BR0111763A - Derivados de indol úteis para o tratamento de distúrbios no sistema nervoso central (cns); composto; composição farmacêutica; uso do composto e método de tratamento - Google Patents
Derivados de indol úteis para o tratamento de distúrbios no sistema nervoso central (cns); composto; composição farmacêutica; uso do composto e método de tratamentoInfo
- Publication number
- BR0111763A BR0111763A BR0111763-7A BR0111763A BR0111763A BR 0111763 A BR0111763 A BR 0111763A BR 0111763 A BR0111763 A BR 0111763A BR 0111763 A BR0111763 A BR 0111763A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- compound
- disorders
- cns
- pharmaceutical composition
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 210000003169 central nervous system Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE INDOL úTEIS PARA O TRATAMENTO DE DISTúRBIOS NO SISTEMA NERVOSO CENTRAL (CNS); COMPOSTO; COMPOSIçãO FARMACêUTICA; USO DO COMPOSTO E MéTODO DE TRATAMENTO". A presente invenção refere-se a ligandos receptores de dopamina e serotonina possuindo a fórmula geral (I) onde o significado de Y, Z, W, n, m, X e R^ 1^-R^ 12^ são dados nas reivindicações e na descrição do relatório. Os compostos da invenção são úteis no tratamento de determinados distúrbios neurológicos e psiquiátricos, isto é esquizofrenia e outras psicoses, distúrbios de ansiedade, depressão, enxaqueca, distúrbios cognitivos, distúrbio de hiperatividade e déficit de atenção ADHD) e na melhora do sono.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200000957 | 2000-06-19 | ||
| PCT/DK2001/000408 WO2001098298A1 (en) | 2000-06-19 | 2001-06-13 | Indole derivatives useful for the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0111763A true BR0111763A (pt) | 2003-06-24 |
Family
ID=8159567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0111763-7A BR0111763A (pt) | 2000-06-19 | 2001-06-13 | Derivados de indol úteis para o tratamento de distúrbios no sistema nervoso central (cns); composto; composição farmacêutica; uso do composto e método de tratamento |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20030162792A1 (pt) |
| BG (1) | BG107450A (pt) |
| BR (1) | BR0111763A (pt) |
| EA (1) | EA200300039A1 (pt) |
| IL (1) | IL153351A0 (pt) |
| IS (1) | IS6652A (pt) |
| PL (1) | PL359147A1 (pt) |
| SK (1) | SK512003A3 (pt) |
| ZA (1) | ZA200209997B (pt) |
-
2001
- 2001-06-13 IL IL15335101A patent/IL153351A0/xx unknown
- 2001-06-13 PL PL01359147A patent/PL359147A1/xx not_active Application Discontinuation
- 2001-06-13 BR BR0111763-7A patent/BR0111763A/pt not_active Application Discontinuation
- 2001-06-13 SK SK51-2003A patent/SK512003A3/sk unknown
- 2001-06-13 EA EA200300039A patent/EA200300039A1/ru unknown
-
2002
- 2002-12-09 IS IS6652A patent/IS6652A/is unknown
- 2002-12-10 ZA ZA200209997A patent/ZA200209997B/en unknown
- 2002-12-11 US US10/316,995 patent/US20030162792A1/en not_active Abandoned
-
2003
- 2003-01-08 BG BG107450A patent/BG107450A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK512003A3 (en) | 2003-05-02 |
| ZA200209997B (en) | 2003-12-10 |
| EA200300039A1 (ru) | 2003-04-24 |
| IL153351A0 (en) | 2003-07-06 |
| BG107450A (en) | 2003-10-31 |
| PL359147A1 (en) | 2004-08-23 |
| IS6652A (is) | 2002-12-09 |
| US20030162792A1 (en) | 2003-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |