BR0012418A - Derivados de peptìdeo cìclicos como inibidores de integrina alfavbeta6 - Google Patents
Derivados de peptìdeo cìclicos como inibidores de integrina alfavbeta6Info
- Publication number
- BR0012418A BR0012418A BR0012418-4A BR0012418A BR0012418A BR 0012418 A BR0012418 A BR 0012418A BR 0012418 A BR0012418 A BR 0012418A BR 0012418 A BR0012418 A BR 0012418A
- Authority
- BR
- Brazil
- Prior art keywords
- peptide derivatives
- phe
- cyclic peptide
- nle
- leu
- Prior art date
Links
- 108010069514 Cyclic Peptides Proteins 0.000 title abstract 2
- 102000001189 Cyclic Peptides Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108010004788 integrin alphavbeta6 Proteins 0.000 title 1
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: "DERIVADOS DE PEPTìDEO CìCLICOS COMO INIBIDORES DE INTEGRINA ALFA~ v~BETA~ 6~". A invenção refere-se a novos derivados de peptídeo de fórmula (I): ciclo(Arg-X~ 1~-ASp-X^ 2^-X^ 3^-X^ 4^-X^ 5^-X^ 6^-R^ 1^) que são biologicamente ativos como ligantes de integrina <244>~ v~<225>~ 6~, X^ 1^ representa Ser, Gly ou Thr; X^ 2^ é Leu, lle, Nle, Val ou Phe; X^ 3^ é Asp, Glu, Lys ou Phe; X^ 4^ é Gly, Ala ou Ser; X^ 5^ é Leu, lle, Nle, Val ou Phe; X^ 6^ é Arg, Har ou Lys; e R^ 1^ é ausente ou representa um ou mais radicais de ácido é-aminocarboxílico, o radical de ácido é-aminocarboxílico constando de 500 a 2500 pm em comprimento. Tais aminoácidos também podem ser derivados das formas D e L dos radicais de aminoácido opticamente ativos incluídos. A invenção também refere-se aos sais fisiologicamente adequados.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19933173A DE19933173A1 (de) | 1999-07-15 | 1999-07-15 | Cyclische Peptidderivate als Inhibitoren des Integrins alpha¶v¶beta¶6¶ |
| PCT/EP2000/006188 WO2001005810A2 (de) | 1999-07-15 | 2000-07-03 | CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS αvβ¿6? |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012418A true BR0012418A (pt) | 2002-03-26 |
Family
ID=7914891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012418-4A BR0012418A (pt) | 1999-07-15 | 2000-07-03 | Derivados de peptìdeo cìclicos como inibidores de integrina alfavbeta6 |
Country Status (23)
| Country | Link |
|---|---|
| EP (2) | EP1196433B1 (pt) |
| JP (1) | JP2003505395A (pt) |
| KR (1) | KR20020010928A (pt) |
| CN (1) | CN1361792A (pt) |
| AR (1) | AR024742A1 (pt) |
| AT (1) | ATE340803T1 (pt) |
| AU (1) | AU772782C (pt) |
| BR (1) | BR0012418A (pt) |
| CA (1) | CA2379022A1 (pt) |
| CZ (1) | CZ200226A3 (pt) |
| DE (2) | DE19933173A1 (pt) |
| DK (1) | DK1196433T3 (pt) |
| ES (1) | ES2273703T3 (pt) |
| HK (1) | HK1048641A1 (pt) |
| HU (1) | HUP0201925A3 (pt) |
| MX (1) | MXPA02000465A (pt) |
| NO (1) | NO20020176L (pt) |
| PL (1) | PL354363A1 (pt) |
| PT (1) | PT1196433E (pt) |
| SK (1) | SK262002A3 (pt) |
| TW (1) | TWI226890B (pt) |
| WO (1) | WO2001005810A2 (pt) |
| ZA (1) | ZA200201275B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2438663C (en) * | 2001-02-19 | 2009-09-15 | Takara Bio Inc. | Cyclic peptide |
| DE10118550A1 (de) * | 2001-04-14 | 2002-10-17 | Merck Patent Gmbh | Liganden des Integrins alpha¶nu¶beta¶6¶ |
| EP1603512A2 (en) | 2003-03-17 | 2005-12-14 | Albany Molecular Research, Inc. | Novel cyclosporins |
| EP1667668B1 (en) * | 2003-10-01 | 2008-07-02 | MERCK PATENT GmbH | Alfavbeta3 and alfavbeta6 integrin antagonists as antifibrotic agents |
| ES2436170T3 (es) * | 2003-12-03 | 2013-12-27 | The Scripps Research Institute | Anticuerpos y péptidos específicos de la integrina alfa II beta3 |
| US7378391B2 (en) | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| WO2006039164A2 (en) | 2004-09-29 | 2006-04-13 | Amr Technology, Inc. | Novel cyclosporin analogues and their pharmaceutical uses |
| WO2006041631A2 (en) | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| GB0520068D0 (en) * | 2005-10-03 | 2005-11-09 | Cancer Res Technology | av peptide ligand |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| TW200815474A (en) | 2006-08-03 | 2008-04-01 | Astrazeneca Ab | Antibodies alphaVbeta6 and uses thereof |
| EP2784511A1 (en) | 2013-03-27 | 2014-10-01 | Universität Zürich | Integrin alpha-v-beta6 for diagnosis/prognosis of colorectal carcinoma |
| SI3350222T1 (sl) | 2015-09-18 | 2022-01-31 | Technische Universitaet Muenchen | Ligandi za integrin avbeta6, sinteza in uporaba le-teh |
| MA47697A (fr) | 2017-02-28 | 2020-01-08 | Morphic Therapeutic Inc | Inhibiteurs de l'(alpha-v)(bêta-6) intégrine |
| MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| US11332498B2 (en) | 2017-03-17 | 2022-05-17 | Technische Universitat Munchen | Ligands for integrin αVβ8, synthesis and uses thereof |
| GB201706472D0 (en) * | 2017-04-24 | 2017-06-07 | Cancer Res Tech Ltd | Tumour-targeting peptide variants |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| EP4086254B1 (en) | 2018-08-29 | 2024-12-18 | Morphic Therapeutic, Inc. | Integrin inhibitors |
| FI3844162T3 (fi) | 2018-08-29 | 2025-03-27 | Morphic Therapeutic Inc | Alfa v beeta6 -integriinin estäjiä |
| JP7787083B2 (ja) * | 2020-03-12 | 2025-12-16 | テフニーシェ ウニヴェルジテート ミュンヘン | アルファ－ｖ－ベータ－６－インテグリンをインビボでアドレッシングするための環状ペプチド及びそれらのコンジュゲート |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472305A (en) | 1983-05-17 | 1984-09-18 | Sterling Drug Inc. | Hexapeptide amides |
| DE4310643A1 (de) | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| DE19538741A1 (de) | 1995-10-18 | 1997-04-24 | Merck Patent Gmbh | Cyclopeptidderivate |
| EP1140989A1 (de) * | 1998-12-19 | 2001-10-10 | MERCK PATENT GmbH | Inhibitoren des integrins alpha(v) beta(6) |
-
1999
- 1999-07-15 DE DE19933173A patent/DE19933173A1/de not_active Withdrawn
-
2000
- 2000-07-03 ES ES00943971T patent/ES2273703T3/es not_active Expired - Lifetime
- 2000-07-03 KR KR1020017015995A patent/KR20020010928A/ko not_active Withdrawn
- 2000-07-03 PT PT00943971T patent/PT1196433E/pt unknown
- 2000-07-03 CN CN00810415A patent/CN1361792A/zh active Pending
- 2000-07-03 CA CA002379022A patent/CA2379022A1/en not_active Abandoned
- 2000-07-03 AU AU58236/00A patent/AU772782C/en not_active Ceased
- 2000-07-03 MX MXPA02000465A patent/MXPA02000465A/es unknown
- 2000-07-03 PL PL00354363A patent/PL354363A1/xx unknown
- 2000-07-03 EP EP00943971A patent/EP1196433B1/de not_active Expired - Lifetime
- 2000-07-03 AT AT00943971T patent/ATE340803T1/de not_active IP Right Cessation
- 2000-07-03 JP JP2001511467A patent/JP2003505395A/ja active Pending
- 2000-07-03 HU HU0201925A patent/HUP0201925A3/hu unknown
- 2000-07-03 HK HK03100378.9A patent/HK1048641A1/zh unknown
- 2000-07-03 DK DK00943971T patent/DK1196433T3/da active
- 2000-07-03 SK SK26-2002A patent/SK262002A3/sk unknown
- 2000-07-03 BR BR0012418-4A patent/BR0012418A/pt not_active Application Discontinuation
- 2000-07-03 WO PCT/EP2000/006188 patent/WO2001005810A2/de not_active Ceased
- 2000-07-03 DE DE50013525T patent/DE50013525D1/de not_active Expired - Fee Related
- 2000-07-03 CZ CZ200226A patent/CZ200226A3/cs unknown
- 2000-07-03 EP EP06019918A patent/EP1754714A1/de not_active Withdrawn
- 2000-07-13 TW TW089113997A patent/TWI226890B/zh not_active IP Right Cessation
- 2000-07-14 AR ARP000103621A patent/AR024742A1/es unknown
-
2002
- 2002-01-14 NO NO20020176A patent/NO20020176L/no unknown
- 2002-02-14 ZA ZA200201275A patent/ZA200201275B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR024742A1 (es) | 2002-10-23 |
| NO20020176D0 (no) | 2002-01-14 |
| WO2001005810A2 (de) | 2001-01-25 |
| CA2379022A1 (en) | 2001-01-25 |
| EP1754714A1 (de) | 2007-02-21 |
| PT1196433E (pt) | 2007-01-31 |
| PL354363A1 (en) | 2004-01-12 |
| AU5823600A (en) | 2001-02-05 |
| AU772782B2 (en) | 2004-05-06 |
| CZ200226A3 (cs) | 2002-04-17 |
| AU772782C (en) | 2005-01-27 |
| EP1196433B1 (de) | 2006-09-27 |
| DE50013525D1 (de) | 2006-11-09 |
| DK1196433T3 (da) | 2007-02-12 |
| DE19933173A1 (de) | 2001-01-18 |
| HUP0201925A3 (en) | 2002-11-28 |
| WO2001005810A3 (de) | 2001-05-17 |
| HK1048641A1 (zh) | 2003-04-11 |
| HUP0201925A2 (en) | 2002-10-28 |
| TWI226890B (en) | 2005-01-21 |
| SK262002A3 (en) | 2002-07-02 |
| KR20020010928A (ko) | 2002-02-06 |
| CN1361792A (zh) | 2002-07-31 |
| ZA200201275B (en) | 2003-08-22 |
| MXPA02000465A (es) | 2002-07-30 |
| NO20020176L (no) | 2002-01-14 |
| EP1196433A2 (de) | 2002-04-17 |
| JP2003505395A (ja) | 2003-02-12 |
| ATE340803T1 (de) | 2006-10-15 |
| ES2273703T3 (es) | 2007-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |