BR0011853A - Agonistas de receptor a2a de tiofeno - Google Patents

Agonistas de receptor a2a de tiofeno

Info

Publication number
BR0011853A
BR0011853A BR0011853-2A BR0011853A BR0011853A BR 0011853 A BR0011853 A BR 0011853A BR 0011853 A BR0011853 A BR 0011853A BR 0011853 A BR0011853 A BR 0011853A
Authority
BR
Brazil
Prior art keywords
thiophene
receptor agonists
disclosed
purposes
alkylthienyl
Prior art date
Application number
BR0011853-2A
Other languages
English (en)
Inventor
Jeffrey A Zablocki
Venkata P Palle
Elfatih O Elzein
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of BR0011853A publication Critical patent/BR0011853A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"AGONISTAS DE RECEPTOR A2A DE TIOFENO". Compostos de 2-adenosina tiofeno tendo a seguinte fórmula (I) e métodos para uso dos compostos como agonistas de receptor A2A para estimular vasodilatação coronariana em mamíferos para objetivos terapêuticos e para objetivos de visualização cardíaca.
BR0011853-2A 1999-06-22 2000-06-20 Agonistas de receptor a2a de tiofeno BR0011853A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14047899P 1999-06-22 1999-06-22
PCT/US2000/016856 WO2000078776A2 (en) 1999-06-22 2000-06-20 Thiophene a2a receptor agonists

Publications (1)

Publication Number Publication Date
BR0011853A true BR0011853A (pt) 2002-04-30

Family

ID=22491411

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011853-2A BR0011853A (pt) 1999-06-22 2000-06-20 Agonistas de receptor a2a de tiofeno

Country Status (19)

Country Link
US (1) US6440948B1 (pt)
EP (1) EP1194441B1 (pt)
JP (1) JP2003502434A (pt)
KR (1) KR100463694B1 (pt)
CN (1) CN1166677C (pt)
AT (1) ATE252595T1 (pt)
AU (1) AU768530B2 (pt)
BR (1) BR0011853A (pt)
CA (1) CA2373410C (pt)
DE (1) DE60006116T2 (pt)
ES (1) ES2206259T3 (pt)
HK (1) HK1048821B (pt)
IL (2) IL147194A0 (pt)
MX (1) MXPA01013323A (pt)
NO (1) NO20016242L (pt)
NZ (1) NZ516336A (pt)
TR (1) TR200200617T2 (pt)
WO (1) WO2000078776A2 (pt)
ZA (1) ZA200200299B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69932173T2 (de) * 1998-10-16 2007-06-06 Pfizer Inc. Adeninderivate
NZ534682A (en) 2002-02-15 2006-10-27 Cv Therapeutics Inc Polymer coating for medical devices
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
WO2005117910A2 (en) * 2004-05-26 2005-12-15 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
MX2007003271A (es) * 2004-09-20 2007-06-05 Inotek Pharmaceuticals Corp Derivados de purina y metodos de uso de los mismos.
EA015683B1 (ru) * 2005-11-30 2011-10-31 Инотек Фармасьютикалз Корпорейшн Производные пурина и способы их применения
SG182285A1 (en) 2010-01-11 2012-08-30 Inotek Pharmaceuticals Corp Combination, kit and method of reducing intraocular pressure
EA201290958A1 (ru) 2010-03-26 2013-04-30 Инотек Фармасьютикалз Корпорейшн Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств
BR112014018413A8 (pt) 2012-01-26 2017-07-11 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo
CA2903114A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
CA3049856C (en) 2017-01-13 2021-10-26 Tobishi Pharmaceutical Co., Ltd. Neutrophil activation regulator

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK135130B (da) * 1970-12-28 1977-03-07 Takeda Chemical Industries Ltd Analogifremgangsmåde til fremstilling af 2-substituerede adenosinderivater eller syreadditionssalte deraf.
JPS4911896A (pt) * 1972-05-15 1974-02-01
JPS5518625B2 (pt) * 1973-07-26 1980-05-20
US5070877A (en) 1988-08-11 1991-12-10 Medco Research, Inc. Novel method of myocardial imaging
JP3141028B2 (ja) * 1991-04-06 2001-03-05 アストラ・フアーマシユウテイカルズ・リミテツド Ａｔｐ類似体

Also Published As

Publication number Publication date
AU5625100A (en) 2001-01-09
CN1166677C (zh) 2004-09-15
ZA200200299B (en) 2003-08-27
AU768530B2 (en) 2003-12-18
CA2373410A1 (en) 2000-12-28
DE60006116D1 (de) 2003-11-27
WO2000078776A2 (en) 2000-12-28
ES2206259T3 (es) 2004-05-16
HK1048821B (zh) 2005-02-25
HK1048821A1 (en) 2003-04-17
JP2003502434A (ja) 2003-01-21
MXPA01013323A (es) 2003-10-15
DE60006116T2 (de) 2004-07-08
IL147194A (en) 2007-08-19
EP1194441B1 (en) 2003-10-22
KR20020028912A (ko) 2002-04-17
NO20016242L (no) 2002-02-21
CN1364170A (zh) 2002-08-14
NO20016242D0 (no) 2001-12-19
KR100463694B1 (ko) 2004-12-29
IL147194A0 (en) 2002-08-14
TR200200617T2 (tr) 2002-06-21
CA2373410C (en) 2006-08-29
US6440948B1 (en) 2002-08-27
EP1194441A2 (en) 2002-04-10
NZ516336A (en) 2004-01-30
WO2000078776A3 (en) 2001-06-28
ATE252595T1 (de) 2003-11-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O C/C 11, 13, 10, 24 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.