BR0013765A - 3-fenil-5-alcóxi-1,3,4-oxdiazol-2-ona substituìda e seu emprego como inibidor de lipase - Google Patents
3-fenil-5-alcóxi-1,3,4-oxdiazol-2-ona substituìda e seu emprego como inibidor de lipaseInfo
- Publication number
- BR0013765A BR0013765A BR0013765-0A BR0013765A BR0013765A BR 0013765 A BR0013765 A BR 0013765A BR 0013765 A BR0013765 A BR 0013765A BR 0013765 A BR0013765 A BR 0013765A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- cycloalkyl
- oxdiazol
- phenyl
- substituted
- Prior art date
Links
- 229940086609 Lipase inhibitor Drugs 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006763 (C3-C9) cycloalkyl group Chemical group 0.000 abstract 1
- 102100026020 Hormone-sensitive lipase Human genes 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000000019 Sterol Esterase Human genes 0.000 abstract 1
- 108010055297 Sterol Esterase Proteins 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Patente de Invenção: "3-FENIL-5-ALCóXI-1,3,4-OXDIAZOL-2-ONA SUBSTITUìDA E SEU EMPREGO COMO INIBIDOR DE LIPASE". São descritas 3-fenil-5-alcóxi-1,3,4-oxdiazol-2-onas substituídas da fórmula 1, assim como seus sais fisiologicamente compatíveis e isómeros óticos, na qual R^ 1^ representa C~ 1~-C~ 6~-alquila, C~ 3~-C~ 9~-cicloalquila, sendo que ambos os grupos podem ser opcionalmente substituídos, e R^ 2^ e R^ 3^ independentemente um do outro representam hidrogênio, C~ 6~-C~ 10~-arila, C~ 3~-C~ 8~-cicloalquila, C~ 6~-C~ 10~-ariloximetila, O-benzila, O-C~ 6~-C~ 10~-arila, O-C~ 3~-C~ 8~-cicloalquila, O-C~ 1~-C~ 6~-alquila, SO~ 2~-NH-C~ 1~-C~ 6~-alquila, SO~ 2~-NH-(2,2,6,6-tetrametilpiperidin-4-il), SO~ 2~-NH-C~ 3~-C~ 8~-cicloalquila, SO~ 2~-N(C~ 1~-C~ 6~-alquila)~ 2~ ou COX, sendo que X representa O-C~ 1~-C~ 6~-alquila, NH-C~ 1~-C~ 6~-alquila, NH-C~ 3~-C~ 8~-cicloalquila ou N(C~ 1~-C~ 6~-alquila)2, e com a condição de que os substituintes R^ 2^ e R^ 3^ em parte podem ser opcionalmente substituídos e ambos não representam concomitantemente hidrogênio. é igualmente descrito um processo para sua preparação. Os compostos apresentam uma eficácia inibidora na lipase sensitiva a hormónio, HSL.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19942354A DE19942354A1 (de) | 1999-09-04 | 1999-09-04 | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneimitteln |
| PCT/EP2000/008150 WO2001017981A1 (de) | 1999-09-04 | 2000-08-22 | Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one und ihre verwendung als lipase-hemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0013765A true BR0013765A (pt) | 2002-04-30 |
Family
ID=7920884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0013765-0A BR0013765A (pt) | 1999-09-04 | 2000-08-22 | 3-fenil-5-alcóxi-1,3,4-oxdiazol-2-ona substituìda e seu emprego como inibidor de lipase |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6596742B1 (pt) |
| EP (1) | EP1214302B1 (pt) |
| JP (1) | JP2003508522A (pt) |
| KR (1) | KR100723817B1 (pt) |
| CN (1) | CN1152024C (pt) |
| AR (1) | AR032430A1 (pt) |
| AT (1) | ATE253059T1 (pt) |
| AU (1) | AU781330B2 (pt) |
| BR (1) | BR0013765A (pt) |
| CA (1) | CA2383731A1 (pt) |
| CZ (1) | CZ2002772A3 (pt) |
| DE (2) | DE19942354A1 (pt) |
| DK (1) | DK1214302T3 (pt) |
| EE (1) | EE04811B1 (pt) |
| ES (1) | ES2204685T3 (pt) |
| HK (1) | HK1048318B (pt) |
| HR (1) | HRP20020187A2 (pt) |
| HU (1) | HUP0202988A3 (pt) |
| IL (2) | IL148275A0 (pt) |
| MX (1) | MXPA02001834A (pt) |
| NO (1) | NO323129B1 (pt) |
| NZ (1) | NZ517551A (pt) |
| PL (1) | PL197314B1 (pt) |
| PT (1) | PT1214302E (pt) |
| RU (1) | RU2265600C2 (pt) |
| SK (1) | SK285924B6 (pt) |
| TR (1) | TR200200553T2 (pt) |
| WO (1) | WO2001017981A1 (pt) |
| YU (1) | YU10402A (pt) |
| ZA (1) | ZA200201594B (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10102265C1 (de) * | 2001-01-18 | 2002-08-08 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| DE10208987A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Substituierte 3-Phenyl-5-alkoxi-1,3,4-oxidiazol-2-one, ihre Herstellung und Verwendung in Arzneistoffen |
| DE10208986A1 (de) * | 2002-02-28 | 2003-09-11 | Aventis Pharma Gmbh | Verwendung substituierter 3-Phenyl-5-alkoxi-1,3,4-oxdiazol-2-one zur Herstellung von Arzneimitteln mit hemmender Wirkung an der pankreatischen Lipase |
| US6900233B2 (en) | 2002-02-28 | 2005-05-31 | Aventis Pharma Deutschland Gmbh | Substituted 3-phenyl-5-alkoxy-3H-(1,3,4)-oxadiazol-2-ones, pharmaceutical composition and method for treating obesity thereof |
| DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| US7208504B2 (en) | 2002-10-12 | 2007-04-24 | Sanofi-Aventis Deutschland Gmbh | Bicyclic inhibitors of hormone sensitive lipase |
| MX2007004488A (es) * | 2004-10-13 | 2007-09-11 | Wyeth Corp | Analogos de anilino-pirimidina n-bencenosulfonilo sustituidos. |
| EP2178821A2 (en) * | 2007-07-12 | 2010-04-28 | Deviris Inc. | Hormone sensitive lipase modulators and methods of use |
| BRPI0821482A2 (pt) * | 2007-12-27 | 2015-07-14 | Bial Portela & Ca Sa | 3-n-fenil-1,3,4-oxadiazolona 5-o-substituída, seu uso, sua composição e seu processo de preparação |
| AR074978A1 (es) | 2008-12-23 | 2011-03-02 | Bial Portela & Ca Sa | 3-n-aril-1,3,4-oxadiazolonas 5-o-sustituidas para uso en el tratamiento del dolor y procedimiento de obtencion |
| US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
| CN114163351B (zh) * | 2020-09-11 | 2024-01-23 | 江苏优嘉植物保护有限公司 | 噁虫酮中间体2-(2-甲氧基)苯肼甲酸甲酯合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB518042A (en) | 1937-09-15 | 1940-02-15 | Ljungstroms Angturbin Ab | Improvements in elastic fluid turbines of the double rotation type |
| US4076824A (en) | 1975-02-03 | 1978-02-28 | Rhone-Poulenc Industries | Anthelmintic oxadiazolinone derivatives |
| FR2299328A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Derives de l'alcoyloxy-5 phenyl-3 oxyde azo |
| FR2299028A1 (fr) | 1975-02-03 | 1976-08-27 | Rhone Poulenc Ind | Nouvea |
| DK156439C (da) | 1980-09-15 | 1990-01-22 | Shell Int Research | 7-substituerede 2,3-dihydrobenzofuranderivater samt pesticidpraeparater indeholdende disse og en fremgangsmaade til bekaempelse af skadelige organismer |
| EP0067471B1 (en) | 1981-06-15 | 1985-11-06 | Shell Internationale Researchmaatschappij B.V. | 7-substituted 2,3-dihydrobenzofurans, their preparation and their use as pesticides or as chemical intermediates |
| JPS60115502A (ja) * | 1983-11-28 | 1985-06-22 | Mitsubishi Chem Ind Ltd | 殺虫剤 |
| DE3931843A1 (de) | 1989-09-23 | 1991-04-04 | Bayer Ag | Substituierte 1,3,4-oxa(thia)diazolinone verfahren zu ihrer herstellung und ihre verwendung der bekaempfung von endoparasiten |
| US5236939A (en) | 1989-09-23 | 1993-08-17 | Bayer Aktiengesellschaft | Substituted 1,3,4-oxa(thia)diazolinones process for their preparation and their use of combating endoparasites |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
-
1999
- 1999-09-04 DE DE19942354A patent/DE19942354A1/de not_active Withdrawn
-
2000
- 2000-08-22 HK HK03100568.9A patent/HK1048318B/zh not_active IP Right Cessation
- 2000-08-22 BR BR0013765-0A patent/BR0013765A/pt not_active Application Discontinuation
- 2000-08-22 EE EEP200200109A patent/EE04811B1/xx not_active IP Right Cessation
- 2000-08-22 WO PCT/EP2000/008150 patent/WO2001017981A1/de not_active Ceased
- 2000-08-22 MX MXPA02001834A patent/MXPA02001834A/es active IP Right Grant
- 2000-08-22 IL IL14827500A patent/IL148275A0/xx active IP Right Grant
- 2000-08-22 SK SK301-2002A patent/SK285924B6/sk not_active IP Right Cessation
- 2000-08-22 TR TR2002/00553T patent/TR200200553T2/xx unknown
- 2000-08-22 HU HU0202988A patent/HUP0202988A3/hu unknown
- 2000-08-22 JP JP2001521728A patent/JP2003508522A/ja active Pending
- 2000-08-22 HR HR20020187A patent/HRP20020187A2/hr not_active Application Discontinuation
- 2000-08-22 PT PT00962346T patent/PT1214302E/pt unknown
- 2000-08-22 PL PL353214A patent/PL197314B1/pl not_active IP Right Cessation
- 2000-08-22 NZ NZ517551A patent/NZ517551A/en unknown
- 2000-08-22 KR KR1020027002775A patent/KR100723817B1/ko not_active Expired - Fee Related
- 2000-08-22 YU YU10402A patent/YU10402A/sh unknown
- 2000-08-22 AU AU74112/00A patent/AU781330B2/en not_active Ceased
- 2000-08-22 CZ CZ2002772A patent/CZ2002772A3/cs unknown
- 2000-08-22 EP EP00962346A patent/EP1214302B1/de not_active Expired - Lifetime
- 2000-08-22 CN CNB008121346A patent/CN1152024C/zh not_active Expired - Fee Related
- 2000-08-22 DE DE50004274T patent/DE50004274D1/de not_active Expired - Lifetime
- 2000-08-22 RU RU2002108509/04A patent/RU2265600C2/ru not_active IP Right Cessation
- 2000-08-22 AT AT00962346T patent/ATE253059T1/de not_active IP Right Cessation
- 2000-08-22 DK DK00962346T patent/DK1214302T3/da active
- 2000-08-22 ES ES00962346T patent/ES2204685T3/es not_active Expired - Lifetime
- 2000-08-22 CA CA002383731A patent/CA2383731A1/en not_active Abandoned
- 2000-09-01 AR ARP000104589A patent/AR032430A1/es not_active Application Discontinuation
- 2000-09-05 US US09/655,373 patent/US6596742B1/en not_active Expired - Lifetime
-
2002
- 2002-02-20 IL IL148275A patent/IL148275A/en not_active IP Right Cessation
- 2002-02-26 ZA ZA200201594A patent/ZA200201594B/en unknown
- 2002-02-28 NO NO20021007A patent/NO323129B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: C07D 271/113, C07D 413/12, C07D 31/4245; A61P 3/10 Ipc: C07D 271/113 (2009.01), C07D 271/10 (2009.01), C07 |
|
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |