BR0108251A - Derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, composição farmacêutica, agente contendo um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, e, uso de um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável - Google Patents

Derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, composição farmacêutica, agente contendo um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, e, uso de um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável

Info

Publication number
BR0108251A
BR0108251A BR0108251-5A BR0108251A BR0108251A BR 0108251 A BR0108251 A BR 0108251A BR 0108251 A BR0108251 A BR 0108251A BR 0108251 A BR0108251 A BR 0108251A
Authority
BR
Brazil
Prior art keywords
pharmaceutically acceptable
acceptable salt
derivative
pyrrolopyridazine derivative
pyrrolopyridazine
Prior art date
Application number
BR0108251-5A
Other languages
English (en)
Inventor
Haruo Iwabuchi
Masahiko Hagihara
Nobuhiko Shibakawa
Keiji Matsunobu
Hiroshi Pujiwara
Original Assignee
Sankyo Co
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co
Publication of BR0108251A publication Critical patent/BR0108251A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

"DERIVADO DE PIRROLOPIRIDAZINA OU UM SAL DESTE FARMACEUTICAMENTE, ACEITáVEL, COMPOSIçãO FARMACêUTICA, AGENTE CONTENDO UM DERIVADO DE PIRROLOPIRIDAZINA OU UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL, E, USO DE UM DERIVADO DE PIRROLOPIRIDAZINA OU UM SAL DESTE FARMACEUTICAMENTE ACEITáVEL". Um composto de pirrolopiridazina representado pela fórmula geral (I) ou um sal deste farmaceuticamente aceitável. (Na fórmula R1 é alquenila C2-6, halogenoalquenila C2-6, cicloalquila C3-7 opcionalmente substituída ou alquila C1-6 opcionalmente substituída por cicloalquila C3-7; R2 é alquila C1-6; R3 é hidroximetila, aciloximetila alifática C1-6, (arila C6-10)carboniloximetila, (alcóxi C1-6) carboniloximetila, formila, carbóxi, (alcóxi C1-6)carbonila ou (arila C6-10)oxicarbonila; R4 é arila C6-10 opcionalmente substituída e A é imino, oxigênio ou enxofre). O composto de pirrolopiridazina é altamente eficaz na inibição da secreção de ácido clorídrico gástrico, protegendo a mucosa gástrica e outros. este é útil como um medicamento, especialmente um preventivo/remédio para doenças ulcerativas.
BR0108251-5A 2000-02-10 2001-02-06 Derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, composição farmacêutica, agente contendo um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, e, uso de um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável BR0108251A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000033627 2000-02-10
PCT/JP2001/000820 WO2001058901A1 (en) 2000-02-10 2001-02-06 Pyrrolopyridazine compound

Publications (1)

Publication Number Publication Date
BR0108251A true BR0108251A (pt) 2003-03-25

Family

ID=18558082

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108251-5A BR0108251A (pt) 2000-02-10 2001-02-06 Derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, composição farmacêutica, agente contendo um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável, e, uso de um derivado de pirrolopiridazina ou um sal deste farmaceuticamente aceitável

Country Status (21)

Country Link
US (1) US6734181B2 (pt)
EP (1) EP1254907B1 (pt)
KR (1) KR100750551B1 (pt)
CN (1) CN1285593C (pt)
AT (1) ATE361925T1 (pt)
AU (2) AU2001230585B2 (pt)
BR (1) BR0108251A (pt)
CA (1) CA2399380A1 (pt)
CZ (1) CZ20022742A3 (pt)
DE (1) DE60128329T2 (pt)
ES (1) ES2286094T3 (pt)
HK (1) HK1049163B (pt)
HU (1) HUP0204579A3 (pt)
IL (1) IL151167A0 (pt)
MX (1) MXPA02007799A (pt)
NO (1) NO20023771L (pt)
NZ (1) NZ520606A (pt)
PL (1) PL358014A1 (pt)
RU (1) RU2254335C2 (pt)
WO (1) WO2001058901A1 (pt)
ZA (1) ZA200206196B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029058A1 (ja) * 2002-09-25 2004-04-08 Sankyo Company, Limited 血中ガストリン濃度上昇の抑制のための医薬組成物
AU2003266621A1 (en) * 2002-09-25 2004-04-19 Sankyo Company, Limited Medicinal composition for treatment for or prevention of visceral pain
EP1682133A1 (en) 2003-11-03 2006-07-26 AstraZeneca AB Imidazo 1,2-a pyridine derivatives for the treatment of silent gastro-esophageal reflux
JP4977465B2 (ja) * 2004-07-28 2012-07-18 武田薬品工業株式会社 ピロロ［２，３−ｃ］ピリジン化合物、その製造方法および用途
ES2426920T3 (es) 2004-09-03 2013-10-25 Yuhan Corporation Derivados de pirrolo[3,2-B]piridina y procesos para su preparación
CN101003537A (zh) * 2006-01-17 2007-07-25 上海恒瑞医药有限公司 吡咯并哒嗪类衍生物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT97467A (pt) 1990-04-27 1992-01-31 Byk Gulden Lomberg Chem Fab Processo para preparacao de novas piridazinas e de composicoes farmaceuticas que as contem
US5416087A (en) * 1990-10-10 1995-05-16 Wong; Jesse K. Bis-benzo, cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use
WO1992006979A1 (de) 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
ATE179419T1 (de) * 1991-10-25 1999-05-15 Byk Gulden Lomberg Chem Fab Pyrrolo-pyridazine mit magen- und darmschutzwirkungen
JP3143571B2 (ja) * 1994-01-19 2001-03-07 三共株式会社 ピロロピリダジン誘導体
HU225920B1 (en) * 1994-01-19 2008-01-28 Sankyo Co Pyrrolo[2,3-d]pyridazine derivatives, process for their preparation and pharmaceutical compositions containing them
JPH0995485A (ja) * 1995-03-16 1997-04-08 Takeda Chem Ind Ltd 複素環化合物、その製造法および剤
US5753664A (en) 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
TWI287014B (en) * 1999-06-15 2007-09-21 Sankyo Co Optically active pyrrolopyridazine compound

Also Published As

Publication number Publication date
AU2001230585B2 (en) 2005-01-06
IL151167A0 (en) 2003-04-10
CZ20022742A3 (cs) 2003-02-12
HUP0204579A3 (en) 2006-01-30
RU2254335C2 (ru) 2005-06-20
EP1254907A4 (en) 2004-11-24
US20040014762A1 (en) 2004-01-22
EP1254907A1 (en) 2002-11-06
HUP0204579A2 (hu) 2003-04-28
ZA200206196B (en) 2003-11-03
MXPA02007799A (es) 2002-10-17
WO2001058901A1 (en) 2001-08-16
ATE361925T1 (de) 2007-06-15
AU3058501A (en) 2001-08-20
NZ520606A (en) 2004-06-25
KR20020072579A (ko) 2002-09-16
HK1049163A1 (en) 2003-05-02
NO20023771D0 (no) 2002-08-09
CN1422272A (zh) 2003-06-04
EP1254907B1 (en) 2007-05-09
ES2286094T3 (es) 2007-12-01
CN1285593C (zh) 2006-11-22
DE60128329D1 (de) 2007-06-21
US6734181B2 (en) 2004-05-11
DE60128329T2 (de) 2008-01-10
PL358014A1 (en) 2004-08-09
CA2399380A1 (en) 2001-08-16
RU2002121482A (ru) 2004-01-10
HK1049163B (en) 2007-09-28
NO20023771L (no) 2002-10-09
KR100750551B1 (ko) 2007-08-20

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2125 DE 27/09/2011.