ECSP055911A - Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación - Google Patents

Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación

Info

Publication number
ECSP055911A
ECSP055911A EC2005005911A ECSP055911A ECSP055911A EC SP055911 A ECSP055911 A EC SP055911A EC 2005005911 A EC2005005911 A EC 2005005911A EC SP055911 A ECSP055911 A EC SP055911A EC SP055911 A ECSP055911 A EC SP055911A
Authority
EC
Ecuador
Prior art keywords
antineoplassic
effectiveness
agents
improve
protein kinase
Prior art date
Application number
EC2005005911A
Other languages
English (en)
Inventor
Sacha Ninkovic
Michael John Bennett
Eugene Yuanjin Rui
Fen Wang
Suzanne Pritchett Benedict
Min Teng
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP055911A publication Critical patent/ECSP055911A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

. Proteína quinasas, tales como CHK-1, que inhiben compuestos tricíclicos de la siguiente fórmula (en la que R2, R3 y R4 son como se han definido en la memoria descriptiva) composiciones farmacéuticas que contienen cantidades eficaces de dichos compuestos o sus sales son útiles como un único agente o en combinación con un agente anti-neoplásico o radiación terapéutica que tienen un efecto anti-neoplásico para tratar enfermedades o afecciones tales como cánceres.
EC2005005911A 2003-01-09 2005-07-08 Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación ECSP055911A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09

Publications (1)

Publication Number Publication Date
ECSP055911A true ECSP055911A (es) 2005-11-22

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005911A ECSP055911A (es) 2003-01-09 2005-07-08 Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación

Country Status (34)

Country Link
US (3) US6967198B2 (es)
EP (2) EP1585749B1 (es)
JP (1) JP3990718B2 (es)
KR (1) KR100697746B1 (es)
CN (1) CN1759118B (es)
AP (1) AP2048A (es)
AT (1) ATE404564T1 (es)
AU (1) AU2004203977B2 (es)
BR (1) BRPI0406701A (es)
CA (1) CA2512683C (es)
CR (1) CR7899A (es)
CY (1) CY1108408T1 (es)
DE (1) DE602004015724D1 (es)
DK (1) DK1585749T3 (es)
EA (1) EA009337B1 (es)
EC (1) ECSP055911A (es)
ES (1) ES2309484T3 (es)
GE (1) GEP20084367B (es)
HR (1) HRP20050624A2 (es)
IL (1) IL169082A (es)
IS (1) IS7884A (es)
MA (1) MA27703A1 (es)
MX (1) MXPA05007352A (es)
NO (1) NO20053775L (es)
NZ (1) NZ540638A (es)
OA (1) OA13017A (es)
PL (1) PL378372A1 (es)
PT (1) PT1585749E (es)
RS (1) RS20050522A (es)
SI (1) SI1585749T1 (es)
TN (1) TNSN05176A1 (es)
UA (1) UA80733C2 (es)
WO (1) WO2004063198A1 (es)
ZA (1) ZA200504674B (es)

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CN103748094B (zh) 2011-05-06 2016-06-29 扎夫根股份有限公司 三环磺酰胺化合物及其制备和使用方法
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MX2014008071A (es) 2011-12-31 2015-07-06 Beigene Ltd Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas.
MX353578B (es) 2011-12-31 2018-01-19 Beigene Ltd Dihidrodiazpinocarbazolonas tetra o penta-ciclicas fusionadas como inhibidores de poli (adp-ribosa) polimerasa (parp).
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JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
CN115433187B (zh) 2017-02-28 2023-10-27 百济神州(苏州)生物科技有限公司 稠合的四环或五环二氢二氮杂䓬并咔唑酮的盐的结晶形式组合物及其用途
US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
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Also Published As

Publication number Publication date
CA2512683A1 (en) 2004-07-29
TNSN05176A1 (fr) 2007-06-11
NZ540638A (en) 2007-12-21
US7462713B2 (en) 2008-12-09
US20070135415A1 (en) 2007-06-14
JP3990718B2 (ja) 2007-10-17
HK1086257A1 (en) 2006-09-15
ES2309484T3 (es) 2008-12-16
DE602004015724D1 (de) 2008-09-25
OA13017A (en) 2006-11-10
WO2004063198A1 (en) 2004-07-29
CN1759118B (zh) 2010-12-08
MXPA05007352A (es) 2006-02-17
CY1108408T1 (el) 2014-02-12
BRPI0406701A (pt) 2005-12-20
ZA200504674B (en) 2006-07-26
CA2512683C (en) 2010-03-16
DK1585749T3 (da) 2008-09-22
EP1585749A1 (en) 2005-10-19
CR7899A (es) 2005-08-05
EP1947102A1 (en) 2008-07-23
MA27703A1 (fr) 2006-01-02
IS7884A (is) 2005-06-09
IL169082A (en) 2011-02-28
EA009337B1 (ru) 2007-12-28
PL378372A1 (pl) 2006-04-03
EA200500893A1 (ru) 2006-02-24
KR20050092397A (ko) 2005-09-21
AP2048A (en) 2009-09-24
GEP20084367B (en) 2008-05-13
HRP20050624A2 (en) 2006-02-28
JP2006516274A (ja) 2006-06-29
US20050075499A1 (en) 2005-04-07
SI1585749T1 (sl) 2008-10-31
UA80733C2 (en) 2007-10-25
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (en) 2008-08-13
AP2005003353A0 (en) 2005-09-30
CN1759118A (zh) 2006-04-12
RS20050522A (sr) 2007-12-31
AU2004203977B2 (en) 2010-06-17
NO20053775D0 (no) 2005-08-08
ATE404564T1 (de) 2008-08-15
US6967198B2 (en) 2005-11-22
NO20053775L (no) 2005-09-16
US7132533B2 (en) 2006-11-07
KR100697746B1 (ko) 2007-03-22
PT1585749E (pt) 2008-10-23
US20060004052A1 (en) 2006-01-05

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