BR0114622A - Composto, composição farmacêutica, métodos para tratar ou prevenir uma doença cardiovascular, uma dislipidemia, uma dislipoproteinemia, um distúrbio do metabolismo da glicose, trombótico e associado com o receptor ativado do proliferador de peroxissoma, a doença de alzheimer, a sìndrome x ou sìndrome metábólica a septicemia, a obesidade, pancreatite, a hipertensão, doença renal, câncer, a inflamação e a impotência, em um paciente e para reduzir o teor de gordura da carne em animal de criação e de colesterol de ovos de aves domésticas - Google Patents

Composto, composição farmacêutica, métodos para tratar ou prevenir uma doença cardiovascular, uma dislipidemia, uma dislipoproteinemia, um distúrbio do metabolismo da glicose, trombótico e associado com o receptor ativado do proliferador de peroxissoma, a doença de alzheimer, a sìndrome x ou sìndrome metábólica a septicemia, a obesidade, pancreatite, a hipertensão, doença renal, câncer, a inflamação e a impotência, em um paciente e para reduzir o teor de gordura da carne em animal de criação e de colesterol de ovos de aves domésticas

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Publication number
BR0114622A
BR0114622A BR0114622-0A BR0114622A BR0114622A BR 0114622 A BR0114622 A BR 0114622A BR 0114622 A BR0114622 A BR 0114622A BR 0114622 A BR0114622 A BR 0114622A
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Brazil
Prior art keywords
disease
methods
treating
syndrome
septicemia
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BR0114622-0A
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English (en)
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BRPI0114622B8 (pt
BRPI0114622B1 (pt
Inventor
Jean-Louis H Dasseux
Carmen Daniela Oniciu
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Esperion Therapeutics Inc
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Publication of BR0114622A publication Critical patent/BR0114622A/pt
Publication of BRPI0114622B1 publication Critical patent/BRPI0114622B1/pt
Publication of BRPI0114622B8 publication Critical patent/BRPI0114622B8/pt

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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA TRATAR OU PREVENIR UMA DOENçA CARDIOVASCULAR, UMA DISLIPIDEMIA, UMA DISLIPOPROTEINEMIA, UM DISTúRBIO DO METABOLISMO DA GLICOSE, TROMBóTICO E ASSOCIADO COM O RECEPTOR ATIVADO DO PROLIFERADOR DE PEROXISSOMA, A DOENçA DE ALZHEIMER, A SìNDROME X OU SìNDROME METABóLICA, A SEPTICEMIA, A OBESIDADE, PANCREATITE, A HIPERTENSãO, DOENçA RENAL, CâNCER, A INFLAMAçãO E A IMPOTêNCIA, EM UM PACIENTE E PARA REDUZIR O TEOR DE GORDURA DA CARNE EM ANIMAL DE CRIAçãO E DE COLESTEROL DE OVOS DE AVES DOMéSTICAS". A presente invenção diz respeito a novos compostos de cetona, às composições que compreendem os compostos de cetona, e aos métodos úteis para tratar e prevenir doenças cardiovasculares, dislipidemias, disproteinemias e distúrbios do metabolismo da glicose que compreendem administrar uma composição que compreenda um composto de cetona. Os compostos, composições e métodos da invenção também são úteis para tratar e prevenir a Doença de Alzheimer, a Síndrome X, distúrbios relacionados com o receptor ativado do proliferador de peroxissoma, septicemia, distúrbios trombóticos, obesidade, pancreatite, hipertensão, doença renal, câncer, inflamação e impotência. Em certas formas de realização, os compostos, composições e métodos da invenção são úteis na terapia de combinação com outros produtos terapêuticos, tais como agentes hipocolesterolêmicos e hipoglicêmicos.
BRPI0114622A 2000-10-11 2001-10-11 composto, composição farmacêutica compreendendo o mesmo e uso do referido composto na preparação de composição farmacêutica BRPI0114622B8 (pt)

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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
US20030171399A1 (en) 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
US8568766B2 (en) 2000-08-24 2013-10-29 Gattadahalli M. Anantharamaiah Peptides and peptide mimetics to treat pathologies associated with eye disease
US20040122091A1 (en) * 2000-10-11 2004-06-24 Esperion Therapeutics, Inc. Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
US7304093B2 (en) * 2000-10-11 2007-12-04 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
AU2002244732A2 (en) * 2001-05-01 2002-11-11 Gerhard Kamil Application of fluid bed technology in brewing
EP1495034A2 (en) * 2002-04-10 2005-01-12 Esperion Therapeutics, Inc. Mimics of acyl coenzyme-a comprising pantolactone and pantothenic acid derivatives, compositions thereof, and methods of cholesterol management and related uses
US20040148013A1 (en) * 2002-04-18 2004-07-29 Epstein Stephen E Stent-based delivery statins to prevent restenosis
US20040048910A1 (en) * 2002-08-22 2004-03-11 Bove Susan Elizabeth Method of treating osteoarthritis
CA2513660C (en) * 2003-01-23 2012-05-08 Esperion Therapeutics, Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
WO2005068412A1 (en) * 2003-12-24 2005-07-28 Esperion Therapeutics, Inc. Ketone compounds and compositions for cholesterol management and related uses
EP1890715A4 (en) 2005-04-29 2009-10-28 Univ California PEPTIDES AND PEPTIDE MIMETICS FOR TREATMENT BY INFLAMMATORY REACTION OF CHARACTERIZED PATHOLOGIES
WO2008021088A2 (en) 2006-08-08 2008-02-21 The Regents Of The University Of Californina Salicylanilides enhance oral delivery of therapeutic peptides
IL181577A0 (en) * 2007-02-26 2007-07-04 Jacob Bar Tana Combination therapy composition and methods for the treatment of cardiovascular disorders and immune-related disorders
EP2195331B1 (en) 2007-08-28 2013-11-20 Uab Research Foundation Synthetic apolipoprotein e mimicking polypeptides and methods of use
US8557767B2 (en) 2007-08-28 2013-10-15 Uab Research Foundation Synthetic apolipoprotein E mimicking polypeptides and methods of use
PE20110565A1 (es) 2008-08-12 2011-09-02 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
EP2334188A4 (en) * 2008-08-15 2012-08-08 Burnham Inst Medical Research COMPOSITION AND METHOD FOR THE DESIGN AND DEVELOPMENT OF METAL OXYCLES
WO2011143362A1 (en) 2010-05-11 2011-11-17 Esperion Therapeutics, Inc. Dimeric oxidation-resistant apolipoprotein a1 variants
US8623897B2 (en) 2010-09-20 2014-01-07 Kareus Therapeutics, Sa Methods and compositions for treatment of diabetes and dyslipidemia
EA201391017A1 (ru) 2011-01-10 2014-04-30 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
DE102011078416A1 (de) * 2011-06-30 2013-01-03 Henkel Ag & Co. Kgaa Photolabile Duftspeicherstoffe
KR20170003611A (ko) 2014-05-02 2017-01-09 세레니스 쎄라퓨틱스 홀딩 에스에이 Ｈｄｌ 요법 마커
CA2954475C (en) 2014-07-31 2023-05-16 Uab Research Foundation Apoe mimetic peptides and higher potency to clear plasma cholesterol
CN107530307A (zh) 2015-03-13 2018-01-02 艾斯柏伦治疗公司 包含etc1002和依泽替米贝的固定剂量组合和制剂以及治疗心血管疾病或降低心血管疾病风险的方法
MA41793A (fr) 2015-03-16 2018-01-23 Esperion Therapeutics Inc Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire
GB201522302D0 (en) * 2015-12-17 2016-02-03 Mars Inc Food product for regulating lipid metabolites
CN107118098B (zh) * 2016-02-25 2020-07-14 中国科学院上海药物研究所 一类脂肪酸类化合物、其制备方法及其用途
WO2020141419A2 (en) * 2018-12-31 2020-07-09 Lupin Limited Novel salts and polymorphic form of bempedoic acid
EP4438114A3 (en) 2019-06-21 2024-12-25 Esperion Therapeutics, Inc. Methods of making bempedoic acid and compositions of the same
EP4003314B1 (en) 2019-07-26 2024-07-10 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids useful for the prevention or treatment of disease
WO2021252607A1 (en) * 2020-06-12 2021-12-16 Novomer, Inc. Beta-propiolactone compounds and ring opened beta-propiolactone compounds and uses for same
TW202245804A (zh) 2021-01-25 2022-12-01 美商艾斯佩維他治療學公司 官能化長鏈烴單羧酸及二羧酸及其衍生物以及其於預防或治療疾病之用途
WO2022159808A2 (en) * 2021-01-25 2022-07-28 Espervita Therapeutics, Inc. Functionalized long-chain hydrocarbon mono- and di-carboxylic acids and derivatives thereof, and their use for the prevention or treatment of disease
CA3235992A1 (en) * 2021-11-03 2023-05-11 Liang Tan Substituted phenylpropionic acid derivative and use thereof
CN116924886B (zh) * 2022-03-29 2025-08-29 武汉武药科技有限公司 8-氧代-2,2,14,14-四甲基十五烷二酸的合成方法
EP4692073A1 (en) * 2023-03-24 2026-02-11 Shanghai Jingxin Biomedical Co., Ltd. Cyclic amine derivative, and composition and use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441605A (en) 1965-02-17 1969-04-29 Wallace & Tiernan Inc Diketo-dicarboxylic acids and salts and preparation thereof by alkaline oxidation
US3930024A (en) 1969-09-02 1975-12-30 Parke Davis & Co Pharmaceutical compositions and methods
US3773946A (en) 1969-09-02 1973-11-20 Parke Davis & Co Triglyceride-lowering compositions and methods
JPS5522636A (en) 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS5639033A (en) 1979-09-04 1981-04-14 Kao Corp Alpha-mono(methyl-branched alkyl glyceryl ether and skin cosmetic containing the same
IL64542A0 (en) 1981-12-15 1982-03-31 Yissum Res Dev Co Long-chain alpha,omega-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them
IT1164254B (it) 1983-05-30 1987-04-08 Luso Farmaco Inst 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione
JPS60136512A (ja) 1983-12-26 1985-07-20 Eisai Co Ltd 脂質代謝改善剤
DE3423166A1 (de) 1984-06-22 1986-01-02 Epis S.A., Zug Alpha-, omega-dicarbonsaeuren, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JP2999579B2 (ja) 1990-07-18 2000-01-17 武田薬品工業株式会社 Ｄｎａおよびその用途
US5254589A (en) 1991-10-15 1993-10-19 Warner-Lambert Company Sulfonyl urea and carbamate ACAT inhibitors
IL109431A (en) 1993-05-14 2001-01-11 Warner Lambert Co Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds
US5420339A (en) 1993-11-22 1995-05-30 Warner-Lambert Company Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors
US5578639A (en) 1994-07-01 1996-11-26 Warner-Lambert Company PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption
US5504073A (en) 1994-07-01 1996-04-02 Warner-Lambert Company PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
CN1217656C (zh) 1995-11-02 2005-09-07 沃尼尔·朗伯公司 用于调节脂浓度的方法和药物组合物
US5807846A (en) 1996-11-14 1998-09-15 Warner-Lambert Company Phosphonamide ACAT inhibitors
IL119971A (en) 1997-01-07 2003-02-12 Yissum Res Dev Co Pharmaceutical compositions containing dicarboxylic acids and derivatives thereof and some novel dicarboxylic acids
US6093744A (en) 1997-04-21 2000-07-25 Warner-Lambert Company N-acyl sulfamic acid esters useful as hypocholesterolemic agents
IL121165A0 (en) 1997-06-26 1997-11-20 Yissum Res Dev Co Pharmaceutical compositions containing carboxylic acids and derivatives thereof
US6479470B1 (en) 1999-04-28 2002-11-12 Georgetown University Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase
CA2395191A1 (en) 1999-12-23 2001-06-28 Tedman Ehlers Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states

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Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2691 DE 02-08-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.