BR0015299A - Benzotiazepinas substituìdas não-peptìdicas como antagonistas de vasopressina - Google Patents
Benzotiazepinas substituìdas não-peptìdicas como antagonistas de vasopressinaInfo
- Publication number
- BR0015299A BR0015299A BR0015299-4A BR0015299A BR0015299A BR 0015299 A BR0015299 A BR 0015299A BR 0015299 A BR0015299 A BR 0015299A BR 0015299 A BR0015299 A BR 0015299A
- Authority
- BR
- Brazil
- Prior art keywords
- heart failure
- formula
- vasopressin antagonists
- vasopressin
- renal
- Prior art date
Links
- 229940116211 Vasopressin antagonist Drugs 0.000 title abstract 2
- 239000003038 vasopressin antagonist Substances 0.000 title abstract 2
- 150000007657 benzothiazepines Chemical class 0.000 title 1
- 206010019280 Heart failures Diseases 0.000 abstract 3
- 206010003225 Arteriospasm coronary Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010008132 Cerebral thrombosis Diseases 0.000 abstract 1
- 208000003890 Coronary Vasospasm Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010016807 Fluid retention Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000011634 coronary artery vasospasm Diseases 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 239000002536 vasopressin receptor antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
"BENZOTIAZEPINAS SUBSTITUìDAS NãO-PEPTìDICAS COMO ANTAGONISTAS DE VASOPRESSINA". A invenção refere-se a benzodiazepinas substituídas com não-peptídeo de Fórmula (I), onde A, X, Z, Bp, W, n, R^ 1^ e R^ 2^ são conforme descrito no pedido, os quais são úteis como antagonistas receptores de vasopressina para tratar condições envolvendo resistência vascular maior e insuficiência cardíaca. Composições farmacêuticas compreendendo um composto da Fórmula (I) e métodos de tratamento de condições tal como hipertensão, falência congestiva do coração, insuficiência cardíaca, vasospasmo coronário, isquemia cardíaca, cirrose do fígado, vasospasmo renal, falência renal, edema e isquemia cerebral, derrame, trombose e retenção de água são também descritos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16354499P | 1999-11-04 | 1999-11-04 | |
| PCT/US2000/030114 WO2001032639A1 (en) | 1999-11-04 | 2000-11-02 | Nonpeptide substituted benzothiazepines as vasopressin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0015299A true BR0015299A (pt) | 2003-04-15 |
Family
ID=22590503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0015299-4A BR0015299A (pt) | 1999-11-04 | 2000-11-02 | Benzotiazepinas substituìdas não-peptìdicas como antagonistas de vasopressina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6489321B1 (pt) |
| EP (1) | EP1226132A1 (pt) |
| JP (1) | JP2003513082A (pt) |
| KR (1) | KR20020047321A (pt) |
| CN (1) | CN1414958A (pt) |
| AR (1) | AR026360A1 (pt) |
| AU (1) | AU778810B2 (pt) |
| BR (1) | BR0015299A (pt) |
| CA (1) | CA2389439A1 (pt) |
| CZ (1) | CZ20021492A3 (pt) |
| HU (1) | HUP0204278A2 (pt) |
| MX (1) | MXPA02004513A (pt) |
| PL (1) | PL354759A1 (pt) |
| RU (1) | RU2002111660A (pt) |
| SK (1) | SK6052002A3 (pt) |
| WO (1) | WO2001032639A1 (pt) |
| YU (1) | YU32702A (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| JP3988832B2 (ja) * | 2004-11-29 | 2007-10-10 | 日本たばこ産業株式会社 | 窒素含有縮合環化合物及びその用途 |
| KR101346902B1 (ko) | 2005-07-09 | 2014-01-02 | 아스트라제네카 아베 | 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체 |
| JO3109B1 (ar) * | 2012-05-10 | 2017-09-20 | Ferring Bv | منبهات لمستقبلات v1a |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2751287B2 (ja) * | 1989-01-09 | 1998-05-18 | 吉富製薬株式会社 | １，５‐ベンゾチアゼピン‐２‐カルボン酸アミド化合物 |
| DK0450097T3 (da) * | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
| TW199153B (pt) | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
| JPH05320135A (ja) | 1992-05-19 | 1993-12-03 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロベンズアゼピン誘導体 |
| JPH0680641A (ja) | 1992-09-01 | 1994-03-22 | Otsuka Pharmaceut Co Ltd | 光学活性な５−ヒドロキシベンゾアゼピン誘導体の製造法 |
| SK94393A3 (en) | 1992-09-11 | 1994-08-10 | Thomae Gmbh Dr K | Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those |
| US5656642A (en) | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
| DE69523182T2 (de) | 1995-06-06 | 2002-02-07 | Pfizer | Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren |
| FI974437A7 (fi) | 1995-06-06 | 1997-12-05 | Pfizer | Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina |
| WO1997030707A1 (en) | 1996-02-23 | 1997-08-28 | Eli Lilly And Company | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS |
| SK285631B6 (sk) | 1996-09-10 | 2007-05-03 | Dr. Karl Thomae Gmbh | Modifikované aminokyseliny, farmaceutický prostriedok s ich obsahom a ich použitie |
| US5952322A (en) | 1996-12-05 | 1999-09-14 | Pfizer Inc. | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors |
| US6063796A (en) | 1997-04-04 | 2000-05-16 | Merck & Co., Inc. | Somatostatin agonists |
| US6057338A (en) | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
| US6025372A (en) | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
| DE19748763A1 (de) | 1997-11-05 | 1999-05-06 | Hans Peter Zenner | Verwendung von Vasopressin-Antagonisten |
| AUPP150098A0 (en) | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
| DK1086086T3 (da) | 1998-06-12 | 2005-01-24 | Sod Conseils Rech Applic | Imidazolylderivater og anvendelse deraf som somatostatinreceptorligander |
| WO2000018764A1 (en) | 1998-09-30 | 2000-04-06 | Merck Sharp & Dohme Limited | Benzimidazolinyl piperidines as cgrp ligands |
| GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| US6297234B1 (en) | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
-
2000
- 2000-11-02 JP JP2001534790A patent/JP2003513082A/ja active Pending
- 2000-11-02 SK SK605-2002A patent/SK6052002A3/sk unknown
- 2000-11-02 AU AU17540/01A patent/AU778810B2/en not_active Ceased
- 2000-11-02 CA CA002389439A patent/CA2389439A1/en not_active Abandoned
- 2000-11-02 CZ CZ20021492A patent/CZ20021492A3/cs unknown
- 2000-11-02 HU HU0204278A patent/HUP0204278A2/hu unknown
- 2000-11-02 EP EP00980254A patent/EP1226132A1/en not_active Withdrawn
- 2000-11-02 WO PCT/US2000/030114 patent/WO2001032639A1/en not_active Ceased
- 2000-11-02 US US09/704,314 patent/US6489321B1/en not_active Expired - Fee Related
- 2000-11-02 BR BR0015299-4A patent/BR0015299A/pt not_active Application Discontinuation
- 2000-11-02 CN CN00818031A patent/CN1414958A/zh active Pending
- 2000-11-02 PL PL00354759A patent/PL354759A1/xx not_active Application Discontinuation
- 2000-11-02 MX MXPA02004513A patent/MXPA02004513A/es unknown
- 2000-11-02 RU RU2002111660/04A patent/RU2002111660A/ru not_active Application Discontinuation
- 2000-11-02 YU YU32702A patent/YU32702A/sh unknown
- 2000-11-02 KR KR1020027005650A patent/KR20020047321A/ko not_active Withdrawn
- 2000-11-03 AR ARP000105813A patent/AR026360A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU778810B2 (en) | 2004-12-23 |
| WO2001032639A1 (en) | 2001-05-10 |
| US6489321B1 (en) | 2002-12-03 |
| EP1226132A1 (en) | 2002-07-31 |
| AR026360A1 (es) | 2003-02-05 |
| HUP0204278A2 (hu) | 2003-04-28 |
| CA2389439A1 (en) | 2001-05-10 |
| SK6052002A3 (en) | 2003-09-11 |
| YU32702A (sh) | 2005-06-10 |
| JP2003513082A (ja) | 2003-04-08 |
| KR20020047321A (ko) | 2002-06-21 |
| CZ20021492A3 (cs) | 2003-06-18 |
| RU2002111660A (ru) | 2003-11-27 |
| AU1754001A (en) | 2001-05-14 |
| PL354759A1 (en) | 2004-02-23 |
| MXPA02004513A (es) | 2004-09-10 |
| CN1414958A (zh) | 2003-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |