ECSP055911A - Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación - Google Patents

Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación

Info

Publication number
ECSP055911A
ECSP055911A EC2005005911A ECSP055911A ECSP055911A EC SP055911 A ECSP055911 A EC SP055911A EC 2005005911 A EC2005005911 A EC 2005005911A EC SP055911 A ECSP055911 A EC SP055911A EC SP055911 A ECSP055911 A EC SP055911A
Authority
EC
Ecuador
Prior art keywords
antineoplassic
effectiveness
agents
improve
protein kinase
Prior art date
Application number
EC2005005911A
Other languages
English (en)
Inventor
Sacha Ninkovic
Michael John Bennett
Eugene Yuanjin Rui
Fen Wang
Suzanne Pritchett Benedict
Min Teng
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP055911A publication Critical patent/ECSP055911A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

. Proteína quinasas, tales como CHK-1, que inhiben compuestos tricíclicos de la siguiente fórmula (en la que R2, R3 y R4 son como se han definido en la memoria descriptiva) composiciones farmacéuticas que contienen cantidades eficaces de dichos compuestos o sus sales son útiles como un único agente o en combinación con un agente anti-neoplásico o radiación terapéutica que tienen un efecto anti-neoplásico para tratar enfermedades o afecciones tales como cánceres.
EC2005005911A 2003-01-09 2005-07-08 Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación ECSP055911A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09

Publications (1)

Publication Number Publication Date
ECSP055911A true ECSP055911A (es) 2005-11-22

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005911A ECSP055911A (es) 2003-01-09 2005-07-08 Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación

Country Status (34)

Country Link
US (3) US6967198B2 (es)
EP (2) EP1947102A1 (es)
JP (1) JP3990718B2 (es)
KR (1) KR100697746B1 (es)
CN (1) CN1759118B (es)
AP (1) AP2048A (es)
AT (1) ATE404564T1 (es)
AU (1) AU2004203977B2 (es)
BR (1) BRPI0406701A (es)
CA (1) CA2512683C (es)
CR (1) CR7899A (es)
CY (1) CY1108408T1 (es)
DE (1) DE602004015724D1 (es)
DK (1) DK1585749T3 (es)
EA (1) EA009337B1 (es)
EC (1) ECSP055911A (es)
ES (1) ES2309484T3 (es)
GE (1) GEP20084367B (es)
HR (1) HRP20050624A2 (es)
IL (1) IL169082A (es)
IS (1) IS7884A (es)
MA (1) MA27703A1 (es)
MX (1) MXPA05007352A (es)
NO (1) NO20053775L (es)
NZ (1) NZ540638A (es)
OA (1) OA13017A (es)
PL (1) PL378372A1 (es)
PT (1) PT1585749E (es)
RS (1) RS20050522A (es)
SI (1) SI1585749T1 (es)
TN (1) TNSN05176A1 (es)
UA (1) UA80733C2 (es)
WO (1) WO2004063198A1 (es)
ZA (1) ZA200504674B (es)

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CN103748094B (zh) 2011-05-06 2016-06-29 扎夫根股份有限公司 三环磺酰胺化合物及其制备和使用方法
EP2793882A4 (en) 2011-12-22 2015-04-29 Threshold Pharmaceuticals Inc ADMINISTRATION OF HYPOXIA-ACTIVATED PRODRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER
NZ626937A (en) 2011-12-31 2016-09-30 Beigene Ltd Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors
RS56616B1 (sr) * 2011-12-31 2018-02-28 Beigene Ltd Kondenzovani tetra ili penta-ciklični dihidrodiazepinokarbazoloni kao parp inhibitori
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
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US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
BR112020005489A2 (pt) * 2017-09-22 2020-09-24 Jubilant Epipad Llc, composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer
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Also Published As

Publication number Publication date
CY1108408T1 (el) 2014-02-12
MA27703A1 (fr) 2006-01-02
RS20050522A (sr) 2007-12-31
ES2309484T3 (es) 2008-12-16
US20060004052A1 (en) 2006-01-05
KR20050092397A (ko) 2005-09-21
BRPI0406701A (pt) 2005-12-20
EA009337B1 (ru) 2007-12-28
SI1585749T1 (sl) 2008-10-31
CR7899A (es) 2005-08-05
OA13017A (en) 2006-11-10
WO2004063198A1 (en) 2004-07-29
US7462713B2 (en) 2008-12-09
NO20053775D0 (no) 2005-08-08
GEP20084367B (en) 2008-05-13
CN1759118A (zh) 2006-04-12
CN1759118B (zh) 2010-12-08
US20050075499A1 (en) 2005-04-07
NO20053775L (no) 2005-09-16
US7132533B2 (en) 2006-11-07
NZ540638A (en) 2007-12-21
ATE404564T1 (de) 2008-08-15
EA200500893A1 (ru) 2006-02-24
IS7884A (is) 2005-06-09
US6967198B2 (en) 2005-11-22
JP3990718B2 (ja) 2007-10-17
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (en) 2008-08-13
JP2006516274A (ja) 2006-06-29
AU2004203977B2 (en) 2010-06-17
HK1086257A1 (en) 2006-09-15
TNSN05176A1 (fr) 2007-06-11
MXPA05007352A (es) 2006-02-17
IL169082A (en) 2011-02-28
ZA200504674B (en) 2006-07-26
AP2048A (en) 2009-09-24
HRP20050624A2 (en) 2006-02-28
CA2512683A1 (en) 2004-07-29
US20070135415A1 (en) 2007-06-14
EP1947102A1 (en) 2008-07-23
UA80733C2 (en) 2007-10-25
DK1585749T3 (da) 2008-09-22
EP1585749A1 (en) 2005-10-19
DE602004015724D1 (de) 2008-09-25
KR100697746B1 (ko) 2007-03-22
PT1585749E (pt) 2008-10-23
CA2512683C (en) 2010-03-16
AP2005003353A0 (en) 2005-09-30
PL378372A1 (pl) 2006-04-03

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