BR0010677A - Composições de gonadotropina altamente purificada e processos para a preparação das mesmas - Google Patents
Composições de gonadotropina altamente purificada e processos para a preparação das mesmasInfo
- Publication number
- BR0010677A BR0010677A BR0010677-1A BR0010677A BR0010677A BR 0010677 A BR0010677 A BR 0010677A BR 0010677 A BR0010677 A BR 0010677A BR 0010677 A BR0010677 A BR 0010677A
- Authority
- BR
- Brazil
- Prior art keywords
- gonadotropins
- compositions
- processes
- preparation
- highly purified
- Prior art date
Links
- 108010086677 Gonadotropins Proteins 0.000 title abstract 5
- 102000006771 Gonadotropins Human genes 0.000 title abstract 5
- 239000002622 gonadotropin Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229940094892 gonadotropins Drugs 0.000 abstract 4
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 2
- 108010057021 Menotropins Proteins 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000700159 Rattus Species 0.000 abstract 1
- 238000004166 bioassay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000000975 dye Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção:"COMPOSIçõES DE GONADOTROPINA ALTAMENTE PURIFICADA E PROCESSOS PARA A PREPARAçãO DAS MESMAS". Processo para a purificação de gonadotropinas urinárias humanas de elevada atividade biológica e de pureza química absolutamente isenta de materiais contaminantes estranhos derivados a partir do uso de reagentes biológicos ou corantes para cromatografia, a partir de gonadotropinas em bruto. A composição de alta atividade biológica e quimicamente pura de gonadotropinas humanas obtidas por este processo são usadas para o tratamento de infertilidade e são selecionadas a partir do grupo de foliotropina ou menotropinas, que tenham uma atividade biológica maior do que 2,500 Ul/mg de proteína, como testado por análise biológica em ratos, para ambos os hormónios FSH e LH para as menotropinas, e maior do que 5.000 UI/mg de proteína para a felotropina, tendo uma proporção de FSH:LH de cerca de 75:1. Também estão compreendidas dentro da presente invenção as preparações farmacêuticas das referidas gonadotropinas isentas de tais materiais contaminantes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12954099P | 1999-04-16 | 1999-04-16 | |
| PCT/EP2000/003357 WO2000063248A2 (en) | 1999-04-16 | 2000-04-14 | Highly purified gonadotropin compositions and process for preparing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0010677A true BR0010677A (pt) | 2002-02-05 |
| BR0010677B1 BR0010677B1 (pt) | 2013-04-30 |
| BRPI0010677B8 BRPI0010677B8 (pt) | 2021-05-25 |
Family
ID=22440494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0010677A BRPI0010677B8 (pt) | 1999-04-16 | 2000-04-14 | processo de purificação de gonadotropinas urinárias humanas a partir de gonadotropinas brutas. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1169349B1 (pt) |
| JP (1) | JP4574865B2 (pt) |
| AT (1) | ATE358139T1 (pt) |
| AU (1) | AU779005B2 (pt) |
| BR (1) | BRPI0010677B8 (pt) |
| CA (1) | CA2370225C (pt) |
| CY (1) | CY1107666T1 (pt) |
| DE (1) | DE60034117T2 (pt) |
| DK (1) | DK1169349T3 (pt) |
| ES (1) | ES2284494T3 (pt) |
| MX (1) | MXPA01010522A (pt) |
| PT (1) | PT1169349E (pt) |
| WO (1) | WO2000063248A2 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1697412B1 (en) * | 2003-12-22 | 2009-10-21 | Ares Trading S.A. | Method for purifying fsh |
| DE602005009856D1 (de) * | 2004-11-09 | 2008-10-30 | Ares Trading Sa | Verfahren zur reinigung von fsh |
| JP4933439B2 (ja) * | 2004-11-09 | 2012-05-16 | アレス トレーディング ソシエテ アノニム | Ｆｓｈの精製方法 |
| WO2007022799A1 (en) | 2005-08-26 | 2007-03-01 | Ares Trading S.A. | Process for the preparation of glycosylated interferon beta |
| EP1960419B1 (en) | 2005-12-09 | 2016-03-16 | Ares Trading S.A. | Method for purifying fsh or a fsh mutant |
| DK2170942T3 (da) | 2007-06-28 | 2013-11-04 | Biogenerix Ag | Fsh-producerende celleklon |
| NZ586588A (en) | 2008-02-08 | 2012-10-26 | Biogenerix Ag | Formulation of ( follice stimulating hormone) fsh and varients with benzalkonium chloride and benzyl alcohol |
| CN101269215B (zh) * | 2008-05-15 | 2011-03-23 | 上海天伟生物制药有限公司 | 一种糖蛋白激素组合物 |
| JP5845170B2 (ja) * | 2009-04-01 | 2016-01-20 | ラティオファーム ゲーエムベーハー | 組換えｆｓｈを精製する方法 |
| EP2325194A1 (en) | 2009-11-24 | 2011-05-25 | Glycotope GmbH | Process for the purification of glycoproteins |
| CN103159846B (zh) * | 2013-04-09 | 2015-04-22 | 邹平县滨渤生物科技有限公司 | Hmg粗品的制备方法 |
| ES2719748T3 (es) | 2014-05-23 | 2019-07-12 | Inst Massone S A | Proceso para obtener HMG-UP (gonadotropina menopáusica humana con grado de ultrapureza) y una composición libre de contaminantes |
| PL3261661T3 (pl) | 2015-02-26 | 2024-03-25 | Ferring B.V. | Menotropina do leczenia niepłodności |
| CN108070640B (zh) * | 2018-01-12 | 2021-09-21 | 浙江省农业科学院 | 一种与卵泡刺激素剂量呈线性相关的基因的筛选方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3819M (fr) * | 1963-03-11 | 1966-01-10 | Serono Ist Farm | Nouvelle hormone hypophysaire a activité différenciée. |
| IT1287138B1 (it) * | 1996-11-07 | 1998-08-04 | Ibsa Inst Biochimique Sa | Procedimento per la separazione e purificazione di fsh e lh |
-
2000
- 2000-04-14 BR BRPI0010677A patent/BRPI0010677B8/pt not_active IP Right Cessation
- 2000-04-14 JP JP2000612334A patent/JP4574865B2/ja not_active Expired - Lifetime
- 2000-04-14 PT PT00926922T patent/PT1169349E/pt unknown
- 2000-04-14 DE DE60034117T patent/DE60034117T2/de not_active Expired - Lifetime
- 2000-04-14 AT AT00926922T patent/ATE358139T1/de active
- 2000-04-14 AU AU45491/00A patent/AU779005B2/en not_active Expired
- 2000-04-14 CA CA2370225A patent/CA2370225C/en not_active Expired - Lifetime
- 2000-04-14 EP EP00926922A patent/EP1169349B1/en not_active Expired - Lifetime
- 2000-04-14 ES ES00926922T patent/ES2284494T3/es not_active Expired - Lifetime
- 2000-04-14 DK DK00926922T patent/DK1169349T3/da active
- 2000-04-14 WO PCT/EP2000/003357 patent/WO2000063248A2/en not_active Ceased
- 2000-04-14 MX MXPA01010522A patent/MXPA01010522A/es active IP Right Grant
-
2007
- 2007-06-11 CY CY20071100763T patent/CY1107666T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000063248A3 (en) | 2001-02-01 |
| CA2370225A1 (en) | 2000-10-26 |
| DK1169349T3 (da) | 2007-07-30 |
| DE60034117T2 (de) | 2007-12-13 |
| DE60034117D1 (de) | 2007-05-10 |
| EP1169349A2 (en) | 2002-01-09 |
| BR0010677B1 (pt) | 2013-04-30 |
| JP2002542260A (ja) | 2002-12-10 |
| AU779005B2 (en) | 2004-12-23 |
| ATE358139T1 (de) | 2007-04-15 |
| CY1107666T1 (el) | 2013-04-18 |
| BRPI0010677B8 (pt) | 2021-05-25 |
| WO2000063248A2 (en) | 2000-10-26 |
| AU4549100A (en) | 2000-11-02 |
| PT1169349E (pt) | 2007-06-18 |
| ES2284494T3 (es) | 2007-11-16 |
| CA2370225C (en) | 2010-06-29 |
| JP4574865B2 (ja) | 2010-11-04 |
| EP1169349B1 (en) | 2007-03-28 |
| MXPA01010522A (es) | 2003-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B09X | Republication of the decision to grant [chapter 9.1.3 patent gazette] |
Free format text: REPUBLICACAO DA PUBLICACAO DE DEFERIMENTO POR TER SIDO EFETUADA COM INCORRECAO. |
|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/04/2000 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 14/04/2020 |