BR0012099A - Transferência citoplásmica para de-diferenciar células recipientes - Google Patents
Transferência citoplásmica para de-diferenciar células recipientesInfo
- Publication number
- BR0012099A BR0012099A BR0012099-5A BR0012099A BR0012099A BR 0012099 A BR0012099 A BR 0012099A BR 0012099 A BR0012099 A BR 0012099A BR 0012099 A BR0012099 A BR 0012099A
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- methods
- differentiate
- cytoplasm
- cytoplasmic transfer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2503/00—Use of cells in diagnostics
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"TRANSFERêNCIA CITOPLáSMICA PARA DE-DIFERENCIAR CéLULAS RECIPIENTES". Métodos para de-diferenciação ou alteração da vida útil de células "recipientes" desejadas, por exemplo, células somáticas humanas, através de introdução de citoplasma de um tipo de célula menos diferenciado mais primitivo, por exemplo, oócito ou blastómero, são proporcionados. Esses métodos podem ser usados para produzir células do tronco embriónico e aumentar a eficiência da terapia genética permitindo que células desejadas sejam submetidas a modificações genéticas múltiplas sem se tornarem senescentes. Tal citoplasma pode ser fracionado e/ou submetido à hibridização subtrativa e os materiais ativos (suficientes para de-diferenciação) identificados e produzidos por meio de métodos recombinantes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14125099P | 1999-06-30 | 1999-06-30 | |
| PCT/US2000/018063 WO2001000650A1 (en) | 1999-06-30 | 2000-06-30 | Cytoplasmic transfer to de-differentiate recipient cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012099A true BR0012099A (pt) | 2003-07-29 |
Family
ID=22494867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012099-5A BR0012099A (pt) | 1999-06-30 | 2000-06-30 | Transferência citoplásmica para de-diferenciar células recipientes |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20020001842A1 (pt) |
| EP (1) | EP1196426A4 (pt) |
| JP (1) | JP2003503071A (pt) |
| CN (1) | CN1362965A (pt) |
| AU (1) | AU782286B2 (pt) |
| BR (1) | BR0012099A (pt) |
| CA (1) | CA2377515C (pt) |
| IL (2) | IL147179A0 (pt) |
| MX (1) | MXPA01013450A (pt) |
| NZ (1) | NZ516236A (pt) |
| WO (1) | WO2001000650A1 (pt) |
Families Citing this family (76)
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|---|---|---|---|---|
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| WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
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| DE60144248D1 (de) * | 2000-12-22 | 2011-04-28 | Kyowa Hakko Kirin Co Ltd | Verfahren zur klonierung von nichtmenschliche säugern unter verwendung von reprogrammiertem donorchromatin oder donorzellen |
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| GB0118984D0 (en) * | 2001-08-03 | 2001-09-26 | Intercytex Ltd | Fusion of cells |
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| EP1391503A1 (en) * | 2002-08-12 | 2004-02-25 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | A method of cell re-programming by cytoplasmic transfer |
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| EP1620546A2 (en) * | 2003-04-21 | 2006-02-01 | The University of Massachusetts | Reprogramming nuclear function with somatic cell cytoplasm |
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| ES2980659T3 (es) | 2015-03-23 | 2024-10-02 | Astellas Inst For Regenerative Medicine | Ensayos mejorados de potencia de células de epitelio pigmentario retiniano (EPR) humano y progenitores de fotorreceptores |
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| JPS6344526A (ja) * | 1986-08-12 | 1988-02-25 | Kingo Yoshida | 幼若細胞の細胞質・ミトコンドリア・イントロン他注入による若返り長寿法 |
| US5480772A (en) | 1993-02-03 | 1996-01-02 | Brandeis University | In vitro activation of a nucleus |
| US5830651A (en) | 1995-06-01 | 1998-11-03 | Signal Pharmaceuticals, Inc. | Human oligodendroglial progenitor cell line |
| GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| WO1997035967A2 (en) | 1996-03-28 | 1997-10-02 | Cold Spring Harbor Laboratory | Transgenic organisms with altered telomerase activity |
| US20010012513A1 (en) | 1996-08-19 | 2001-08-09 | University Of Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
| CA2262817A1 (en) * | 1996-08-19 | 1998-02-26 | James Robl | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
| US6011197A (en) * | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
| AU8587598A (en) * | 1997-07-26 | 1999-02-16 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| GB9809178D0 (en) | 1998-04-29 | 1998-07-01 | Univ Edinburgh | Nuclear reprogramming of somatic cells |
| EP1204790A4 (en) * | 1999-04-23 | 2004-08-04 | Monica Palacios-Boyce | MICROELECTROMECHANICAL DEVICE FOR HANDLING CELLS OR EMBRYONS, KITS THEREFOR, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE USE THEREOF |
| US20040199935A1 (en) | 1999-06-30 | 2004-10-07 | Chapman Karen B. | Cytoplasmic transfer to de-differentiate recipient cells |
| CN1362965A (zh) | 1999-06-30 | 2002-08-07 | 先进细胞技术公司 | 细胞质转移使受体细胞去分化 |
| AU784731B2 (en) * | 1999-12-20 | 2006-06-08 | University Of Massachusetts | Embryonic or stem-like cells produced by cross species nuclear transplantation |
| WO2003018780A1 (en) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
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- 2000-06-30 MX MXPA01013450A patent/MXPA01013450A/es not_active Application Discontinuation
- 2000-06-30 NZ NZ516236A patent/NZ516236A/xx not_active IP Right Cessation
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- 2000-06-30 WO PCT/US2000/018063 patent/WO2001000650A1/en not_active Ceased
- 2000-06-30 BR BR0012099-5A patent/BR0012099A/pt not_active IP Right Cessation
- 2000-06-30 CA CA2377515A patent/CA2377515C/en not_active Expired - Lifetime
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| US20130104253A1 (en) | 2013-04-25 |
| EP1196426A4 (en) | 2003-09-03 |
| US9580683B2 (en) | 2017-02-28 |
| IL147179A (en) | 2015-01-29 |
| EP1196426A1 (en) | 2002-04-17 |
| MXPA01013450A (es) | 2003-09-04 |
| AU782286B2 (en) | 2005-07-14 |
| CA2377515C (en) | 2013-09-03 |
| IL147179A0 (en) | 2002-08-14 |
| US20150132853A1 (en) | 2015-05-14 |
| WO2001000650A1 (en) | 2001-01-04 |
| US20020001842A1 (en) | 2002-01-03 |
| AU5902800A (en) | 2001-01-31 |
| CA2377515A1 (en) | 2001-01-04 |
| JP2003503071A (ja) | 2003-01-28 |
| NZ516236A (en) | 2004-12-24 |
| US20170226475A1 (en) | 2017-08-10 |
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