR MUDANçAS PATOLóGICAS MEDIADASPELA ENZIMA QUE CONVERTE O TNF-alfa (TACE) EM UMMAMìFERO EM NECESSIDADE DESTE, MéTODO PARATRATAR UM PACIENTE QUE SOFRE DE UMA CONDIçãO, E,COMPOSIçãO FARMACêUTICA". Os compostos das fórmulas (a),(b), (c) ou (d) são fornecidos em que P e Q são (e) ou (f), contantoque quando P é (e) Q seja (f) e vice versa; que são utilizáveis nascondições de doença mediadas pela TNF-<244>, tal como artritereumatóide, osteoartrite, sépsis, AIDS, colite ulcerativa, esclerosemúltipla, doença de Crohn e perda degenerativa de cartilagem.
BR0007760-7A 1999-01-27 2000-01-27 Composto, processo para preparar o mesmo,método para inibir mudanças patológicas mediadaspela enzima que converte o tnf-alfa (tace) em ummamìfero em necessidade deste, método paratratar um paciente que sofre de uma condição, e,composição farmacêutica BR0007760A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23908499A 1999-01-27 1999-01-27
PCT/US2000/002144 WO2000044749A1 (en) 1999-01-27 2000-01-27 Acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as tace inhibitors

Publications (1)

Publication Number Publication Date
BR0007760A true BR0007760A (pt) 2001-11-13

Family

ID=22900535

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007760-7A BR0007760A (pt) 1999-01-27 2000-01-27 Composto, processo para preparar o mesmo,método para inibir mudanças patológicas mediadaspela enzima que converte o tnf-alfa (tace) em ummamìfero em necessidade deste, método paratratar um paciente que sofre de uma condição, e,composição farmacêutica

Country Status (22)

Country Link
EP (2) EP1279674A3 (pt)
JP (1) JP2002535404A (pt)
KR (1) KR20010101690A (pt)
CN (1) CN1207294C (pt)
AR (1) AR022424A1 (pt)
AT (1) ATE227288T1 (pt)
AU (1) AU2741800A (pt)
BR (1) BR0007760A (pt)
CA (1) CA2355735A1 (pt)
CZ (1) CZ20012721A3 (pt)
DE (1) DE60000724T2 (pt)
DK (1) DK1157024T3 (pt)
EA (1) EA200100814A1 (pt)
ES (1) ES2186628T3 (pt)
HK (1) HK1038562B (pt)
HU (1) HUP0105307A3 (pt)
IL (1) IL144291A0 (pt)
NO (1) NO20013673L (pt)
PL (1) PL349070A1 (pt)
PT (1) PT1157024E (pt)
WO (1) WO2000044749A1 (pt)
ZA (1) ZA200104324B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
WO2005021489A2 (en) 2002-12-23 2005-03-10 Wyeth Holdings Corporation Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
EP1449538A1 (en) * 2003-02-21 2004-08-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibition of TACE or amphiregulin for the modulation of EGF receptor signal transactivation
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
EP2170884A2 (en) * 2007-06-25 2010-04-07 Boehringer Ingelheim International GmbH Chemical compounds
CA3115038A1 (en) 2018-10-04 2020-04-09 Inserm (Institut National De La Sante Et De La Recherche Medicale) Egfr inhibitors for treating keratodermas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU743898B2 (en) * 1996-10-16 2002-02-07 American Cyanamid Company The preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
AU743901B2 (en) * 1996-10-16 2002-02-07 Wyeth Holdings Corporation Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors

Also Published As

Publication number Publication date
HK1038562B (en) 2003-02-21
IL144291A0 (en) 2002-05-23
DE60000724T2 (de) 2003-08-21
EP1157024B1 (en) 2002-11-06
CN1207294C (zh) 2005-06-22
WO2000044749A1 (en) 2000-08-03
KR20010101690A (ko) 2001-11-14
HK1038562A1 (en) 2002-03-22
ES2186628T3 (es) 2003-05-16
ATE227288T1 (de) 2002-11-15
CZ20012721A3 (cs) 2002-03-13
JP2002535404A (ja) 2002-10-22
NO20013673L (no) 2001-09-21
PL349070A1 (en) 2002-07-01
DE60000724D1 (en) 2002-12-12
PT1157024E (pt) 2003-02-28
NO20013673D0 (no) 2001-07-26
HUP0105307A3 (en) 2002-10-28
HUP0105307A2 (hu) 2002-05-29
AU2741800A (en) 2000-08-18
ZA200104324B (en) 2002-08-26
CA2355735A1 (en) 2000-08-03
AR022424A1 (es) 2002-09-04
EA200100814A1 (ru) 2001-12-24
EP1279674A2 (en) 2003-01-29
DK1157024T3 (da) 2003-03-03
EP1279674A3 (en) 2003-10-01
CN1337962A (zh) 2002-02-27
EP1157024A1 (en) 2001-11-28

Similar Documents

Publication Publication Date Title
BR0007752A (pt) Composto, processo para preparar o mesmo,método de inibir mudanças patológicas mediadaspela enzima que converte tnf-&#34;alfa&#34; (tace) em ummamìfero em necessidade deste, e, composiçãofarmacêutica
BR9811573A (pt) Compostos de benzila que inibem a adesão de leucócitos mediada por vla-4
MX2025010403A (es) Moleculas que tienen ciertas utilidades plaguicidas e intermedios, composiciones y procesos relacionados con ellas
WO2019191092A8 (en) Compounds for treating huntington&#39;s disease
BR0016665A (pt) Composição alvejante, e, métodos de alvejamento e de preparação de uma composição alvejante
BR9811569A (pt) Compostos que inibem a adesão de leucócito mediada por vla-4
BR9608041A (pt) Oligossacarídeo sulfatado processo para o tratamento anti-angiogênico anti-metastático e/ou anti-inflamatório de um paciente humano ou outro paciente animal de sangue quente uso de um oligossacarídeo e composição farmacêutica ou veterinária para tratamento anti-angiogênico anti-metastático e/ou anti-inflamatório
BR0313743A (pt) Benzimidazol quinolinonas e usos destas
BR0009651A (pt) Composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, e, método para tratar artrite reumatóide e uma doença obstrutiva das vias aéreas
EA200100809A1 (ru) 2,3,4,5-тетрагидро-1h-[1,4]бензодиазепин-3-гидроксамовые кислоты как ингибиторы матриксных металлопротеиназ
ATE209187T1 (de) Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen
BR0004977A (pt) Processos para preparação de fenol, acetona e metiletilcetona
BR0007783A (pt) Composto, método de inibir mudanças patológicas mediadas pela enzima que converte o tnf-a (tace) em um mamìfero em necessidade deste, composição farmacêutica, e, processos para preparar um composto
BRPI0610644B8 (pt) composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.
BR0007727A (pt) Composto, processo para preparar os compostos,método para inibir mudanças patológicas mediadaspela enzima que converte o tnf-alfa (tace) em ummamìfero em necessidade deste, e, composiçãofarmacêutica
BR0213583A (pt) Processo para preparar um composto de insulina, e, composto de insulina
BR0313419A (pt) Processo de obtenção de um extrato de folhas de abacateiro rico em lipìdios furânicos
MX2024014435A (es) Compuestos heterociclicos y heteroarilo para el tratamiento de la enfermedad de huntington
IL181267A0 (en) Vla-4 antagonists
CL2009000791A1 (es) Compuestos derivados de labirintopeptina; procedimiento para prepararlos que comprende fermentar la cepa actinomadura namibiensis (dsm 6313); uso de los compuestos para tratar infecciones bacterianas, infecciones viricas y/o dolor; composicion farmaceutica que los comprenden; dna que codifica la preprolabirintopeptina a2.
BR0210776A (pt) Compostos de imunomodulação
BR0007750A (pt) Composto, processo para preparar o mesmo,método para inibir mudanças patológicas mediadaspela enzima que converte o tnfalfa (tace) em ummamìfero com necessidade desta, e, composiçãofarmacêutica
BR0007754A (pt) ácido de hidroxamida, processo para preparar osmesmos, composto, método de inibir mudançaspatológicas mediadas pela enzima que converte atnf-alfa (tage) em mamìfero em necessidade deste,e, composição farmacêutica
BR0012481A (pt) Processo para desacilação de lipodepsipeptìdeos
EA200100814A1 (ru) Применение ацетиленового орто-сульфонамида и фосфинамидозамещенных бициклических гетероарильных гидроксамовых кислот в качестве ингибиторов tace

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.