BR0010984A - Matrizes porosas de medicamento e processos para fabricação das mesmas - Google Patents
Matrizes porosas de medicamento e processos para fabricação das mesmasInfo
- Publication number
- BR0010984A BR0010984A BR0010984-3A BR0010984A BR0010984A BR 0010984 A BR0010984 A BR 0010984A BR 0010984 A BR0010984 A BR 0010984A BR 0010984 A BR0010984 A BR 0010984A
- Authority
- BR
- Brazil
- Prior art keywords
- drug
- porous matrix
- forming agent
- pore forming
- volatile
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 14
- 239000003814 drug Substances 0.000 title abstract 14
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000011159 matrix material Substances 0.000 abstract 7
- 239000002904 solvent Substances 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 239000011148 porous material Substances 0.000 abstract 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 2
- 229930012538 Paclitaxel Natural products 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 239000002775 capsule Substances 0.000 abstract 2
- 238000004090 dissolution Methods 0.000 abstract 2
- 229960003668 docetaxel Drugs 0.000 abstract 2
- 239000000839 emulsion Substances 0.000 abstract 2
- 239000011859 microparticle Substances 0.000 abstract 2
- 229960001592 paclitaxel Drugs 0.000 abstract 2
- 238000010561 standard procedure Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003684 drug solvent Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Epoxy Compounds (AREA)
Abstract
"MATRIZES POROSAS DE MEDICAMENTO E PROCESSOS PARA FABRICAçãO DAS MESMAS". Medicamentos, especialmente medicamentos de solubilidade aquosa baixa são providos em uma forma de matriz porosa, preferivelmente micropartículas, o que melhora a dissolução do medicamento em um meio aquoso. As matrizes de medicamento preferivelmente são feitas usando um processo que inclui (i) dissolução de um medicamento, preferivelmente um medicamento possuindo uma solubilidade aquosa baixa, em um solvente volátil, para formar uma solução de medicamento, (ii) combinação de pelo menos um agente de formação de poro com a solução de medicamento para formar uma emulsão, suspensão ou segunda solução e (iii) remoção do solvente volátil e agente de formação de poro da emulsão, suspensão ou segunda solução para render a matriz porosa do medicamento. O agente de formação de poro pode ser tanto um líquido volátil que é imiscível com o solvente de medicamento ou um composto sólido volátil, preferivelmente um sal volátil. Em uma concretização preferida, a secagem por aspersão é usada para remover os solventes e o agente de formação de poro. A matriz porosa resultante possui uma razão mais rápida de dissolução, seguindo administração a um paciente, conforme comparado às formas de matriz não porosa do medicamento. Em uma concretização preferida, as micropartículas da matriz de medicamento porosa são reconstituídas com um meio aquoso e administradas parenteralmente ou processadas usando técnica padrão em comprimidos ou cápsulas para administração oral. Paclitaxel ou docetaxel podem ser providos em forma de matriz porosa, o que permite que o medicamento seja formulado sem agentes de solubilização e administrado como um bolo.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13632399P | 1999-05-27 | 1999-05-27 | |
| US15865999P | 1999-10-08 | 1999-10-08 | |
| US09/433,486 US6395300B1 (en) | 1999-05-27 | 1999-11-04 | Porous drug matrices and methods of manufacture thereof |
| US18631000P | 2000-03-02 | 2000-03-02 | |
| PCT/US2000/014578 WO2000072827A2 (en) | 1999-05-27 | 2000-05-25 | Porous drug matrices and methods of manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010984A true BR0010984A (pt) | 2002-04-30 |
Family
ID=27495210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010984-3A BR0010984A (pt) | 1999-05-27 | 2000-05-25 | Matrizes porosas de medicamento e processos para fabricação das mesmas |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1180020B2 (pt) |
| JP (1) | JP4722295B2 (pt) |
| KR (2) | KR100883477B1 (pt) |
| CN (1) | CN1240373C (pt) |
| AT (1) | ATE312601T1 (pt) |
| AU (1) | AU768022B2 (pt) |
| BR (1) | BR0010984A (pt) |
| CA (1) | CA2371836C (pt) |
| DE (1) | DE60024811T3 (pt) |
| DK (1) | DK1180020T4 (pt) |
| ES (1) | ES2250141T5 (pt) |
| HK (1) | HK1048956B (pt) |
| IL (2) | IL146659A0 (pt) |
| MX (1) | MXPA01012106A (pt) |
| NO (1) | NO323761B1 (pt) |
| NZ (1) | NZ516083A (pt) |
| TW (1) | TWI274589B (pt) |
| WO (1) | WO2000072827A2 (pt) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6342533B1 (en) | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| PL350924A1 (en) | 1999-04-06 | 2003-02-10 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
| US8771740B2 (en) * | 1999-12-20 | 2014-07-08 | Nicholas J. Kerkhof | Process for producing nanoparticles by spray drying |
| MY120279A (en) * | 2000-05-26 | 2005-09-30 | Pharmacia Corp | Use of a celecoxib composition for fast pain relief |
| US6589557B2 (en) * | 2000-06-15 | 2003-07-08 | Acusphere, Inc. | Porous celecoxib matrices and methods of manufacture thereof |
| US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6514482B1 (en) | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| DE10059020A1 (de) * | 2000-11-28 | 2002-05-29 | Gruenenthal Gmbh | Parenteral applizierbare Darreichungsformen |
| KR100743404B1 (ko) | 2000-12-21 | 2007-07-30 | 넥타르 테라퓨틱스 | 폴리엔 항균제의 폐 전달 |
| CA2434641A1 (en) * | 2001-01-18 | 2002-08-22 | Pharmacia And Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| US7115565B2 (en) | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| AU2002250058B2 (en) † | 2001-02-12 | 2007-08-16 | Wyeth Llc | Novel succinate salt of O-desmethyl-venlafaxine |
| JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| WO2002094231A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of analgesics through an inhalation route |
| US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7105178B2 (en) | 2001-07-17 | 2006-09-12 | Sun Pharmaceutical Industries Limited | Cardiotonic composition |
| WO2003041693A1 (en) * | 2001-11-09 | 2003-05-22 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
| US7005138B2 (en) * | 2001-12-21 | 2006-02-28 | Duramed Pharmaceuticals, Inc. | Method of systematically delivering SSRIs |
| AU2003218307B8 (en) | 2002-03-20 | 2006-08-31 | Alkermes, Inc. | Pulmonary delivery for levodopa |
| JP4452970B2 (ja) * | 2002-03-27 | 2010-04-21 | 日本臓器製薬株式会社 | ジクロフェナクナトリウム経口製剤 |
| US9060941B2 (en) | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7785627B2 (en) | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US8980870B2 (en) | 2002-09-24 | 2015-03-17 | Boehringer Ingelheim International Gmbh | Solid telmisartan pharmaceutical formulations |
| US20040105821A1 (en) * | 2002-09-30 | 2004-06-03 | Howard Bernstein | Sustained release pharmaceutical formulation for inhalation |
| PT1610791E (pt) | 2003-03-31 | 2011-05-23 | Titan Pharmaceuticals Inc | Dispositivo polim?rico implant?vel para liberta??o sustentada de agonista da dopamina |
| US7306812B2 (en) | 2003-05-09 | 2007-12-11 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
| US7276246B2 (en) | 2003-05-09 | 2007-10-02 | Cephalon, Inc. | Dissolvable backing layer for use with a transmucosal delivery device |
| US20040234916A1 (en) | 2003-05-21 | 2004-11-25 | Alexza Molecular Delivery Corporation | Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same |
| GB0401947D0 (en) | 2004-01-28 | 2004-03-03 | Unilever Plc | Porous bodies and method of production thereof |
| KR100681660B1 (ko) * | 2004-03-17 | 2007-02-09 | 주식회사종근당 | 방출제어 펠릿의 약제학적 조성물 |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| EP1781360A1 (en) | 2004-08-12 | 2007-05-09 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
| EP1681056A1 (en) | 2005-01-14 | 2006-07-19 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for preparing lansoprazole |
| US20080200533A1 (en) * | 2005-07-04 | 2008-08-21 | Ramu Krishnan | Drug or Pharmaceutical Compounds and a Preparation Thereof |
| GB0517688D0 (en) * | 2005-08-31 | 2005-10-05 | Cambridge Biostability Ltd | Improvements in the stabilisation of biological materials |
| GB0523638D0 (en) | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
| AR054215A1 (es) * | 2006-01-20 | 2007-06-13 | Eriochem Sa | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
| CA2640165A1 (en) * | 2006-01-27 | 2007-08-02 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivid Ed Trinity Of Queen Elizabeth Near Dublin | A method of producing porous microparticles |
| KR100917809B1 (ko) * | 2006-05-22 | 2009-09-18 | 에스케이케미칼주식회사 | 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물 |
| GB0613925D0 (en) * | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| CA2685397C (en) | 2007-04-27 | 2016-07-26 | Endo Pharmaceuticals Solutions Inc. | Implant device release agents and methods of using same |
| PT103743B (pt) * | 2007-05-16 | 2013-01-15 | Hovione Farmaciencia S A | Processo para preparar derivados de 21-disódio fosfato de pregnanos. |
| WO2010020799A2 (en) * | 2008-08-22 | 2010-02-25 | Slotervaart Participaties Bv | Composition |
| GB0716591D0 (en) * | 2007-08-24 | 2007-10-03 | Vereniging Het Nl Kanker I | Composition |
| MX2010002179A (es) | 2007-08-24 | 2010-04-27 | Stichting Het Nl Kanker I | Composicion para el tratamiento de enfermedades neoplasicas. |
| CN101888829A (zh) * | 2007-10-09 | 2010-11-17 | 诺瓦提斯公司 | 缬沙坦的药物制剂 |
| US9801818B2 (en) | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
| KR101024742B1 (ko) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
| WO2010009492A1 (en) * | 2008-07-25 | 2010-01-28 | Alphapharm Pty Ltd | ATOVAQUONE WITH A PARTICLE SIZE DIAMETER RANGE (D90) OF GREATER THAN 3 μM TO ABOUT 10 μM |
| US8685458B2 (en) | 2009-03-05 | 2014-04-01 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
| EP2411137B1 (en) | 2009-03-27 | 2016-09-07 | Bend Research, Inc. | Spray-drying process |
| EP2611529B1 (en) | 2010-09-03 | 2019-01-23 | Bend Research, Inc. | Spray-drying method |
| WO2012031133A2 (en) | 2010-09-03 | 2012-03-08 | Bench Research, Inc. | Spray-drying apparatus and methods of using the same |
| WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
| ES2702848T3 (es) | 2011-02-23 | 2019-03-05 | Coeruleus Ltd | Complejos de flumazenil, composiciones que los comprenden y usos de los mismos |
| US9060938B2 (en) | 2011-05-10 | 2015-06-23 | Bend Research, Inc. | Pharmaceutical compositions of active agents and cationic dextran polymer derivatives |
| CN103301095B (zh) * | 2012-03-13 | 2016-04-13 | 中国科学院上海药物研究所 | 一种用于提高普罗布考口服吸收的多孔复合载药组合物及其制备方法 |
| ES3042580T3 (en) * | 2012-06-22 | 2025-11-21 | Unisa Ventures Pty Ltd | Method and composition for delivering a compound through a biological barrier |
| US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| DK3154528T3 (da) * | 2014-06-11 | 2023-04-24 | SpecGx LLC | Sprøjtetørrede sammensætninger med forskellige opløsningsprofiler og fremgangsmåder til fremstilling deraf |
| WO2016067132A1 (en) | 2014-10-31 | 2016-05-06 | Bend Research Inc. | Process for forming active domains dispersed in a matrix |
| CN107205938A (zh) * | 2014-12-18 | 2017-09-26 | 温德加普医疗股份有限公司 | 用于溶解或增溶治疗剂的方法和组合物 |
| CA3026454C (en) | 2015-06-04 | 2023-07-04 | Crititech, Inc. | Collection device and methods for use |
| ES3055492T3 (en) | 2015-09-16 | 2026-02-12 | Dfb Soria Llc | Delivery of drug nanoparticles and methods of use thereof |
| EP3854381A1 (en) * | 2016-04-04 | 2021-07-28 | Crititech, Inc. | Methods for solid tumor treatment |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| KR101965708B1 (ko) * | 2016-08-30 | 2019-04-04 | 이화여자대학교 산학협력단 | 스폰지 유사 구조를 갖는 고분자 미립자 및 이의 제조방법 |
| WO2018170196A1 (en) | 2017-03-15 | 2018-09-20 | Dfb Soria, Llc | Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes |
| CA3063420A1 (en) | 2017-06-09 | 2018-12-13 | Crititech, Inc. | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| WO2018231908A1 (en) | 2017-06-14 | 2018-12-20 | Crititech, Inc. | Methods for treating lung disorders |
| KR20250057947A (ko) | 2017-10-03 | 2025-04-29 | 크리티테크, 인크. | 암의 치료를 위한 면역치료제의 전신 전달과 조합된 항신생물성 입자의 국소 전달 |
| BR112020013750A8 (pt) | 2018-01-05 | 2022-10-18 | Impel Neuropharma Inc | Dispensação intranasal de olanzapina por dispositivo olfativo de precisão |
| US12214118B2 (en) | 2018-02-02 | 2025-02-04 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
| EP3765035A4 (en) | 2018-03-16 | 2021-10-27 | DFB Soria, LLC | TOPICAL THERAPY FOR THE TREATMENT OF CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN) AND COLD CANCER USING TAXANE NANOPARTICLES |
| WO2020159676A1 (en) * | 2019-01-29 | 2020-08-06 | Bayer Healthcare Llc | Topical gel compositions of naproxen |
| WO2020227816A1 (en) * | 2019-05-10 | 2020-11-19 | Anomera Inc. | Porous cellulose microparticles and methods of manufacture thereof |
| HUE067496T2 (hu) | 2020-12-08 | 2024-10-28 | Ruminant Biotech Corp Ltd | Az állatoknak szánt anyagok bejuttatására szolgáló eszközök és módszerek fejlesztése |
| CN113081971A (zh) * | 2021-05-14 | 2021-07-09 | 江西中医药大学 | 一种中药多孔核壳型复合粒子粉体及其制备方法和应用 |
| CN117538462B (zh) * | 2024-01-10 | 2024-03-26 | 地奥集团成都药业股份有限公司 | 一种氨氯地平贝那普利胶囊有关物质的检测方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1265615A (pt) * | 1970-09-10 | 1972-03-01 | ||
| NL7313626A (nl) † | 1973-10-04 | 1975-04-08 | Philips Nv | Gecombineerde inrichting voor het produceren en sselen van warmte met een warmte ver- ende inrichting. |
| GB8322007D0 (en) † | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
| IL82245A (en) * | 1986-04-25 | 1990-07-26 | Basf Ag | Preparation of spray-dried granules of active ingredients |
| EP0655237A1 (de) * | 1993-11-27 | 1995-05-31 | Hoechst Aktiengesellschaft | Medizinische Aerosolformulierung |
| US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
| CA2277801C (en) * | 1997-01-16 | 2002-10-15 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| AU756693B2 (en) * | 1997-09-29 | 2003-01-23 | Novartis Ag | Stabilized bioactive preparations and methods of use |
| JP4758525B2 (ja) * | 1998-03-20 | 2011-08-31 | 武田薬品工業株式会社 | 生理活性ポリペプチドの徐放性製剤およびその製造法 |
| US6423345B2 (en) † | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
-
2000
- 2000-05-25 NZ NZ516083A patent/NZ516083A/en not_active IP Right Cessation
- 2000-05-25 DK DK00939365T patent/DK1180020T4/da active
- 2000-05-25 HK HK03101310.8A patent/HK1048956B/zh not_active IP Right Cessation
- 2000-05-25 CN CNB008081611A patent/CN1240373C/zh not_active Expired - Fee Related
- 2000-05-25 WO PCT/US2000/014578 patent/WO2000072827A2/en not_active Ceased
- 2000-05-25 BR BR0010984-3A patent/BR0010984A/pt not_active IP Right Cessation
- 2000-05-25 DE DE60024811T patent/DE60024811T3/de not_active Expired - Lifetime
- 2000-05-25 KR KR1020077012286A patent/KR100883477B1/ko not_active Expired - Fee Related
- 2000-05-25 ES ES00939365T patent/ES2250141T5/es not_active Expired - Lifetime
- 2000-05-25 AU AU54459/00A patent/AU768022B2/en not_active Ceased
- 2000-05-25 IL IL14665900A patent/IL146659A0/xx unknown
- 2000-05-25 KR KR1020017015052A patent/KR100752000B1/ko not_active Expired - Fee Related
- 2000-05-25 CA CA002371836A patent/CA2371836C/en not_active Expired - Fee Related
- 2000-05-25 JP JP2000620939A patent/JP4722295B2/ja not_active Expired - Fee Related
- 2000-05-25 AT AT00939365T patent/ATE312601T1/de active
- 2000-05-25 EP EP00939365A patent/EP1180020B2/en not_active Expired - Lifetime
- 2000-05-25 MX MXPA01012106A patent/MXPA01012106A/es active IP Right Grant
- 2000-05-29 TW TW089110363A patent/TWI274589B/zh not_active IP Right Cessation
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2001
- 2001-11-21 IL IL146659A patent/IL146659A/en not_active IP Right Cessation
- 2001-11-26 NO NO20015753A patent/NO323761B1/no not_active IP Right Cessation
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