BR0112286A - Derivados de indol úteis para o tratamento de distúrbios do sistema nervoso central (cns); composto; sua composição farmacêutica; uso e método para tratamento - Google Patents
Derivados de indol úteis para o tratamento de distúrbios do sistema nervoso central (cns); composto; sua composição farmacêutica; uso e método para tratamentoInfo
- Publication number
- BR0112286A BR0112286A BR0112286-0A BR0112286A BR0112286A BR 0112286 A BR0112286 A BR 0112286A BR 0112286 A BR0112286 A BR 0112286A BR 0112286 A BR0112286 A BR 0112286A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- disorders
- cns
- compound
- pharmaceutical composition
- Prior art date
Links
- 210000003169 central nervous system Anatomy 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 102000015554 Dopamine receptor Human genes 0.000 abstract 1
- 108050004812 Dopamine receptor Proteins 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE INDOL úTEIS PARA O TRATAMENTO DE DISTúRBIOS DO SISTEMA NERVOSO CENTRAL (CNS); COMPOSTO; SUA COMPOSIçãO FARMACêUTICA; USO E MéTODO PARA TRATAMENTO". A presente invenção refere-se aos ligandos receptores de dopamina e serotonina tendo a fórmula geral (I) onde um de Y^ 1^ e y^ 2^ é N, o qual é unido a Z, e os significados adicionais de Y^ 1^, Y^ 2^, Y^ 3^, Y^ 4^, Z, W, n, m, X, R, e R^ 1^-R^ 12^ são fornecidos nas reivindicações e na descrição. Os compostos da invenção são úteis no tratamento de determinados distúrbios psiquiátricos e neurológicos, por exemplo, esquizofrenia, outras psicoses, distúrbios de ansiedade, tais como, distúrbios de ansiedade generalizada, distúrbio de pânico e distúrbios de compulsividade obsessiva, depressão, agressão, distúrbios cognitivos, efeitos colaterais induzidos por agentes antipsicóticos convencionais, enxaqueca, distúrbio de hiperatividade com déficit de atenção e na melhora do sono.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001018 | 2000-06-29 | ||
| PCT/DK2001/000407 WO2002000645A1 (en) | 2000-06-29 | 2001-06-13 | Indole derivatives useful for the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0112286A true BR0112286A (pt) | 2003-05-13 |
Family
ID=8159589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0112286-0A BR0112286A (pt) | 2000-06-29 | 2001-06-13 | Derivados de indol úteis para o tratamento de distúrbios do sistema nervoso central (cns); composto; sua composição farmacêutica; uso e método para tratamento |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20030232822A1 (pt) |
| EP (1) | EP1299380B1 (pt) |
| JP (1) | JP2004501912A (pt) |
| KR (1) | KR20030011365A (pt) |
| CN (1) | CN1439004A (pt) |
| AR (1) | AR028736A1 (pt) |
| AT (1) | ATE268765T1 (pt) |
| AU (1) | AU2001273882A1 (pt) |
| BG (1) | BG107471A (pt) |
| BR (1) | BR0112286A (pt) |
| CA (1) | CA2414115A1 (pt) |
| CZ (1) | CZ20024192A3 (pt) |
| DE (1) | DE60103761D1 (pt) |
| EA (1) | EA200300084A1 (pt) |
| HU (1) | HUP0300786A2 (pt) |
| IL (1) | IL153254A0 (pt) |
| IS (1) | IS6642A (pt) |
| MX (1) | MXPA02012506A (pt) |
| NO (1) | NO20026029L (pt) |
| PL (1) | PL358966A1 (pt) |
| SK (1) | SK1092003A3 (pt) |
| WO (1) | WO2002000645A1 (pt) |
| ZA (1) | ZA200209886B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| AU2003257407A1 (en) * | 2002-08-29 | 2004-03-19 | H. Lundbeck A/S | S-(+)-3-{1-(2-(2,3-dihydro-1h-indol-3-yl)ethyl)-3,6-dihydro-2h-pyridin-4-yl}-6-chloro-1h-indole and acid addition salts thereof |
| DE102004027358A1 (de) * | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyrimidinverbindungen und ihre Verwendung |
| EP2049120A4 (en) * | 2006-07-31 | 2011-09-07 | Janssen Pharmaceutica Nv | UROTENSIN II RECEPTOR ANTAGONISTS |
| SE531698C2 (sv) | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
| FR2953839A1 (fr) * | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL310443A1 (en) * | 1993-03-01 | 1995-12-11 | Merck Sharp & Dohme | Derivatives of pyrolo-pyridine |
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
-
2001
- 2001-06-13 HU HU0300786A patent/HUP0300786A2/hu unknown
- 2001-06-13 PL PL01358966A patent/PL358966A1/xx not_active Application Discontinuation
- 2001-06-13 CN CN01811847A patent/CN1439004A/zh active Pending
- 2001-06-13 BR BR0112286-0A patent/BR0112286A/pt not_active Application Discontinuation
- 2001-06-13 DE DE60103761T patent/DE60103761D1/de not_active Expired - Fee Related
- 2001-06-13 WO PCT/DK2001/000407 patent/WO2002000645A1/en not_active Ceased
- 2001-06-13 KR KR1020027017614A patent/KR20030011365A/ko not_active Withdrawn
- 2001-06-13 AT AT01940241T patent/ATE268765T1/de not_active IP Right Cessation
- 2001-06-13 MX MXPA02012506A patent/MXPA02012506A/es unknown
- 2001-06-13 CA CA002414115A patent/CA2414115A1/en not_active Abandoned
- 2001-06-13 EA EA200300084A patent/EA200300084A1/ru unknown
- 2001-06-13 IL IL15325401A patent/IL153254A0/xx unknown
- 2001-06-13 CZ CZ20024192A patent/CZ20024192A3/cs unknown
- 2001-06-13 SK SK109-2003A patent/SK1092003A3/sk unknown
- 2001-06-13 JP JP2002505393A patent/JP2004501912A/ja not_active Withdrawn
- 2001-06-13 AU AU2001273882A patent/AU2001273882A1/en not_active Abandoned
- 2001-06-13 EP EP01940241A patent/EP1299380B1/en not_active Expired - Lifetime
- 2001-06-19 AR ARP010102901A patent/AR028736A1/es unknown
-
2002
- 2002-11-29 IS IS6642A patent/IS6642A/is unknown
- 2002-12-05 ZA ZA200209886A patent/ZA200209886B/en unknown
- 2002-12-16 NO NO20026029A patent/NO20026029L/no not_active Application Discontinuation
- 2002-12-17 US US10/327,670 patent/US20030232822A1/en not_active Abandoned
-
2003
- 2003-01-17 BG BG107471A patent/BG107471A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR028736A1 (es) | 2003-05-21 |
| HUP0300786A2 (hu) | 2003-07-28 |
| CZ20024192A3 (cs) | 2003-04-16 |
| EA200300084A1 (ru) | 2003-06-26 |
| CA2414115A1 (en) | 2002-01-03 |
| US20030232822A1 (en) | 2003-12-18 |
| MXPA02012506A (es) | 2003-04-25 |
| SK1092003A3 (en) | 2003-05-02 |
| EP1299380B1 (en) | 2004-06-09 |
| ZA200209886B (en) | 2003-12-05 |
| AU2001273882A1 (en) | 2002-01-08 |
| WO2002000645A1 (en) | 2002-01-03 |
| ATE268765T1 (de) | 2004-06-15 |
| EP1299380A1 (en) | 2003-04-09 |
| JP2004501912A (ja) | 2004-01-22 |
| DE60103761D1 (de) | 2004-07-15 |
| IL153254A0 (en) | 2003-07-06 |
| NO20026029D0 (no) | 2002-12-16 |
| NO20026029L (no) | 2002-12-16 |
| BG107471A (en) | 2003-10-31 |
| PL358966A1 (en) | 2004-08-23 |
| KR20030011365A (ko) | 2003-02-07 |
| IS6642A (is) | 2002-11-29 |
| CN1439004A (zh) | 2003-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |