BRPI0515573A - copolìmero por blocos, preparação de micela e agente anticáncer contendo a mesma como o ingrediente ativo - Google Patents

copolìmero por blocos, preparação de micela e agente anticáncer contendo a mesma como o ingrediente ativo

Info

Publication number
BRPI0515573A
BRPI0515573A BRPI0515573-8A BRPI0515573A BRPI0515573A BR PI0515573 A BRPI0515573 A BR PI0515573A BR PI0515573 A BRPI0515573 A BR PI0515573A BR PI0515573 A BRPI0515573 A BR PI0515573A
Authority
BR
Brazil
Prior art keywords
anticancer agent
block copolymer
drug
water
preparation
Prior art date
Application number
BRPI0515573-8A
Other languages
English (en)
Inventor
Kazuhisa Shimizu
Keizou Ishikawa
Takeshi Nakanishi
Original Assignee
Nippon Kayaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk
Publication of BRPI0515573A publication Critical patent/BRPI0515573A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Epoxy Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

"COPOLìMERO POR BLOCOS, PREPARAçãO DE MICELA E AGENTE ANTICáNCER CONTENDO A MESMA COMO O INGREDIENTE ATIVO". Uma preparação medicinal é desejada que não tenha efeitos nocivos colateriais nocivos tal como reação hipersensível, aumenta a solubilidade em água de um agente anticâncer moderadamente solúvel em água, mantém uma alta de um agente de droga no sangue, acumula uma droga em um tecido de tumor a uma alta concentação, aumenta o efeito farmacológico do agente anticâncer moderadamente solúvel em água, e diminui os efeitos colaterais do agente anticâncer. Providos são: um novo copolímero por blocos que pode ser um veículo de droga não tendo efeitos colaterais nocivos tal como reação hipersensível; uma preparação de micela em que micelas são formadas e que contém um agente anticâncer moderadamente solúvel em água, especialmente paclitaxel, incorporado nas micelas em uma quantidade necessária de um tratamento de doença sem ligá-lo ao copolímero por blocos e que pode aumentar a solubilidade da droga em água; e um agente anticâncer que compreende a preparação de micela como um ingrediente médico, mantém uma alta concentração no sangue, tem atividade de droga mais potente, e é reduzido em toxicidade.
BRPI0515573-8A 2004-09-22 2005-09-16 copolìmero por blocos, preparação de micela e agente anticáncer contendo a mesma como o ingrediente ativo BRPI0515573A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004275625 2004-09-22
PCT/JP2005/017127 WO2006033296A1 (ja) 2004-09-22 2005-09-16 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤

Publications (1)

Publication Number Publication Date
BRPI0515573A true BRPI0515573A (pt) 2008-07-29

Family

ID=36090056

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515573-8A BRPI0515573A (pt) 2004-09-22 2005-09-16 copolìmero por blocos, preparação de micela e agente anticáncer contendo a mesma como o ingrediente ativo

Country Status (15)

Country Link
US (3) US20080113028A1 (pt)
EP (1) EP1792927B1 (pt)
JP (2) JP4820758B2 (pt)
KR (1) KR101203475B1 (pt)
CN (1) CN101023119B (pt)
AU (1) AU2005285953B2 (pt)
BR (1) BRPI0515573A (pt)
CA (1) CA2581125C (pt)
DK (1) DK1792927T3 (pt)
ES (1) ES2410591T3 (pt)
PL (1) PL1792927T3 (pt)
PT (1) PT1792927E (pt)
RU (1) RU2375384C2 (pt)
TW (2) TWI394774B (pt)
WO (1) WO2006033296A1 (pt)

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JP4820758B2 (ja) * 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
AU2006300451A1 (en) * 2005-10-05 2007-04-19 National University Corporation Gunma University Biocompatible block copolymer, use thereof, and production method thereof
JP5249016B2 (ja) * 2006-03-28 2013-07-31 日本化薬株式会社 タキサン類の高分子結合体
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ES2584840T3 (es) * 2006-10-03 2016-09-29 Nippon Kayaku Kabushiki Kaisha Compuesto de un derivado de resorcinol con un polímero
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CN104086769A (zh) * 2014-07-13 2014-10-08 成都市绿科华通科技有限公司 新型医用功能性聚乙二醇材料
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RU2007115075A (ru) 2008-10-27
TWI394774B (zh) 2013-05-01
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CA2581125A1 (en) 2006-03-30
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CA2581125C (en) 2013-04-23
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TW201302850A (zh) 2013-01-16
KR20070056113A (ko) 2007-05-31
PT1792927E (pt) 2013-05-15
EP1792927A4 (en) 2011-11-30
US20140024703A1 (en) 2014-01-23
EP1792927B1 (en) 2013-03-06
AU2005285953B2 (en) 2011-01-20
AU2005285953A1 (en) 2006-03-30
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US9434822B2 (en) 2016-09-06
DK1792927T3 (da) 2013-06-10
JP5369137B2 (ja) 2013-12-18
CN101023119A (zh) 2007-08-22
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