BR0209552A - Dispositivo de modulação de imunidade para uso em animais - Google Patents

Dispositivo de modulação de imunidade para uso em animais

Info

Publication number
BR0209552A
BR0209552A BR0209552-1A BR0209552A BR0209552A BR 0209552 A BR0209552 A BR 0209552A BR 0209552 A BR0209552 A BR 0209552A BR 0209552 A BR0209552 A BR 0209552A
Authority
BR
Brazil
Prior art keywords
modulation device
animal immunity
immunity modulation
lymphokines
cytokines
Prior art date
Application number
BR0209552-1A
Other languages
English (en)
Other versions
BRPI0209552B1 (pt
Inventor
Kevor S Tenhuisen
Joel Rosenblatt
Ilya S Koyfmann
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0209552A publication Critical patent/BR0209552A/pt
Publication of BRPI0209552B1 publication Critical patent/BRPI0209552B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"DISPOSITIVO DE MODULAçãO DE IMUNIDADE PARA USO EM ANIMAIS". A presente invenção refere-se a um dispositivo de modulação de imunidade que pode ser implantado que é útil para modulação de uma resposta imunológica nos mamíferos, compreendendo uma pluralidade de fibras, dentro de um revestimento poroso. O enchimento de fibra é carregado com antígenos únicos ou múltiplos, e opcionalmente um ou mais compostos biologicamente ativos tais como citocinas (por exemplo linfocinas, quimiocinas, etc.), fatores de fixação, genes, peptídios, proteínas, nucleotídeos, carboidratos ou células dependendo da aplicação.
BRPI0209552A 2001-05-11 2002-03-21 dispositivo de modulação de imunidade e método para fabrica-lo BRPI0209552B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29054201P 2001-05-11 2001-05-11
PCT/US2002/008872 WO2002092054A2 (en) 2001-05-11 2002-03-21 Immune modulation device for use in animals

Publications (2)

Publication Number Publication Date
BR0209552A true BR0209552A (pt) 2004-05-04
BRPI0209552B1 BRPI0209552B1 (pt) 2016-05-10

Family

ID=23116478

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0209552A BRPI0209552B1 (pt) 2001-05-11 2002-03-21 dispositivo de modulação de imunidade e método para fabrica-lo

Country Status (11)

Country Link
US (3) US6958158B2 (pt)
EP (1) EP1387670B1 (pt)
JP (1) JP4866535B2 (pt)
KR (1) KR20030096381A (pt)
CN (1) CN1289063C (pt)
AT (1) ATE411001T1 (pt)
AU (1) AU2002305079B8 (pt)
BR (1) BRPI0209552B1 (pt)
CA (1) CA2447030C (pt)
DE (1) DE60229375D1 (pt)
WO (1) WO2002092054A2 (pt)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
US20030118630A1 (en) * 2001-12-07 2003-06-26 Anthony Cerami Immune modulation device for use in animals
DE10203644A1 (de) * 2002-01-30 2003-08-07 Fraunhofer Ges Forschung Kryokonservierung an textilen Geweben
US20040156878A1 (en) * 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
US6974862B2 (en) * 2003-06-20 2005-12-13 Kensey Nash Corporation High density fibrous polymers suitable for implant
US20050118145A1 (en) * 2003-07-03 2005-06-02 Jannette Dufour Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
US20050260258A1 (en) * 2003-12-18 2005-11-24 The Texas A&M University System Use of vitelline protein B as a microencapsulating additive
PT2347775T (pt) 2005-12-13 2020-07-14 The President And Fellows Of Harvard College Estruturas em andaime para transplante celular
WO2008013713A2 (en) * 2006-07-24 2008-01-31 Duke University Coaxial electrospun fibers and structures and methods of forming same
AU2007278850B2 (en) * 2006-07-28 2013-06-06 Sertocell Biotechnology (Us) Corp. Adult sertoli cells and uses thereof
CA2664770C (en) * 2006-09-29 2014-05-27 Toray Industries, Inc. Cell adsorption column
US10328133B2 (en) 2008-02-13 2019-06-25 President And Fellows Of Harvard College Continuous cell programming devices
WO2009145842A2 (en) 2008-04-04 2009-12-03 Forsight Labs, Llc Therapeutic device for pain management and vision
WO2011050327A1 (en) 2009-10-23 2011-04-28 Forsight Labs Llc Corneal denervation for treatment of ocular pain
US9498385B2 (en) 2009-10-23 2016-11-22 Nexisvision, Inc. Conformable therapeutic shield for vision and pain
UA112155C2 (uk) 2009-12-21 2016-08-10 ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі Розкладаний видалюваний імплантат для безперервного вивільнення активної сполуки
EP2550362B1 (en) 2010-03-25 2017-01-04 Oregon Health&Science University Cmv glycoproteins and recombinant vectors
WO2011138689A2 (en) * 2010-05-03 2011-11-10 Izhar Halahmi Releasing device for administering a bio-active agent
CA2804032C (en) * 2010-06-30 2018-05-01 Evonik Degussa Corporation Core-sheath implant device having an inner core lobe
JP6104806B2 (ja) 2010-10-06 2017-03-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 材料に基づく細胞治療のための注射可能孔形成性ハイドロゲル
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US12044905B2 (en) 2011-04-28 2024-07-23 Journey1 Inc Contact lenses for refractive correction
KR101275163B1 (ko) * 2011-05-26 2013-06-17 한국생산기술연구원 다공질의 3차원 지지체 및 그의 제조방법
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
EP2568289A3 (en) 2011-09-12 2013-04-03 International AIDS Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
CN104244929B (zh) 2012-04-16 2017-04-05 哈佛学院董事会 用于调节免疫反应的介孔二氧化硅组合物
EP2679596B1 (en) 2012-06-27 2017-04-12 International Aids Vaccine Initiative HIV-1 env glycoprotein variant
CA2916885A1 (en) 2013-06-26 2014-12-31 Nexisvision, Inc. Contact lenses for refractive correction
EP2848937A1 (en) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Methods of identifying novel HIV-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
HK1247861A1 (zh) 2015-01-30 2018-10-05 President And Fellows Of Harvard College 用於癌症治疗的肿瘤周围和肿瘤内部材料
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
WO2016164705A1 (en) 2015-04-10 2016-10-13 Omar Abdel-Rahman Ali Immune cell trapping devices and methods for making and using the same
EP3411475B1 (en) 2016-02-06 2025-08-27 President and Fellows of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
CN115404196A (zh) 2016-07-13 2022-11-29 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
CN110418651A (zh) 2016-08-02 2019-11-05 哈佛学院院长等 用于调节免疫应答的生物材料
WO2020061129A1 (en) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions and methods for labeling and modulation of cells in vitro and in vivo
CN111001226B (zh) * 2018-10-07 2023-02-10 嘉兴启净涂装科技有限公司 一种在管状物中填充纤维材料的方法
JP7396269B2 (ja) * 2019-02-22 2023-12-12 東レ株式会社 神経再生誘導チューブ
WO2021061837A1 (en) 2019-09-23 2021-04-01 President And Fellows Of Harvard College Biomaterial-based antigen free vaccine and the use thereof
CN111202836A (zh) * 2020-02-07 2020-05-29 嫦娥创新(武汉)生物科技有限公司 鲟鱼蛋白肽在制备免疫调节制剂中的应用
WO2021185373A1 (zh) * 2020-03-20 2021-09-23 苏州医本生命科技有限公司 载药用微粒、载药微粒、蓄粒管及其植入系统
CN111467319A (zh) * 2020-03-20 2020-07-31 苏州医本生命科技有限公司 载药用微粒、储存该微粒的蓄粒管及植入系统
US12383246B2 (en) 2020-10-12 2025-08-12 Abbott Cardiovascular Systems, Inc. Vessel closure device with improved safety and tract hemostasis
CN120241585A (zh) * 2025-05-07 2025-07-04 长江大学 一种疫苗缓释埋植体及其应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US118630A (en) * 1871-08-29 Improvement in ice-pitchers
US3887699A (en) 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US4052550A (en) 1973-06-06 1977-10-04 Rhone-Poulenc-Textile Poly(vinylidene fluoride) yarns and fibers
US3937223A (en) * 1974-04-19 1976-02-10 American Cyanamid Company Compacted surgical hemostatic felt
US4052988A (en) 1976-01-12 1977-10-11 Ethicon, Inc. Synthetic absorbable surgical devices of poly-dioxanone
US4164560A (en) 1977-01-05 1979-08-14 Folkman Moses J Systems for the controlled release of macromolecules
US4208511A (en) 1977-01-19 1980-06-17 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4141087A (en) 1977-01-19 1979-02-27 Ethicon, Inc. Isomorphic copolyoxalates and sutures thereof
US4105034A (en) 1977-06-10 1978-08-08 Ethicon, Inc. Poly(alkylene oxalate) absorbable coating for sutures
US4140678A (en) 1977-06-13 1979-02-20 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4205399A (en) 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4130639A (en) 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US4224946A (en) 1978-08-14 1980-09-30 American Cyanamid Company Surgical sutures derived from segmented polyether-ester block copolymers
US5102419A (en) 1978-12-08 1992-04-07 Ethicon, Inc. Elastomeric surgical sutures comprising segmented copolyether/esters
US5147382A (en) 1978-12-08 1992-09-15 Ethicon, Inc. Elastomeric surgical sutures comprising segmented copolyether/esters
US4314561A (en) 1979-01-29 1982-02-09 American Cyanamid Company Surgical suture derived from segmented polyether-ester block copolymers
US4919929A (en) 1984-02-01 1990-04-24 Stolle Research & Development Corporation Mammal immunization
US4605730A (en) 1982-10-01 1986-08-12 Ethicon, Inc. Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same
US4700704A (en) 1982-10-01 1987-10-20 Ethicon, Inc. Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same
US4520822A (en) 1982-10-04 1985-06-04 Ethicon, Inc. Ethylene-propylene copolymer sutures
US4689220A (en) * 1984-02-16 1987-08-25 Unigene Laboratories, Inc. Immunization by immunogenic implant
US4557264A (en) 1984-04-09 1985-12-10 Ethicon Inc. Surgical filament from polypropylene blended with polyethylene
US4564013A (en) 1984-05-24 1986-01-14 Ethicon, Inc. Surgical filaments from vinylidene fluoride copolymers
US4732155A (en) 1985-08-27 1988-03-22 The Children's Medical Center Corporation Implantable chemoattractant system
EP0287899A3 (en) 1987-04-23 1989-12-27 American Cyanamid Company Surgical closure device
EP0300102B1 (en) 1987-07-21 1993-03-24 The Stolle Research And Development Corporation Improved method of obtaining immune regulatory factors by mammal immunization
ES2054784T3 (es) 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
CA1329100C (en) * 1988-05-16 1994-05-03 Arnold Kastner Portable manually operable cigarette making machine
US5133739A (en) 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
EP0448840A3 (en) 1990-02-26 1993-03-10 American Cyanamid Company Bicomponent or blended wound closure device
WO1991019464A1 (en) * 1990-06-15 1991-12-26 E.I. Du Pont De Nemours And Company Crimped fiber composite articles and processes for the preparation thereof
JPH06506366A (ja) * 1990-12-06 1994-07-21 ダブリュ.エル.ゴア アンド アソシエーツ,インコーポレイティド 植設可能な生体吸収性部材
WO1993017662A1 (en) 1992-03-02 1993-09-16 Daratech Pty. Ltd. Improved implants
JPH05312065A (ja) * 1992-05-06 1993-11-22 Nippondenso Co Ltd 内燃機関のバイパス空気量制御装置
US5269807A (en) 1992-08-27 1993-12-14 United States Surgical Corporation Suture fabricated from syndiotactic polypropylene
CA2114290C (en) 1993-01-27 2006-01-10 Nagabushanam Totakura Post-surgical anti-adhesion device
ATE218893T1 (de) * 1993-08-12 2002-06-15 Neurotech Sa Biokompatible immunoisolatorische kapseln, die genetisch veränderte zellen enthalten
US5542594A (en) 1993-10-06 1996-08-06 United States Surgical Corporation Surgical stapling apparatus with biocompatible surgical fabric
US5431679A (en) 1994-03-10 1995-07-11 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5442032A (en) 1994-03-15 1995-08-15 Ethicon, Inc. Copolymers of 1,4-dioxepan-2-one and 1,5,8,12-tetraoxacyclotetradecane-7-14-dione
DE69525151T2 (de) 1994-04-13 2002-08-14 Research Corp. Technologies, Inc. Methoden zur krankheitsbehandlung unter verwendung von sertoli-zellen und allotransplantat oder xenotransplantat
TW369414B (en) * 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
US5648088A (en) 1995-03-06 1997-07-15 Ethicon, Inc. Blends of absorbable polyoxaesters containing amines and/or amide groups
US5607687A (en) 1995-03-06 1997-03-04 Ethicon, Inc. Polymer blends containing absorbable polyoxaesters
US5597579A (en) 1995-03-06 1997-01-28 Ethicon, Inc. Blends of absorbable polyoxaamides
US5618552A (en) 1995-03-06 1997-04-08 Ethicon, Inc. Absorbable polyoxaesters
US5595751A (en) 1995-03-06 1997-01-21 Ethicon, Inc. Absorbable polyoxaesters containing amines and/or amido groups
US5698213A (en) 1995-03-06 1997-12-16 Ethicon, Inc. Hydrogels of absorbable polyoxaesters
US5464929A (en) 1995-03-06 1995-11-07 Ethicon, Inc. Absorbable polyoxaesters
US5859150A (en) 1995-03-06 1999-01-12 Ethicon, Inc. Prepolymers of absorbable polyoxaesters
US5696213A (en) * 1995-04-21 1997-12-09 Exxon Chemical Patents Inc. Ethylene-α-olefin-diolefin elastomers solution polymerization process
US5700533A (en) 1995-10-05 1997-12-23 You; Chin-San Fiber Braid Material
JP4071283B2 (ja) * 1996-02-05 2008-04-02 旭化成クラレメディカル株式会社 滅菌保護剤及び滅菌方法
US5703200A (en) 1996-03-15 1997-12-30 Ethicon, Inc. Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer
US5796584A (en) 1996-04-30 1998-08-18 Telefonaktiebolaget Lm Ericsson Bridge for power transistors with improved cooling
IL118376A0 (en) * 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
US6200589B1 (en) * 1996-09-13 2001-03-13 The University Of Akron Biological implants of semipermeable amphiphilic membranes
US5854383A (en) 1997-10-06 1998-12-29 Ethicon, Inc. Aliphatic polyesters of trimethylene carbonate epsilon-caprolactone and glycolide
IL138207A0 (en) 1998-03-02 2001-10-31 Applied Vaccine Technologies C Methods and devices for modulating the immune response
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US6551355B1 (en) * 1998-08-14 2003-04-22 Cambridge Scientific, Inc. Tissue transplant coated with biocompatible biodegradable polymer
US20030118630A1 (en) 2001-12-07 2003-06-26 Anthony Cerami Immune modulation device for use in animals

Also Published As

Publication number Publication date
CN1527697A (zh) 2004-09-08
WO2002092054A2 (en) 2002-11-21
CA2447030A1 (en) 2002-11-21
BRPI0209552B1 (pt) 2016-05-10
AU2002305079B8 (en) 2006-05-25
JP2004532243A (ja) 2004-10-21
US20040086517A1 (en) 2004-05-06
WO2002092054A3 (en) 2003-03-27
EP1387670A2 (en) 2004-02-11
DE60229375D1 (de) 2008-11-27
EP1387670B1 (en) 2008-10-15
US7094419B2 (en) 2006-08-22
KR20030096381A (ko) 2003-12-24
US6958158B2 (en) 2005-10-25
US20050106129A1 (en) 2005-05-19
US20030068812A1 (en) 2003-04-10
CN1289063C (zh) 2006-12-13
JP4866535B2 (ja) 2012-02-01
CA2447030C (en) 2010-07-13
AU2002305079B2 (en) 2006-05-11
ATE411001T1 (de) 2008-10-15

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