BR0207889A - Proteìna, molécula de ácido nucleico codificando a mesma, molécula de ácido nucleico recombinante, hospedeiro de microorganismo transformado, processo para produzir uma aminopeptidase, e , aminopeptidase - Google Patents
Proteìna, molécula de ácido nucleico codificando a mesma, molécula de ácido nucleico recombinante, hospedeiro de microorganismo transformado, processo para produzir uma aminopeptidase, e , aminopeptidaseInfo
- Publication number
- BR0207889A BR0207889A BR0207889-9A BR0207889A BR0207889A BR 0207889 A BR0207889 A BR 0207889A BR 0207889 A BR0207889 A BR 0207889A BR 0207889 A BR0207889 A BR 0207889A
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- aminopeptidase
- protein
- acid molecule
- same
- Prior art date
Links
- 102000004400 Aminopeptidases Human genes 0.000 title abstract 7
- 108090000915 Aminopeptidases Proteins 0.000 title abstract 7
- 108020004707 nucleic acids Proteins 0.000 title abstract 6
- 102000039446 nucleic acids Human genes 0.000 title abstract 6
- 150000007523 nucleic acids Chemical class 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 244000005700 microbiome Species 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- -1 AND Proteins 0.000 abstract 1
- 241000351920 Aspergillus nidulans Species 0.000 abstract 1
- 240000006439 Aspergillus oryzae Species 0.000 abstract 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 abstract 1
- 238000007792 addition Methods 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
"PROTEìNA, MOLéCULA DE áCIDO NUCLEICO CODIFICANDO A MESMA, MOLéCULA DE áCIDO NUCLEICO RECOMBINANTE, HOSPEDEIRO DE MICROORGANISMO TRANSFORMADO, PROCESSO PARA PRODUZIR UMA AMINOPEPTIDASE, E, AMINOPEPTIDASE". O objeto da presente invenção é prover aminopeptidases de bolor Koji capazes de hidrolisar de modo eficiente peptídeos persistentes e também genes codificando as aminopeptidases. A presente invenção provê Aspergillus nidulans aminopeptidase e moléculas de ácido nucleico codificando a mesma. Particularmente, a presente invenção provê uma proteína tendo uma seq³ência de aminoácidos representada pelos aminoácidos 1 a 519 em SEQ ID NO: 2, ou uma proteína contendo a substituição, deleção, inserção, adição ou inversão de um ou mais aminoácidos na referida seq³ência e cuja proteína tem uma atividade de catálise da reação para liberar um aminoácido em um N-terminal de um peptídeo, e moléculas de ácido nucleico codificando a mesma.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001078930 | 2001-03-19 | ||
| JP2001293348 | 2001-09-26 | ||
| PCT/JP2002/002476 WO2002077223A1 (fr) | 2001-03-19 | 2002-03-15 | Nouvelle aminopeptidase et son gene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0207889A true BR0207889A (pt) | 2004-07-27 |
Family
ID=26611572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0207889-9A BR0207889A (pt) | 2001-03-19 | 2002-03-15 | Proteìna, molécula de ácido nucleico codificando a mesma, molécula de ácido nucleico recombinante, hospedeiro de microorganismo transformado, processo para produzir uma aminopeptidase, e , aminopeptidase |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7087422B2 (pt) |
| EP (1) | EP1371725B1 (pt) |
| JP (1) | JPWO2002077223A1 (pt) |
| CN (1) | CN1501975A (pt) |
| AT (1) | ATE318898T1 (pt) |
| BR (1) | BR0207889A (pt) |
| DE (1) | DE60209467T2 (pt) |
| WO (1) | WO2002077223A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100558244C (zh) * | 2003-05-27 | 2009-11-11 | 味之素株式会社 | 饮食品的口味和/或风味的改善方法 |
| WO2017119511A1 (ja) * | 2016-01-06 | 2017-07-13 | 学校法人沖縄科学技術大学院大学学園 | 加水分解活性を示す新規ペプチドおよびその用途 |
| CN112961848B (zh) * | 2021-02-24 | 2022-09-09 | 中国海洋大学 | 一种新型氨肽酶及其可溶性表达方法 |
| CN121592626A (zh) * | 2026-01-29 | 2026-03-03 | 山东农业大学 | 一种养分降解酶、工程菌剂及其在聚合缓释肥养分调控中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU975797A1 (ru) * | 1980-12-12 | 1982-11-23 | Предприятие П/Я Г-4740 | Способ выделени лейцинаминопептидазы из aSpeRGILLUS oRYZae |
| WO1990002814A1 (en) * | 1988-09-13 | 1990-03-22 | The General Hospital Corporation | Isolation, purification, and characterization of the aminopeptidases: ap2, api, and apx |
| US5742297A (en) | 1994-11-04 | 1998-04-21 | Lockheed Martin Corporation | Apparatus and method for constructing a mosaic of data |
| DE69632630T2 (de) | 1995-03-16 | 2005-05-25 | Novozymes A/S | Enzym mit aminopeptidaseactivität |
| DE19526485A1 (de) | 1995-07-20 | 1997-01-23 | Roehm Gmbh | Rekombinant hergestellte Leucinaminopeptidase aus Aspergillus sojae |
| JPH09294583A (ja) | 1996-03-08 | 1997-11-18 | Ajinomoto Co Inc | アミノペプチダーゼｇｘ及びそれを用いるタンパク質の加水分解方法 |
| AU4608097A (en) | 1996-10-04 | 1998-04-24 | Novo Nordisk A/S | Carboxypeptidases from aspergillus oryzae and nucleic acids encoding same |
| ATE414775T1 (de) | 1997-05-16 | 2008-12-15 | Novozymes Inc | Polypeptide mit prolyldipeptidylaminopeptidase- aktivität und dafür kodierende nukleinsäuren |
| WO1998051163A2 (en) | 1997-05-16 | 1998-11-19 | Novo Nordisk Biotech, Inc. | Methods of producing protein hydrolysates |
| JP3727780B2 (ja) | 1998-06-12 | 2005-12-14 | キッコーマン株式会社 | ロイシンアミノペプチダーゼ遺伝子、組み換え体ｄｎａ及びロイシンアミノペプチダーゼの製造法 |
| US6303359B1 (en) * | 1999-03-15 | 2001-10-16 | Ajinomoto Co., Inc. | DNA molecule encoding new aminopeptidase, and method of producing the aminopeptidase |
| JP2000325090A (ja) | 1999-03-15 | 2000-11-28 | Ajinomoto Co Inc | 新規アミノペプチダーゼをコードするｄｎａ及び該アミノペプチダーゼの製造方法 |
-
2002
- 2002-03-15 WO PCT/JP2002/002476 patent/WO2002077223A1/ja not_active Ceased
- 2002-03-15 CN CNA02806724XA patent/CN1501975A/zh active Pending
- 2002-03-15 AT AT02705238T patent/ATE318898T1/de not_active IP Right Cessation
- 2002-03-15 DE DE60209467T patent/DE60209467T2/de not_active Expired - Lifetime
- 2002-03-15 JP JP2002576666A patent/JPWO2002077223A1/ja active Pending
- 2002-03-15 BR BR0207889-9A patent/BR0207889A/pt not_active IP Right Cessation
- 2002-03-15 EP EP02705238A patent/EP1371725B1/en not_active Expired - Lifetime
-
2003
- 2003-09-22 US US10/664,958 patent/US7087422B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1501975A (zh) | 2004-06-02 |
| US7087422B2 (en) | 2006-08-08 |
| WO2002077223A1 (fr) | 2002-10-03 |
| EP1371725A1 (en) | 2003-12-17 |
| US20040219636A1 (en) | 2004-11-04 |
| EP1371725B1 (en) | 2006-03-01 |
| EP1371725A4 (en) | 2004-09-22 |
| JPWO2002077223A1 (ja) | 2004-07-15 |
| DE60209467T2 (de) | 2006-10-19 |
| ATE318898T1 (de) | 2006-03-15 |
| DE60209467D1 (de) | 2006-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |