BR0014652A - Fabricação de conjugados de agente terapêutico-poliglutamato - Google Patents

Fabricação de conjugados de agente terapêutico-poliglutamato

Info

Publication number
BR0014652A
BR0014652A BR0014652-8A BR0014652A BR0014652A BR 0014652 A BR0014652 A BR 0014652A BR 0014652 A BR0014652 A BR 0014652A BR 0014652 A BR0014652 A BR 0014652A
Authority
BR
Brazil
Prior art keywords
therapeutic agent
manufacture
conjugates
polyglutamate
polyglutamate conjugates
Prior art date
Application number
BR0014652-8A
Other languages
English (en)
Other versions
BRPI0014652B1 (pt
Inventor
Anil M Kumar
J Peter Klein
Rama Bhatt
Edward Vanter
Original Assignee
Cell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Therapeutics Inc filed Critical Cell Therapeutics Inc
Publication of BR0014652A publication Critical patent/BR0014652A/pt
Publication of BRPI0014652B1 publication Critical patent/BRPI0014652B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

"FABRICAçãO DE CONJUGADOS DE AGENTE TERAPêUTICO-POLIGLUTAMATO". A invenção provê novos processos para preparação de conjugados de agente terapêutico e ácido poliglutâmico para desenvolvimento clínico e uso farmacêutico e conjugados de agente terapêutico-ácido poliglutâmico preparados de acordo com estes processos.
BRPI0014652A 1999-10-12 2000-10-12 fabricação de conjugados de agente terapêutico-poliglutamato BRPI0014652B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15913599P 1999-10-12 1999-10-12
PCT/US2000/028109 WO2001026693A2 (en) 1999-10-12 2000-10-12 Manufacture of polyglutamate-therapeutic agent conjugates

Publications (2)

Publication Number Publication Date
BR0014652A true BR0014652A (pt) 2003-06-10
BRPI0014652B1 BRPI0014652B1 (pt) 2016-08-09

Family

ID=22571222

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0014652A BRPI0014652B1 (pt) 1999-10-12 2000-10-12 fabricação de conjugados de agente terapêutico-poliglutamato

Country Status (16)

Country Link
US (2) US20020077279A1 (pt)
EP (2) EP1225917A2 (pt)
JP (1) JP2003511423A (pt)
KR (1) KR100821437B1 (pt)
CN (2) CN101507820A (pt)
AU (1) AU781735B2 (pt)
BR (1) BRPI0014652B1 (pt)
CA (1) CA2387611C (pt)
HU (1) HUP0203123A3 (pt)
MX (1) MXPA02003719A (pt)
NO (1) NO20021701L (pt)
NZ (1) NZ529789A (pt)
PL (1) PL354623A1 (pt)
SG (1) SG147286A1 (pt)
WO (1) WO2001026693A2 (pt)
ZA (1) ZA200202695B (pt)

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EP2090607B1 (en) 2006-11-08 2015-05-20 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
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BRPI0810717A2 (pt) 2007-04-30 2016-05-24 Arqule Inc sulfonato hidroxi de composto de quinona e seus usos
JP2010528122A (ja) * 2007-05-09 2010-08-19 日東電工株式会社 白金薬剤と結合されたポリマー
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DK2155255T3 (da) * 2007-05-09 2013-09-02 Nitto Denko Corp Sammensætninger der omfatter en hydrofob forbindelse og et polyaminosyrekonjugat
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
KR20100122510A (ko) * 2008-03-06 2010-11-22 닛토덴코 가부시키가이샤 중합체 파클리탁셀 접합체 및 암 치료 방법
KR101589582B1 (ko) 2008-03-18 2016-01-28 니폰 가야꾸 가부시끼가이샤 생리활성물질의 고분자량 결합체
JP5366940B2 (ja) 2008-05-08 2013-12-11 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
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WO2010042638A2 (en) * 2008-10-07 2010-04-15 Young Bok Lee Hpma - docetaxel or gemcitabine conjugates and uses therefore
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US20100098654A1 (en) * 2008-10-21 2010-04-22 Fabio Pastorino Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
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JP5544357B2 (ja) 2009-05-15 2014-07-09 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
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JP5856069B2 (ja) 2010-11-17 2016-02-09 日本化薬株式会社 新規なシチジン系代謝拮抗剤の高分子誘導体
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JP5711378B2 (ja) 2011-09-11 2015-04-30 日本化薬株式会社 ブロック共重合体の製造方法
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CN106267227A (zh) * 2016-08-12 2017-01-04 北京蓝贝望生物医药科技股份有限公司 抗肿瘤药物
CN106750272B (zh) * 2016-12-05 2019-05-28 福建卫生职业技术学院 一种水溶性蛇葡萄素聚合物
CN110123748A (zh) * 2019-04-22 2019-08-16 南京师范大学 一种叶酸介导的靶向双载药聚合物胶束及其制备方法和应用
CN113773282A (zh) * 2021-09-22 2021-12-10 无锡紫杉药业有限公司 一种10-乙酰紫杉醇的制备方法

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Also Published As

Publication number Publication date
HUP0203123A3 (en) 2004-12-28
US20020077279A1 (en) 2002-06-20
US20030224971A1 (en) 2003-12-04
CA2387611A1 (en) 2001-04-19
US7399860B2 (en) 2008-07-15
EP1225917A2 (en) 2002-07-31
KR100821437B1 (ko) 2008-04-10
KR20020059616A (ko) 2002-07-13
CN101507820A (zh) 2009-08-19
WO2001026693A2 (en) 2001-04-19
WO2001026693A3 (en) 2001-12-27
CA2387611C (en) 2011-03-29
AU781735B2 (en) 2005-06-09
PL354623A1 (en) 2004-02-09
NO20021701L (no) 2002-05-23
NZ529789A (en) 2005-04-29
AU1079301A (en) 2001-04-23
BRPI0014652B1 (pt) 2016-08-09
SG147286A1 (en) 2008-11-28
EP1466627A1 (en) 2004-10-13
MXPA02003719A (es) 2002-08-30
NO20021701D0 (no) 2002-04-11
JP2003511423A (ja) 2003-03-25
HUP0203123A2 (hu) 2003-01-28
CN1607962A (zh) 2005-04-20
ZA200202695B (en) 2004-02-25

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/08/2016, OBSERVADAS AS CONDICOES LEGAIS.

B15K Others concerning applications: alteration of classification

Ipc: A61K 47/64 (2017.01)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2483 DE 07-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.