BG101582A - Пиперазинови производни, съдържащите ги лекарствени форми, приложението им и метод за тяхното получаване - Google Patents

Пиперазинови производни, съдържащите ги лекарствени форми, приложението им и метод за тяхното получаване

Info

Publication number
BG101582A
BG101582A BG101582A BG10158297A BG101582A BG 101582 A BG101582 A BG 101582A BG 101582 A BG101582 A BG 101582A BG 10158297 A BG10158297 A BG 10158297A BG 101582 A BG101582 A BG 101582A
Authority
BG
Bulgaria
Prior art keywords
piperazine derivatives
receiving
application
containing medicinal
medicinal forms
Prior art date
Application number
BG101582A
Other languages
English (en)
Inventor
Helmut Pieper
Volkhard Austel
Frank Himmelsbach
Guenter Linz
Brian Guth
Johannes Weisenberger
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944446301 external-priority patent/DE4446301A1/de
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Publication of BG101582A publication Critical patent/BG101582A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Пиперазиновите производни имат обща формула, в която Rа, Y1 до Y3 и E имат значенията, посочени в описанието. Изобретението се отнася още до техните тавтомери, стереоизомери, включително и смесите им, до техните соли, по-специално физиологично съвместимите им соли с неорганични или органични киселини или бази, имащи ценни фармакологични свойства, преди всичко действие, инхибиращо на агрегацията, до лекарствените форми, съдържащи тези съединения и до тяхното приложение и метод за получаването им.
BG101582A 1994-12-23 1997-06-06 Пиперазинови производни, съдържащите ги лекарствени форми, приложението им и метод за тяхното получаване BG101582A (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19944446301 DE4446301A1 (de) 1994-12-23 1994-12-23 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19526678A DE19526678A1 (de) 1994-12-23 1995-07-21 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995133639 DE19533639A1 (de) 1994-12-23 1995-09-12 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1995/005031 WO1996020173A1 (de) 1994-12-23 1995-12-19 Piperazinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
BG101582A true BG101582A (bg) 1998-01-30

Family

ID=27207101

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101582A BG101582A (bg) 1994-12-23 1997-06-06 Пиперазинови производни, съдържащите ги лекарствени форми, приложението им и метод за тяхното получаване

Country Status (20)

Country Link
US (1) US5922717A (bg)
EP (1) EP0799202A1 (bg)
JP (1) JPH10511374A (bg)
CN (1) CN1183770A (bg)
AR (1) AR002950A1 (bg)
AU (1) AU4432496A (bg)
BG (1) BG101582A (bg)
BR (1) BR9510360A (bg)
CA (1) CA2207618A1 (bg)
CZ (1) CZ189197A3 (bg)
EE (1) EE9700141A (bg)
FI (1) FI972646L (bg)
HR (1) HRP950609A2 (bg)
IL (1) IL116517A0 (bg)
MX (1) MX9704745A (bg)
NO (1) NO972881L (bg)
PL (1) PL321003A1 (bg)
SK (1) SK79797A3 (bg)
TR (1) TR199501634A2 (bg)
WO (1) WO1996020173A1 (bg)

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WO1996019223A1 (en) * 1994-12-22 1996-06-27 Smithkline Beecham Corporation Fibrinogen receptor antagonists
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
EP0858457A1 (de) * 1995-10-20 1998-08-19 Dr. Karl Thomae GmbH 5-gliedrige heterocyclen, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
US6472397B1 (en) 1998-04-09 2002-10-29 Meiji Seika Kaisha, Ltd. Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof
CA2352957A1 (en) * 1999-09-29 2001-04-05 Ortho-Mcneil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
EP1533310A1 (en) * 1999-09-29 2005-05-25 Ortho-McNeil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
DE60208186T2 (de) * 2001-04-09 2006-08-24 Ortho-Mcneil Pharmaceutical Research Inc. Chinazolin- und chinazolinähnliche verbindungen zur behandlung von integrin-vermittelten erkrankungen
EP1427418B1 (en) 2001-08-24 2009-11-11 Yale University Piperazinone compounds as anti-tumor and anti-cancer agents
FR2829766A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
WO2003066589A1 (en) 2002-02-08 2003-08-14 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
JP5299810B2 (ja) * 2004-02-27 2013-09-25 アムジエン・インコーポレーテツド 代謝疾患の治療に使用するための、化合物、薬学的組成物及び方法
US7851474B2 (en) * 2005-08-02 2010-12-14 Neurogen Corporation Dipiperazinyl ketones and related analogues
AU2006309050B2 (en) 2005-10-28 2012-08-16 Merck Sharp & Dohme Corp. Piperidine glycine transporter inhibitors
NZ573129A (en) 2006-06-28 2011-06-30 Amgen Inc Piperazine acetic acid glycine transporter-1 inhibitors
WO2008013622A2 (en) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
EP2280008B1 (en) 2007-01-16 2013-05-29 Purdue Pharma L.P. Heterocyclic-substituted piperidines as orl-1 ligands
TW201322983A (zh) * 2007-08-31 2013-06-16 Purdue Pharma Lp 經取代之喹□啉型哌啶化合物及其用途
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
US8710043B2 (en) 2011-06-24 2014-04-29 Amgen Inc. TRPM8 antagonists and their use in treatments
CN104334541A (zh) * 2012-02-16 2015-02-04 纽约大学 使用低聚氧代哌嗪非肽螺旋模拟物对低氧诱导基因表达的控制
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
EP2945631A4 (en) 2013-01-19 2016-06-29 Univ New York OLIGOOXOPIPERAZINE FOR THE REACTIVATION OF P53
EP3145921A4 (en) 2014-05-21 2017-11-08 New York University Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression
CN118434717A (zh) * 2021-12-20 2024-08-02 西格马-奥尔德里奇有限责任公司 化学接头

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2926472A1 (de) * 1979-06-30 1981-01-15 Thomae Gmbh Dr K Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel
ZA825719B (en) * 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
US4895846A (en) * 1984-04-11 1990-01-23 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties
US4778796A (en) * 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4332168A1 (de) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
EP0691959B1 (en) * 1993-03-29 1998-07-22 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4326344A1 (de) * 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW397831B (en) * 1994-07-15 2000-07-11 Meiji Seika Kaisha The anti-platelet-agglutination hexahydrogenated pyridine and its derivatives
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives

Also Published As

Publication number Publication date
CZ189197A3 (cs) 1998-01-14
CN1183770A (zh) 1998-06-03
FI972646A7 (fi) 1997-08-19
NO972881D0 (no) 1997-06-20
CA2207618A1 (en) 1996-07-04
AU4432496A (en) 1996-07-19
FI972646A0 (fi) 1997-06-19
US5922717A (en) 1999-07-13
TR199501634A2 (tr) 1996-07-21
EE9700141A (et) 1997-12-15
AR002950A1 (es) 1998-05-27
EP0799202A1 (de) 1997-10-08
JPH10511374A (ja) 1998-11-04
MX9704745A (es) 1997-10-31
FI972646L (fi) 1997-08-19
NO972881L (no) 1997-06-20
SK79797A3 (en) 1997-11-05
IL116517A0 (en) 1996-03-31
HRP950609A2 (en) 1997-10-31
WO1996020173A1 (de) 1996-07-04
PL321003A1 (en) 1997-11-24
BR9510360A (pt) 1997-12-23

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