BR0013017A - Usos de composições para o tratamento ou prevenção dos distúrbios do sono usando doses muito baixas de ciclobenzaprina - Google Patents
Usos de composições para o tratamento ou prevenção dos distúrbios do sono usando doses muito baixas de ciclobenzaprinaInfo
- Publication number
- BR0013017A BR0013017A BR0013017-6A BR0013017A BR0013017A BR 0013017 A BR0013017 A BR 0013017A BR 0013017 A BR0013017 A BR 0013017A BR 0013017 A BR0013017 A BR 0013017A
- Authority
- BR
- Brazil
- Prior art keywords
- sleep disorders
- compositions
- cyclobenzaprine
- prevention
- treatment
- Prior art date
Links
- 208000019116 sleep disease Diseases 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 4
- JURKNVYFZMSNLP-UHFFFAOYSA-N cyclobenzaprine Chemical compound C1=CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 JURKNVYFZMSNLP-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003572 cyclobenzaprine Drugs 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 3
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 abstract 2
- 208000001640 Fibromyalgia Diseases 0.000 abstract 2
- 208000036992 Psychogenic pain disease Diseases 0.000 abstract 2
- 208000022371 chronic pain syndrome Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 abstract 2
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 206010016256 fatigue Diseases 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"USOS DE COMPOSIçõES PARA O TRATAMENTO OU PREVENçãO DOS DISTúRBIOS DO SONO USANDO DOSES MUITO BAIXAS DE CICLOBENZAPRINA". A presente invenção refere-se à métodos e composições contendo uma dose muito baixa de ciclobenzaprina ou seu metabólito para a prevenção e tratamento de distúrbios do sono e doenças manifestadas com a disfunção do sono incluindo síndrome de fibromialgia, síndrome da fadiga crónica, desordens do sono, desordens da dor psicogênica, ou síndromes da dor crónica ou seus sintomas. A presente invenção refere-se ainda à métodos e composições para tratamento dos distúrbios do sono, dor crónica ou fadiga em seres humanos sofrendo de síndrome de fibromialgia, síndrome da fadiga crónica, desordens do sono, desordens da dor psicogênica, síndromes da dor crónica usando uma dose muito baixa de ciclobenzaprina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14888199P | 1999-08-13 | 1999-08-13 | |
| PCT/US2000/022082 WO2001012175A1 (en) | 1999-08-13 | 2000-08-11 | Uses compositions for treating or preventing sleep disturbances using very low doses of cyclobenzaprine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0013017A true BR0013017A (pt) | 2002-04-16 |
Family
ID=22527835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0013017-6A BR0013017A (pt) | 1999-08-13 | 2000-08-11 | Usos de composições para o tratamento ou prevenção dos distúrbios do sono usando doses muito baixas de ciclobenzaprina |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6395788B1 (pt) |
| EP (1) | EP1202722B1 (pt) |
| JP (1) | JP2003506484A (pt) |
| AR (1) | AR025110A1 (pt) |
| AT (1) | ATE299369T1 (pt) |
| AU (1) | AU6635400A (pt) |
| BR (1) | BR0013017A (pt) |
| CA (1) | CA2380432A1 (pt) |
| DE (1) | DE60021266T2 (pt) |
| ES (2) | ES2192156B1 (pt) |
| GB (1) | GB2368522A (pt) |
| HK (2) | HK1047883A1 (pt) |
| IL (1) | IL147777A0 (pt) |
| MX (1) | MXPA02001569A (pt) |
| NZ (1) | NZ516749A (pt) |
| PT (1) | PT1202722E (pt) |
| WO (1) | WO2001012175A1 (pt) |
| ZA (2) | ZA200200619B (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3422800A (en) * | 1999-02-18 | 2000-09-04 | Novartis Ag | Use of 5-ht3 receptor antagonists |
| US6635675B2 (en) | 2001-11-05 | 2003-10-21 | Cypress Bioscience, Inc. | Method of treating chronic fatigue syndrome |
| US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| GB0128674D0 (en) * | 2001-11-30 | 2002-01-23 | Boots Co Plc | Treatment of sleep disorders and the like |
| GB0312425D0 (en) * | 2003-05-30 | 2003-07-09 | Boots Co Plc | Use of a compound in the treatment of sleep disorders and the like,in providing refreshedness on waking and a method for the treatment of grogginess therewith |
| JP4578083B2 (ja) * | 2003-09-30 | 2010-11-10 | 小林製薬株式会社 | 催眠剤組成物 |
| US7994220B2 (en) * | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
| US20070087055A1 (en) * | 2005-10-14 | 2007-04-19 | David Jan | Directly compressible extended release alprazolam formulation |
| PT1954669E (pt) * | 2005-12-01 | 2015-10-23 | Auspex Pharmaceuticals Inc | Feniletilaminas substituídas com actividade serotoninérgica e/ou norepinefrinérgica |
| WO2007098200A2 (en) * | 2006-02-16 | 2007-08-30 | Imthera Medical, Inc. | An rfid-based apparatus, system, and method for therapeutic treatment of obstructive sleep apnea |
| US20100179215A1 (en) * | 2006-05-19 | 2010-07-15 | Somaxon Pharmaceuticals, Inc. | Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders |
| US20080081067A1 (en) * | 2006-10-03 | 2008-04-03 | Gupta Manishkumar | Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof |
| SI2125698T1 (sl) | 2007-03-15 | 2016-12-30 | Auspex Pharmaceuticals, Inc. | Devterirani d9-venlafaksin |
| EP2197536A1 (en) | 2007-10-09 | 2010-06-23 | Imthera Medical, Inc. | System and method for neural stimulation |
| CA2730190A1 (en) * | 2008-07-14 | 2010-01-21 | Queen's University At Kingston | Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer |
| BRPI0920548B8 (pt) | 2008-10-09 | 2021-06-22 | Imthera Medical Inc | aparelho para controlar posição da língua de um paciente |
| US9498440B2 (en) | 2009-05-22 | 2016-11-22 | Inventia Healthcare Private Limited | Extended release pharmaceutical compositions |
| JP2013509943A (ja) * | 2009-11-10 | 2013-03-21 | イムセラ・メディカル・インコーポレーテッド | 舌下神経を刺激して患者の舌の位置を調節するシステム |
| SMT201700578T1 (it) | 2009-11-20 | 2018-01-11 | Tonix Pharma Holdings Ltd | Metodo e composizioni per trattare i sintomi associati al disturbo da stress post-traumatico usando ciclobenzaprina |
| US20110319389A1 (en) | 2010-06-24 | 2011-12-29 | Tonix Pharmaceuticals, Inc. | Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine |
| US11998516B2 (en) * | 2011-03-07 | 2024-06-04 | Tonix Pharma Holdings Limited | Methods and compositions for treating depression using cyclobenzaprine |
| ITMI20110558A1 (it) * | 2011-04-06 | 2012-10-07 | Campiglio Consulting Srl | Composizione farmaceutica contenente ciclobenzaprina adatta alla somministrazione endonasale |
| WO2013168004A2 (en) * | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of fibromyalgia pain |
| RS63822B1 (sr) | 2012-06-15 | 2023-01-31 | Tonix Pharma Holdings Ltd | Kompozicije i postupci za transmukoznu apsorpciju |
| SMT202400324T1 (it) | 2013-03-15 | 2024-11-15 | Tonix Pharma Ltd | Formulazioni eutettiche di ciclobenzaprina cloridrato e mannitolo |
| MY186047A (en) | 2014-09-18 | 2021-06-17 | Tonix Pharma Holdings Ltd | Eutectic formulations of cyclobenzaprine hydrochloride |
| WO2019014651A1 (en) | 2017-07-13 | 2019-01-17 | Tonix Pharmaceuticals Holding Corp. | ANALOGUES OF CYCLOBENZAPRINE AND AMITRYPTILENE |
| MX2020006140A (es) * | 2017-12-11 | 2020-08-13 | Tonix Pharma Holdings Ltd | Tratamiento con ciclobenzaprina para la agitacion, psicosis y deterioro cognitivo en la demencia y enfermedades neurodegenerativas. |
| US20190381056A1 (en) | 2018-06-17 | 2019-12-19 | Axsome Therapeutics, Inc. | Compositions for delivery of reboxetine |
| US20220117915A1 (en) * | 2018-08-20 | 2022-04-21 | Tonix Pharma Holdings Limited | Methods of treating acute stress disorder and posttraumatic stress disorder |
| US20200147093A1 (en) | 2018-10-15 | 2020-05-14 | Axsome Therapeutics, Inc. | Use of esreboxetine to treat nervous system disorders such as fibromyalgia |
| US11020402B2 (en) | 2018-10-15 | 2021-06-01 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| AU2021253592A1 (en) * | 2020-04-08 | 2022-11-10 | Tonix Pharmaceuticals Holding Corp. | Cyclobenzaprine treatment for sexual dysfunction |
| MX2023005899A (es) | 2020-11-20 | 2023-08-16 | TONIX Pharmaceuticals Holding Corp | Tratamiento con ciclobenzaprina para el trastorno por consumo de alcohol. |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
| US12565478B1 (en) | 2025-01-21 | 2026-03-03 | Axsome Therapeutics, Inc. | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1339636A (en) * | 1917-02-23 | 1920-05-11 | Tulloch Thomas Gregorie | Fluid-tight joint for steam-pipes and the like |
| GB859187A (en) | 1958-11-25 | 1961-01-18 | United States Borax Chem | Method for preparing substituted tris amino boranes |
| CA958643A (en) | 1970-07-07 | 1974-12-03 | Frosst (Charles E.) And Co. | Pharmaceutical compositions containing cyclobenzaprine |
| FR2121529A1 (en) * | 1971-01-05 | 1972-08-25 | Merck & Co Inc | Compsns contg cyclobenzaprine and indomethacin - chlordiazepoxide, phenylbutazone oxyphenbutazone or corticosteroid |
| AR025111A1 (es) * | 1999-08-13 | 2002-11-06 | Janus Pharmaceuticals Inc | Metodos y composiciones para tratar trastornos de ansiedad generalizada |
-
2000
- 2000-08-11 BR BR0013017-6A patent/BR0013017A/pt not_active Application Discontinuation
- 2000-08-11 JP JP2001516521A patent/JP2003506484A/ja active Pending
- 2000-08-11 DE DE60021266T patent/DE60021266T2/de not_active Expired - Lifetime
- 2000-08-11 CA CA002380432A patent/CA2380432A1/en not_active Abandoned
- 2000-08-11 GB GB0202908A patent/GB2368522A/en not_active Withdrawn
- 2000-08-11 US US09/637,557 patent/US6395788B1/en not_active Expired - Lifetime
- 2000-08-11 PT PT00953996T patent/PT1202722E/pt unknown
- 2000-08-11 HK HK02107660.2A patent/HK1047883A1/zh unknown
- 2000-08-11 AR ARP000104189A patent/AR025110A1/es unknown
- 2000-08-11 AT AT00953996T patent/ATE299369T1/de active
- 2000-08-11 ES ES200250016A patent/ES2192156B1/es not_active Withdrawn - After Issue
- 2000-08-11 HK HK02107664.8A patent/HK1047691B/en not_active IP Right Cessation
- 2000-08-11 NZ NZ516749A patent/NZ516749A/en not_active IP Right Cessation
- 2000-08-11 MX MXPA02001569A patent/MXPA02001569A/es unknown
- 2000-08-11 ES ES00953996T patent/ES2245944T3/es not_active Expired - Lifetime
- 2000-08-11 EP EP00953996A patent/EP1202722B1/en not_active Expired - Lifetime
- 2000-08-11 AU AU66354/00A patent/AU6635400A/en not_active Abandoned
- 2000-08-11 WO PCT/US2000/022082 patent/WO2001012175A1/en not_active Ceased
- 2000-08-11 IL IL14777700A patent/IL147777A0/xx unknown
-
2001
- 2001-06-27 US US09/893,758 patent/US6541523B2/en not_active Expired - Lifetime
-
2002
- 2002-01-23 ZA ZA200200619A patent/ZA200200619B/xx unknown
- 2002-01-30 ZA ZA200200852A patent/ZA200200852B/en unknown
-
2003
- 2003-03-17 US US10/392,366 patent/US20040029869A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60021266T2 (de) | 2006-05-24 |
| AU6635400A (en) | 2001-03-13 |
| EP1202722A1 (en) | 2002-05-08 |
| GB2368522A8 (en) | 2002-06-13 |
| GB0202908D0 (en) | 2002-03-27 |
| IL147777A0 (en) | 2002-08-14 |
| NZ516749A (en) | 2004-03-26 |
| US20010046988A1 (en) | 2001-11-29 |
| US6541523B2 (en) | 2003-04-01 |
| JP2003506484A (ja) | 2003-02-18 |
| ES2192156A1 (es) | 2003-09-16 |
| GB2368522A (en) | 2002-05-08 |
| ES2245944T3 (es) | 2006-02-01 |
| EP1202722B1 (en) | 2005-07-13 |
| ES2192156B1 (es) | 2005-02-16 |
| PT1202722E (pt) | 2005-11-30 |
| WO2001012175A1 (en) | 2001-02-22 |
| HK1047691B (en) | 2006-05-12 |
| WO2001012175A8 (en) | 2001-05-10 |
| DE60021266D1 (de) | 2005-08-18 |
| HK1047691A1 (en) | 2003-03-07 |
| ZA200200619B (en) | 2003-04-23 |
| US20040029869A1 (en) | 2004-02-12 |
| HK1047883A1 (zh) | 2003-03-14 |
| AR025110A1 (es) | 2002-11-06 |
| ATE299369T1 (de) | 2005-07-15 |
| MXPA02001569A (es) | 2002-07-02 |
| CA2380432A1 (en) | 2001-02-22 |
| US6395788B1 (en) | 2002-05-28 |
| ZA200200852B (en) | 2003-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |