BR0010373A - Uso de um agonista de cobre e método para identificação de um agonista de cobre - Google Patents

Uso de um agonista de cobre e método para identificação de um agonista de cobre

Info

Publication number
BR0010373A
BR0010373A BR0010373-0A BR0010373A BR0010373A BR 0010373 A BR0010373 A BR 0010373A BR 0010373 A BR0010373 A BR 0010373A BR 0010373 A BR0010373 A BR 0010373A
Authority
BR
Brazil
Prior art keywords
copper
identifying
agonists
copper agonist
agonist
Prior art date
Application number
BR0010373-0A
Other languages
English (en)
Inventor
Konrad Beyreuther
Gerd Multhaup
Colin Masters
Original Assignee
Konrad Beyreuther
Gerd Multhaup
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konrad Beyreuther, Gerd Multhaup filed Critical Konrad Beyreuther
Publication of BR0010373A publication Critical patent/BR0010373A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"USO DE UM AGONISTA DE COBRE E MéTODO PARA IDENTIFICAçãO DE UM AGONISTA DE COBRE". A invenção refere-se a um agonista do cobre que se liga ao sítio de ligação de cobre na APP e/ou exerce um efeito inibidor na liberação do peptídeo Ab amilóide participante no surgimento de doença de Alzheimer. A invenção também se refere a drogas contendo dito agonista de cobre ou à utilização de dito agonista do cobre para o preparo de uma droga para a detecção e/ou o tratamento da doença de Alzheimer. A invenção refere-se adicionalmente, ao método para identificação de agonistas de cobre tendo o efeito desejado descrito na invenção.
BR0010373-0A 1999-03-03 2000-03-01 Uso de um agonista de cobre e método para identificação de um agonista de cobre BR0010373A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19909357A DE19909357A1 (de) 1999-03-03 1999-03-03 Kupferagonist, der an die Kupferbindungsstelle von APP bindet und/oder eine hemmende Wirkung auf die Freisetzung des Amyloid-Aß-Peptids ausübt
PCT/DE2000/000693 WO2000051632A2 (de) 1999-03-03 2000-03-01 Kupferagonist, der an die amyloid precursorprotein (app) bindet und/oder eine hemmende wirkung auf die amyloid-a beta-peptids ausübt

Publications (1)

Publication Number Publication Date
BR0010373A true BR0010373A (pt) 2002-05-21

Family

ID=7899589

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010373-0A BR0010373A (pt) 1999-03-03 2000-03-01 Uso de um agonista de cobre e método para identificação de um agonista de cobre

Country Status (11)

Country Link
US (1) US20050186287A1 (pt)
EP (1) EP1156811B1 (pt)
JP (1) JP2002538168A (pt)
CN (1) CN1263465C (pt)
AT (1) ATE314079T1 (pt)
AU (1) AU768715B2 (pt)
BR (1) BR0010373A (pt)
CA (1) CA2371934A1 (pt)
DE (2) DE19909357A1 (pt)
RU (1) RU2236235C2 (pt)
WO (1) WO2000051632A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696263B1 (en) 1999-09-23 2004-02-24 Rigel Pharmaceuticals, Inc. PCNA associated cell cycle proteins, compositions and methods of use
EP1242824A2 (en) * 1999-12-30 2002-09-25 7TM Pharma Screening using biological target molecules with metal-ion binding sites
AUPR202400A0 (en) * 2000-12-12 2001-01-11 Beyreuther, Konrad Method of screening for inhibitors of alzheimer's disease
AU2009319864A1 (en) 2008-11-25 2011-07-14 Biogen Idec Ma Inc. Use of DR6 and P75 antagonists to promote survival of cells of the nervous system
WO2012015050A1 (ja) * 2010-07-29 2012-02-02 独立行政法人理化学研究所 アミロイドβペプチド蓄積を伴う疾患の診断の為の可溶型アミロイドβ前駆体タンパク質７７０β切断産物の検出方法
CN104122400B (zh) * 2014-07-01 2016-03-02 上海依科赛生物制品有限公司 一种人体β淀粉样蛋白检测试剂盒及其用途
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
WO2020160156A2 (en) 2019-01-30 2020-08-06 Immutics, Inc. Anti-gal3 antibodies and uses thereof
EP4157338A4 (en) 2020-05-26 2024-11-13 TrueBinding, Inc. METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3277211B2 (ja) * 1991-11-12 2002-04-22 プラナ・バイオテクノロジー・リミテッド アルツハイマー病の試験方法と治療方法
CA2086165A1 (en) * 1992-04-09 1993-10-10 Paul P. Tamburini Diagnostic assay for alzheimer's disease based on the proteolysis of alzheimer's precursor protein
AUPN649395A0 (en) * 1995-11-10 1995-12-07 Ramsay Health Care Pty Ltd A method for diagnosing alzheimer's disease
JP2001514661A (ja) * 1997-03-11 2001-09-11 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病の処置における使用のための薬剤の同定
DE19725619A1 (de) * 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
CN100429230C (zh) * 1997-10-24 2008-10-29 阿文蒂斯药物股份有限公司 能抑制早老素和β-淀粉样肽或其前体间相互作用的肽
US6323218B1 (en) * 1998-03-11 2001-11-27 The General Hospital Corporation Agents for use in the treatment of Alzheimer's disease
AU1618000A (en) * 1998-11-12 2000-05-29 Du Pont Pharmaceuticals Company Use of radioligands to screen inhibitors of amyloid-beta peptide production

Also Published As

Publication number Publication date
RU2236235C2 (ru) 2004-09-20
WO2000051632A2 (de) 2000-09-08
AU768715B2 (en) 2004-01-08
CN1263465C (zh) 2006-07-12
EP1156811B1 (de) 2005-12-28
WO2000051632A3 (de) 2001-10-04
DE50011974D1 (de) 2006-02-02
CN1352562A (zh) 2002-06-05
EP1156811A2 (de) 2001-11-28
DE19909357A1 (de) 2000-09-07
US20050186287A1 (en) 2005-08-25
CA2371934A1 (en) 2000-09-08
AU4099100A (en) 2000-09-21
JP2002538168A (ja) 2002-11-12
ATE314079T1 (de) 2006-01-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.