BR0016712A - Derivados do ácido n-benzil-indol-3-il-glioxìlico com efeito antitumor - Google Patents

Derivados do ácido n-benzil-indol-3-il-glioxìlico com efeito antitumor

Info

Publication number
BR0016712A
BR0016712A BR0016712-6A BR0016712A BR0016712A BR 0016712 A BR0016712 A BR 0016712A BR 0016712 A BR0016712 A BR 0016712A BR 0016712 A BR0016712 A BR 0016712A
Authority
BR
Brazil
Prior art keywords
indol
benzyl
compounds
salts
antitumor effect
Prior art date
Application number
BR0016712-6A
Other languages
English (en)
Inventor
Eckhard Guenther
Peter Emig
Dietmar Reichert
Guillaume Lebaut
Bernd Nickel
Gerald Bacher
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of BR0016712A publication Critical patent/BR0016712A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

"DERIVADOS DO áCIDO N-BENZIL-INDOL-3-IL-GLIOXìLICO COM EFEITO ANTITUMOR". A invenção refere-se a novos derivados de ácido N-benzil-indol-3-il-glioxílico substituídos da fórmula (1) e a seu uso para o tratamento de doenças que causam tumores. Além disso, são objetivos da invenção seus sais de adição de ácido fisiologicamente compatíveis e desde que possível, seus N-óxidos. Além disso, a invenção refere-se a composições farmacêuticas com um teor de pelo menos um dos compostos da fórmula mencionada acima ou de seus sais ou N-óxidos com ácidos orgânicos ou inorgânicos fisiologicamente compatíveis e eventualmente veículos e/ou diluentes farmaceuticamente empregáveis ou substâncias auxiliares bem como formas de aplicação dos compostos da fórmula mencionada acima com um teor de pelo menos um dos compostos destas fórmulas ou seus sais em forma de comprimidos, drágeas, cápsulas, soluções para infusão ou ampolas, supositórios, emplastros, preparações em forma de pó para inalações, suspensões, cremes e pomadas.
BR0016712-6A 1999-12-23 2000-12-19 Derivados do ácido n-benzil-indol-3-il-glioxìlico com efeito antitumor BR0016712A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (1)

Publication Number Publication Date
BR0016712A true BR0016712A (pt) 2002-09-03

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016712-6A BR0016712A (pt) 1999-12-23 2000-12-19 Derivados do ácido n-benzil-indol-3-il-glioxìlico com efeito antitumor

Country Status (31)

Country Link
US (1) US6432987B2 (pt)
EP (1) EP1240157B1 (pt)
JP (1) JP2003519137A (pt)
KR (1) KR100747425B1 (pt)
CN (1) CN1283637C (pt)
AR (1) AR027098A1 (pt)
AT (1) ATE259364T1 (pt)
AU (1) AU772745B2 (pt)
BG (1) BG106924A (pt)
BR (1) BR0016712A (pt)
CA (1) CA2395259A1 (pt)
CO (1) CO5251472A1 (pt)
CZ (1) CZ20022094A3 (pt)
DE (2) DE19962300A1 (pt)
DK (1) DK1240157T3 (pt)
ES (1) ES2215768T3 (pt)
HK (1) HK1054038B (pt)
HU (1) HUP0203716A3 (pt)
IL (1) IL150235A0 (pt)
MX (1) MXPA02006229A (pt)
NO (1) NO324750B1 (pt)
NZ (2) NZ533731A (pt)
PL (1) PL195014B1 (pt)
PT (1) PT1240157E (pt)
RU (1) RU2266280C2 (pt)
SK (1) SK8752002A3 (pt)
TR (1) TR200400601T4 (pt)
TW (1) TWI284128B (pt)
UA (1) UA75060C2 (pt)
WO (1) WO2001047913A2 (pt)
ZA (1) ZA200204896B (pt)

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DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
RS20050901A (sr) * 2003-06-05 2007-12-31 Zentaris Gmbh., Derivati indola sa efektom na apoptozu
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
DK1848430T3 (da) 2004-12-31 2017-11-06 Dr Reddys Laboratories Ltd Nye benzylamin-derivativer som cetp-inhibitors
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
WO2006099256A2 (en) * 2005-03-11 2006-09-21 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
EP2049520A4 (en) * 2006-08-07 2011-01-05 Ironwood Pharmaceuticals Inc indole compounds
AU2007325797B2 (en) * 2006-11-28 2014-03-13 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
JP6140168B2 (ja) 2011-09-27 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての５−ベンジルアミノメチル−６−アミノピラゾロ［３，４−ｂ］ピリジン誘導体

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US5496844A (en) * 1992-05-08 1996-03-05 Otsuka Pharmaceutical Factory, Inc. Indole derivatives
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
EP0746544B1 (en) * 1994-02-22 1998-09-09 Merrell Pharmaceuticals Inc. Novel indole derivatives useful to treat estrogen-related neoplasms and disorders
JP3109974B2 (ja) * 1994-04-01 2000-11-20 イーライ・リリー・アンド・カンパニー １Ｈ−インドール−３−グリオキシルアミドｓＰＬＡ２阻害剤
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
WO1998037069A1 (en) * 1997-02-20 1998-08-27 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
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DE59913617D1 (de) * 1998-04-28 2006-08-03 Elbion Ag Indolderivate und deren Verwendung als Inhibitoren der Phosphodiesterase 4.
DE19818964A1 (de) * 1998-04-28 1999-11-04 Dresden Arzneimittel Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phospodiesterase 4 und Verfahren zu deren Herstellung
CN1303290A (zh) * 1998-05-01 2001-07-11 伊莱利利公司 sPLA2抑制剂酯
TR200003194T2 (tr) * 1998-05-01 2001-03-21 Eli Lilly And Company Hastalık tedavisine mahsus sPLA2 önleyici bileşikler
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TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action

Also Published As

Publication number Publication date
EP1240157B1 (de) 2004-02-11
DE19962300A1 (de) 2001-06-28
DK1240157T3 (da) 2004-06-14
ZA200204896B (en) 2002-12-20
NZ519977A (en) 2004-08-27
IL150235A0 (en) 2002-12-01
EP1240157A2 (de) 2002-09-18
NO20023039L (no) 2002-08-09
HK1054038A1 (en) 2003-11-14
CN1420880A (zh) 2003-05-28
AU772745B2 (en) 2004-05-06
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
TR200400601T4 (tr) 2004-04-21
RU2002120462A (ru) 2004-01-10
HUP0203716A3 (en) 2004-05-28
HUP0203716A2 (hu) 2003-03-28
TWI284128B (en) 2007-07-21
PL355684A1 (en) 2004-05-17
CN1283637C (zh) 2006-11-08
NO20023039D0 (no) 2002-06-21
JP2003519137A (ja) 2003-06-17
KR100747425B1 (ko) 2007-08-09
PL195014B1 (pl) 2007-07-31
NO324750B1 (no) 2007-12-03
DE50005284D1 (de) 2004-03-18
CA2395259A1 (en) 2001-07-05
US6432987B2 (en) 2002-08-13
AU2011901A (en) 2001-07-09
BG106924A (bg) 2003-04-30
ATE259364T1 (de) 2004-02-15
US20010014690A1 (en) 2001-08-16
PT1240157E (pt) 2004-06-30
CO5251472A1 (es) 2003-02-28
WO2001047913A3 (de) 2002-04-25
WO2001047913A2 (de) 2001-07-05
AR027098A1 (es) 2003-03-12
KR20020063245A (ko) 2002-08-01
RU2266280C2 (ru) 2005-12-20
HK1054038B (zh) 2007-04-13
UA75060C2 (en) 2006-03-15
NZ533731A (en) 2005-03-24
CZ20022094A3 (cs) 2002-10-16
ES2215768T3 (es) 2004-10-16

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Owner name: BLITZ F02-570 GMBH (DE)

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B25D Requested change of name of applicant approved

Owner name: ZENTARIS GMBH (DE)

Free format text: ALTERADO DE: BLITZ F02-570 GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B09B Patent application refused [chapter 9.2 patent gazette]

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