BR0108695A - Processo para a preparação simples de (3-cloro-4-fluorofenil)-[7(3-morfolin-4-il-propóxi)-6-ni troquinazolin-4-il]amina ou (3-cloro-4-fluorofenil)-[7-(3-morfolin-4-il-propóxi)-6-a minoquinazolin-4-il]-amina - Google Patents

Processo para a preparação simples de (3-cloro-4-fluorofenil)-[7(3-morfolin-4-il-propóxi)-6-ni troquinazolin-4-il]amina ou (3-cloro-4-fluorofenil)-[7-(3-morfolin-4-il-propóxi)-6-a minoquinazolin-4-il]-amina

Info

Publication number
BR0108695A
BR0108695A BR0108695-2A BR0108695A BR0108695A BR 0108695 A BR0108695 A BR 0108695A BR 0108695 A BR0108695 A BR 0108695A BR 0108695 A BR0108695 A BR 0108695A
Authority
BR
Brazil
Prior art keywords
propoxy
amine
fluorophenyl
chloro
morpholin
Prior art date
Application number
BR0108695-2A
Other languages
English (en)
Inventor
Hubert Barth
Klaus Steiner
Simon Schneider
Original Assignee
Goedecke Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Gmbh filed Critical Goedecke Gmbh
Publication of BR0108695A publication Critical patent/BR0108695A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO SIMPLES DE (3-CLORO-4-FLUOROFENIL)-[7-(3-MORFOLIN-4-IL-PROPóXI)-6-N ITROQUINAZOLIN-4-IL]AMINA OU (3-CLORO-4-FLUOROFENIL)-[7-(3-MORFOLIN-4-IL-PROPóXI)-6-A MINOQUINAZOLIN-4-IL]-AMINA". A invenção refere-se a uma reação em recipiente único para a preparação de (3-cloro-4-fluorofenil)-[7-(3-morfolin-4-il-propóxi)-6-nitroquinazolin-4-il] amina (I) ou de (3-cloro-4-fluorofenil)-[7-(3-morfolino-4-il-propóxi)-6-aminoquinazolin-4 -il]amina (VII)
BR0108695-2A 2000-02-26 2001-01-23 Processo para a preparação simples de (3-cloro-4-fluorofenil)-[7(3-morfolin-4-il-propóxi)-6-ni troquinazolin-4-il]amina ou (3-cloro-4-fluorofenil)-[7-(3-morfolin-4-il-propóxi)-6-a minoquinazolin-4-il]-amina BR0108695A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10009267A DE10009267A1 (de) 2000-02-26 2000-02-26 Verfahren zur einfachen Herstellung von (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazolin-4-yl]-amin bzw. (3-Chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino-quinazolin-4-yl]-amin
PCT/EP2001/000695 WO2001062743A2 (de) 2000-02-26 2001-01-23 Verfahren zur einfachen herstellung von (3-chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-nitro-quinazolin-4-yl]-amin bzw. (3-chlor-4-fluor-phenyl)-[7-(3-morpholin-4-yl-propoxy)-6-amino -quinazolin-4-yl]-amin

Publications (1)

Publication Number Publication Date
BR0108695A true BR0108695A (pt) 2002-12-10

Family

ID=7632648

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108695-2A BR0108695A (pt) 2000-02-26 2001-01-23 Processo para a preparação simples de (3-cloro-4-fluorofenil)-[7(3-morfolin-4-il-propóxi)-6-ni troquinazolin-4-il]amina ou (3-cloro-4-fluorofenil)-[7-(3-morfolin-4-il-propóxi)-6-a minoquinazolin-4-il]-amina

Country Status (32)

Country Link
US (1) US20030050313A1 (pt)
EP (1) EP1265874B1 (pt)
JP (1) JP2003524006A (pt)
KR (1) KR20030011773A (pt)
CN (1) CN1171877C (pt)
AR (1) AR027377A1 (pt)
AT (1) ATE296810T1 (pt)
AU (1) AU2001228478A1 (pt)
BR (1) BR0108695A (pt)
CA (1) CA2401171A1 (pt)
CO (1) CO5280058A1 (pt)
DE (2) DE10009267A1 (pt)
EA (1) EA005213B1 (pt)
EG (1) EG23221A (pt)
ES (1) ES2240483T3 (pt)
GT (1) GT200100025A (pt)
HK (1) HK1054551B (pt)
HU (1) HUP0204510A3 (pt)
IL (1) IL151206A0 (pt)
MX (1) MXPA02008301A (pt)
MY (1) MY133846A (pt)
PA (1) PA8512701A1 (pt)
PE (1) PE20011073A1 (pt)
PL (1) PL357774A1 (pt)
PT (1) PT1265874E (pt)
PY (1) PY0102711A (pt)
SV (1) SV2002000320A (pt)
TN (1) TNSN01031A1 (pt)
UY (1) UY26594A1 (pt)
WO (1) WO2001062743A2 (pt)
YU (1) YU62502A (pt)
ZA (1) ZA200206107B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20040945A1 (es) * 2003-02-05 2004-12-14 Warner Lambert Co Preparacion de quinazolinas substituidas
WO2006081741A1 (en) * 2005-02-05 2006-08-10 Piaoyang Sun Quinazoline compounds or their medical salts and preparation and medical usage thereof
JP5250901B2 (ja) * 2007-02-23 2013-07-31 学校法人慶應義塾 アニリノキナゾリン系化合物及びその用途
US7829574B2 (en) 2008-05-09 2010-11-09 Hutchison Medipharma Enterprises Limited Substituted quinazoline compounds and their use in treating angiogenesis-related diseases
CN105399688A (zh) * 2015-12-02 2016-03-16 西南科技大学 一种吉非替尼的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228446B1 (en) * 1996-04-12 2013-03-28 Warner Lambert Co Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof

Also Published As

Publication number Publication date
AU2001228478A1 (en) 2001-09-03
JP2003524006A (ja) 2003-08-12
HK1054551B (zh) 2005-06-03
WO2001062743A3 (de) 2002-03-14
GT200100025A (es) 2003-09-22
DE50106391D1 (de) 2005-07-07
ES2240483T3 (es) 2005-10-16
EA005213B1 (ru) 2004-12-30
PY0102711A (es) 2003-10-01
CN1171877C (zh) 2004-10-20
ATE296810T1 (de) 2005-06-15
MXPA02008301A (es) 2004-05-14
HUP0204510A2 (en) 2003-05-28
CO5280058A1 (es) 2003-05-30
DE10009267A1 (de) 2001-08-30
EA200200885A1 (ru) 2003-02-27
EP1265874A2 (de) 2002-12-18
TNSN01031A1 (en) 2005-11-10
YU62502A (sh) 2005-03-15
WO2001062743A2 (de) 2001-08-30
AR027377A1 (es) 2003-03-26
ZA200206107B (en) 2003-07-31
UY26594A1 (es) 2001-09-28
CA2401171A1 (en) 2001-08-30
IL151206A0 (en) 2003-04-10
KR20030011773A (ko) 2003-02-11
US20030050313A1 (en) 2003-03-13
SV2002000320A (es) 2002-06-07
EP1265874B1 (de) 2005-06-01
CN1406232A (zh) 2003-03-26
PT1265874E (pt) 2005-08-31
HUP0204510A3 (en) 2003-07-28
MY133846A (en) 2007-11-30
PA8512701A1 (es) 2002-02-21
EG23221A (en) 2004-08-31
PE20011073A1 (es) 2001-12-16
PL357774A1 (pl) 2004-07-26
HK1054551A1 (en) 2003-12-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O, 7O E 8O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009