BR0016087A - Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico - Google Patents
Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmicoInfo
- Publication number
- BR0016087A BR0016087A BR0016087-3A BR0016087A BR0016087A BR 0016087 A BR0016087 A BR 0016087A BR 0016087 A BR0016087 A BR 0016087A BR 0016087 A BR0016087 A BR 0016087A
- Authority
- BR
- Brazil
- Prior art keywords
- oxazolidin
- difluorophenyl
- benzyl
- processes
- propanoyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 201000006747 infectious mononucleosis Diseases 0.000 title abstract 2
- 239000013461 intermediate chemical Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 238000001311 chemical methods and process Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- -1 (S) -hydroxy-3-phosphoryl-propanoyl Chemical group 0.000 abstract 1
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9928499.4A GB9928499D0 (en) | 1999-12-03 | 1999-12-03 | Chemical processes and intermediates |
| PCT/GB2000/004527 WO2001040236A2 (en) | 1999-12-03 | 2000-11-28 | Phosphorylation of terminal primary alcohol groups |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0016087A true BR0016087A (pt) | 2002-08-06 |
Family
ID=10865576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0016087-3A BR0016087A (pt) | 1999-12-03 | 2000-11-28 | Processo para a formação de um grupo de mono-fosforila primária em uma funcionalidade de 1,2-diol-propanóila terminal, processos para a preparação de 5-(het-x-metil)-3-(4-(1-benzil-1,2,5,6-tetraidropirid-4-il)- 3,5-difluorofenil)oxazolidin-2-ona, e de 5-isoxazol-3-iloximetil-3-(4-(1-benzil-1,2,5,6-tetraidrop irid-4-il)-3,5-difluorofenil)oxazolidin-2-ona, e, composto intermediário quìmico |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1237895A2 (cs) |
| JP (1) | JP2003515539A (cs) |
| KR (1) | KR20020058072A (cs) |
| CN (1) | CN1433421A (cs) |
| AR (1) | AR026700A1 (cs) |
| AU (1) | AU762241B2 (cs) |
| BG (1) | BG106728A (cs) |
| BR (1) | BR0016087A (cs) |
| CA (1) | CA2395052A1 (cs) |
| CO (1) | CO5271712A1 (cs) |
| CZ (1) | CZ20021912A3 (cs) |
| EE (1) | EE200200282A (cs) |
| GB (1) | GB9928499D0 (cs) |
| HU (1) | HUP0204052A2 (cs) |
| IL (1) | IL149641A0 (cs) |
| IS (1) | IS6401A (cs) |
| MX (1) | MXPA02005396A (cs) |
| NO (1) | NO20022605L (cs) |
| PL (1) | PL364762A1 (cs) |
| SK (1) | SK7862002A3 (cs) |
| WO (1) | WO2001040236A2 (cs) |
| ZA (1) | ZA200203876B (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| GB0113297D0 (en) * | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
| SI1427711T1 (sl) | 2001-09-11 | 2005-12-31 | Astrazeneca Ab | Oksazolidinonski in/ali izoksazolinski derivati kot antibakterijska sredstva |
| EP1443930A1 (en) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazoline derivatives useful as antimicrobials |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| CN1649866A (zh) | 2002-02-28 | 2005-08-03 | 阿斯特拉曾尼卡有限公司 | 3－环状基－5－(含氮5－元环)甲基－噁唑烷酮衍生物及其作为抗菌药物的用途 |
| CN1653064A (zh) | 2002-02-28 | 2005-08-10 | 阿斯特拉曾尼卡有限公司 | 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物 |
| DE60304360T2 (de) | 2002-08-12 | 2006-11-16 | Pharmacia & Upjohn Co. Llc, Kalamazoo | N-aryl-2-oxazolidinone und deren derivate |
| TW200420573A (en) | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
| ATE344036T1 (de) | 2002-11-21 | 2006-11-15 | Pharmacia & Upjohn Co Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| EP1656370B1 (en) | 2003-06-03 | 2012-08-15 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| AR046782A1 (es) | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| EP1723159B1 (en) | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
| JP5534497B2 (ja) | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス，インコーポレイテッド | トリアゾール類の合成方法 |
| EP2069339B1 (en) | 2006-09-25 | 2011-05-18 | Wockhardt Research Centre | Substituted piperidinophenyl oxazolidinones |
| WO2014014845A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999064417A2 (en) * | 1998-06-05 | 1999-12-16 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
-
1999
- 1999-12-03 GB GBGB9928499.4A patent/GB9928499D0/en not_active Ceased
-
2000
- 2000-11-24 CO CO00090190A patent/CO5271712A1/es not_active Application Discontinuation
- 2000-11-28 PL PL00364762A patent/PL364762A1/xx unknown
- 2000-11-28 HU HU0204052A patent/HUP0204052A2/hu unknown
- 2000-11-28 CN CN00818735A patent/CN1433421A/zh active Pending
- 2000-11-28 AU AU17156/01A patent/AU762241B2/en not_active Ceased
- 2000-11-28 WO PCT/GB2000/004527 patent/WO2001040236A2/en not_active Ceased
- 2000-11-28 SK SK786-2002A patent/SK7862002A3/sk unknown
- 2000-11-28 CZ CZ20021912A patent/CZ20021912A3/cs unknown
- 2000-11-28 BR BR0016087-3A patent/BR0016087A/pt not_active Application Discontinuation
- 2000-11-28 KR KR1020027007072A patent/KR20020058072A/ko not_active Withdrawn
- 2000-11-28 MX MXPA02005396A patent/MXPA02005396A/es unknown
- 2000-11-28 EP EP00979764A patent/EP1237895A2/en not_active Withdrawn
- 2000-11-28 EE EEP200200282A patent/EE200200282A/xx unknown
- 2000-11-28 JP JP2001540991A patent/JP2003515539A/ja active Pending
- 2000-11-28 CA CA002395052A patent/CA2395052A1/en not_active Abandoned
- 2000-11-28 IL IL14964100A patent/IL149641A0/xx unknown
- 2000-12-01 AR ARP000106370A patent/AR026700A1/es unknown
-
2002
- 2002-05-15 ZA ZA200203876A patent/ZA200203876B/xx unknown
- 2002-05-20 BG BG106728A patent/BG106728A/xx unknown
- 2002-05-28 IS IS6401A patent/IS6401A/is unknown
- 2002-05-31 NO NO20022605A patent/NO20022605L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001040236A3 (en) | 2002-05-10 |
| HUP0204052A2 (hu) | 2003-03-28 |
| NO20022605L (no) | 2002-06-26 |
| EE200200282A (et) | 2003-06-16 |
| KR20020058072A (ko) | 2002-07-12 |
| SK7862002A3 (en) | 2003-02-04 |
| BG106728A (en) | 2003-02-28 |
| CO5271712A1 (es) | 2003-04-30 |
| CA2395052A1 (en) | 2001-06-07 |
| MXPA02005396A (es) | 2002-11-29 |
| WO2001040236A2 (en) | 2001-06-07 |
| AR026700A1 (es) | 2003-02-26 |
| CZ20021912A3 (cs) | 2002-08-14 |
| IL149641A0 (en) | 2002-11-10 |
| IS6401A (is) | 2002-05-28 |
| AU762241B2 (en) | 2003-06-19 |
| CN1433421A (zh) | 2003-07-30 |
| ZA200203876B (en) | 2003-08-15 |
| EP1237895A2 (en) | 2002-09-11 |
| PL364762A1 (en) | 2004-12-13 |
| AU1715601A (en) | 2001-06-12 |
| GB9928499D0 (en) | 2000-02-02 |
| JP2003515539A (ja) | 2003-05-07 |
| NO20022605D0 (no) | 2002-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |