BR0101332A - Formulação oftálmica tópica na forma de uma solução aquosa, e, uso de uma ciclosporina em associação com ácido hialurÈnico ou um de seus sais e com polisorbato 80 - Google Patents
Formulação oftálmica tópica na forma de uma solução aquosa, e, uso de uma ciclosporina em associação com ácido hialurÈnico ou um de seus sais e com polisorbato 80Info
- Publication number
- BR0101332A BR0101332A BR0101332-7A BR0101332A BR0101332A BR 0101332 A BR0101332 A BR 0101332A BR 0101332 A BR0101332 A BR 0101332A BR 0101332 A BR0101332 A BR 0101332A
- Authority
- BR
- Brazil
- Prior art keywords
- polysorbate
- salts
- cyclosporine
- combination
- aqueous solution
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 229930182912 cyclosporin Natural products 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 title abstract 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 title abstract 3
- 229920000053 polysorbate 80 Polymers 0.000 title abstract 3
- 229940068968 polysorbate 80 Drugs 0.000 title abstract 3
- 230000000699 topical effect Effects 0.000 title abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 239000007864 aqueous solution Substances 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"FORMULAçãO OFTáLMICA TóPICA NA FORMA DE UMA SOLUçãO AQUOSA, E, USO DE UMA CICLOSPORINA EM ASSOCIAçãO COM áCIDO HIALURÈNICO OU UM DE SEUS SAIS E COM POLISORBATO 80". Uma formulação oftálmica tópica na forma de uma solução aquosa compreendendo uma ciclosporina, ácido hialurónico ou um de seus sais, e polisorbato 80 é descrito.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6942000 | 2000-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0101332A true BR0101332A (pt) | 2001-11-06 |
Family
ID=4529494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0101332-7A BR0101332A (pt) | 2000-04-07 | 2001-04-06 | Formulação oftálmica tópica na forma de uma solução aquosa, e, uso de uma ciclosporina em associação com ácido hialurÈnico ou um de seus sais e com polisorbato 80 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6677304B2 (pt) |
| EP (1) | EP1142566B1 (pt) |
| JP (1) | JP2001316284A (pt) |
| CN (1) | CN1185009C (pt) |
| AR (1) | AR028291A1 (pt) |
| AT (1) | ATE250924T1 (pt) |
| AU (1) | AU778858B2 (pt) |
| BR (1) | BR0101332A (pt) |
| CA (1) | CA2342133C (pt) |
| CZ (1) | CZ294385B6 (pt) |
| DE (1) | DE60100866T2 (pt) |
| DK (1) | DK1142566T3 (pt) |
| ES (1) | ES2206363T3 (pt) |
| IL (1) | IL142268A (pt) |
| PL (1) | PL201055B1 (pt) |
| PT (1) | PT1142566E (pt) |
| SK (1) | SK285220B6 (pt) |
| TR (1) | TR200302105T4 (pt) |
| ZA (1) | ZA200102769B (pt) |
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| KR20220157405A (ko) * | 2020-03-23 | 2022-11-29 | 키오라 파마슈티칼스, 인크. | 안구 병태의 치료를 위한 조성물 및 방법 |
| GR1010012B (el) | 2020-05-12 | 2021-05-27 | Φαρματεν Α.Β.Ε.Ε. | Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση περιεχον κυκλοσπορινη |
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| US12102632B2 (en) | 2020-08-26 | 2024-10-01 | Somerset Therapeutics, Llc | Quinolone dispersions |
| US11510930B2 (en) * | 2020-08-26 | 2022-11-29 | Somerset Therapeutics, Llc | Gatifloxacin, prednisolone, and bromfenac compositions and methods |
| US12440510B2 (en) | 2021-05-10 | 2025-10-14 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| WO2022240598A1 (en) | 2021-05-10 | 2022-11-17 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| TWI868812B (zh) * | 2022-07-20 | 2025-01-01 | 日商旭化成股份有限公司 | 玻尿酸衍生物醫藥組合物及醫藥組合物之製造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US592048A (en) * | 1897-10-19 | Drill-press | ||
| KR920003601B1 (ko) * | 1987-09-03 | 1992-05-04 | 유니버시티 어브 죠지아 리서취 화운데이션 인코포레이티드 | 점안 싸이클로스포린(cyclosporin)의 조성물 |
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| JPH0558906A (ja) * | 1991-09-06 | 1993-03-09 | Sankyo Co Ltd | シクロスポリン点眼製剤 |
| SG45449A1 (en) * | 1992-05-13 | 1998-01-16 | Sandoz Ltd | Ophthalmic compositions |
| US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| US5739105A (en) * | 1994-06-01 | 1998-04-14 | Yuhan Corporation | Cyclosporin containing composition and process for the preparation thereof |
| JPH1160505A (ja) * | 1997-05-20 | 1999-03-02 | Senju Pharmaceut Co Ltd | 防腐組成物 |
-
2001
- 2001-03-23 DE DE60100866T patent/DE60100866T2/de not_active Expired - Lifetime
- 2001-03-23 EP EP01107223A patent/EP1142566B1/fr not_active Expired - Lifetime
- 2001-03-23 ES ES01107223T patent/ES2206363T3/es not_active Expired - Lifetime
- 2001-03-23 AT AT01107223T patent/ATE250924T1/de active
- 2001-03-23 TR TR2003/02105T patent/TR200302105T4/xx unknown
- 2001-03-23 PT PT01107223T patent/PT1142566E/pt unknown
- 2001-03-23 DK DK01107223T patent/DK1142566T3/da active
- 2001-03-26 AR ARP010101408A patent/AR028291A1/es not_active Application Discontinuation
- 2001-03-27 CA CA2342133A patent/CA2342133C/en not_active Expired - Fee Related
- 2001-03-27 US US09/818,213 patent/US6677304B2/en not_active Expired - Fee Related
- 2001-03-27 IL IL142268A patent/IL142268A/en not_active IP Right Cessation
- 2001-04-04 CZ CZ20011229A patent/CZ294385B6/cs not_active IP Right Cessation
- 2001-04-04 AU AU33404/01A patent/AU778858B2/en not_active Ceased
- 2001-04-04 ZA ZA200102769A patent/ZA200102769B/xx unknown
- 2001-04-05 SK SK460-2001A patent/SK285220B6/sk not_active IP Right Cessation
- 2001-04-06 PL PL346926A patent/PL201055B1/pl unknown
- 2001-04-06 BR BR0101332-7A patent/BR0101332A/pt active Search and Examination
- 2001-04-06 CN CNB011124849A patent/CN1185009C/zh not_active Expired - Fee Related
- 2001-04-06 JP JP2001109077A patent/JP2001316284A/ja active Pending
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2003
- 2003-11-21 US US10/721,007 patent/US6953776B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60100866D1 (de) | 2003-11-06 |
| CN1317342A (zh) | 2001-10-17 |
| EP1142566B1 (fr) | 2003-10-01 |
| TR200302105T4 (tr) | 2004-02-23 |
| US6953776B2 (en) | 2005-10-11 |
| PT1142566E (pt) | 2004-02-27 |
| EP1142566A1 (fr) | 2001-10-10 |
| ATE250924T1 (de) | 2003-10-15 |
| PL201055B1 (pl) | 2009-03-31 |
| AU3340401A (en) | 2001-10-11 |
| PL346926A1 (en) | 2001-10-08 |
| DK1142566T3 (da) | 2004-02-09 |
| CA2342133A1 (en) | 2001-10-07 |
| ES2206363T3 (es) | 2004-05-16 |
| IL142268A (en) | 2007-08-19 |
| DE60100866T2 (de) | 2004-07-29 |
| SK285220B6 (sk) | 2006-09-07 |
| AU778858B2 (en) | 2004-12-23 |
| CZ294385B6 (cs) | 2004-12-15 |
| SK4602001A3 (en) | 2001-11-06 |
| JP2001316284A (ja) | 2001-11-13 |
| AR028291A1 (es) | 2003-04-30 |
| US20040106546A1 (en) | 2004-06-03 |
| CN1185009C (zh) | 2005-01-19 |
| IL142268A0 (en) | 2002-03-10 |
| CA2342133C (en) | 2011-02-01 |
| US20010041671A1 (en) | 2001-11-15 |
| CZ20011229A3 (cs) | 2001-11-14 |
| ZA200102769B (en) | 2001-10-05 |
| US6677304B2 (en) | 2004-01-13 |
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