CN1433421A - 化学方法和中间体 - Google Patents

化学方法和中间体 Download PDF

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Publication number
CN1433421A
CN1433421A CN00818735A CN00818735A CN1433421A CN 1433421 A CN1433421 A CN 1433421A CN 00818735 A CN00818735 A CN 00818735A CN 00818735 A CN00818735 A CN 00818735A CN 1433421 A CN1433421 A CN 1433421A
Authority
CN
China
Prior art keywords
group
compound
isoxazole
tetrahydropyridine
difluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN00818735A
Other languages
English (en)
Chinese (zh)
Inventor
M·B·格拉维斯托克
K·E·H·瓦尔伦
D·S·恩尼斯
A·C·柯里
D·艾恩格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1433421A publication Critical patent/CN1433421A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
CN00818735A 1999-12-03 2000-11-28 化学方法和中间体 Pending CN1433421A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9928499.4 1999-12-03
GBGB9928499.4A GB9928499D0 (en) 1999-12-03 1999-12-03 Chemical processes and intermediates

Publications (1)

Publication Number Publication Date
CN1433421A true CN1433421A (zh) 2003-07-30

Family

ID=10865576

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00818735A Pending CN1433421A (zh) 1999-12-03 2000-11-28 化学方法和中间体

Country Status (22)

Country Link
EP (1) EP1237895A2 (cs)
JP (1) JP2003515539A (cs)
KR (1) KR20020058072A (cs)
CN (1) CN1433421A (cs)
AR (1) AR026700A1 (cs)
AU (1) AU762241B2 (cs)
BG (1) BG106728A (cs)
BR (1) BR0016087A (cs)
CA (1) CA2395052A1 (cs)
CO (1) CO5271712A1 (cs)
CZ (1) CZ20021912A3 (cs)
EE (1) EE200200282A (cs)
GB (1) GB9928499D0 (cs)
HU (1) HUP0204052A2 (cs)
IL (1) IL149641A0 (cs)
IS (1) IS6401A (cs)
MX (1) MXPA02005396A (cs)
NO (1) NO20022605L (cs)
PL (1) PL364762A1 (cs)
SK (1) SK7862002A3 (cs)
WO (1) WO2001040236A2 (cs)
ZA (1) ZA200203876B (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101616588B (zh) * 2006-09-25 2013-09-25 沃克哈特研究中心 取代的哌啶子基苯基噁唑烷酮

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
GB0113297D0 (en) * 2001-06-01 2001-07-25 Astrazeneca Ab Chemical Process
AU2002329393B2 (en) 2001-09-11 2008-06-12 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
IL163688A0 (en) 2002-02-28 2005-12-18 Astrazeneca Ab 3-Cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and theiruse as antibacterial agents
RU2004129278A (ru) 2002-02-28 2005-06-10 Астразенека Аб (Se) Химические соединения
ES2258234T3 (es) 2002-08-12 2006-08-16 PHARMACIA & UPJOHN COMPANY LLC N-aril-2-oxazolidinonas y sus derivados.
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
US7141570B2 (en) 2002-11-21 2006-11-28 Pharmacia & Upjohn Company N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
DK1656370T3 (da) 2003-06-03 2012-11-26 Rib X Pharmaceuticals Inc Heterocykliske biarylforbindelser og fremgangsmåder til fremstilling og anvendelse af samme
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
EP1713785A1 (en) 2003-12-17 2006-10-25 Rib-X Pharmaceuticals, Inc. Halogenated biaryl heterocyclic compounds and methods of making and using the same
CN102816194A (zh) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
DE602006019870D1 (de) 2005-06-08 2011-03-10 Rib X Pharmaceuticals Inc Verfahren zur synthese von triazolen
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064417A2 (en) * 1998-06-05 1999-12-16 Astrazeneca Ab Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101616588B (zh) * 2006-09-25 2013-09-25 沃克哈特研究中心 取代的哌啶子基苯基噁唑烷酮

Also Published As

Publication number Publication date
WO2001040236A2 (en) 2001-06-07
IS6401A (is) 2002-05-28
BG106728A (en) 2003-02-28
NO20022605L (no) 2002-06-26
BR0016087A (pt) 2002-08-06
MXPA02005396A (es) 2002-11-29
AR026700A1 (es) 2003-02-26
WO2001040236A3 (en) 2002-05-10
PL364762A1 (en) 2004-12-13
HUP0204052A2 (hu) 2003-03-28
AU762241B2 (en) 2003-06-19
AU1715601A (en) 2001-06-12
EP1237895A2 (en) 2002-09-11
IL149641A0 (en) 2002-11-10
KR20020058072A (ko) 2002-07-12
CO5271712A1 (es) 2003-04-30
ZA200203876B (en) 2003-08-15
GB9928499D0 (en) 2000-02-02
JP2003515539A (ja) 2003-05-07
NO20022605D0 (no) 2002-05-31
CA2395052A1 (en) 2001-06-07
SK7862002A3 (en) 2003-02-04
EE200200282A (et) 2003-06-16
CZ20021912A3 (cs) 2002-08-14

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WD01 Invention patent application deemed withdrawn after publication