NO20033698D0 - Quinolin, isoquinolin og ftalazinderivater som antagonister av gonadotropinfrigivende hormon - Google Patents

Quinolin, isoquinolin og ftalazinderivater som antagonister av gonadotropinfrigivende hormon

Info

Publication number: NO20033698D0
Authority: NO; Norway
Prior art keywords: gonadotropin; isoquinoline; quinoline; antagonists; releasing hormone
Prior art date: 2001-02-21

Application number

NO20033698A

Other languages

English (en)

Other versions

NO325675B1 (no

NO20033698L (no

Inventor

Peter Strehlke

Peter Droescher

Ulrich Buehmann

Norbert Schmees

Peter Muhn

Holger Hess-Stumpp

Roland Kuehne

Eckhard Guenther

Emmanuel Polymeropoulos

Antonius Marinus Ter Laak

Original Assignee

Zentaris Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-21

Filing date

2003-08-20

Publication date

2003-08-20

2001-02-21 Priority claimed from DE2001108271 external-priority patent/DE10108271A1/de

2003-08-20 Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh

2003-08-20 Publication of NO20033698D0 publication Critical patent/NO20033698D0/no

2003-10-20 Publication of NO20033698L publication Critical patent/NO20033698L/no

2008-07-07 Publication of NO325675B1 publication Critical patent/NO325675B1/no

Links

SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 2
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 title 1
LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Epidemiology (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

NO20033698A 2001-02-21 2003-08-20 Quinolin, isoquinolin og ftalazinderivater, fremgangsmate for fremstilling derav samt anvendelse av forbindelsene NO325675B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE2001108271 DE10108271A1 (de)	2001-02-21	2001-02-21	Chinolin-, Isochinolin- und Phthalazinderivate als Antagonisten des Gonadotropin freisetzenden Hormons
US27491401P	2001-03-13	2001-03-13
PCT/EP2002/001882 WO2002066437A1 (de)	2001-02-21	2002-02-21	Chinolin-, isochinolin- und phthalazinderivate als antagonisten des gonadotropin freisetzenden hormons

Publications (3)

Publication Number	Publication Date
NO20033698D0 true NO20033698D0 (no)	2003-08-20
NO20033698L NO20033698L (no)	2003-10-20
NO325675B1 NO325675B1 (no)	2008-07-07

Family

ID=26008581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20033698A NO325675B1 (no)	2001-02-21	2003-08-20	Quinolin, isoquinolin og ftalazinderivater, fremgangsmate for fremstilling derav samt anvendelse av forbindelsene

Country Status (17)

Country	Link
EP (1)	EP1362034A1 (no)
JP (1)	JP2004528298A (no)
CN (1)	CN1496354A (no)
AU (1)	AU2002247737B2 (no)
BG (1)	BG108165A (no)
BR (1)	BR0207451A (no)
CA (1)	CA2438709A1 (no)
CZ (1)	CZ20032514A3 (no)
HU (1)	HUP0303219A2 (no)
IL (1)	IL157303A0 (no)
MX (1)	MXPA03007348A (no)
NO (1)	NO325675B1 (no)
NZ (1)	NZ527597A (no)
PL (1)	PL367285A1 (no)
RU (1)	RU2280031C2 (no)
SK (1)	SK11622003A3 (no)
WO (1)	WO2002066437A1 (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2968323A4 (en)	2013-03-13	2016-12-14	Flatley Discovery Lab	PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4120646A1 (de) *	1991-06-22	1992-12-24	Bayer Ag	7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
CN1200114A (zh) *	1995-10-19	1998-11-25	武田药品工业株式会社	作为gnrh拮抗剂的喹啉衍生物
WO1997044041A1 (en) *	1996-05-20	1997-11-27	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone

2002
- 2002-02-21 JP JP2002565954A patent/JP2004528298A/ja active Pending
- 2002-02-21 IL IL15730302A patent/IL157303A0/xx unknown
- 2002-02-21 MX MXPA03007348A patent/MXPA03007348A/es active IP Right Grant
- 2002-02-21 CA CA002438709A patent/CA2438709A1/en not_active Abandoned
- 2002-02-21 SK SK1162-2003A patent/SK11622003A3/sk unknown
- 2002-02-21 EP EP02716803A patent/EP1362034A1/de not_active Withdrawn
- 2002-02-21 HU HU0303219A patent/HUP0303219A2/hu unknown
- 2002-02-21 CZ CZ20032514A patent/CZ20032514A3/cs unknown
- 2002-02-21 NZ NZ527597A patent/NZ527597A/en unknown
- 2002-02-21 WO PCT/EP2002/001882 patent/WO2002066437A1/de not_active Ceased
- 2002-02-21 RU RU2003128647/04A patent/RU2280031C2/ru not_active IP Right Cessation
- 2002-02-21 AU AU2002247737A patent/AU2002247737B2/en not_active Ceased
- 2002-02-21 BR BR0207451-6A patent/BR0207451A/pt not_active IP Right Cessation
- 2002-02-21 CN CNA028063597A patent/CN1496354A/zh active Pending
- 2002-02-21 PL PL02367285A patent/PL367285A1/xx not_active Application Discontinuation
2003
- 2003-08-20 NO NO20033698A patent/NO325675B1/no not_active IP Right Cessation
- 2003-09-09 BG BG108165A patent/BG108165A/xx unknown

Also Published As

Publication number	Publication date
MXPA03007348A (es)	2003-12-04
AU2002247737B2 (en)	2006-05-18
CZ20032514A3 (cs)	2004-05-12
CA2438709A1 (en)	2002-08-29
SK11622003A3 (sk)	2004-01-08
NO325675B1 (no)	2008-07-07
NO20033698L (no)	2003-10-20
CN1496354A (zh)	2004-05-12
BR0207451A (pt)	2004-06-01
PL367285A1 (en)	2005-02-21
RU2280031C2 (ru)	2006-07-20
NZ527597A (en)	2004-10-29
IL157303A0 (en)	2004-02-19
BG108165A (en)	2004-08-31
JP2004528298A (ja)	2004-09-16
HUP0303219A2 (hu)	2003-12-29
EP1362034A1 (de)	2003-11-19
RU2003128647A (ru)	2005-03-27
WO2002066437A1 (de)	2002-08-29

Legal Events

Date	Code	Title	Description
2010-09-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20021910L (no)	2002-07-01	Stabil polymorf av N-(3-etynylfenylamino)-6,7-bis(2- metoksyetoksy)-4-quinazolinamin hydroklorid, fremgangsmåter forfremstilling og farmasöytisk anvendelse
NL1029596A1 (nl)	2006-01-24	Nieuwe piperidylderivaten van chinazoline en isochinoline.
HUP0105133A3 (en)	2002-09-30	Quinoline derivatives and quinazoline derivatives, pharmaceutical compositions containing them and their use
EE05330B1 (et)	2010-08-16	Kinasoliini derivaadid kui VEGF-i inhibiitorid
NO20042121D0 (no)	2004-05-24	Kinolinforbindelse
DK1406628T3 (da)	2006-07-03	Tetrahydroquinolin-derivater
NO20031097D0 (no)	2003-03-10	Kinolinderivater
AU2003209119A1 (en)	2003-09-04	Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
FI20000480A0 (fi)	2000-03-01	Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina
PL347721A1 (en)	2002-04-22	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
PL370414A1 (en)	2005-05-30	Quinoline derivatives as neuropeptide y antagonists
EE200200573A (et)	2004-04-15	Indoliin-2-ooni derivaadid, nende valmistamine jakasutamine oksütotsiiniretseptorite ligandidena
ATE244711T1 (de)	2003-07-15	Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten
NO20040724L (no)	2004-02-19	C-14-oksidasjon av morfin-derivater.
AU2002215043A1 (en)	2002-05-21	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
NO20005031D0 (no)	2000-10-06	Kinolin-4-yl-derivater II
NO20033698L (no)	2003-10-20	Quinolin, isoquinolin og ftalazinderivater som antagonister av gonadotropinfrigivende hormon
NO20035605D0 (no)	2003-12-16	Pediatrisk formulering av gatifloxacin
DE60015471D1 (de)	2004-12-09	Chinolin-4-yl-derivate
DK1088818T3 (da)	2005-03-14	Quinolin-4-yl-derivater
DE60129445D1 (de)	2007-08-30	Quinolin-derivate als antientzündungsmittel
ATE229956T1 (de)	2003-01-15	Trizyclische pyridin n-oxide vasopressin agonisten
AU2002247737A1 (en)	2003-02-27	Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone
NO20021475D0 (no)	2002-03-25	Vasopressinantagonist, formulering og fremgangsmåte
AU2002310838A1 (en)	2002-10-28	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists