BRPI0713439A2 - derivados aminados de b-homoandrostanos e b-heteroandrostanos - Google Patents

derivados aminados de b-homoandrostanos e b-heteroandrostanos Download PDF

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Publication number
BRPI0713439A2
BRPI0713439A2 BRPI0713439-8A BRPI0713439A BRPI0713439A2 BR PI0713439 A2 BRPI0713439 A2 BR PI0713439A2 BR PI0713439 A BRPI0713439 A BR PI0713439A BR PI0713439 A2 BRPI0713439 A2 BR PI0713439A2
Authority
BR
Brazil
Prior art keywords
homoandrostanes
heteroandrostanes
amino derivatives
derivatives
homoandrostans
Prior art date
Application number
BRPI0713439-8A
Other languages
English (en)
Inventor
Cerri Alberto
Moro Barbara
Torri Marco
Carzana Giulio
Bianchi Giuseppe
Ferrandi Mara
Ferrari Patrizia
Pia Zappavigna Maria
Banfi Leonardo
Giacalone Giuseppe
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riuinite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riuinite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riuinite S.P.A.
Publication of BRPI0713439A2 publication Critical patent/BRPI0713439A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/004—Expansion of ring B by one atom, e.g. B homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

DERIVADOS AMINADOS DE B-HOMOANDROSTANOS E B-HETEROANDROSTANOS.A presente invenção refere-se aos derivados do aminoalcoximino na posição 3 de B-homoandrostanos e B-heteroandrostanos substituídos, processos para a sua preparação e para as composições farmacêuticas que os contêm, para o tratamento de distúrbios cardiovasculares, como a insuficiência cardíaca e a hipertensão. Em particular, são descritos compostos tendo fórmula geral (I) em que os radicais têm o seu significado descrito em detalhe no pedido.
BRPI0713439-8A 2006-06-23 2007-05-31 derivados aminados de b-homoandrostanos e b-heteroandrostanos BRPI0713439A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06116001 2006-06-23
EP06116001.6 2006-06-23
PCT/EP2007/055366 WO2007147713A1 (en) 2006-06-23 2007-05-31 Amino derivatives of b-homoandrostanes and b-heteroandrostanes

Publications (1)

Publication Number Publication Date
BRPI0713439A2 true BRPI0713439A2 (pt) 2012-03-06

Family

ID=37603055

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0713439-8A BRPI0713439A2 (pt) 2006-06-23 2007-05-31 derivados aminados de b-homoandrostanos e b-heteroandrostanos

Country Status (20)

Country Link
US (1) US8022203B2 (pt)
EP (1) EP2032593B1 (pt)
JP (1) JP4664433B2 (pt)
KR (1) KR101446166B1 (pt)
CN (1) CN101479291B (pt)
AR (1) AR061561A1 (pt)
AT (1) ATE497504T1 (pt)
AU (1) AU2007263117B2 (pt)
BR (1) BRPI0713439A2 (pt)
CA (1) CA2654354C (pt)
CY (1) CY1112012T1 (pt)
DE (1) DE602007012348D1 (pt)
DK (1) DK2032593T3 (pt)
EA (1) EA014333B1 (pt)
ES (1) ES2359544T3 (pt)
MX (1) MX2008016425A (pt)
PL (1) PL2032593T3 (pt)
SI (1) SI2032593T1 (pt)
TW (1) TWI372762B (pt)
WO (1) WO2007147713A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2422603T3 (es) 2007-05-31 2013-09-12 Shionogi & Co Compuestos oxiimino y el uso de estos
JP5450387B2 (ja) * 2008-04-02 2014-03-26 株式会社カネカ （ｓ）−３−（１−シアノ−１，１−ジフェニルメチル）−ピロリジンの製造法
US8518934B2 (en) 2008-06-11 2013-08-27 Shonogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
HUE027408T2 (en) * 2009-03-23 2016-10-28 Sigma Tau Ind Farmaceuti Proteinuria, 5ß, 14β-androstane derivatives for the treatment of glomerulosclerosis and renal failure
GB201104199D0 (en) 2011-03-11 2011-04-27 Syngenta Participations Ag Plant growth regulator compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2806029A (en) * 1956-07-16 1957-09-10 Searle & Co 3-oxygenated 12a-aza-c-homopregnane-12, 20-diones and congeners
US3136584A (en) * 1963-01-25 1964-06-09 Whitlock Associates Inc Bulk material hopper unloader
US3328408A (en) * 1964-01-30 1967-06-27 Smith 6-azaestranes, intermediates and process
DE19633349A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
WO2003015715A2 (en) * 2001-08-20 2003-02-27 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives as antithrombotic agents
US7053076B2 (en) * 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
WO2006002381A1 (en) * 2004-06-24 2006-01-05 Wisconsin Alumni Research Foundation Neoglycorandomization and digitoxin analogs

Also Published As

Publication number Publication date
KR20090023730A (ko) 2009-03-05
DE602007012348D1 (de) 2011-03-17
ES2359544T3 (es) 2011-05-24
US20090209506A1 (en) 2009-08-20
CN101479291A (zh) 2009-07-08
TW200817427A (en) 2008-04-16
JP2009541410A (ja) 2009-11-26
EA014333B1 (ru) 2010-10-29
WO2007147713A1 (en) 2007-12-27
ATE497504T1 (de) 2011-02-15
AR061561A1 (es) 2008-09-03
HK1134097A1 (en) 2010-04-16
CY1112012T1 (el) 2015-11-04
US8022203B2 (en) 2011-09-20
CA2654354A1 (en) 2007-12-27
AU2007263117A1 (en) 2007-12-27
SI2032593T1 (sl) 2011-05-31
MX2008016425A (es) 2009-01-21
TWI372762B (en) 2012-09-21
AU2007263117A2 (en) 2009-03-12
DK2032593T3 (da) 2011-05-16
CA2654354C (en) 2014-12-23
EA200970046A1 (ru) 2009-06-30
PL2032593T3 (pl) 2011-05-31
JP4664433B2 (ja) 2011-04-06
EP2032593B1 (en) 2011-02-02
CN101479291B (zh) 2012-09-19
KR101446166B1 (ko) 2014-10-01
EP2032593A1 (en) 2009-03-11
AU2007263117B2 (en) 2012-05-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2412 DE 28-03-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.