BR0116084A - Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio - Google Patents

Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio

Info

Publication number
BR0116084A
BR0116084A BR0116084-2A BR0116084A BR0116084A BR 0116084 A BR0116084 A BR 0116084A BR 0116084 A BR0116084 A BR 0116084A BR 0116084 A BR0116084 A BR 0116084A
Authority
BR
Brazil
Prior art keywords
acid amides
atrial
arylated
potassium channel
furanecarboxylic
Prior art date
Application number
BR0116084-2A
Other languages
English (en)
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0116084A publication Critical patent/BR0116084A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"AMIDAS DE áCIDO FURANOCARBOXìLICO E TIOFENOCARBOXìLICO ARILADAS COM EFEITO BLOQUEADOR DE CANAL DE POTáSSIO". Amidas de ácido furanocarboxílico e tiofenocarboxílico ariladas, processo para sua preparação, seu emprego como medicamento, assim como preparados farmacêuticos contendo-as. Compostos de fórmula (Ia) e (Ib) nas quais X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), e R(30) e R(31) têm os significados indicados nas reivindicações, são muito particularmente apropriados como substâncias ativas anti-arrítmicas novas, particularmente para tratamento e profilaxia de arritmias do átrio, por exemplo, vibração atrial (fibrilação atrial, AF) ou instabilidade atrial (instabilidade do átrio).
BR0116084-2A 2000-12-12 2001-11-29 Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio BR0116084A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (de) 2000-12-12 2001-11-29 Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung

Publications (1)

Publication Number Publication Date
BR0116084A true BR0116084A (pt) 2003-10-14

Family

ID=7666837

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116084-2A BR0116084A (pt) 2000-12-12 2001-11-29 Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio

Country Status (29)

Country Link
US (1) US6982279B2 (pt)
EP (1) EP1349846B1 (pt)
JP (1) JP4252798B2 (pt)
KR (1) KR20030061846A (pt)
CN (1) CN1225463C (pt)
AR (1) AR032781A1 (pt)
AT (1) ATE288906T1 (pt)
AU (2) AU3574302A (pt)
BR (1) BR0116084A (pt)
CA (1) CA2431095A1 (pt)
CZ (1) CZ20031633A3 (pt)
DE (2) DE10061876A1 (pt)
DK (1) DK1349846T3 (pt)
EE (1) EE05306B1 (pt)
ES (1) ES2236335T3 (pt)
HR (1) HRP20030469A2 (pt)
HU (1) HUP0303665A3 (pt)
IL (2) IL156314A0 (pt)
MX (1) MXPA03004770A (pt)
NO (1) NO329163B1 (pt)
NZ (1) NZ526383A (pt)
PL (1) PL362410A1 (pt)
PT (1) PT1349846E (pt)
RS (1) RS50336B (pt)
RU (1) RU2275366C2 (pt)
SK (1) SK287464B6 (pt)
TW (1) TWI288134B (pt)
WO (1) WO2002048131A1 (pt)
ZA (1) ZA200304091B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
CN101624391A (zh) * 2001-06-11 2010-01-13 病毒化学医药公司 用作黄病毒感染抗病毒剂的噻吩衍生物
US7402608B2 (en) * 2002-12-10 2008-07-22 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of Flavivirus infections
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
BRPI0610283A2 (pt) * 2005-05-13 2010-10-19 Virochem Pharma Inc composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica
WO2007015775A2 (en) * 2005-07-22 2007-02-08 Merck & Co., Inc. Potassium channel inhibitors
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
RU2436577C2 (ru) * 2006-04-27 2011-12-20 Санофи-Авентис Дойчланд Гмбх Ингибиторы ионных task-1 и task-3 каналов
CA2670260A1 (en) 2006-11-15 2008-05-22 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of flavivirus infections
JP5411141B2 (ja) * 2007-09-10 2014-02-12 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
US8389567B2 (en) 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
US7906553B2 (en) 2008-08-27 2011-03-15 Calcimedica, Inc. Substituted thiophene modulators of intracellular calcium
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
US20110288142A1 (en) * 2009-01-30 2011-11-24 Chen Pingyun Y CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
WO2011034962A2 (en) 2009-09-16 2011-03-24 Calcimedica Inc. Compounds that modulate intracellular calcium
MX2012014273A (es) 2010-06-07 2013-03-22 Novomedix Llc Compuestos furanilo y su uso.
EP2609095A4 (en) 2010-08-27 2014-06-18 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (pt) 2011-07-01 2018-04-28
US20150045305A1 (en) 2012-01-27 2015-02-12 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014059333A1 (en) 2012-10-12 2014-04-17 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9214120D0 (en) * 1991-07-25 1992-08-12 Ici Plc Therapeutic amides
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5670504A (en) 1995-02-23 1997-09-23 Merck & Co. Inc. 2,6-diaryl pyridazinones with immunosuppressant activity
US6083986A (en) 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US5935945A (en) 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US5969017A (en) 1996-10-31 1999-10-19 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US6013664A (en) * 1996-11-27 2000-01-11 Bayer Aktiengesellschaft Microbicidal agents based on thiophene-2-carboxylic acid derivatives
BR9811828A (pt) * 1997-08-05 2000-08-15 American Home Prod Análogos do ácido antranìlico
EP1040108B1 (en) * 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
US6333337B1 (en) * 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
US6358960B1 (en) * 1998-02-17 2002-03-19 Ono Pharmaceutical Co., Ltd. Amidino derivatives and drugs containing the same as the active ingredient
EP0960882A1 (en) * 1998-05-19 1999-12-01 Hoechst Marion Roussel Deutschland GmbH Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists
JP2002517385A (ja) 1998-06-05 2002-06-18 イカゲン インク． カリウムチャネル阻害剤
AU754204B2 (en) 1998-09-01 2002-11-07 Bristol-Myers Squibb Company Potassium channel inhibitors and method
WO2000075129A1 (en) * 1999-06-07 2000-12-14 Shire Biochem Inc. Thiophene integrin inhibitors
BR0212101A (pt) * 2001-08-24 2004-08-24 Pharmacia & Up John Company 7-aza [2.2.1] biciclo-heptanos substituìdos com heteroarila para o tratamento de doenças

Also Published As

Publication number Publication date
CA2431095A1 (en) 2002-06-20
DK1349846T3 (da) 2005-05-30
AU3574302A (en) 2002-06-24
CN1479734A (zh) 2004-03-03
HK1061850A1 (en) 2004-10-08
IL156314A (en) 2008-12-29
NZ526383A (en) 2004-11-26
EP1349846B1 (de) 2005-02-09
RS50336B (sr) 2009-11-10
SK7252003A3 (en) 2003-12-02
ATE288906T1 (de) 2005-02-15
NO20032535L (no) 2003-07-29
EE200300240A (et) 2003-08-15
YU42503A (sh) 2006-05-25
EP1349846A1 (de) 2003-10-08
HUP0303665A2 (hu) 2004-03-01
CN1225463C (zh) 2005-11-02
IL156314A0 (en) 2004-01-04
AR032781A1 (es) 2003-11-26
HUP0303665A3 (en) 2005-02-28
TWI288134B (en) 2007-10-11
ES2236335T3 (es) 2005-07-16
PT1349846E (pt) 2005-05-31
WO2002048131A1 (de) 2002-06-20
NO20032535D0 (no) 2003-06-04
CZ20031633A3 (cs) 2003-08-13
MXPA03004770A (es) 2003-09-10
KR20030061846A (ko) 2003-07-22
US20040068120A1 (en) 2004-04-08
DE10061876A1 (de) 2002-06-20
JP2004526680A (ja) 2004-09-02
AU2002235743B2 (en) 2006-07-20
JP4252798B2 (ja) 2009-04-08
ZA200304091B (en) 2004-04-23
HRP20030469A2 (en) 2005-04-30
PL362410A1 (en) 2004-11-02
RU2275366C2 (ru) 2006-04-27
US6982279B2 (en) 2006-01-03
EE05306B1 (et) 2010-06-15
SK287464B6 (sk) 2010-10-07
DE50105337D1 (de) 2005-03-17
NO329163B1 (no) 2010-08-30

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.