BR0116575A - Terapia combinada que usa inibidores de tirosina cinase receptora e inibidores de angiogênese - Google Patents

Terapia combinada que usa inibidores de tirosina cinase receptora e inibidores de angiogênese

Info

Publication number
BR0116575A
BR0116575A BR0116575-5A BR0116575A BR0116575A BR 0116575 A BR0116575 A BR 0116575A BR 0116575 A BR0116575 A BR 0116575A BR 0116575 A BR0116575 A BR 0116575A
Authority
BR
Brazil
Prior art keywords
therapy
inhibitors
antagonists
tyrosine kinase
receptor tyrosine
Prior art date
Application number
BR0116575-5A
Other languages
English (en)
Inventor
Simon Goodman
Hans-Georg Kreysch
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0116575A publication Critical patent/BR0116575A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"TERAPIA COMBINADA QUE USA INIBIDORES DE TIROSINA CINASE RECEPTORA E INIBIDORES DE ANGIOGêNESE". A presente invenção refere-se a uma terapia de combinação para o tratamento de tumores e de metástases de tumor que compreende a administração de antagonistas/inibidores de tirosina cinase receptora, especialmente antagonistas para receptor ErbB, mais preferivelmente antagonistas para receptor EGF (Her 1) e agentes antiangiogênicos, de preferência antagonistas para integrina, opcionalmente juntamente com agentes ou formas de terapia que têm eficácia aditiva ou sinergística quando administrados juntamente com a dita combinação de antagonistas/inibidores, tais como agentes quimioterápicos e ou terapia de radiação. A terapia pode resultar em um aumento potencial sinergístico do efeito de inibição de cada agente terapêutico individual sobre a proliferação da célula tumoral, fornecendo tratamento mais eficaz do que encontrado pela administração de um único componente individual.
BR0116575-5A 2001-01-09 2001-12-21 Terapia combinada que usa inibidores de tirosina cinase receptora e inibidores de angiogênese BR0116575A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01100507 2001-01-09
PCT/EP2001/015241 WO2002055106A2 (en) 2001-01-09 2001-12-21 Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors

Publications (1)

Publication Number Publication Date
BR0116575A true BR0116575A (pt) 2004-01-06

Family

ID=8176174

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116575-5A BR0116575A (pt) 2001-01-09 2001-12-21 Terapia combinada que usa inibidores de tirosina cinase receptora e inibidores de angiogênese

Country Status (16)

Country Link
US (2) US20040052785A1 (pt)
EP (1) EP1349574A2 (pt)
JP (2) JP4364510B2 (pt)
KR (2) KR100983997B1 (pt)
CN (1) CN100335132C (pt)
AU (1) AU2002219221B2 (pt)
BR (1) BR0116575A (pt)
CA (1) CA2436326C (pt)
CZ (1) CZ20031927A3 (pt)
HU (1) HUP0302544A3 (pt)
MX (1) MXPA03006121A (pt)
PL (1) PL206142B1 (pt)
RU (1) RU2292904C2 (pt)
SK (1) SK9072003A3 (pt)
WO (1) WO2002055106A2 (pt)
ZA (1) ZA200306125B (pt)

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CA2436326C (en) * 2001-01-09 2012-08-14 Merck Patent Gesellschaft Mit Beschraenkter Haftung Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
JP2006505546A (ja) * 2002-10-10 2006-02-16 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 二重特異性抗ＥｒｂＢ抗体および腫瘍治療でのその使用

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CA2436326C (en) 2012-08-14
KR20030068205A (ko) 2003-08-19
AU2002219221B2 (en) 2007-05-17
PL362407A1 (en) 2004-11-02
CZ20031927A3 (cs) 2003-10-15
JP2009102359A (ja) 2009-05-14
HUP0302544A2 (hu) 2003-10-28
RU2292904C2 (ru) 2007-02-10
SK9072003A3 (en) 2003-11-04
US20040052785A1 (en) 2004-03-18
KR100983997B1 (ko) 2010-09-28
CN100335132C (zh) 2007-09-05
US20110223167A1 (en) 2011-09-15
KR20090038037A (ko) 2009-04-17
MXPA03006121A (es) 2003-09-10
EP1349574A2 (en) 2003-10-08
HUP0302544A3 (en) 2012-09-28
JP4364510B2 (ja) 2009-11-18
WO2002055106A2 (en) 2002-07-18
ZA200306125B (en) 2005-01-26
WO2002055106A3 (en) 2003-03-06
CA2436326A1 (en) 2002-07-18
HK1060056A1 (en) 2004-07-30

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