BR0114552A - N1- (benzenosulfonil) indóis 2-,3-,4-, 5- substituìdos e seu uso em terapia - Google Patents

N1- (benzenosulfonil) indóis 2-,3-,4-, 5- substituìdos e seu uso em terapia

Info

Publication number
BR0114552A
BR0114552A BR0114552-5A BR0114552A BR0114552A BR 0114552 A BR0114552 A BR 0114552A BR 0114552 A BR0114552 A BR 0114552A BR 0114552 A BR0114552 A BR 0114552A
Authority
BR
Brazil
Prior art keywords
benzenesulfonyl
therapy
substituted
indoles
compounds
Prior art date
Application number
BR0114552-5A
Other languages
English (en)
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0003810A external-priority patent/SE0003810D0/xx
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of BR0114552A publication Critical patent/BR0114552A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"N1- (BENZENOSULFONIL) INDóIS 2-, 3-, 4-, OU 5- SUBSTITUìDOS E SEU USO EM TERAPIA". A presente invenção proporciona compostos de N1-(benzenosulfonil)indóis 2-, 3-, 4-, ou 5-substituídos de fórmula geral (I), em que Ar, R^ 2^, R^ 3^, R^ 4^ e R^ 5^ são como definidos no presente relatório descritivo. Os ditos compostos possuem afinidade pelo receptor 5-HT~ 6~ e são de utilidade no tratamento e profilaxia de distúrbios correlacionados ao dito receptor, tais como, obesidade e distúrbios do sistema nervoso central (CNS).
BR0114552-5A 2000-10-20 2001-10-19 N1- (benzenosulfonil) indóis 2-,3-,4-, 5- substituìdos e seu uso em terapia BR0114552A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0003810A SE0003810D0 (sv) 2000-10-20 2000-10-20 Novel compounds their use and preparations
US24311500P 2000-10-25 2000-10-25
PCT/SE2001/002319 WO2002032863A1 (en) 2000-10-20 2001-10-19 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy

Publications (1)

Publication Number Publication Date
BR0114552A true BR0114552A (pt) 2003-07-01

Family

ID=26655269

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114552-5A BR0114552A (pt) 2000-10-20 2001-10-19 N1- (benzenosulfonil) indóis 2-,3-,4-, 5- substituìdos e seu uso em terapia

Country Status (13)

Country Link
US (2) US7087750B2 (pt)
EP (1) EP1326830A1 (pt)
KR (1) KR100823908B1 (pt)
AU (2) AU9619301A (pt)
BR (1) BR0114552A (pt)
CA (1) CA2422717A1 (pt)
EA (1) EA006132B1 (pt)
IL (1) IL154685A0 (pt)
MX (1) MXPA03003397A (pt)
NO (1) NO325259B1 (pt)
NZ (1) NZ524675A (pt)
PL (1) PL361887A1 (pt)
WO (1) WO2002032863A1 (pt)

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AU9619301A (en) 2000-10-20 2002-04-29 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy
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Also Published As

Publication number Publication date
NZ524675A (en) 2004-09-24
EP1326830A1 (en) 2003-07-16
US20050256106A1 (en) 2005-11-17
KR100823908B1 (ko) 2008-04-21
MXPA03003397A (es) 2004-06-30
EA200300492A1 (ru) 2003-10-30
KR20030038825A (ko) 2003-05-16
NO20031589L (no) 2003-05-28
AU2001296193B2 (en) 2006-04-27
PL361887A1 (en) 2004-10-04
NO20031589D0 (no) 2003-04-08
EA006132B1 (ru) 2005-10-27
US7087750B2 (en) 2006-08-08
CA2422717A1 (en) 2002-04-25
WO2002032863A1 (en) 2002-04-25
NO325259B1 (no) 2008-03-17
US20020165251A1 (en) 2002-11-07
AU9619301A (en) 2002-04-29
US7524839B2 (en) 2009-04-28
HK1084109A1 (en) 2006-07-21
IL154685A0 (en) 2003-09-17

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