BR0113236A - Processo estereosseletivo para a preparação de butanos (3s,2r)-1-halo-2-hidróxi-3-(protegido)amino-4-substitu ìdos, e, processo para preparação de um composto epóxi - Google Patents
Processo estereosseletivo para a preparação de butanos (3s,2r)-1-halo-2-hidróxi-3-(protegido)amino-4-substitu ìdos, e, processo para preparação de um composto epóxiInfo
- Publication number
- BR0113236A BR0113236A BR0113236-9A BR0113236A BR0113236A BR 0113236 A BR0113236 A BR 0113236A BR 0113236 A BR0113236 A BR 0113236A BR 0113236 A BR0113236 A BR 0113236A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- halo
- protected
- amino
- hydroxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000004593 Epoxy Substances 0.000 title abstract 2
- 230000000707 stereoselective effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 abstract 2
- 101710185050 Angiotensin-converting enzyme Proteins 0.000 abstract 1
- 241000186146 Brevibacterium Species 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000013844 butane Nutrition 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
"PROCESSO ESTEREOSSELETIVO PARA A PREPARAçãO DE BUTANOS (3S,2R)-1-HALO-2-HIDRóXI-3-(PROTEGIDO)AMINO-4SUBSTITUì DOS, E, PROCESSO PARA PREPARAçãO DE UM COMPOSTO EPóXI". A presente invenção refere-se a um processo para a redução enzimática estereosseletiva de butanos 1-halo-2-oxo-3-(protegido)amino-4substituídos utilizando certas espécies de Rhodococcus e de Brevibacterium. O produto de 1-butanos halo-2-oxo-3-(protegido)amino-4-substituídos, que são úteis como intermediários na síntese de compostos que são inibidores de ACE, renina e proteases de HIV, são obtidos com alto rendimento e, particularmente, com pureza diastereoisomérica muito elevada. O processo é vantajosamente elevadamente seletivo para o 3S, 2R enanciómero do produto.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22569500P | 2000-08-16 | 2000-08-16 | |
| US60/225,695 | 2000-08-16 | ||
| US27753101P | 2001-03-21 | 2001-03-21 | |
| US60/277,531 | 2001-03-21 | ||
| PCT/US2001/023113 WO2002014528A1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR0113236A true BR0113236A (pt) | 2005-12-13 |
| BR0113236B1 BR0113236B1 (pt) | 2014-04-22 |
Family
ID=26919835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0113236-9A BR0113236B1 (pt) | 2000-08-16 | 2001-07-20 | Processo estereosseletivo para a preparação de butanos(3S,2R)-1-halo-2-hidróxi-3-(protegido)amino-4-substituídos |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20020042124A1 (pt) |
| EP (1) | EP1309714B1 (pt) |
| JP (1) | JP3843255B2 (pt) |
| KR (1) | KR20040031674A (pt) |
| CN (1) | CN100335643C (pt) |
| AT (1) | ATE431422T1 (pt) |
| AU (2) | AU8069801A (pt) |
| BR (1) | BR0113236B1 (pt) |
| CA (1) | CA2417086A1 (pt) |
| CZ (1) | CZ303884B6 (pt) |
| DE (1) | DE60138712D1 (pt) |
| ES (1) | ES2325309T3 (pt) |
| HU (1) | HU229338B1 (pt) |
| IL (1) | IL154376A0 (pt) |
| MX (1) | MXPA03001312A (pt) |
| PL (1) | PL366098A1 (pt) |
| TW (1) | TWI287579B (pt) |
| WO (1) | WO2002014528A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003000290A (ja) * | 2001-06-25 | 2003-01-07 | Kanegafuchi Chem Ind Co Ltd | 光学活性（ｒ）−２−クロロ−１−（３′−クロロフェニル）エタノールの製造法 |
| US7741082B2 (en) | 2004-04-14 | 2010-06-22 | Bristol-Myers Squibb Company | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor |
| US7582468B2 (en) | 2005-05-25 | 2009-09-01 | Bristol-Myers Squibb Company | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof |
| TWD118424S1 (zh) | 2005-11-21 | 2007-08-01 | 普樂士文具股份有限公司 | 修正帶 |
| ES2310143B1 (es) * | 2007-06-15 | 2010-02-08 | Universitat Jaume I | Inhibidores de cisteina proteasas. |
| ES2360336T3 (es) * | 2007-06-22 | 2011-06-03 | Bristol-Myers Squibb Company | Composiciones en comprimidos que contienen atazanavir. |
| EP2178512B1 (en) * | 2007-06-22 | 2011-03-09 | Bristol-Myers Squibb Company | Tableted compositions containing atazanavir |
| SI2178513T1 (sl) * | 2007-06-22 | 2011-05-31 | Bristol Myers Squibb Co | Tabletni sestavki vsebujoäśi atazanavir |
| DK2170292T3 (da) * | 2007-06-22 | 2014-04-07 | Bristol Myers Squibb Holdings Ireland | Atazanavirholdige sammensætninger i tabletform |
| TWI601825B (zh) | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| CN102482648B (zh) | 2009-06-22 | 2014-12-10 | 科德克希思公司 | 酮还原酶介导的产生α氯代醇的立体选择性途径 |
| WO2011100265A2 (en) | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| CN113026036B (zh) * | 2021-03-11 | 2022-06-07 | 南京工业大学 | 一种利用连续流电化学氧化合成硫叶立德类化合物的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61108394A (ja) | 1984-10-30 | 1986-05-27 | Sumitomo Chem Co Ltd | 光学活性１−（４−フエノキシフエノキシ）プロパン−２−オ−ルの生物化学的製造方法 |
| JPH02295969A (ja) | 1989-05-10 | 1990-12-06 | Asahi Chem Ind Co Ltd | 光学活性なアミノアルコール誘導体の製造法 |
| JPH02295970A (ja) | 1989-05-10 | 1990-12-06 | Asahi Chem Ind Co Ltd | 光学活性なプロパン―２―オール誘導体の製造法 |
| CA2103932A1 (en) * | 1992-11-05 | 1994-05-06 | Ramesh N. Patel | Stereoselective reduction of ketones |
| JP3529904B2 (ja) | 1995-06-19 | 2004-05-24 | 鐘淵化学工業株式会社 | 光学活性１−ハロ−３−アミノ−４−フェニル−２−ブタノール誘導体の製造法 |
| JP3814766B2 (ja) | 1996-02-28 | 2006-08-30 | 日本農薬株式会社 | 光学活性な２−ハロ−１−（置換フェニル）エタノールの製造法 |
| US5849911A (en) * | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
| JP3941184B2 (ja) | 1997-10-06 | 2007-07-04 | 三菱化学株式会社 | 光学活性１−アシロキシ−３−クロロ−２−プロパノール、及び光学活性３−クロロ−１，２−プロパンジオールの製造法 |
-
2001
- 2001-07-20 JP JP2002519654A patent/JP3843255B2/ja not_active Expired - Lifetime
- 2001-07-20 HU HU0300873A patent/HU229338B1/hu unknown
- 2001-07-20 CA CA002417086A patent/CA2417086A1/en not_active Abandoned
- 2001-07-20 WO PCT/US2001/023113 patent/WO2002014528A1/en not_active Ceased
- 2001-07-20 KR KR10-2003-7002257A patent/KR20040031674A/ko not_active Ceased
- 2001-07-20 BR BRPI0113236-9A patent/BR0113236B1/pt not_active IP Right Cessation
- 2001-07-20 DE DE60138712T patent/DE60138712D1/de not_active Expired - Lifetime
- 2001-07-20 MX MXPA03001312A patent/MXPA03001312A/es active IP Right Grant
- 2001-07-20 EP EP01959109A patent/EP1309714B1/en not_active Expired - Lifetime
- 2001-07-20 US US09/909,684 patent/US20020042124A1/en not_active Abandoned
- 2001-07-20 CN CNB01814196XA patent/CN100335643C/zh not_active Expired - Lifetime
- 2001-07-20 ES ES01959109T patent/ES2325309T3/es not_active Expired - Lifetime
- 2001-07-20 PL PL01366098A patent/PL366098A1/xx not_active Application Discontinuation
- 2001-07-20 CZ CZ20030758A patent/CZ303884B6/cs not_active IP Right Cessation
- 2001-07-20 IL IL15437601A patent/IL154376A0/xx unknown
- 2001-07-20 AT AT01959109T patent/ATE431422T1/de not_active IP Right Cessation
- 2001-07-20 AU AU8069801A patent/AU8069801A/xx active Pending
- 2001-07-20 AU AU2001280698A patent/AU2001280698B2/en not_active Expired
- 2001-08-16 TW TW090120123A patent/TWI287579B/zh not_active IP Right Cessation
-
2003
- 2003-09-12 US US10/661,893 patent/US7083973B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1309714B1 (en) | 2009-05-13 |
| EP1309714A4 (en) | 2006-04-05 |
| JP2004511225A (ja) | 2004-04-15 |
| JP3843255B2 (ja) | 2006-11-08 |
| WO2002014528A1 (en) | 2002-02-21 |
| ATE431422T1 (de) | 2009-05-15 |
| TWI287579B (en) | 2007-10-01 |
| AU8069801A (en) | 2002-02-25 |
| HU229338B1 (en) | 2013-11-28 |
| EP1309714A1 (en) | 2003-05-14 |
| DE60138712D1 (de) | 2009-06-25 |
| CA2417086A1 (en) | 2002-02-21 |
| AU2001280698B2 (en) | 2005-08-25 |
| CN100335643C (zh) | 2007-09-05 |
| PL366098A1 (en) | 2005-01-24 |
| BR0113236B1 (pt) | 2014-04-22 |
| HUP0300873A3 (en) | 2006-02-28 |
| IL154376A0 (en) | 2003-09-17 |
| CZ303884B6 (cs) | 2013-06-12 |
| US20040058431A1 (en) | 2004-03-25 |
| CN1492932A (zh) | 2004-04-28 |
| CZ2003758A3 (cs) | 2003-11-12 |
| KR20040031674A (ko) | 2004-04-13 |
| ES2325309T3 (es) | 2009-09-01 |
| HUP0300873A2 (hu) | 2003-12-29 |
| US20020042124A1 (en) | 2002-04-11 |
| US7083973B2 (en) | 2006-08-01 |
| MXPA03001312A (es) | 2003-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/04/2014, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 21A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2680 DE 17-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |