BR0012093A - Composto tricìclico tendo união espiro - Google Patents

Composto tricìclico tendo união espiro

Info

Publication number
BR0012093A
BR0012093A BR0012093-6A BR0012093A BR0012093A BR 0012093 A BR0012093 A BR 0012093A BR 0012093 A BR0012093 A BR 0012093A BR 0012093 A BR0012093 A BR 0012093A
Authority
BR
Brazil
Prior art keywords
spiro union
tricyclic compound
compound
useful
relates
Prior art date
Application number
BR0012093-6A
Other languages
English (en)
Inventor
Hidemitsu Nishida
Fumihiko Saitoh
Kousuke Harada
Ikuya Shiromizu
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Publication of BR0012093A publication Critical patent/BR0012093A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444—Factor X (3.4.21.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"COMPOSTO TRICìCLICO TENDO UNIãO ESPIRO". A presente invenção refere-se a compostos tricíclicos que possuem união espiro representados pelo fórmula (I) seguinte ou seus sais que são úteis como uma droga e, em particular, como um inibidor para fator X de coagulação sang³ínea ativada, que podem ser administrados oralmente e que exibem forte ação de anticoagulação. A presente invenção também se refere a um farmacóforo que foi derivado do composto e é útil no projeto molecular do inibidor Fxa.
BR0012093-6A 1999-06-30 2000-06-30 Composto tricìclico tendo união espiro BR0012093A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22288399 1999-06-30
PCT/JP2000/004374 WO2001002397A1 (en) 1999-06-30 2000-06-30 Tricyclic compounds having spiro union

Publications (1)

Publication Number Publication Date
BR0012093A true BR0012093A (pt) 2002-07-16

Family

ID=16789385

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012093-6A BR0012093A (pt) 1999-06-30 2000-06-30 Composto tricìclico tendo união espiro

Country Status (21)

Country Link
EP (1) EP1191028B1 (pt)
JP (1) JP4890707B2 (pt)
KR (1) KR20020015061A (pt)
CN (1) CN1371375A (pt)
AT (1) ATE281457T1 (pt)
AU (1) AU774397B2 (pt)
BR (1) BR0012093A (pt)
CA (1) CA2380852C (pt)
CZ (1) CZ20014696A3 (pt)
DE (1) DE60015541T2 (pt)
HK (1) HK1049157A1 (pt)
HU (1) HUP0202188A3 (pt)
IL (1) IL147348A0 (pt)
MX (1) MXPA02000003A (pt)
NO (1) NO20016402L (pt)
NZ (1) NZ516363A (pt)
PL (1) PL352862A1 (pt)
SK (1) SK19292001A3 (pt)
TR (1) TR200103853T2 (pt)
WO (1) WO2001002397A1 (pt)
ZA (1) ZA200110558B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302462A4 (en) * 2000-07-17 2007-07-18 Takeda Pharmaceutical SULFONATE DERIVATIVES, PROCESS FOR PRODUCTION AND USE THEREOF
WO2002053568A1 (en) * 2000-12-28 2002-07-11 Mochida Pharmaceutical Co., Ltd. Cholesterol biosynthesis inhibitors containing as the active ingredient tricyclic spiro compounds
CN100513398C (zh) 2002-12-03 2009-07-15 Axys药物公司 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
WO2006006490A1 (ja) * 2004-07-08 2006-01-19 Ono Pharmaceutical Co., Ltd. スピロ化合物
WO2006106804A1 (ja) 2005-03-31 2006-10-12 Mochida Pharmaceutical Co., Ltd. 環内窒素原子にアシル基が結合した三環系スピロ化合物
WO2007136085A1 (ja) 2006-05-23 2007-11-29 Mochida Pharmaceutical Co., Ltd. スピロ四環系化合物
US7739434B2 (en) 2008-01-11 2010-06-15 International Business Machines Corporation Performing a configuration virtual topology change and instruction therefore

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300541B1 (en) * 1987-07-20 1996-03-27 Duphar International Research B.V 8,9-anellated-1,2,3,4-tetrahydro-beta-carboline derivatives
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles

Also Published As

Publication number Publication date
CA2380852A1 (en) 2001-01-11
MXPA02000003A (es) 2003-07-21
DE60015541T2 (de) 2005-12-08
HUP0202188A2 (en) 2002-10-28
CZ20014696A3 (cs) 2002-05-15
DE60015541D1 (de) 2004-12-09
AU5572000A (en) 2001-01-22
WO2001002397A1 (en) 2001-01-11
EP1191028A4 (en) 2002-10-23
NZ516363A (en) 2004-05-28
HK1049157A1 (zh) 2003-05-02
EP1191028A1 (en) 2002-03-27
ZA200110558B (en) 2002-09-12
NO20016402D0 (no) 2001-12-28
WO2001002397A9 (en) 2001-04-05
EP1191028B1 (en) 2004-11-03
PL352862A1 (en) 2003-09-08
AU774397B2 (en) 2004-06-24
KR20020015061A (ko) 2002-02-27
ATE281457T1 (de) 2004-11-15
TR200103853T2 (tr) 2002-11-21
NO20016402L (no) 2002-02-27
SK19292001A3 (sk) 2002-06-04
CA2380852C (en) 2009-10-20
IL147348A0 (en) 2002-08-14
JP4890707B2 (ja) 2012-03-07
CN1371375A (zh) 2002-09-25
HUP0202188A3 (en) 2004-04-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.