ATE414519T1 - Kombination aus einem nmda-antagonist und acetylcholinesterase-hemmern zur behandlung der alzheimer-krankheit - Google Patents

Kombination aus einem nmda-antagonist und acetylcholinesterase-hemmern zur behandlung der alzheimer-krankheit

Info

Publication number
ATE414519T1
ATE414519T1 AT03724895T AT03724895T ATE414519T1 AT E414519 T1 ATE414519 T1 AT E414519T1 AT 03724895 T AT03724895 T AT 03724895T AT 03724895 T AT03724895 T AT 03724895T AT E414519 T1 ATE414519 T1 AT E414519T1
Authority
AT
Austria
Prior art keywords
alzheimer
disease
treatment
combination
acetylcholinesterase inhibitors
Prior art date
Application number
AT03724895T
Other languages
English (en)
Inventor
Lars Thomsen
Anders Pedersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29713304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE414519(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Application granted granted Critical
Publication of ATE414519T1 publication Critical patent/ATE414519T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT03724895T 2002-05-31 2003-05-22 Kombination aus einem nmda-antagonist und acetylcholinesterase-hemmern zur behandlung der alzheimer-krankheit ATE414519T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38446702P 2002-05-31 2002-05-31
DKPA200200844 2002-05-31

Publications (1)

Publication Number Publication Date
ATE414519T1 true ATE414519T1 (de) 2008-12-15

Family

ID=29713304

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03724895T ATE414519T1 (de) 2002-05-31 2003-05-22 Kombination aus einem nmda-antagonist und acetylcholinesterase-hemmern zur behandlung der alzheimer-krankheit

Country Status (17)

Country Link
EP (1) EP1509232B1 (de)
JP (1) JP2005528431A (de)
AT (1) ATE414519T1 (de)
AU (1) AU2003227516B2 (de)
BR (1) BR0311375A (de)
CY (1) CY1108725T1 (de)
DE (1) DE60324788D1 (de)
DK (1) DK1509232T3 (de)
ES (1) ES2314200T3 (de)
IL (1) IL165255A0 (de)
MX (1) MXPA04011762A (de)
NO (1) NO332754B1 (de)
NZ (1) NZ536603A (de)
PL (1) PL373903A1 (de)
PT (1) PT1509232E (de)
SI (1) SI1509232T1 (de)
WO (1) WO2003101458A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2260839A3 (de) * 2002-10-24 2012-05-02 Merz Pharma GmbH & Co. KGaA Kombinationstherapie unter Verwendung von 1-Aminocyclohexan Derivaten und Acetylcholinesterase Inhibitoren
PL1703902T3 (pl) * 2004-01-05 2011-04-29 Merz Pharma Gmbh & Co Kgaa Memantyna do leczenia choroby Alzheimera o łagodnym do umiarkowanego stopniu zaawansowania
WO2005070429A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist
TW200531680A (en) * 2004-03-03 2005-10-01 Merz Pharma Gmbh & Co Kgaa Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease
US20070213388A1 (en) * 2004-03-19 2007-09-13 Bruinsma Gosse B Acetylcholinesterase Inhibitors and N-Methyl-D-Aspartate Antagonists Useful in the Treatment of of Cognitive Disorders
RU2404750C2 (ru) * 2004-11-23 2010-11-27 Адамас Фармасьютикалс, Инк. Композиция, содержащая основу или покрытие для замедленного высвобождения и антагонист nmda рецептора, способ введения такого nmda антагониста субъекту
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
EP2243475B1 (de) 2005-04-06 2016-01-13 Adamas Pharmaceuticals, Inc. Kombination von Memantin und Donepezil zur Behandlung von Erkrankungen des ZNS
RU2445092C2 (ru) * 2005-04-28 2012-03-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Композиция, содержащая средство против деменции
TWI389709B (zh) * 2005-12-01 2013-03-21 Novartis Ag 經皮治療系統
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
RU2414856C1 (ru) * 2009-12-01 2011-03-27 Государственное образовательное учреждение высшего профессионального образования Первый Московский медицинский университет имени И.М.Сеченова Министерства здравоохранения и социального развития Российской Федерации (ГОУ ВПО Первый МГМУ им. И.М.Сеченова Минздравсоцразвития России) Способ определения эффективности противодементной терапии болезни альцгеймера
CA2782556C (en) 2009-12-02 2018-03-27 Adamas Pharma, Llc Amantadine compositions and methods of use
EA037187B1 (ru) 2010-02-09 2021-02-17 Дзе Джонс Хопкинс Юниверсити Способ и композиция для лечения когнитивного расстройства
EP2542549B1 (de) 2010-03-03 2016-05-11 Probiodrug AG Glutaminylcyclase-hemmer
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
CA2804370C (en) 2010-07-05 2019-07-02 Gambro Lundia Ab An ambulatory ultrafiltration device, related methods and a computer program product
TR201007110A2 (tr) 2010-08-25 2012-03-21 Bi̇lgi̇ç Mahmut Sinerjik etki gösteren kombinasyonlar
WO2012048871A1 (en) 2010-10-12 2012-04-19 Merz Pharma Gmbh & Co. Kgaa Memantine for improving cognitive performance in subjects
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
FR2983732B1 (fr) * 2011-12-09 2013-11-22 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent
WO2013160728A1 (en) * 2012-04-26 2013-10-31 Alma Mater Studiorum - Universita' Di Bologna Dual targeting compounds for the treatment of alzheimer's disease
WO2014035355A1 (en) * 2012-08-31 2014-03-06 Mahmut Bilgic Pharmaceutical combination comprising idebenone and memantine
WO2014055047A1 (en) * 2012-08-31 2014-04-10 Mahmut Bilgic Combination of idebenone and donezepil
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
BR112015013675B1 (pt) * 2012-12-13 2022-04-26 H. Lundbeck A/S Composição compreendendo vortioxetina e donepezil e usos dos mesmos
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
US11160785B2 (en) 2013-03-15 2021-11-02 Agenebio Inc. Methods and compositions for improving cognitive function
WO2014204933A1 (en) 2013-06-17 2014-12-24 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.
MX384146B (es) * 2016-05-18 2025-03-14 Suven Life Sciences Ltd Triple combinación de antagonistas del receptor de 5-ht6 puro, inhibidores de acetilcolinesterasa y antagonista del receptor de nmda.
SI3487505T1 (sl) 2016-07-25 2023-10-30 Wista Laboratories Ltd., Dajanje in odmerek diaminofenotiazinov
GB201614834D0 (en) * 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
KR101938872B1 (ko) * 2016-09-30 2019-01-16 주식회사 바이오파마티스 도네페질 또는 그의 약학적으로 허용 가능한 염 및 메만틴 또는 그의 약학적으로 허용 가능한 염을 함유하는 치매 및 인지기능 장애 예방 또는 치료용 약학 조성물 및 이의 제조방법
WO2018081508A1 (en) * 2016-10-28 2018-05-03 Chase Pharmaceutical Corporation Memantine combinations and use
TR201619184A2 (tr) 2016-12-22 2018-07-23 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Donepezi̇l ve memanti̇n i̇çeren kapsül bi̇leşi̇mleri̇
CA3072764A1 (en) 2017-08-24 2019-02-28 Adamas Pharma, Llc Amantadine compositions, preparations thereof, and methods of use
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
FI3826639T3 (fi) 2018-07-26 2024-10-30 Wista Lab Ltd Diaminofenotiatsiinien optimoitu annostus populaatioille
HRP20231200T1 (hr) 2019-05-31 2024-01-19 Tecnimede, Sociedade Técnico-Medicinal, Sa Kombinacija fiksne doze memantina i donepezila s trenutnim otpuštanjem

Also Published As

Publication number Publication date
CY1108725T1 (el) 2014-04-09
DE60324788D1 (de) 2009-01-02
WO2003101458A1 (en) 2003-12-11
MXPA04011762A (es) 2005-03-31
BR0311375A (pt) 2005-03-15
ES2314200T3 (es) 2009-03-16
IL165255A0 (en) 2005-12-18
DK1509232T3 (da) 2009-02-23
NO332754B1 (no) 2013-01-07
SI1509232T1 (sl) 2009-04-30
NZ536603A (en) 2007-06-29
AU2003227516A1 (en) 2003-12-19
EP1509232A1 (de) 2005-03-02
PL373903A1 (en) 2005-09-19
PT1509232E (pt) 2009-01-07
NO20045434L (no) 2004-12-13
EP1509232B1 (de) 2008-11-19
AU2003227516B2 (en) 2008-03-20
JP2005528431A (ja) 2005-09-22

Similar Documents

Publication Publication Date Title
ATE414519T1 (de) Kombination aus einem nmda-antagonist und acetylcholinesterase-hemmern zur behandlung der alzheimer-krankheit
BR0308243A (pt) Composto, formulação farmacêutica, e, métodos de tratar diabetes, doença de alzheimer, e de inibir gsk-3 em um mamìfero
MA25809A1 (fr) Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase
ATE350375T1 (de) 17beta-hydroxysteroid dehydrogenase type 3 inhibitoren zur behandlung von androgen- abhängigen erkrankungen
BRPI0407993B8 (pt) compostos inibidores de p38 e composições farmacêuticas compreendendo os mesmos
ATE371656T1 (de) Heteroaryl-pyrimidinderivate als jak-inhibitoren
ATE416761T1 (de) Prävention und behandlung von durch entzündung ausgelöstem und/oder immunvermitteltem knochenschwund
BR0316350A (pt) Diaminotriazóis úteis como inibidores de proteìna cinases
DE60137329D1 (de) Zusammensetzungen zur behandlung von diabetes die einen dp iv-inhibitoren und einen andere antidiabetikum enthalten
DE69736441D1 (de) Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
ATE484494T1 (de) Substituierte indolderivate für eine pharmazeutische zusammensetzung zur behandlung von atemwegserkrankungen
GB0223040D0 (en) Therapeutic compounds
IL165264A (en) Protein kinase inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating protein kinase-associated diseases
DE60335560D1 (de) Zusammensetzungen enthaltend zitronensäure zur behandlung von nagelpilzerkrankungen
UY27993A1 (es) Derivados de 4-pirrolidino-fenil-bencil eter
EA200201276A1 (ru) Производные арилметиламина для использования в качестве ингибиторов триптазы
CY1106927T1 (el) Φαρμακευτικη συνθεση ενος pde4 ή pde3/4 αναστολεα και ανταγωνιστη υποδοχεα ισταμινης
BRPI0411864A (pt) combinação de inibidores de src quinase e agentes quimioterápicos para o tratamento de doenças proliferativas
PL350568A1 (en) N-(2-phenyl-4-aminobutyl)-1-naphtamides as antagonists of neurokinin 1 receptors
DE60134735D1 (de) Neue neurokinin-antagonisten zum gebrauch als arzneimittel
DE69917005D1 (de) Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
ATE425756T1 (de) Verwendung von carbamazepinderivaten zur behandlung von agitatio in demenspatienten
IL160272A0 (en) Pharmaceutical compositions containing a pde4 or a pde3/4 inhibitor and a leukotriene receptor antagonist
SE0004827D0 (sv) Therapeutic compounds
EA200401617A1 (ru) Комбинация nmda-антагониста и ингибиторов ацетилхолинэстеразы для лечения болезни альцгеймера

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1509232

Country of ref document: EP